asco@alo33:167505 JSONTXT

{"project":"ASCO_abstracts","denotations":[{"id":"T1","span":{"begin":116,"end":119},"obj":"CellLine"},{"id":"T2","span":{"begin":275,"end":278},"obj":"CellLine"},{"id":"T3","span":{"begin":1198,"end":1201},"obj":"CellLine"},{"id":"T4","span":{"begin":1324,"end":1327},"obj":"CellLine"},{"id":"T5","span":{"begin":1425,"end":1428},"obj":"CellLine"},{"id":"T6","span":{"begin":1751,"end":1754},"obj":"CellLine"}],"attributes":[{"id":"A1","pred":"cellosaurus_accession_id","subj":"T1","obj":"CVCL_1R13"},{"id":"A2","pred":"cellosaurus_accession_id","subj":"T2","obj":"CVCL_1R13"},{"id":"A3","pred":"cellosaurus_accession_id","subj":"T3","obj":"CVCL_1R13"},{"id":"A4","pred":"cellosaurus_accession_id","subj":"T4","obj":"CVCL_1R13"},{"id":"A5","pred":"cellosaurus_accession_id","subj":"T5","obj":"CVCL_1R13"},{"id":"A6","pred":"cellosaurus_accession_id","subj":"T6","obj":"CVCL_1R13"}],"text":" Background: Since the 1980s, adenocarcinoma AC of the lung has become more common than squamous cell carcinoma SCC . Given the differences in smoking patterns, it is unclear if the same holds true among veterans. In this study, e compare the distribution of lung AC and SCC in the veterans population to that in the general population. We also looked at the survival of patients ith different histologies in the VA population. Methods: We performed a retrospective analysis of the Veteranx0027;s Affairs Comprehensive Cancer Registry of NSCLC non-small cell lung cancer patients diagnosed beteen 1995 and 2009. Data as analyzed on SPSS program. Survival estimates ere derived using the Kaplan Meier Method and Cox proportional hazard model. A value of P lt0.05 as considered statistically significant. Data as compared to data from the Surveillance, Epidemiology, and End Results SEER . The study as approved by the local institutional IRB. Results: This analysis included 64,689 patients ith NSCLC. The histological subtypes of NSCLC in the VA population and comparison ith SEER data is summarized in the table belo. The proportion of AC as significantly higher in the SEER database, hile SCC as more common in the VA population. Veteran patients ith AC presented more frequently ith metastatic disease compared to SCC 47.0 percent vs 32.2 percent, plt0.001 . On multivariate analysis, median survival as higher in SCC than in AC 9.6 vs 8.2 months, plt0.001 . AC as associated ith orse overall survival hazard ratio 1.06; 95 percent confidence interval 1.03-1.09 . Conclusions: There is a significant difference in histologic subtypes of NSCLC beteen veterans and the general population. AC tended to present at a more advanced stage than SCC, and as associated ith inferior survival. Veteran specific research is necessary in order to improve lung cancer outcomes for that specific cohort. HistologyVA population percent n = 64689SEER data percent n = 101018One-tailed P-valueAdenocarcinoma35.147.0lt0.001Squamous cell carcinoma43.131.9lt0.001Large cell carcinoma5.52.6lt0.001NOS16.318.5lt0.001,J Clin Oncol 34, 2016 suppl; abstr e20590 ,Publication Only:"}