SeeDev-binary@ldeleger:SeeDev-binary-21330492-6 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/SeeDev-binary@ldeleger/sourceid/SeeDev-binary-21330492-6","sourcedb":"SeeDev-binary@ldeleger","sourceid":"SeeDev-binary-21330492-6","text":"Identification of Repressors of the Maturation Program during Embryogenesis\nOne lingering mystery has been the identity of the genes directly repressing the maturation program early in development.\nOur microarray analysis indicated that ASIL1, HDA6/SIL1, and CLF were down-regulated in dcl1-15. These genes have previously been shown to repress the transcription of the LEC genes and other maturation-related genes in seedlings. Interestingly, several other histone deacetylases were down-regulated\n(HDA5, -9, -10, and HDT1) as well as the closest homolog to ASIL1 (ASIL2). It has already been shown that ASIL1 binds to a GT-box, which is present in both the promoters of the LEC genes and of\nthe genes encoding storage products, regulating the program at least at two levels (Gao et al., 2009). We analyzed single and double mutant combinations of asil1-1, asil2-1, and sil1-1 and found that these genes redundantly repress the maturation program during early embryogenesis, downstream of miRNA targets.\nThus, our studies demonstrate, to our knowledge for the first time, that the same genetic mechanism negatively regulates seed\nstorage genes during early embryogenesis and seedling development.\n","tracks":[{"project":"bionlp-ost-19-SeeDev-bin-train","denotations":[{"id":"T1","span":{"begin":36,"end":54},"obj":"Regulatory_Network"},{"id":"T2","span":{"begin":36,"end":46},"obj":"Development_Phase"},{"id":"T3","span":{"begin":62,"end":75},"obj":"Development_Phase"},{"id":"T4","span":{"begin":127,"end":196},"obj":"Regulatory_Network"},{"id":"T5","span":{"begin":157,"end":167},"obj":"Development_Phase"},{"id":"T6","span":{"begin":176,"end":196},"obj":"Development_Phase"},{"id":"T7","span":{"begin":237,"end":242},"obj":"Gene"},{"id":"T8","span":{"begin":244,"end":248},"obj":"Gene"},{"id":"T9","span":{"begin":249,"end":253},"obj":"Gene"},{"id":"T10","span":{"begin":259,"end":262},"obj":"Gene"},{"id":"T11","span":{"begin":286,"end":293},"obj":"Genotype"},{"id":"T12","span":{"begin":370,"end":373},"obj":"Gene_Family"},{"id":"T13","span":{"begin":418,"end":427},"obj":"Tissue"},{"id":"T14","span":{"begin":458,"end":478},"obj":"Protein_Family"},{"id":"T15","span":{"begin":500,"end":504},"obj":"Gene"},{"id":"T17-0","span":{"begin":500,"end":503},"obj":"_FRAGMENT"},{"id":"T17-1","span":{"begin":507,"end":508},"obj":"Gene"},{"id":"T16-0","span":{"begin":500,"end":503},"obj":"_FRAGMENT"},{"id":"T16-1","span":{"begin":511,"end":513},"obj":"Gene"},{"id":"T18","span":{"begin":519,"end":523},"obj":"Gene"},{"id":"T19","span":{"begin":559,"end":564},"obj":"Gene"},{"id":"T20","span":{"begin":566,"end":571},"obj":"Gene"},{"id":"T21","span":{"begin":605,"end":610},"obj":"Protein"},{"id":"T22","span":{"begin":622,"end":628},"obj":"Box"},{"id":"T23","span":{"begin":659,"end":685},"obj":"Promoter"},{"id":"T24-0","span":{"begin":659,"end":668},"obj":"_FRAGMENT"},{"id":"T24-1","span":{"begin":690,"end":728},"obj":"Promoter"},{"id":"T25","span":{"begin":676,"end":685},"obj":"Gene_Family"},{"id":"T26","span":{"begin":712,"end":728},"obj":"Pathway"},{"id":"T27","span":{"begin":849,"end":856},"obj":"Genotype"},{"id":"T28","span":{"begin":858,"end":865},"obj":"Genotype"},{"id":"T29","span":{"begin":871,"end":877},"obj":"Genotype"},{"id":"T30","span":{"begin":929,"end":947},"obj":"Regulatory_Network"},{"id":"T31","span":{"begin":929,"end":939},"obj":"Development_Phase"},{"id":"T32","span":{"begin":955,"end":974},"obj":"Development_Phase"},{"id":"T33","span":{"begin":990,"end":995},"obj":"RNA"},{"id":"T34","span":{"begin":1126,"end":1130},"obj":"Tissue"},{"id":"T35","span":{"begin":1152,"end":1171},"obj":"Development_Phase"},{"id":"T36","span":{"begin":1176,"end":1196},"obj":"Development_Phase"},{"id":"T37","span":{"begin":1176,"end":1184},"obj":"Tissue"},{"id":"E1","span":{"begin":286,"end":293},"obj":"Regulates_Expression"},{"id":"E2","span":{"begin":286,"end":293},"obj":"Regulates_Expression"},{"id":"E3","span":{"begin":286,"end":293},"obj":"Regulates_Expression"},{"id":"E4","span":{"begin":849,"end":856},"obj":"Regulates_Process"},{"id":"E5","span":{"begin":871,"end":877},"obj":"Regulates_Process"},{"id":"E6","span":{"begin":858,"end":865},"obj":"Regulates_Process"},{"id":"E7","span":{"begin":559,"end":564},"obj":"Is_Functionally_Equivalent_To"},{"id":"E8","span":{"begin":249,"end":253},"obj":"Has_Sequence_Identical_To"},{"id":"E9","span":{"begin":605,"end":610},"obj":"Binds_To"},{"id":"E10","span":{"begin":622,"end":628},"obj":"Composes_Primary_Structure"},{"id":"E11","span":{"begin":622,"end":628},"obj":"Composes_Primary_Structure"},{"id":"E12-0","span":{"begin":500,"end":503},"obj":"_FRAGMENT"},{"id":"E12-1","span":{"begin":511,"end":513},"obj":"Transcribes_Or_Translates_To"},{"id":"E13","span":{"begin":500,"end":504},"obj":"Transcribes_Or_Translates_To"},{"id":"E14-0","span":{"begin":500,"end":503},"obj":"_FRAGMENT"},{"id":"E14-1","span":{"begin":507,"end":508},"obj":"Transcribes_Or_Translates_To"},{"id":"E15","span":{"begin":519,"end":523},"obj":"Transcribes_Or_Translates_To"},{"id":"E16","span":{"begin":955,"end":974},"obj":"Regulates_Process"}],"relations":[{"id":"R19","pred":"DNA_Part","subj":"E10","obj":"T22"},{"id":"R20","pred":"DNA","subj":"E10","obj":"T24-0"},{"id":"R21","pred":"DNA_Part","subj":"E11","obj":"T22"},{"id":"R22","pred":"DNA","subj":"E11","obj":"T23"},{"id":"R23","pred":"Source","subj":"E12-0","obj":"T16-0"},{"id":"R24","pred":"Product","subj":"E12-0","obj":"T14"},{"id":"R25","pred":"Source","subj":"E13","obj":"T15"},{"id":"R26","pred":"Product","subj":"E13","obj":"T14"},{"id":"R27","pred":"Source","subj":"E14-0","obj":"T17-0"},{"id":"R28","pred":"Product","subj":"E14-0","obj":"T14"},{"id":"R29","pred":"Source","subj":"E15","obj":"T18"},{"id":"R30","pred":"Product","subj":"E15","obj":"T14"},{"id":"R31","pred":"Agent","subj":"E16","obj":"T32"},{"id":"R32","pred":"Process","subj":"E16","obj":"T30"},{"id":"R1","pred":"Agent","subj":"E1","obj":"T11"},{"id":"R2","pred":"DNA","subj":"E1","obj":"T8"},{"id":"R3","pred":"Agent","subj":"E2","obj":"T11"},{"id":"R4","pred":"DNA","subj":"E2","obj":"T10"},{"id":"R5","pred":"Agent","subj":"E3","obj":"T11"},{"id":"R6","pred":"DNA","subj":"E3","obj":"T7"},{"id":"R7","pred":"Agent","subj":"E4","obj":"T27"},{"id":"R8","pred":"Process","subj":"E4","obj":"T30"},{"id":"R9","pred":"Agent","subj":"E5","obj":"T29"},{"id":"R10","pred":"Process","subj":"E5","obj":"T30"},{"id":"R11","pred":"Agent","subj":"E6","obj":"T28"},{"id":"R12","pred":"Process","subj":"E6","obj":"T30"},{"id":"R13","pred":"Element1","subj":"E7","obj":"T19"},{"id":"R14","pred":"Element2","subj":"E7","obj":"T20"},{"id":"R15","pred":"Element1","subj":"E8","obj":"T9"},{"id":"R16","pred":"Element2","subj":"E8","obj":"T8"},{"id":"R17","pred":"Functional_Molecule","subj":"E9","obj":"T21"},{"id":"R18","pred":"Molecule","subj":"E9","obj":"T22"},{"id":"C-T17-0","pred":"_lexicallyChainedTo","subj":"T17-1","obj":"T17-0"},{"id":"C-T16-0","pred":"_lexicallyChainedTo","subj":"T16-1","obj":"T16-0"},{"id":"C-T24-0","pred":"_lexicallyChainedTo","subj":"T24-1","obj":"T24-0"},{"id":"C-E12-0","pred":"_lexicallyChainedTo","subj":"E12-1","obj":"E12-0"},{"id":"C-E14-0","pred":"_lexicallyChainedTo","subj":"E14-1","obj":"E14-0"}],"attributes":[{"subj":"T1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T2","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T3","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T4","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T5","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T6","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T7","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T8","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T9","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T10","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T11","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T12","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T13","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T14","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T15","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T17-0","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T17-1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T16-0","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T16-1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T18","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T19","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T20","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T21","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T22","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T23","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T24-0","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T24-1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T25","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T26","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T27","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T28","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T29","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T30","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T31","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T32","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T33","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T34","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T35","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T36","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"T37","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E2","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E3","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E4","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E5","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E6","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E7","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E8","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E9","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E10","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E11","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E12-0","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E12-1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E13","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E14-0","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E14-1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E15","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"},{"subj":"E16","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-train"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bionlp-ost-19-SeeDev-bin-train","color":"#93eccb","default":true}]}]}}