asco@alo33:161361 JSONTXT

{"project":"ASCO_abstracts","denotations":[{"id":"T1","span":{"begin":139,"end":141},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":369,"end":371},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":551,"end":553},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":577,"end":579},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":882,"end":907},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":920,"end":926},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1134,"end":1136},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1393,"end":1395},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1714,"end":1716},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1834,"end":1854},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1917,"end":1919},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1939,"end":1942},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1998,"end":2000},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":2136,"end":2139},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":2211,"end":2213},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":2360,"end":2376},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0008377"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0008377"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0008377"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0008377"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0003330"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0021178"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0008377"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0008377"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0008377"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0005362"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0008377"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"0017169"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0008377"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"0012833"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"0008377"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"0008315"}],"text":" Background: The impact of multiple transrectal ultrasound-guided prostate biopsies TRUS-Bx on the complexity of radical prostatectomy RP remains unknon. Data analyzing the effect of multiple previous biopsies in surgical outcomes is sparse and no information about immediate postoperative outcomes is available. We evaluated the impact of repeated TRUS-Bx before RP on surgical outcomes. Methods: A population-based cohort study as designed to compare surgical outcomes beteen patients ith one previous biopsy to patients ith 2 biopsies before RP. All patients ho had a RP performed in the province of Ontario from April 1, 2002 to March 31, 2013 ere categorized according to the number of prior TRUS-Bx. The primary end point as a composite complication index encompassing the need of postoperative treatment of urinary or rectourethral fistula, intestinal diversion, upper urinary tract obstruction or ureteral injury. Secondary outcomes included functional and health care related. Follo-up time for all outcomes ranged from 12-24 months. Results: Among 27,637 patients, 4780 17.3 percent had 2 biopsies performed before RP. The proportion of cases ho experienced the composite end point as similar beteen patients ith one TRUS-Bx compared to those ith 2 TRUS-Bx 1.1 percent vs 1.2 percent, p = 0.38 . Patients ith 2 biopsies ere more likely to have a blood transfusion during RP hospitalization compared to patients ith only one biopsy 15.5 percent vs 12.8 percent, OR 1.25 95 percent CI 1.15-1.37, p lt 0.01 , hile readmission rate and 30-day mortality ere similar 3.6 percent vs 3.3 percent p = 0.35, 0.2 vs 0.1 percent p = 0.43 . Patients ith multiple TRUS-Bx ere more likely to require post RP urodynamic evaluation OR 1.53, 95 percent CI 1.23-1.91, p lt 0.01 but ere not at increased risk of incontinence or erectile dysfunction invasive therapies. Conclusions: Perioperative outcomes after RP are similar beteen men ith single or mutiple TRUS-Bx. Multiple TRUS-Bx before RP is associated ith slightly increased risk of perioperative blood transfusion and postoperative urodynamic evaluation. This information can be used to counsel patients about similar postoperative outcomes after RP despite having multiple biopsies, including those under AS protocols.,J Clin Oncol 34, 2016 suppl; abstr e16554 ,Publication Only Genitourinary Prostate Cancer \n"}