PMC:1064873 / 28065-28262 JSONTXT

{"project":"LappsTest","denotations":[{"id":"T22126","span":{"begin":164,"end":171},"obj":"Protein"},{"id":"T22125","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T22124","span":{"begin":44,"end":49},"obj":"Protein"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"pmc-enju-pas","denotations":[{"id":"T25261","span":{"begin":188,"end":196},"obj":"NN"},{"id":"T25260","span":{"begin":185,"end":187},"obj":"NN"},{"id":"T25259","span":{"begin":180,"end":184},"obj":"IN"},{"id":"T25258","span":{"begin":174,"end":179},"obj":"NN"},{"id":"T25257","span":{"begin":172,"end":173},"obj":"NN"},{"id":"T25256","span":{"begin":167,"end":171},"obj":"JJ"},{"id":"T25255","span":{"begin":164,"end":166},"obj":"JJ"},{"id":"T25254","span":{"begin":160,"end":163},"obj":"CC"},{"id":"T25253","span":{"begin":157,"end":159},"obj":"NN"},{"id":"T25252","span":{"begin":148,"end":156},"obj":"VB"},{"id":"T25251","span":{"begin":140,"end":147},"obj":"RB"},{"id":"T25250","span":{"begin":137,"end":139},"obj":"IN"},{"id":"T25249","span":{"begin":135,"end":136},"obj":"-RRB-"},{"id":"T25248","span":{"begin":130,"end":135},"obj":"NN"},{"id":"T25247","span":{"begin":128,"end":129},"obj":"CD"},{"id":"T25246","span":{"begin":125,"end":127},"obj":"TO"},{"id":"T25245","span":{"begin":122,"end":124},"obj":"RB"},{"id":"T25244","span":{"begin":121,"end":122},"obj":"-LRB-"},{"id":"T25243","span":{"begin":108,"end":120},"obj":"RB"},{"id":"T25242","span":{"begin":93,"end":107},"obj":"VB"},{"id":"T25241","span":{"begin":84,"end":92},"obj":"NN"},{"id":"T25240","span":{"begin":81,"end":83},"obj":"VB"},{"id":"T25239","span":{"begin":78,"end":80},"obj":"TO"},{"id":"T25238","span":{"begin":72,"end":77},"obj":"VB"},{"id":"T25237","span":{"begin":68,"end":71},"obj":"VB"},{"id":"T25236","span":{"begin":62,"end":67},"obj":"NN"},{"id":"T25235","span":{"begin":60,"end":61},"obj":"-COMMA-"},{"id":"T25234","span":{"begin":50,"end":60},"obj":"NN"},{"id":"T25233","span":{"begin":44,"end":49},"obj":"NN"},{"id":"T25232","span":{"begin":29,"end":43},"obj":"JJ"},{"id":"T25231","span":{"begin":20,"end":28},"obj":"JJ"},{"id":"T25230","span":{"begin":15,"end":19},"obj":"IN"},{"id":"T25229","span":{"begin":3,"end":14},"obj":"NN"},{"id":"T25228","span":{"begin":0,"end":2},"obj":"IN"}],"relations":[{"id":"R12295","pred":"arg2Of","subj":"T25229","obj":"T25228"},{"id":"R12296","pred":"arg1Of","subj":"T25229","obj":"T25230"},{"id":"R12297","pred":"arg1Of","subj":"T25232","obj":"T25231"},{"id":"R12298","pred":"arg2Of","subj":"T25234","obj":"T25230"},{"id":"R12299","pred":"arg1Of","subj":"T25234","obj":"T25232"},{"id":"R12300","pred":"arg1Of","subj":"T25234","obj":"T25233"},{"id":"R12301","pred":"arg1Of","subj":"T25236","obj":"T25237"},{"id":"R12302","pred":"arg2Of","subj":"T25236","obj":"T25238"},{"id":"R12303","pred":"arg1Of","subj":"T25236","obj":"T25240"},{"id":"R12304","pred":"arg1Of","subj":"T25238","obj":"T25228"},{"id":"R12305","pred":"arg1Of","subj":"T25238","obj":"T25235"},{"id":"R12306","pred":"arg2Of","subj":"T25238","obj":"T25237"},{"id":"R12307","pred":"arg3Of","subj":"T25240","obj":"T25238"},{"id":"R12308","pred":"arg1Of","subj":"T25240","obj":"T25239"},{"id":"R12309","pred":"arg2Of","subj":"T25241","obj":"T25240"},{"id":"R12310","pred":"arg2Of","subj":"T25241","obj":"T25242"},{"id":"R12311","pred":"arg1Of","subj":"T25241","obj":"T25250"},{"id":"R12312","pred":"arg1Of","subj":"T25242","obj":"T25243"},{"id":"R12313","pred":"arg1Of","subj":"T25243","obj":"T25244"},{"id":"R12314","pred":"arg1Of","subj":"T25247","obj":"T25245"},{"id":"R12315","pred":"arg1Of","subj":"T25247","obj":"T25246"},{"id":"R12316","pred":"arg2Of","subj":"T25248","obj":"T25244"},{"id":"R12317","pred":"arg1Of","subj":"T25248","obj":"T25247"},{"id":"R12318","pred":"arg3Of","subj":"T25249","obj":"T25244"},{"id":"R12319","pred":"arg1Of","subj":"T25252","obj":"T25251"},{"id":"R12320","pred":"arg1Of","subj":"T25253","obj":"T25254"},{"id":"R12321","pred":"arg2Of","subj":"T25255","obj":"T25254"},{"id":"R12322","pred":"arg2Of","subj":"T25258","obj":"T25250"},{"id":"R12323","pred":"arg1Of","subj":"T25258","obj":"T25252"},{"id":"R12324","pred":"arg1Of","subj":"T25258","obj":"T25253"},{"id":"R12325","pred":"arg1Of","subj":"T25258","obj":"T25255"},{"id":"R12326","pred":"arg1Of","subj":"T25258","obj":"T25256"},{"id":"R12327","pred":"arg1Of","subj":"T25258","obj":"T25257"},{"id":"R12328","pred":"arg1Of","subj":"T25258","obj":"T25259"},{"id":"R12329","pred":"arg2Of","subj":"T25261","obj":"T25259"},{"id":"R12330","pred":"arg1Of","subj":"T25261","obj":"T25260"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T23420","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T23419","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T23418","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T23417","span":{"begin":29,"end":34},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T26400","span":{"begin":62,"end":67},"obj":"http://www.uniprot.org/uniprot/P40763"},{"id":"T26399","span":{"begin":44,"end":49},"obj":"http://www.uniprot.org/uniprot/P40763"},{"id":"T26354","span":{"begin":29,"end":34},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T24246","span":{"begin":167,"end":170},"obj":"http://www.uniprot.org/uniprot/P01730"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"GO-CC","denotations":[{"id":"T23668","span":{"begin":174,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"GO-MF","denotations":[{"id":"T23574","span":{"begin":29,"end":34},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"sentences","denotations":[{"id":"T22822","span":{"begin":0,"end":197},"obj":"Sentence"},{"id":"T165","span":{"begin":0,"end":197},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"simple1","denotations":[{"id":"T24362","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T24361","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T24360","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T24359","span":{"begin":29,"end":34},"obj":"Protein"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T30196","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T30195","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T30194","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T30193","span":{"begin":29,"end":34},"obj":"Protein"},{"id":"T30363","span":{"begin":50,"end":60},"obj":"Positive_regulation"},{"id":"T30362","span":{"begin":93,"end":107},"obj":"Phosphorylation"}],"relations":[{"id":"R16127","pred":"themeOf","subj":"T30194","obj":"T30363"},{"id":"R16129","pred":"themeOf","subj":"T30195","obj":"T30362"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T26730","span":{"begin":35,"end":43},"obj":"Positive_regulation"},{"id":"T26729","span":{"begin":50,"end":60},"obj":"Positive_regulation"},{"id":"T26728","span":{"begin":20,"end":28},"obj":"Negative_regulation"},{"id":"T26552","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T26551","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T26550","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T26549","span":{"begin":29,"end":34},"obj":"Protein"}],"relations":[{"id":"R13469","pred":"themeOf","subj":"T26550","obj":"T26729"},{"id":"R13593","pred":"themeOf","subj":"T26729","obj":"T26728"},{"id":"R13596","pred":"themeOf","subj":"T26729","obj":"T26730"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"DLUT931","denotations":[{"id":"T28819","span":{"begin":35,"end":43},"obj":"Positive_regulation"},{"id":"T28818","span":{"begin":20,"end":28},"obj":"Negative_regulation"},{"id":"T28817","span":{"begin":93,"end":107},"obj":"Phosphorylation"},{"id":"T28816","span":{"begin":50,"end":60},"obj":"Positive_regulation"},{"id":"T28815","span":{"begin":3,"end":14},"obj":"Binding"},{"id":"T28636","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T28635","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T28634","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T28633","span":{"begin":29,"end":34},"obj":"Protein"}],"relations":[{"id":"R15416","pred":"causeOf","subj":"T28633","obj":"T28819"},{"id":"R15417","pred":"themeOf","subj":"T28634","obj":"T28816"},{"id":"R15419","pred":"themeOf","subj":"T28635","obj":"T28815"},{"id":"R15420","pred":"themeOf","subj":"T28635","obj":"T28817"},{"id":"R15483","pred":"themeOf","subj":"T28816","obj":"T28818"},{"id":"R15484","pred":"themeOf","subj":"T28816","obj":"T28819"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T30076","span":{"begin":15,"end":60},"obj":"Regulation"},{"id":"T30063","span":{"begin":20,"end":43},"obj":"Negative_regulation"},{"id":"T30030","span":{"begin":15,"end":60},"obj":"Positive_regulation"},{"id":"T30004","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T29960","span":{"begin":20,"end":43},"obj":"Protein"},{"id":"T29938","span":{"begin":185,"end":187},"obj":"Protein"},{"id":"T29730","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T29768","span":{"begin":157,"end":179},"obj":"Entity"},{"id":"T29766","span":{"begin":84,"end":92},"obj":"Entity"},{"id":"T29764","span":{"begin":157,"end":159},"obj":"Protein"},{"id":"T29820","span":{"begin":164,"end":171},"obj":"Protein"}],"relations":[{"id":"R16017","pred":"themeOf","subj":"T30004","obj":"T30030"},{"id":"R16032","pred":"themeOf","subj":"T30030","obj":"T30076"},{"id":"R16057","pred":"themeOf","subj":"T29960","obj":"T30063"},{"id":"R16059","pred":"causeOf","subj":"T29960","obj":"T30076"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T27615","span":{"begin":196,"end":197},"obj":"."},{"id":"T27614","span":{"begin":188,"end":196},"obj":"NNS"},{"id":"T27613","span":{"begin":185,"end":187},"obj":"NNP"},{"id":"T27612","span":{"begin":180,"end":184},"obj":"IN"},{"id":"T27611","span":{"begin":174,"end":179},"obj":"NNS"},{"id":"T27610","span":{"begin":172,"end":173},"obj":"NNP"},{"id":"T27609","span":{"begin":170,"end":171},"obj":"VBD"},{"id":"T27608","span":{"begin":167,"end":170},"obj":"NNP"},{"id":"T27607","span":{"begin":164,"end":166},"obj":"NNP"},{"id":"T27606","span":{"begin":160,"end":163},"obj":"CC"},{"id":"T27605","span":{"begin":157,"end":159},"obj":"NNP"},{"id":"T27604","span":{"begin":148,"end":156},"obj":"VBN"},{"id":"T27603","span":{"begin":140,"end":147},"obj":"RB"},{"id":"T27601","span":{"begin":135,"end":136},"obj":"-RRB-"},{"id":"T27600","span":{"begin":130,"end":135},"obj":"NNS"},{"id":"T27599","span":{"begin":128,"end":129},"obj":"CD"},{"id":"T27598","span":{"begin":125,"end":127},"obj":"TO"},{"id":"T27597","span":{"begin":122,"end":124},"obj":"IN"},{"id":"T27596","span":{"begin":121,"end":122},"obj":"-LRB-"},{"id":"T27595","span":{"begin":108,"end":120},"obj":"RB"},{"id":"T27594","span":{"begin":93,"end":107},"obj":"VBN"},{"id":"T27593","span":{"begin":84,"end":92},"obj":"JJ"},{"id":"T27592","span":{"begin":81,"end":83},"obj":"VB"},{"id":"T27591","span":{"begin":78,"end":80},"obj":"TO"},{"id":"T27590","span":{"begin":72,"end":77},"obj":"VBN"},{"id":"T27589","span":{"begin":68,"end":71},"obj":"VBD"},{"id":"T27588","span":{"begin":62,"end":67},"obj":"NNP"},{"id":"T27587","span":{"begin":60,"end":61},"obj":","},{"id":"T27586","span":{"begin":50,"end":60},"obj":"NN"},{"id":"T27585","span":{"begin":44,"end":49},"obj":"CD"},{"id":"T27584","span":{"begin":29,"end":43},"obj":"JJ"},{"id":"T27583","span":{"begin":20,"end":28},"obj":"JJ"},{"id":"T27582","span":{"begin":15,"end":19},"obj":"IN"},{"id":"T27581","span":{"begin":3,"end":14},"obj":"NN"},{"id":"T27580","span":{"begin":0,"end":2},"obj":"IN"},{"id":"T27602","span":{"begin":137,"end":139},"obj":"IN"}],"relations":[{"id":"R14351","pred":"prep","subj":"T27580","obj":"T27590"},{"id":"R14356","pred":"pobj","subj":"T27581","obj":"T27580"},{"id":"R14359","pred":"prep","subj":"T27582","obj":"T27581"},{"id":"R14364","pred":"amod","subj":"T27583","obj":"T27586"},{"id":"R14367","pred":"amod","subj":"T27584","obj":"T27586"},{"id":"R14372","pred":"nummod","subj":"T27585","obj":"T27586"},{"id":"R14378","pred":"pobj","subj":"T27586","obj":"T27582"},{"id":"R14382","pred":"punct","subj":"T27587","obj":"T27590"},{"id":"R14386","pred":"nsubjpass","subj":"T27588","obj":"T27590"},{"id":"R14390","pred":"auxpass","subj":"T27589","obj":"T27590"},{"id":"R14393","pred":"ROOT","subj":"T27590","obj":"T27590"},{"id":"R14395","pred":"aux","subj":"T27591","obj":"T27592"},{"id":"R14396","pred":"xcomp","subj":"T27592","obj":"T27590"},{"id":"R14397","pred":"punct","subj":"T27601","obj":"T27594"},{"id":"R14398","pred":"prep","subj":"T27602","obj":"T27594"},{"id":"R14399","pred":"advmod","subj":"T27593","obj":"T27594"},{"id":"R14400","pred":"advmod","subj":"T27603","obj":"T27604"},{"id":"R14401","pred":"attr","subj":"T27594","obj":"T27592"},{"id":"R14402","pred":"amod","subj":"T27604","obj":"T27605"},{"id":"R14403","pred":"pobj","subj":"T27605","obj":"T27602"},{"id":"R14404","pred":"advmod","subj":"T27595","obj":"T27594"},{"id":"R14405","pred":"cc","subj":"T27606","obj":"T27605"},{"id":"R14406","pred":"conj","subj":"T27607","obj":"T27605"},{"id":"R14407","pred":"punct","subj":"T27596","obj":"T27594"},{"id":"R14408","pred":"compound","subj":"T27608","obj":"T27609"},{"id":"R14409","pred":"advcl","subj":"T27609","obj":"T27590"},{"id":"R14410","pred":"compound","subj":"T27610","obj":"T27611"},{"id":"R14411","pred":"quantmod","subj":"T27597","obj":"T27599"},{"id":"R14412","pred":"dobj","subj":"T27611","obj":"T27609"},{"id":"R14413","pred":"prep","subj":"T27612","obj":"T27609"},{"id":"R14414","pred":"quantmod","subj":"T27598","obj":"T27599"},{"id":"R14415","pred":"compound","subj":"T27613","obj":"T27614"},{"id":"R14416","pred":"pobj","subj":"T27614","obj":"T27612"},{"id":"R14417","pred":"punct","subj":"T27615","obj":"T27590"},{"id":"R14418","pred":"nummod","subj":"T27599","obj":"T27600"},{"id":"R14422","pred":"appos","subj":"T27600","obj":"T27594"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T24037","span":{"begin":35,"end":43},"obj":"Positive_regulation"},{"id":"T24036","span":{"begin":93,"end":107},"obj":"Phosphorylation"},{"id":"T24035","span":{"begin":50,"end":60},"obj":"Positive_regulation"},{"id":"T24034","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T24033","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T24032","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T24031","span":{"begin":29,"end":34},"obj":"Protein"}],"relations":[{"id":"R11458","pred":"causeOf","subj":"T24031","obj":"T24037"},{"id":"R11459","pred":"themeOf","subj":"T24032","obj":"T24035"},{"id":"R11460","pred":"themeOf","subj":"T24033","obj":"T24036"},{"id":"R11461","pred":"themeOf","subj":"T24035","obj":"T24037"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"test3","denotations":[{"id":"T22599","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T22598","span":{"begin":93,"end":107},"obj":"Phosphorylation"},{"id":"T22597","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T22596","span":{"begin":50,"end":60},"obj":"Positive_regulation"},{"id":"T22595","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T22594","span":{"begin":35,"end":43},"obj":"Positive_regulation"},{"id":"T22593","span":{"begin":29,"end":34},"obj":"Protein"},{"id":"T22592","span":{"begin":20,"end":28},"obj":"Negative_regulation"},{"id":"T22332","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T22331","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T22330","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T22329","span":{"begin":29,"end":34},"obj":"Protein"}],"relations":[{"id":"R11056","pred":"causeOf","subj":"T22593","obj":"T22594"},{"id":"R11057","pred":"themeOf","subj":"T22594","obj":"T22592"},{"id":"R11058","pred":"themeOf","subj":"T22595","obj":"T22596"},{"id":"R11059","pred":"themeOf","subj":"T22596","obj":"T22594"},{"id":"R11060","pred":"themeOf","subj":"T22597","obj":"T22598"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}

{"project":"testone","denotations":[{"id":"T21799","span":{"begin":167,"end":170},"obj":"Protein"},{"id":"T21798","span":{"begin":62,"end":67},"obj":"Protein"},{"id":"T21797","span":{"begin":44,"end":49},"obj":"Protein"},{"id":"T21796","span":{"begin":29,"end":34},"obj":"Protein"},{"id":"T21980","span":{"begin":93,"end":107},"obj":"Phosphorylation"},{"id":"T21979","span":{"begin":84,"end":92},"obj":"Entity"},{"id":"T21978","span":{"begin":50,"end":60},"obj":"Positive_regulation"},{"id":"T21977","span":{"begin":35,"end":43},"obj":"Positive_regulation"},{"id":"T21976","span":{"begin":20,"end":28},"obj":"Negative_regulation"},{"id":"T21975","span":{"begin":3,"end":14},"obj":"Binding"}],"relations":[{"id":"R10883","pred":"causeOf","subj":"T21796","obj":"T21977"},{"id":"R10884","pred":"themeOf","subj":"T21797","obj":"T21978"},{"id":"R10885","pred":"themeOf","subj":"T21798","obj":"T21980"},{"id":"R10967","pred":"themeOf","subj":"T21977","obj":"T21976"},{"id":"R10968","pred":"themeOf","subj":"T21978","obj":"T21977"},{"id":"R10969","pred":"themeOf","subj":"T21979","obj":"T21980"}],"text":"In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients."}