CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 63580-64056 JSONTXT

{"project":"CORD-19-SciBite-sentences","denotations":[{"id":"T731","span":{"begin":0,"end":476},"obj":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SDC4"},{"id":"T733","span":{"begin":0,"end":476},"obj":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PRKCA"},{"id":"T737","span":{"begin":0,"end":476},"obj":"http://purl.obolibrary.org/obo/GO0003924"},{"id":"T738","span":{"begin":0,"end":476},"obj":"http://purl.obolibrary.org/obo/GO0015629"}],"attributes":[{"id":"A731","pred":"class","subj":"T731","obj":"GENE"},{"id":"A733","pred":"class","subj":"T733","obj":"GENE"},{"id":"A737","pred":"class","subj":"T737","obj":"GOONTOL"},{"id":"A738","pred":"class","subj":"T738","obj":"GOONTOL"}],"text":"This potentiation is accomplished by a clustering-dependent increase in the association of syndecan-4 with both PIP 2 and PKCα, resulting in the formation of a multimeric ternary complex of these three molecules (Bass and Humphries, 2002; Lim et al., 2003) . Syndecan-4 clustering also induces the activation of Rho family GTPases and FAK, leading to substantial reorganization of the actin cytoskeleton downstream from syndecan-4 multimerization (Yoneda and Couchman, 2003) ."}

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T74","span":{"begin":0,"end":258},"obj":"Sentence"},{"id":"T75","span":{"begin":259,"end":476},"obj":"Sentence"}],"text":"This potentiation is accomplished by a clustering-dependent increase in the association of syndecan-4 with both PIP 2 and PKCα, resulting in the formation of a multimeric ternary complex of these three molecules (Bass and Humphries, 2002; Lim et al., 2003) . Syndecan-4 clustering also induces the activation of Rho family GTPases and FAK, leading to substantial reorganization of the actin cytoskeleton downstream from syndecan-4 multimerization (Yoneda and Couchman, 2003) ."}

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T316","span":{"begin":0,"end":258},"obj":"Sentence"},{"id":"TextSentencer_T317","span":{"begin":259,"end":476},"obj":"Sentence"},{"id":"TextSentencer_T316","span":{"begin":0,"end":258},"obj":"Sentence"},{"id":"TextSentencer_T317","span":{"begin":259,"end":476},"obj":"Sentence"},{"id":"T59071","span":{"begin":0,"end":258},"obj":"Sentence"},{"id":"T88857","span":{"begin":259,"end":476},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This potentiation is accomplished by a clustering-dependent increase in the association of syndecan-4 with both PIP 2 and PKCα, resulting in the formation of a multimeric ternary complex of these three molecules (Bass and Humphries, 2002; Lim et al., 2003) . Syndecan-4 clustering also induces the activation of Rho family GTPases and FAK, leading to substantial reorganization of the actin cytoskeleton downstream from syndecan-4 multimerization (Yoneda and Couchman, 2003) ."}

{"project":"Epistemic_Statements","denotations":[{"id":"T134","span":{"begin":0,"end":258},"obj":"Epistemic_statement"}],"text":"This potentiation is accomplished by a clustering-dependent increase in the association of syndecan-4 with both PIP 2 and PKCα, resulting in the formation of a multimeric ternary complex of these three molecules (Bass and Humphries, 2002; Lim et al., 2003) . Syndecan-4 clustering also induces the activation of Rho family GTPases and FAK, leading to substantial reorganization of the actin cytoskeleton downstream from syndecan-4 multimerization (Yoneda and Couchman, 2003) ."}