> top > docs > PubMed:9988767 > annotations

PubMed:9988767 JSONTXT

Annnotations TAB JSON ListView MergeView

GGDB-2020

Id Subject Object Predicate Lexical cue
T1 474-479 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T2 604-609 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T3 837-844 https://acgg.asia/db/ggdb/info/gg015 denotes 3-OST-2
T4 837-842 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T5 846-851 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T6 860-865 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T7 1117-1124 https://acgg.asia/db/ggdb/info/gg018 denotes 3-OST-4
T8 1426-1431 https://acgg.asia/db/ggdb/info/gg014 denotes 3OST1
T9 1433-1438 https://acgg.asia/db/ggdb/info/gg015 denotes 3OST2
T10 1444-1449 https://acgg.asia/db/ggdb/info/gg018 denotes 3OST4
T11 1680-1685 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T12 1753-1758 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T13 2219-2226 https://acgg.asia/db/ggdb/info/gg018 denotes 3-OST-4
T14 2231-2238 https://acgg.asia/db/ggdb/info/gg015 denotes 3-OST-2
T15 2231-2236 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T16 2275-2280 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T17 2288-2293 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T18 2398-2403 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T19 2527-2531 https://acgg.asia/db/ggdb/info/gg014 denotes 3OST
T20 2619-2624 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T21 2639-2644 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST

ggdb-test

Id Subject Object Predicate Lexical cue
T1 474-479 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T2 604-609 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T3 837-844 https://acgg.asia/db/ggdb/info/gg015 denotes 3-OST-2
T4 837-842 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T5 846-851 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T6 860-865 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T7 1117-1124 https://acgg.asia/db/ggdb/info/gg018 denotes 3-OST-4
T8 1426-1431 https://acgg.asia/db/ggdb/info/gg014 denotes 3OST1
T9 1433-1438 https://acgg.asia/db/ggdb/info/gg015 denotes 3OST2
T10 1444-1449 https://acgg.asia/db/ggdb/info/gg018 denotes 3OST4
T11 1680-1685 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T12 1753-1758 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T13 2219-2226 https://acgg.asia/db/ggdb/info/gg018 denotes 3-OST-4
T14 2231-2238 https://acgg.asia/db/ggdb/info/gg015 denotes 3-OST-2
T15 2231-2236 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T16 2275-2280 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T17 2288-2293 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T18 2398-2403 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T19 2527-2531 https://acgg.asia/db/ggdb/info/gg014 denotes 3OST
T20 2619-2624 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
T21 2639-2644 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST

sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase.
T2 74-177 Sentence denotes Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
T3 178-322 Sentence denotes 3-O-Sulfated glucosaminyl residues are rare constituents of heparan sulfate and are essential for the activity of anticoagulant heparan sulfate.
T4 323-497 Sentence denotes Cellular production of the critical active structure is controlled by the rate-limiting enzyme, heparan sulfate D-glucosaminyl 3-O-sulfotransferase-1 (3-OST-1) (EC 2.8.2.23).
T5 498-658 Sentence denotes We have probed the expressed sequence tag data base with the carboxyl-terminal sulfotransferase domain of 3-OST-1 to reveal three novel, incomplete human cDNAs.
T6 659-727 Sentence denotes These were utilized in library screens to isolate full-length cDNAs.
T7 728-883 Sentence denotes Clones corresponding to predominant transcripts were obtained for the 367-, 406-, and 390-amino acid enzymes 3-OST-2, 3-OST-3A, and 3-OST-3B, respectively.
T8 884-1070 Sentence denotes These type II integral membrane proteins are comprised of a divergent amino-terminal region and a very homologous carboxyl-terminal sulfotransferase domain of approximately 260 residues.
T9 1071-1125 Sentence denotes Also recovered were partial length clones for 3-OST-4.
T10 1126-1269 Sentence denotes Expression of the full-length enzymes confirms the 3-O-sulfation of specific glucosaminyl residues within heparan sulfate (Liu, J., Shworak, N.
T11 1270-1297 Sentence denotes W., Sinaÿ, P., Schwartz, J.
T12 1298-1300 Sentence denotes J.
T13 1301-1322 Sentence denotes Zhang, L., Fritze, L.
T14 1323-1325 Sentence denotes M.
T15 1326-1347 Sentence denotes S., and Rosenberg, R.
T16 1348-1360 Sentence denotes D. (1999) J.
T17 1361-1366 Sentence denotes Biol.
T18 1367-1372 Sentence denotes Chem.
T19 1373-1389 Sentence denotes 274, 5185-5192).
T20 1390-1510 Sentence denotes Southern analyses suggest the human 3OST1, 3OST2, and 3OST4 genes, and the corresponding mouse isologs, are single copy.
T21 1511-1614 Sentence denotes However, 3OST3A and 3OST3B genes are each duplicated in humans and show at least one copy each in mice.
T22 1615-1762 Sentence denotes Intriguingly, the entire sulfotransferase domain sequence of the 3-OST-3B cDNA (774 base pairs) was 99.2% identical to the same region of 3-OST-3A.
T23 1763-1920 Sentence denotes Together, these data argue that the structure of this functionally important region is actively maintained by gene conversion between 3OST3A and 3OST3B loci.
T24 1921-2134 Sentence denotes Interspecific mouse back-cross analysis identified the loci for mouse 3Ost genes and syntenic assignments of corresponding human isologs were confirmed by the identification of mapped sequence-tagged site markers.
T25 2135-2357 Sentence denotes Northern blot analyses indicate brain exclusive and brain predominant expression of 3-OST-4 and 3-OST-2 transcripts, respectively; whereas, 3-OST-3A and 3-OST-3B isoforms show widespread expression of multiple transcripts.
T26 2358-2492 Sentence denotes The reiteration and conservation of the 3-OST sulfotransferase domain suggest that this structure is a self-contained functional unit.
T27 2493-2720 Sentence denotes Moreover, the extensive number of 3OST genes with diverse expression patterns of multiple transcripts suggests that the novel 3-OST enzymes, like 3-OST-1, regulate important biologic properties of heparan sulfate proteoglycans.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 21-36 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T2 238-253 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T3 306-321 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T4 419-434 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T5 1232-1247 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T6 2690-2705 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 2167-2172 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 2187-2192 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

glycogenes

Id Subject Object Predicate Lexical cue
PD-GlycoGenes20190927-B_T1 474-479 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T2 604-609 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T3 837-844 https://acgg.asia/db/ggdb/info/gg015 denotes 3-OST-2
PD-GlycoGenes20190927-B_T4 837-842 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T5 846-851 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T6 860-865 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T7 895-897 https://acgg.asia/db/ggdb/info/gg111 denotes II
PD-GlycoGenes20190927-B_T8 1117-1124 https://acgg.asia/db/ggdb/info/gg018 denotes 3-OST-4
PD-GlycoGenes20190927-B_T9 1426-1431 https://acgg.asia/db/ggdb/info/gg014 denotes 3OST1
PD-GlycoGenes20190927-B_T10 1433-1438 https://acgg.asia/db/ggdb/info/gg015 denotes 3OST2
PD-GlycoGenes20190927-B_T11 1444-1449 https://acgg.asia/db/ggdb/info/gg018 denotes 3OST4
PD-GlycoGenes20190927-B_T12 1680-1685 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T13 1753-1758 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T14 1991-1995 https://acgg.asia/db/ggdb/info/gg014 denotes 3Ost
PD-GlycoGenes20190927-B_T15 2219-2226 https://acgg.asia/db/ggdb/info/gg018 denotes 3-OST-4
PD-GlycoGenes20190927-B_T16 2231-2238 https://acgg.asia/db/ggdb/info/gg015 denotes 3-OST-2
PD-GlycoGenes20190927-B_T17 2231-2236 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T18 2275-2280 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T19 2288-2293 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T20 2398-2403 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T21 2527-2531 https://acgg.asia/db/ggdb/info/gg014 denotes 3OST
PD-GlycoGenes20190927-B_T22 2619-2624 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST
PD-GlycoGenes20190927-B_T23 2639-2644 https://acgg.asia/db/ggdb/info/gg014 denotes 3-OST

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 2167-2172 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 2187-2192 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase.
T2 74-177 Sentence denotes Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
T3 178-322 Sentence denotes 3-O-Sulfated glucosaminyl residues are rare constituents of heparan sulfate and are essential for the activity of anticoagulant heparan sulfate.
T4 323-497 Sentence denotes Cellular production of the critical active structure is controlled by the rate-limiting enzyme, heparan sulfate D-glucosaminyl 3-O-sulfotransferase-1 (3-OST-1) (EC 2.8.2.23).
T5 498-658 Sentence denotes We have probed the expressed sequence tag data base with the carboxyl-terminal sulfotransferase domain of 3-OST-1 to reveal three novel, incomplete human cDNAs.
T6 659-727 Sentence denotes These were utilized in library screens to isolate full-length cDNAs.
T7 728-883 Sentence denotes Clones corresponding to predominant transcripts were obtained for the 367-, 406-, and 390-amino acid enzymes 3-OST-2, 3-OST-3A, and 3-OST-3B, respectively.
T8 884-1070 Sentence denotes These type II integral membrane proteins are comprised of a divergent amino-terminal region and a very homologous carboxyl-terminal sulfotransferase domain of approximately 260 residues.
T9 1071-1125 Sentence denotes Also recovered were partial length clones for 3-OST-4.
T10 1126-1389 Sentence denotes Expression of the full-length enzymes confirms the 3-O-sulfation of specific glucosaminyl residues within heparan sulfate (Liu, J., Shworak, N. W., Sinaÿ, P., Schwartz, J. J. Zhang, L., Fritze, L. M. S., and Rosenberg, R. D. (1999) J. Biol. Chem. 274, 5185-5192).
T11 1390-1510 Sentence denotes Southern analyses suggest the human 3OST1, 3OST2, and 3OST4 genes, and the corresponding mouse isologs, are single copy.
T12 1511-1614 Sentence denotes However, 3OST3A and 3OST3B genes are each duplicated in humans and show at least one copy each in mice.
T13 1615-1762 Sentence denotes Intriguingly, the entire sulfotransferase domain sequence of the 3-OST-3B cDNA (774 base pairs) was 99.2% identical to the same region of 3-OST-3A.
T14 1763-1920 Sentence denotes Together, these data argue that the structure of this functionally important region is actively maintained by gene conversion between 3OST3A and 3OST3B loci.
T15 1921-2134 Sentence denotes Interspecific mouse back-cross analysis identified the loci for mouse 3Ost genes and syntenic assignments of corresponding human isologs were confirmed by the identification of mapped sequence-tagged site markers.
T16 2135-2357 Sentence denotes Northern blot analyses indicate brain exclusive and brain predominant expression of 3-OST-4 and 3-OST-2 transcripts, respectively; whereas, 3-OST-3A and 3-OST-3B isoforms show widespread expression of multiple transcripts.
T17 2358-2492 Sentence denotes The reiteration and conservation of the 3-OST sulfotransferase domain suggest that this structure is a self-contained functional unit.
T18 2493-2720 Sentence denotes Moreover, the extensive number of 3OST genes with diverse expression patterns of multiple transcripts suggests that the novel 3-OST enzymes, like 3-OST-1, regulate important biologic properties of heparan sulfate proteoglycans.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 21-36 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 238-253 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T3 306-321 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T4 419-434 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T5 1232-1247 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T6 2690-2705 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 121-126 OrganismTaxon denotes human 9606
T2 646-651 OrganismTaxon denotes human 9606
T3 1420-1425 OrganismTaxon denotes human 9606
T4 1479-1484 OrganismTaxon denotes mouse 10088|10090
T6 1609-1613 OrganismTaxon denotes mice 10088
T7 1935-1940 OrganismTaxon denotes mouse 10088|10090
T9 1985-1990 OrganismTaxon denotes mouse 10088|10090
T11 2044-2049 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 907-915 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1941-1945 Body_part denotes back http://purl.obolibrary.org/obo/UBERON_0001137
T5 2167-2172 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T7 2187-2192 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636