BB-rel@ldeleger:BB-rel-17687514 JSONTXT

Annnotations TAB JSON ListView MergeView

bionlp-ost-19-BB-rel-train

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1 0-130 Title denotes Unveiling molecular mechanisms of bacterial surface proteins: Streptococcus pneumoniae as a model organism for structural studies.
T3 62-86 Microorganism denotes Streptococcus pneumoniae
T2 131-1204 Paragraph denotes Bacteria present a variety of molecules either on their surface or in a cell-free form. These molecules take part in numerous processes in the interactions with their host, with its tissues and other molecules. These molecules are essential to bacterial pathogenesis either during colonization or the spread/invasion stages, and most are virulence factors. This review is focused on such molecules using Streptococcus pneumoniae, a Gram-positive bacterium, as an example. Selected surface proteins are introduced, their structure described, and, whenever available, their mechanisms of function on an atomic level are explained. Such mechanisms for hyaluronate lyase, pneumococcal surface protein A, pneumolysin, histidine-triad and fibronectin-binding proteins are discussed. Elucidation of molecular mechanisms of virulence factors is essential for the understanding of bacteria and their functional properties. Structural biology appears pivotal for these studies, as structural and mechanistic insights facilitate rational approach to the development of new treatments.
T4 375-397 Phenotype denotes bacterial pathogenesis
T5 469-478 Phenotype denotes virulence
T6 535-559 Microorganism denotes Streptococcus pneumoniae
T7 563-576 Phenotype denotes Gram-positive
T8 947-956 Phenotype denotes virulence
E1 535-559 Exhibits denotes Streptococcus pneumoniae
R1 E1 T6 Microorganism Streptococcus pneumoniae,Streptococcus pneumoniae
R2 E1 T7 Property Streptococcus pneumoniae,Gram-positive