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PubMed:17450505 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Effect of essential oils and isolated compounds from Pimpinella species on NF-kappaB: a target for antiinflammatory therapy.
T2 125-275 Sentence denotes Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-kappaB mediated transcription in SW1353 cells.
T3 276-350 Sentence denotes Twelve oils were effective in inhibiting NF-kappaB mediated transcription.
T4 351-498 Sentence denotes Especially the roots of P. corymbosa, P. tragium and P. rhodanta showed potent activities with IC(50) values of 2, 3 and 6 microg/mL, respectively.
T5 499-864 Sentence denotes Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3-methyloxiranyl)phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3-methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-kappaB mediated transcription with IC(50) values of 5.5, 1.2, 0.01, 3.6 and 11 microg/mL, respectively.
T6 865-921 Sentence denotes None of the compounds were cytotoxic to mammalian cells.
T7 922-1119 Sentence denotes These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation.
T1 0-124 Sentence denotes Effect of essential oils and isolated compounds from Pimpinella species on NF-kappaB: a target for antiinflammatory therapy.
T2 125-275 Sentence denotes Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-kappaB mediated transcription in SW1353 cells.
T3 276-350 Sentence denotes Twelve oils were effective in inhibiting NF-kappaB mediated transcription.
T4 351-498 Sentence denotes Especially the roots of P. corymbosa, P. tragium and P. rhodanta showed potent activities with IC(50) values of 2, 3 and 6 microg/mL, respectively.
T5 499-864 Sentence denotes Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3-methyloxiranyl)phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3-methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-kappaB mediated transcription with IC(50) values of 5.5, 1.2, 0.01, 3.6 and 11 microg/mL, respectively.
T6 865-921 Sentence denotes None of the compounds were cytotoxic to mammalian cells.
T7 922-1119 Sentence denotes These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation.