SeeDev-binary@ldeleger:SeeDev-binary-9657152-3 JSONTXT

{"project":"bionlp-ost-19-SeeDev-bin-test","denotations":[{"id":"T1","span":{"begin":23,"end":27},"obj":"Protein"},{"id":"T2","span":{"begin":61,"end":90},"obj":"Protein_Family"},{"id":"T3","span":{"begin":61,"end":65},"obj":"Protein"},{"id":"T4","span":{"begin":94,"end":104},"obj":"Genotype"},{"id":"T5","span":{"begin":146,"end":150},"obj":"Protein_Family"},{"id":"T6","span":{"begin":152,"end":155},"obj":"Protein"},{"id":"T7","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T9-0","span":{"begin":161,"end":164},"obj":"_FRAGMENT"},{"id":"T9-1","span":{"begin":166,"end":167},"obj":"Protein"},{"id":"T8-0","span":{"begin":161,"end":164},"obj":"_FRAGMENT"},{"id":"T8-1","span":{"begin":168,"end":169},"obj":"Protein"},{"id":"T10-0","span":{"begin":161,"end":164},"obj":"_FRAGMENT"},{"id":"T10-1","span":{"begin":170,"end":171},"obj":"Protein"},{"id":"T11","span":{"begin":233,"end":237},"obj":"Protein"},{"id":"T12","span":{"begin":248,"end":261},"obj":"Protein_Family"},{"id":"T13","span":{"begin":283,"end":291},"obj":"Protein_Domain"},{"id":"T14","span":{"begin":420,"end":425},"obj":"Genotype"},{"id":"T15","span":{"begin":430,"end":439},"obj":"Genotype"},{"id":"T16","span":{"begin":440,"end":453},"obj":"Protein_Family"},{"id":"T17","span":{"begin":511,"end":523},"obj":"Protein_Family"},{"id":"T18","span":{"begin":541,"end":545},"obj":"Protein"},{"id":"T19","span":{"begin":604,"end":609},"obj":"Genotype"},{"id":"T20","span":{"begin":614,"end":623},"obj":"Genotype"},{"id":"T21","span":{"begin":624,"end":636},"obj":"Protein_Family"},{"id":"T22","span":{"begin":782,"end":786},"obj":"Protein_Family"},{"id":"T23","span":{"begin":862,"end":867},"obj":"Genotype"},{"id":"T24","span":{"begin":868,"end":871},"obj":"Protein_Family"},{"id":"T25","span":{"begin":892,"end":897},"obj":"Genotype"},{"id":"T26","span":{"begin":944,"end":948},"obj":"Protein"},{"id":"T28-0","span":{"begin":944,"end":947},"obj":"_FRAGMENT"},{"id":"T28-1","span":{"begin":950,"end":951},"obj":"Protein"},{"id":"T27-0","span":{"begin":944,"end":947},"obj":"_FRAGMENT"},{"id":"T27-1","span":{"begin":953,"end":954},"obj":"Protein"},{"id":"T29-0","span":{"begin":944,"end":947},"obj":"_FRAGMENT"},{"id":"T29-1","span":{"begin":960,"end":961},"obj":"Protein"},{"id":"T30","span":{"begin":993,"end":1002},"obj":"Genotype"},{"id":"T31","span":{"begin":1003,"end":1006},"obj":"Protein_Family"}],"relations":[{"id":"C-T9-0","pred":"_lexicallyChainedTo","subj":"T9-1","obj":"T9-0"},{"id":"C-T8-0","pred":"_lexicallyChainedTo","subj":"T8-1","obj":"T8-0"},{"id":"C-T10-0","pred":"_lexicallyChainedTo","subj":"T10-1","obj":"T10-0"},{"id":"C-T28-0","pred":"_lexicallyChainedTo","subj":"T28-1","obj":"T28-0"},{"id":"C-T27-0","pred":"_lexicallyChainedTo","subj":"T27-1","obj":"T27-0"},{"id":"C-T29-0","pred":"_lexicallyChainedTo","subj":"T29-1","obj":"T29-0"}],"text":"We\nhave shown that the LEC1 polypeptide is homologous to the HAP3 subunit\nof the CBF class of eukaryotic transcriptional activators that includes\nNF-Y, CP1, and HAP2/3/4/5 (Johnson and McKnight 1989).\nThe sequence similarity between LEC1 and other HAP3 subunits is\nrestricted to the B domain, consistent with the finding that this domain\nis conserved evolutionarily (Li et al. 1992).\nFurthermore, amino acid residues of yeast and mammalian HAP3 subunits\nrequired for DNA binding and for interactions with other CBF subunits\nare conserved in LEC1 (Figure 4;\n[55] and [44]).\nExperiments demonstrating that yeast and mammalian CBF subunits can be\ncombined to form DNA-binding complexes indicate that this amino acid\nsequence similarity underlies functional conservation ([6] and [43]).CBFs\nare heteroligomeric transcription factors, but it is not known whether\nthe plant CBF is organized as its yeast counterpart into four\nnonhomologous subunits, HAP2, 3, 4, and 5, or is similar to the trimeric\nmammalian CBF ([24] and [27]).\n"}