SeeDev-binary@ldeleger:SeeDev-binary-19594710-4 JSONTXT

{"project":"bionlp-ost-19-SeeDev-bin-train","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"Protein"},{"id":"T2","span":{"begin":18,"end":24},"obj":"Box"},{"id":"T3","span":{"begin":50,"end":68},"obj":"Box"},{"id":"T4","span":{"begin":50,"end":54},"obj":"Protein"},{"id":"T5","span":{"begin":76,"end":103},"obj":"Promoter"},{"id":"T6-0","span":{"begin":76,"end":96},"obj":"_FRAGMENT"},{"id":"T6-1","span":{"begin":105,"end":109},"obj":"Promoter"},{"id":"T7-0","span":{"begin":76,"end":95},"obj":"_FRAGMENT"},{"id":"T7-1","span":{"begin":111,"end":116},"obj":"Promoter"},{"id":"T8-0","span":{"begin":76,"end":95},"obj":"_FRAGMENT"},{"id":"T8-1","span":{"begin":122,"end":126},"obj":"Promoter"},{"id":"T9","span":{"begin":96,"end":103},"obj":"Gene"},{"id":"T10","span":{"begin":105,"end":109},"obj":"Gene"},{"id":"T11","span":{"begin":111,"end":116},"obj":"Gene"},{"id":"T12","span":{"begin":122,"end":126},"obj":"Gene"},{"id":"T13","span":{"begin":151,"end":157},"obj":"Box"},{"id":"T14","span":{"begin":167,"end":188},"obj":"Box"},{"id":"T15","span":{"begin":240,"end":257},"obj":"Box"},{"id":"T16","span":{"begin":250,"end":257},"obj":"Gene"},{"id":"T17","span":{"begin":328,"end":332},"obj":"Protein"},{"id":"T18","span":{"begin":382,"end":393},"obj":"Genotype"},{"id":"T19","span":{"begin":394,"end":397},"obj":"Protein"},{"id":"T20","span":{"begin":508,"end":511},"obj":"Protein"},{"id":"T21","span":{"begin":542,"end":553},"obj":"Protein_Domain"},{"id":"T22","span":{"begin":542,"end":545},"obj":"Protein"},{"id":"T23","span":{"begin":625,"end":663},"obj":"Box"},{"id":"T24","span":{"begin":709,"end":715},"obj":"Box"},{"id":"T25-0","span":{"begin":803,"end":807},"obj":"_FRAGMENT"},{"id":"T25-1","span":{"begin":817,"end":829},"obj":"Box"},{"id":"T26","span":{"begin":803,"end":806},"obj":"Protein"},{"id":"T27","span":{"begin":812,"end":829},"obj":"Box"},{"id":"T28","span":{"begin":812,"end":816},"obj":"Protein"},{"id":"T29","span":{"begin":905,"end":915},"obj":"Protein_Domain"},{"id":"T30","span":{"begin":905,"end":908},"obj":"Protein"},{"id":"T31","span":{"begin":921,"end":962},"obj":"Box"},{"id":"T32","span":{"begin":942,"end":945},"obj":"Protein"},{"id":"T33","span":{"begin":981,"end":994},"obj":"Box"},{"id":"T34","span":{"begin":996,"end":1001},"obj":"Box"},{"id":"T35","span":{"begin":1013,"end":1023},"obj":"Protein_Family"},{"id":"T36","span":{"begin":1013,"end":1018},"obj":"Protein"},{"id":"T37","span":{"begin":1031,"end":1041},"obj":"Protein_Domain"},{"id":"T38","span":{"begin":1031,"end":1034},"obj":"Protein"},{"id":"T39","span":{"begin":1077,"end":1088},"obj":"Protein_Domain"},{"id":"T40","span":{"begin":1077,"end":1080},"obj":"Protein"},{"id":"T41","span":{"begin":1092,"end":1095},"obj":"Protein"},{"id":"T42","span":{"begin":1182,"end":1244},"obj":"Box"},{"id":"T43","span":{"begin":1214,"end":1244},"obj":"Box"},{"id":"T44","span":{"begin":1214,"end":1217},"obj":"Protein"},{"id":"T45","span":{"begin":1246,"end":1285},"obj":"Box"},{"id":"T46","span":{"begin":1297,"end":1304},"obj":"Box"},{"id":"T47","span":{"begin":1317,"end":1323},"obj":"Box"},{"id":"T48","span":{"begin":1377,"end":1379},"obj":"Box"},{"id":"T49","span":{"begin":1392,"end":1394},"obj":"Box"},{"id":"T50","span":{"begin":1402,"end":1408},"obj":"Box"},{"id":"T51","span":{"begin":1414,"end":1444},"obj":"Protein_Family"},{"id":"T52","span":{"begin":1414,"end":1417},"obj":"Protein"},{"id":"T53","span":{"begin":1505,"end":1522},"obj":"Regulatory_Network"},{"id":"T54","span":{"begin":1505,"end":1513},"obj":"Tissue"},{"id":"T55","span":{"begin":1527,"end":1544},"obj":"Development_Phase"},{"id":"T56","span":{"begin":1527,"end":1532},"obj":"Tissue"},{"id":"T57","span":{"begin":1559,"end":1562},"obj":"Protein"},{"id":"T58","span":{"begin":1700,"end":1709},"obj":"Regulatory_Network"},{"id":"T59","span":{"begin":1700,"end":1704},"obj":"Tissue"},{"id":"T60","span":{"begin":1731,"end":1734},"obj":"Protein"},{"id":"T61","span":{"begin":1745,"end":1762},"obj":"Development_Phase"},{"id":"T62","span":{"begin":1745,"end":1750},"obj":"Tissue"},{"id":"T63","span":{"begin":1767,"end":1786},"obj":"Development_Phase"},{"id":"T64","span":{"begin":1767,"end":1779},"obj":"Tissue"},{"id":"T65","span":{"begin":1843,"end":1852},"obj":"Protein"},{"id":"T66","span":{"begin":1854,"end":1858},"obj":"Protein"},{"id":"T67","span":{"begin":1864,"end":1868},"obj":"Protein"},{"id":"T68","span":{"begin":1886,"end":1909},"obj":"Regulatory_Network"},{"id":"T69","span":{"begin":1886,"end":1895},"obj":"Tissue"},{"id":"T70-0","span":{"begin":1886,"end":1895},"obj":"_FRAGMENT"},{"id":"T70-1","span":{"begin":1914,"end":1925},"obj":"Regulatory_Network"},{"id":"T71","span":{"begin":1933,"end":1946},"obj":"Tissue"},{"id":"T72","span":{"begin":1972,"end":2003},"obj":"Protein_Family"},{"id":"T73","span":{"begin":2017,"end":2022},"obj":"Genotype"},{"id":"T74","span":{"begin":2102,"end":2106},"obj":"Protein"},{"id":"T75","span":{"begin":2138,"end":2142},"obj":"Protein"},{"id":"T76","span":{"begin":2143,"end":2148},"obj":"Protein"},{"id":"T77","span":{"begin":2164,"end":2168},"obj":"Protein"},{"id":"T78","span":{"begin":2170,"end":2179},"obj":"Gene"},{"id":"T79","span":{"begin":2189,"end":2193},"obj":"Protein"},{"id":"T80","span":{"begin":2195,"end":2204},"obj":"Gene"},{"id":"T81","span":{"begin":2210,"end":2221},"obj":"Genotype"},{"id":"T82","span":{"begin":2260,"end":2263},"obj":"Protein"},{"id":"T83","span":{"begin":2330,"end":2338},"obj":"Protein_Family"},{"id":"T84","span":{"begin":2330,"end":2333},"obj":"Protein"},{"id":"T85","span":{"begin":2437,"end":2476},"obj":"Protein_Family"},{"id":"T86","span":{"begin":2444,"end":2454},"obj":"Protein_Domain"},{"id":"T87","span":{"begin":2444,"end":2447},"obj":"Protein"},{"id":"E1","span":{"begin":1731,"end":1734},"obj":"Regulates_Development_Phase"},{"id":"E2","span":{"begin":1854,"end":1858},"obj":"Regulates_Process"},{"id":"E3","span":{"begin":1854,"end":1858},"obj":"Regulates_Process"},{"id":"E4","span":{"begin":1731,"end":1734},"obj":"Regulates_Development_Phase"},{"id":"E5","span":{"begin":1864,"end":1868},"obj":"Regulates_Process"},{"id":"E6","span":{"begin":1864,"end":1868},"obj":"Regulates_Process"},{"id":"E7","span":{"begin":1559,"end":1562},"obj":"Regulates_Process"},{"id":"E8","span":{"begin":1414,"end":1444},"obj":"Regulates_Development_Phase"},{"id":"E9","span":{"begin":1414,"end":1444},"obj":"Regulates_Process"},{"id":"E10","span":{"begin":151,"end":157},"obj":"Composes_Primary_Structure"},{"id":"E11","span":{"begin":151,"end":157},"obj":"Composes_Primary_Structure"},{"id":"E12","span":{"begin":1031,"end":1041},"obj":"Is_Protein_Domain_Of"},{"id":"E13","span":{"begin":167,"end":188},"obj":"Composes_Primary_Structure"},{"id":"E14","span":{"begin":1297,"end":1304},"obj":"Composes_Primary_Structure"},{"id":"E15","span":{"begin":151,"end":157},"obj":"Composes_Primary_Structure"},{"id":"E16","span":{"begin":151,"end":157},"obj":"Composes_Primary_Structure"},{"id":"E17","span":{"begin":0,"end":4},"obj":"Binds_To"},{"id":"E18","span":{"begin":1031,"end":1041},"obj":"Binds_To"},{"id":"E19","span":{"begin":542,"end":553},"obj":"Binds_To"},{"id":"E20","span":{"begin":328,"end":332},"obj":"Binds_To"},{"id":"E21","span":{"begin":50,"end":54},"obj":"Binds_To"},{"id":"E22","span":{"begin":50,"end":54},"obj":"Binds_To"},{"id":"E23","span":{"begin":50,"end":54},"obj":"Binds_To"},{"id":"E24","span":{"begin":50,"end":54},"obj":"Binds_To"},{"id":"E25","span":{"begin":709,"end":715},"obj":"Has_Sequence_Identical_To"},{"id":"E26","span":{"begin":1182,"end":1244},"obj":"Is_Functionally_Equivalent_To"},{"id":"E27","span":{"begin":981,"end":994},"obj":"Is_Functionally_Equivalent_To"},{"id":"E28","span":{"begin":1854,"end":1858},"obj":"Is_Functionally_Equivalent_To"},{"id":"E29","span":{"begin":2102,"end":2106},"obj":"Is_Member_Of_Family"},{"id":"E30","span":{"begin":2189,"end":2193},"obj":"Is_Member_Of_Family"},{"id":"E31","span":{"begin":2260,"end":2263},"obj":"Is_Member_Of_Family"},{"id":"E32","span":{"begin":2164,"end":2168},"obj":"Is_Member_Of_Family"},{"id":"E33","span":{"begin":2195,"end":2204},"obj":"Transcribes_Or_Translates_To"},{"id":"E34","span":{"begin":2170,"end":2179},"obj":"Transcribes_Or_Translates_To"},{"id":"E35","span":{"begin":2195,"end":2204},"obj":"Exists_In_Genotype"},{"id":"E36","span":{"begin":2170,"end":2179},"obj":"Exists_In_Genotype"},{"id":"E37","span":{"begin":2189,"end":2193},"obj":"Exists_In_Genotype"},{"id":"E38","span":{"begin":2164,"end":2168},"obj":"Exists_In_Genotype"},{"id":"E39","span":{"begin":1854,"end":1858},"obj":"Is_Localized_In"},{"id":"E40","span":{"begin":1864,"end":1868},"obj":"Is_Localized_In"},{"id":"E41","span":{"begin":1933,"end":1946},"obj":"Regulates_Process"},{"id":"E42","span":{"begin":1933,"end":1946},"obj":"Regulates_Process"}],"relations":[{"id":"R50","pred":"Element2","subj":"E25","obj":"T23"},{"id":"R51","pred":"Element1","subj":"E26","obj":"T42"},{"id":"R52","pred":"Element2","subj":"E26","obj":"T45"},{"id":"R53","pred":"Element1","subj":"E27","obj":"T33"},{"id":"R54","pred":"Element2","subj":"E27","obj":"T34"},{"id":"R55","pred":"Element1","subj":"E28","obj":"T66"},{"id":"R56","pred":"Element2","subj":"E28","obj":"T65"},{"id":"R57","pred":"Element","subj":"E29","obj":"T74"},{"id":"R58","pred":"Family","subj":"E29","obj":"T72"},{"id":"R59","pred":"Element","subj":"E30","obj":"T79"},{"id":"R60","pred":"Family","subj":"E30","obj":"T72"},{"id":"R61","pred":"Element","subj":"E31","obj":"T82"},{"id":"R62","pred":"Family","subj":"E31","obj":"T72"},{"id":"R63","pred":"Element","subj":"E32","obj":"T77"},{"id":"R64","pred":"Family","subj":"E32","obj":"T72"},{"id":"R65","pred":"Source","subj":"E33","obj":"T80"},{"id":"R66","pred":"Product","subj":"E33","obj":"T79"},{"id":"R67","pred":"Source","subj":"E34","obj":"T78"},{"id":"R68","pred":"Product","subj":"E34","obj":"T77"},{"id":"R69","pred":"Molecule","subj":"E35","obj":"T80"},{"id":"R70","pred":"Genotype","subj":"E35","obj":"T81"},{"id":"R71","pred":"Molecule","subj":"E36","obj":"T78"},{"id":"R72","pred":"Genotype","subj":"E36","obj":"T81"},{"id":"R73","pred":"Molecule","subj":"E37","obj":"T79"},{"id":"R74","pred":"Genotype","subj":"E37","obj":"T81"},{"id":"R75","pred":"Molecule","subj":"E38","obj":"T77"},{"id":"R76","pred":"Genotype","subj":"E38","obj":"T81"},{"id":"R1","pred":"Agent","subj":"E1","obj":"T60"},{"id":"R2","pred":"Development","subj":"E1","obj":"T63"},{"id":"R3","pred":"Agent","subj":"E2","obj":"T66"},{"id":"R4","pred":"Process","subj":"E2","obj":"T70-0"},{"id":"R5","pred":"Agent","subj":"E3","obj":"T66"},{"id":"R6","pred":"Process","subj":"E3","obj":"T68"},{"id":"R7","pred":"Agent","subj":"E4","obj":"T60"},{"id":"R8","pred":"Development","subj":"E4","obj":"T61"},{"id":"R9","pred":"Agent","subj":"E5","obj":"T67"},{"id":"R10","pred":"Process","subj":"E5","obj":"T68"},{"id":"R11","pred":"Agent","subj":"E6","obj":"T67"},{"id":"R12","pred":"Process","subj":"E6","obj":"T70-0"},{"id":"R13","pred":"Agent","subj":"E7","obj":"T57"},{"id":"R14","pred":"Process","subj":"E7","obj":"T58"},{"id":"R15","pred":"Agent","subj":"E8","obj":"T51"},{"id":"R16","pred":"Development","subj":"E8","obj":"T55"},{"id":"R17","pred":"Agent","subj":"E9","obj":"T51"},{"id":"R18","pred":"Process","subj":"E9","obj":"T53"},{"id":"R19","pred":"DNA_Part","subj":"E10","obj":"T13"},{"id":"R20","pred":"DNA","subj":"E10","obj":"T6-0"},{"id":"R21","pred":"DNA_Part","subj":"E11","obj":"T13"},{"id":"R22","pred":"DNA","subj":"E11","obj":"T5"},{"id":"R23","pred":"Domain","subj":"E12","obj":"T37"},{"id":"R24","pred":"Product","subj":"E12","obj":"T35"},{"id":"R25","pred":"DNA_Part","subj":"E13","obj":"T14"},{"id":"R26","pred":"DNA","subj":"E13","obj":"T13"},{"id":"R27","pred":"DNA_Part","subj":"E14","obj":"T46"},{"id":"R28","pred":"DNA","subj":"E14","obj":"T47"},{"id":"R29","pred":"DNA_Part","subj":"E15","obj":"T13"},{"id":"R30","pred":"DNA","subj":"E15","obj":"T8-0"},{"id":"R31","pred":"DNA_Part","subj":"E16","obj":"T13"},{"id":"R32","pred":"DNA","subj":"E16","obj":"T7-0"},{"id":"R33","pred":"Functional_Molecule","subj":"E17","obj":"T1"},{"id":"R34","pred":"Molecule","subj":"E17","obj":"T2"},{"id":"R35","pred":"Functional_Molecule","subj":"E18","obj":"T37"},{"id":"R36","pred":"Molecule","subj":"E18","obj":"T34"},{"id":"R37","pred":"Functional_Molecule","subj":"E19","obj":"T21"},{"id":"R38","pred":"Molecule","subj":"E19","obj":"T23"},{"id":"R39","pred":"Functional_Molecule","subj":"E20","obj":"T17"},{"id":"R40","pred":"Molecule","subj":"E20","obj":"T15"},{"id":"R41","pred":"Functional_Molecule","subj":"E21","obj":"T4"},{"id":"R42","pred":"Molecule","subj":"E21","obj":"T7-0"},{"id":"R43","pred":"Functional_Molecule","subj":"E22","obj":"T4"},{"id":"R44","pred":"Molecule","subj":"E22","obj":"T8-0"},{"id":"R45","pred":"Functional_Molecule","subj":"E23","obj":"T4"},{"id":"R46","pred":"Molecule","subj":"E23","obj":"T5"},{"id":"R47","pred":"Functional_Molecule","subj":"E24","obj":"T4"},{"id":"R48","pred":"Molecule","subj":"E24","obj":"T6-0"},{"id":"R49","pred":"Element1","subj":"E25","obj":"T24"},{"id":"R77","pred":"Functional_Molecule","subj":"E39","obj":"T66"},{"id":"R78","pred":"Target_Tissue","subj":"E39","obj":"T71"},{"id":"R79","pred":"Functional_Molecule","subj":"E40","obj":"T67"},{"id":"R80","pred":"Target_Tissue","subj":"E40","obj":"T71"},{"id":"R81","pred":"Agent","subj":"E41","obj":"T71"},{"id":"R82","pred":"Process","subj":"E41","obj":"T68"},{"id":"R83","pred":"Agent","subj":"E42","obj":"T71"},{"id":"R84","pred":"Process","subj":"E42","obj":"T70-0"},{"id":"C-T6-0","pred":"_lexicallyChainedTo","subj":"T6-1","obj":"T6-0"},{"id":"C-T7-0","pred":"_lexicallyChainedTo","subj":"T7-1","obj":"T7-0"},{"id":"C-T8-0","pred":"_lexicallyChainedTo","subj":"T8-1","obj":"T8-0"},{"id":"C-T25-0","pred":"_lexicallyChainedTo","subj":"T25-1","obj":"T25-0"},{"id":"C-T70-0","pred":"_lexicallyChainedTo","subj":"T70-1","obj":"T70-0"}],"text":"WRI1 binds to the AW-box with two core motifs\nThe WRI1 binding sites in the upstream regions of Pl-PKβ1, KAS1, BCCP2, and SUS2 contained the conserved AW-box sequence 5′-[CnTnG](n)7[CG]-3′ (Figure 4f), and mutational analysis of the site 1 AW-box of Pl-PKβ1 indicated that each of the five conserved nucleotides is critical for WRI1 binding (Figure 5c).\nThe DNA-binding activity of Arabidopsis ANT has been characterized previously. Repeated selection of random oligonucleotides that bind with a recombinant ANT fragment corresponding to two AP2 domains results in enrichment of oligonucleotides with a consensus sequence of 5′-gCAC(A/G)N(A/T)TcCC(a/g)ANG(c/t)-3′ (Nole-Wilson and Krizek, 2000). Although the AW-box sequences do not match to this sequence, there are some similarities between them. The ANT- and WRI1-binding site sequences are both longer than those for transcription factors with single AP2 domain. The 3′-half of the 16-bp ANT-binding sequence is similar to the DRE sequences (CCGAC), to which EREBP-like single AP2 domain factors binds, suggesting that two AP2 domains of ANT uniquely participate in DNA binding (Nole-Wilson and Krizek, 2000; Krizek, 2003). The opposite strand sequence of the ANT-binding consensus sequence, 5′-(g/a)CnT(t/c)GggA(A/T)n-(T/C)GTGc-3′, shows the [CnTnG] core of the AW-box in the 5′-half, while the sequence of the 3′-half is TG rather than CG in the AW-box.\nThe AP2-type transcription factors characterized previously act as important key regulators in meristem function and organ development. For example, AP2 is a class A floral homeotic gene (Bowman et al., 1989; Jofuku et al., 1994; Okamuro et al., 1997) and it is also involved in control of seed size (Ohto et al., 2005). ANT regulates ovule development and floral organ growth (Elliott et al., 1996; Mizukami and Fischer, 2000), and PLETHORA1 (PLT1) and PLT2 are required for stem cell specification and maintenance in the root meristem (Aida et al., 2004). The AP-2 type transcription factors from various plant species have been classified into three major lineages (Kim et al., 2006), and WRI1 and two other related factors [WRI1/ASML1-related Two-1 (WAT1; At1g16060) and -2 (WAT2; At1g79700)] of Arabidopsis are in the lineage different from the ANT lineage. Comparison of the consensus binding site sequences among AP2-type factors in different lineages is expected to elucidate the structure–function relationship of the double AP2 domain transcription factors and also to help identify their direct target genes.\n"}