BB-norm+ner@ldeleger:BB-norm+ner-18789156 / 1809-2536 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/BB-norm+ner@ldeleger/sourceid/BB-norm+ner-18789156","sourcedb":"BB-norm+ner@ldeleger","sourceid":"BB-norm+ner-18789156","text":"Altogether, our results demonstrate that the interaction between surface nucleolin and its bacterial ligand EF-Tu plays an important role in Francisella tularensis adhesion and entry process and may therefore facilitate invasion of host tissues. Since phagosomal escape and intra-cytosolic multiplication of LVS in infected monocytes are very similar to those of human pathogenic F. tularensis ssp tularensis, the mechanism of entry into monocyte-like THP-1 cells, involving interaction between EF-Tu and nucleolin, might be similar in the two subspecies. Thus, the use of either nucleolin-specific pseudopeptide HB-19 or recombinant EF-Tu could provide attractive therapeutic approaches for modulating F. tularensis infection.","tracks":[{"project":"bionlp-ost-19-BB-norm-ner-dev","denotations":[{"id":"T4","span":{"begin":0,"end":727},"obj":"Paragraph"},{"id":"T33","span":{"begin":141,"end":163},"obj":"Microorganism"},{"id":"T34","span":{"begin":164,"end":172},"obj":"Phenotype"},{"id":"T35","span":{"begin":220,"end":244},"obj":"Phenotype"},{"id":"T36","span":{"begin":232,"end":244},"obj":"Habitat"},{"id":"T37","span":{"begin":308,"end":311},"obj":"Microorganism"},{"id":"T38","span":{"begin":315,"end":333},"obj":"Habitat"},{"id":"T40","span":{"begin":363,"end":379},"obj":"Phenotype"},{"id":"T39","span":{"begin":363,"end":368},"obj":"Habitat"},{"id":"T41","span":{"begin":380,"end":408},"obj":"Microorganism"},{"id":"T42","span":{"begin":438,"end":463},"obj":"Habitat"},{"id":"T43","span":{"begin":703,"end":716},"obj":"Microorganism"}],"attributes":[{"id":"A41","pred":"OntoBiotope","subj":"T40","obj":"OBT:002806"},{"id":"A35","pred":"OntoBiotope","subj":"T34","obj":"OBT:000029"},{"id":"A45","pred":"NCBI_Taxonomy","subj":"T43","obj":"263"},{"id":"A36","pred":"OntoBiotope","subj":"T35","obj":"OBT:002806"},{"id":"A43","pred":"OntoBiotope","subj":"T42","obj":"OBT:003001"},{"id":"A44","pred":"OntoBiotope","subj":"T42","obj":"OBT:000062"},{"id":"A38","pred":"NCBI_Taxonomy","subj":"T37","obj":"263"},{"id":"A39","pred":"OntoBiotope","subj":"T38","obj":"OBT:003001"},{"id":"A40","pred":"OntoBiotope","subj":"T39","obj":"OBT:002488"},{"id":"A34","pred":"NCBI_Taxonomy","subj":"T33","obj":"263"},{"id":"A37","pred":"OntoBiotope","subj":"T36","obj":"OBT:000196"},{"id":"A42","pred":"NCBI_Taxonomy","subj":"T41","obj":"119856"},{"subj":"T4","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T33","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T34","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T35","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T36","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T37","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T38","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T40","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T39","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T41","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T42","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"},{"subj":"T43","pred":"source","obj":"bionlp-ost-19-BB-norm-ner-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bionlp-ost-19-BB-norm-ner-dev","color":"#ecd993","default":true}]}]}}