PubMed:9988767
Annnotations
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 474-479 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T2 | 604-609 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T3 | 837-844 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T4 | 837-842 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T5 | 846-851 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T6 | 860-865 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T7 | 1117-1124 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3-OST-4 |
| T8 | 1426-1431 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3OST1 |
| T9 | 1433-1438 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3OST2 |
| T10 | 1444-1449 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3OST4 |
| T11 | 1680-1685 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T12 | 1753-1758 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T13 | 2219-2226 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3-OST-4 |
| T14 | 2231-2238 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T15 | 2231-2236 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T16 | 2275-2280 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T17 | 2288-2293 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T18 | 2398-2403 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T19 | 2527-2531 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3OST |
| T20 | 2619-2624 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T21 | 2639-2644 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 474-479 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T2 | 604-609 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T3 | 837-844 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T4 | 837-842 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T5 | 846-851 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T6 | 860-865 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T7 | 1117-1124 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3-OST-4 |
| T8 | 1426-1431 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3OST1 |
| T9 | 1433-1438 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3OST2 |
| T10 | 1444-1449 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3OST4 |
| T11 | 1680-1685 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T12 | 1753-1758 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T13 | 2219-2226 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3-OST-4 |
| T14 | 2231-2238 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T15 | 2231-2236 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T16 | 2275-2280 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T17 | 2288-2293 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T18 | 2398-2403 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T19 | 2527-2531 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3OST |
| T20 | 2619-2624 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T21 | 2639-2644 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-73 | Sentence | denotes | Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. |
| T2 | 74-177 | Sentence | denotes | Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. |
| T3 | 178-322 | Sentence | denotes | 3-O-Sulfated glucosaminyl residues are rare constituents of heparan sulfate and are essential for the activity of anticoagulant heparan sulfate. |
| T4 | 323-497 | Sentence | denotes | Cellular production of the critical active structure is controlled by the rate-limiting enzyme, heparan sulfate D-glucosaminyl 3-O-sulfotransferase-1 (3-OST-1) (EC 2.8.2.23). |
| T5 | 498-658 | Sentence | denotes | We have probed the expressed sequence tag data base with the carboxyl-terminal sulfotransferase domain of 3-OST-1 to reveal three novel, incomplete human cDNAs. |
| T6 | 659-727 | Sentence | denotes | These were utilized in library screens to isolate full-length cDNAs. |
| T7 | 728-883 | Sentence | denotes | Clones corresponding to predominant transcripts were obtained for the 367-, 406-, and 390-amino acid enzymes 3-OST-2, 3-OST-3A, and 3-OST-3B, respectively. |
| T8 | 884-1070 | Sentence | denotes | These type II integral membrane proteins are comprised of a divergent amino-terminal region and a very homologous carboxyl-terminal sulfotransferase domain of approximately 260 residues. |
| T9 | 1071-1125 | Sentence | denotes | Also recovered were partial length clones for 3-OST-4. |
| T10 | 1126-1269 | Sentence | denotes | Expression of the full-length enzymes confirms the 3-O-sulfation of specific glucosaminyl residues within heparan sulfate (Liu, J., Shworak, N. |
| T11 | 1270-1297 | Sentence | denotes | W., Sinaÿ, P., Schwartz, J. |
| T12 | 1298-1300 | Sentence | denotes | J. |
| T13 | 1301-1322 | Sentence | denotes | Zhang, L., Fritze, L. |
| T14 | 1323-1325 | Sentence | denotes | M. |
| T15 | 1326-1347 | Sentence | denotes | S., and Rosenberg, R. |
| T16 | 1348-1360 | Sentence | denotes | D. (1999) J. |
| T17 | 1361-1366 | Sentence | denotes | Biol. |
| T18 | 1367-1372 | Sentence | denotes | Chem. |
| T19 | 1373-1389 | Sentence | denotes | 274, 5185-5192). |
| T20 | 1390-1510 | Sentence | denotes | Southern analyses suggest the human 3OST1, 3OST2, and 3OST4 genes, and the corresponding mouse isologs, are single copy. |
| T21 | 1511-1614 | Sentence | denotes | However, 3OST3A and 3OST3B genes are each duplicated in humans and show at least one copy each in mice. |
| T22 | 1615-1762 | Sentence | denotes | Intriguingly, the entire sulfotransferase domain sequence of the 3-OST-3B cDNA (774 base pairs) was 99.2% identical to the same region of 3-OST-3A. |
| T23 | 1763-1920 | Sentence | denotes | Together, these data argue that the structure of this functionally important region is actively maintained by gene conversion between 3OST3A and 3OST3B loci. |
| T24 | 1921-2134 | Sentence | denotes | Interspecific mouse back-cross analysis identified the loci for mouse 3Ost genes and syntenic assignments of corresponding human isologs were confirmed by the identification of mapped sequence-tagged site markers. |
| T25 | 2135-2357 | Sentence | denotes | Northern blot analyses indicate brain exclusive and brain predominant expression of 3-OST-4 and 3-OST-2 transcripts, respectively; whereas, 3-OST-3A and 3-OST-3B isoforms show widespread expression of multiple transcripts. |
| T26 | 2358-2492 | Sentence | denotes | The reiteration and conservation of the 3-OST sulfotransferase domain suggest that this structure is a self-contained functional unit. |
| T27 | 2493-2720 | Sentence | denotes | Moreover, the extensive number of 3OST genes with diverse expression patterns of multiple transcripts suggests that the novel 3-OST enzymes, like 3-OST-1, regulate important biologic properties of heparan sulfate proteoglycans. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-36 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 238-253 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 306-321 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T4 | 419-434 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T5 | 1232-1247 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T6 | 2690-2705 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 2167-2172 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T2 | 2187-2192 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 474-479 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T2 | 604-609 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T3 | 837-844 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| PD-GlycoGenes20190927-B_T4 | 837-842 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T5 | 846-851 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T6 | 860-865 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T7 | 895-897 | https://acgg.asia/db/ggdb/info/gg111 | denotes | II |
| PD-GlycoGenes20190927-B_T8 | 1117-1124 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3-OST-4 |
| PD-GlycoGenes20190927-B_T9 | 1426-1431 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3OST1 |
| PD-GlycoGenes20190927-B_T10 | 1433-1438 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3OST2 |
| PD-GlycoGenes20190927-B_T11 | 1444-1449 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3OST4 |
| PD-GlycoGenes20190927-B_T12 | 1680-1685 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T13 | 1753-1758 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T14 | 1991-1995 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3Ost |
| PD-GlycoGenes20190927-B_T15 | 2219-2226 | https://acgg.asia/db/ggdb/info/gg018 | denotes | 3-OST-4 |
| PD-GlycoGenes20190927-B_T16 | 2231-2238 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| PD-GlycoGenes20190927-B_T17 | 2231-2236 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T18 | 2275-2280 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T19 | 2288-2293 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T20 | 2398-2403 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T21 | 2527-2531 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3OST |
| PD-GlycoGenes20190927-B_T22 | 2619-2624 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T23 | 2639-2644 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 2167-2172 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 2187-2192 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 121-126 | OrganismTaxon | denotes | human | 9606 |
| T2 | 646-651 | OrganismTaxon | denotes | human | 9606 |
| T3 | 1420-1425 | OrganismTaxon | denotes | human | 9606 |
| T4 | 1479-1484 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T6 | 1609-1613 | OrganismTaxon | denotes | mice | 10088 |
| T7 | 1935-1940 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T9 | 1985-1990 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T11 | 2044-2049 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 907-915 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 1941-1945 | Body_part | denotes | back | http://purl.obolibrary.org/obo/UBERON_0001137 |
| T5 | 2167-2172 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 2187-2192 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |