BB-rel@ldeleger:BB-rel-20174624 / 665-1672
Annnotations
bionlp-ost-19-BB-rel-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-1007 | Paragraph | denotes | In this study, we utilized wild-type and mutant strains of Yersinia to test the contribution of YopJ and YopP on induction of apoptosis in human monocyte-derived macrophages (HMDM) and neutrophils. Whereas YopJ and YopP similarly induced apoptosis in HMDMs, interaction of human neutrophils with virulence plasmid-containing Yersinia did not result in PMN caspase activation, release of LDH, or loss of membrane integrity greater than PMN controls. In contrast, interaction of human PMNs with the virulence plasmid-deficient Y. pestis strain KIM6 resulted in increased surface exposure of phosphatidylserine (PS) and cell death. PMN reactive oxygen species (ROS) production was inhibited in a virulence plasmid-dependent but YopJ/YopP-independent manner. Following phagocytic interaction with Y. pestis strain KIM6, inhibition of PMN ROS production with diphenyleneiodonium chloride resulted in a reduction of PMN cell death similar to that induced by the virulence plasmid-containing strain Y. pestis KIM5. |
| T27 | 27-36 | Phenotype | denotes | wild-type |
| T28 | 41-47 | Phenotype | denotes | mutant |
| T29 | 59-67 | Microorganism | denotes | Yersinia |
| T30 | 139-173 | Habitat | denotes | human monocyte-derived macrophages |
| T31 | 139-144 | Habitat | denotes | human |
| T32 | 175-179 | Habitat | denotes | HMDM |
| T33 | 185-196 | Habitat | denotes | neutrophils |
| T34 | 251-256 | Habitat | denotes | HMDMs |
| T35 | 273-290 | Habitat | denotes | human neutrophils |
| T36 | 273-278 | Habitat | denotes | human |
| T37 | 296-305 | Phenotype | denotes | virulence |
| T38 | 325-333 | Microorganism | denotes | Yersinia |
| T39 | 352-355 | Habitat | denotes | PMN |
| T40 | 435-438 | Habitat | denotes | PMN |
| T41 | 477-487 | Habitat | denotes | human PMNs |
| T42 | 477-482 | Habitat | denotes | human |
| T43 | 497-506 | Phenotype | denotes | virulence |
| T44 | 525-546 | Microorganism | denotes | Y. pestis strain KIM6 |
| T45 | 617-621 | Habitat | denotes | cell |
| T46 | 629-632 | Habitat | denotes | PMN |
| T47 | 693-702 | Phenotype | denotes | virulence |
| T48 | 793-814 | Microorganism | denotes | Y. pestis strain KIM6 |
| T49 | 830-833 | Habitat | denotes | PMN |
| T50 | 910-918 | Habitat | denotes | PMN cell |
| T51 | 956-965 | Phenotype | denotes | virulence |
| T52 | 992-1006 | Microorganism | denotes | Y. pestis KIM5 |
| E7 | 59-67 | Lives_In | denotes | Yersinia |
| E8 | 59-67 | Exhibits | denotes | Yersinia |
| E9 | 325-333 | Lives_In | denotes | Yersinia |
| E10 | 325-333 | Exhibits | denotes | Yersinia |
| E11 | 992-1006 | Exhibits | denotes | Y. pestis KIM5 |
| R13 | E7 | T29 | Microorganism | Yersinia,Yersinia |
| R14 | E7 | T31 | Location | Yersinia,human |
| R15 | E8 | T29 | Microorganism | Yersinia,Yersinia |
| R16 | E8 | T27 | Property | Yersinia,wild-type |
| R17 | E9 | T38 | Microorganism | Yersinia,Yersinia |
| R18 | E9 | T36 | Location | Yersinia,human |
| R19 | E10 | T38 | Microorganism | Yersinia,Yersinia |
| R20 | E10 | T37 | Property | Yersinia,virulence |
| R21 | E11 | T52 | Microorganism | Y. pestis KIM5,Y. pestis KIM5 |
| R22 | E11 | T51 | Property | Y. pestis KIM5,virulence |