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PubMed:9988731 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 199-209 Glycan_Motif denotes TF antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-171 Sentence denotes Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import.
T2 172-357 Sentence denotes The Galbeta1-3GalNAcalpha (TF antigen)-binding lectin (ABL) from the common edible mushroom (Agaricus bisporus) has a potent anti-proliferative effect without any apparent cytotoxicity.
T3 358-447 Sentence denotes This unusual combination of properties prompted investigation of its mechanism of action.
T4 448-590 Sentence denotes In contrast to soluble lectin, agarose-immobilized, and hence noninternalizable ABL had no effect on proliferation of HT29 colon cancer cells.
T5 591-766 Sentence denotes Electron microscopy of HT29 cells incubated with fluorescein- and gold-conjugated ABL showed internalization of the lectin into endocytotic vesicles and multivesicular bodies.
T6 767-996 Sentence denotes Confocal microscopy showed perinuclear accumulation of fluorescein isothiocyanate-conjugated lectin, which also inhibits HT29 cell proliferation, raising the possibility that the lectin might interfere with nuclear pore function.
T7 997-1152 Sentence denotes Transport of heat shock protein 70 into the nucleus in response to heat shock was blocked by preincubation of HT29 cells for 6 h with 40 micrograms/ml ABL.
T8 1153-1366 Sentence denotes In digitonin-permeabilized cells, nuclear uptake of bovine albumin conjugated to a nuclear localization sequence (NLS)-containing peptide was also inhibited by a 15-min preincubation with 40-100 micrograms/ml ABL.
T9 1367-1540 Sentence denotes In contrast, serum-stimulated nuclear translocation of mitogen-activated protein kinase, which is NLS-independent, was not affected by pretreatment of cells with the lectin.
T10 1541-1749 Sentence denotes These results suggest that the anti-proliferative effect of ABL is likely to be a consequence of the lectin trafficking to the nuclear periphery, where it blocks NLS-dependent protein uptake into the nucleus.
T1 0-171 Sentence denotes Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import.
T2 172-357 Sentence denotes The Galbeta1-3GalNAcalpha (TF antigen)-binding lectin (ABL) from the common edible mushroom (Agaricus bisporus) has a potent anti-proliferative effect without any apparent cytotoxicity.
T3 358-447 Sentence denotes This unusual combination of properties prompted investigation of its mechanism of action.
T4 448-590 Sentence denotes In contrast to soluble lectin, agarose-immobilized, and hence noninternalizable ABL had no effect on proliferation of HT29 colon cancer cells.
T5 591-766 Sentence denotes Electron microscopy of HT29 cells incubated with fluorescein- and gold-conjugated ABL showed internalization of the lectin into endocytotic vesicles and multivesicular bodies.
T6 767-996 Sentence denotes Confocal microscopy showed perinuclear accumulation of fluorescein isothiocyanate-conjugated lectin, which also inhibits HT29 cell proliferation, raising the possibility that the lectin might interfere with nuclear pore function.
T7 997-1152 Sentence denotes Transport of heat shock protein 70 into the nucleus in response to heat shock was blocked by preincubation of HT29 cells for 6 h with 40 micrograms/ml ABL.
T8 1153-1366 Sentence denotes In digitonin-permeabilized cells, nuclear uptake of bovine albumin conjugated to a nuclear localization sequence (NLS)-containing peptide was also inhibited by a 15-min preincubation with 40-100 micrograms/ml ABL.
T9 1367-1540 Sentence denotes In contrast, serum-stimulated nuclear translocation of mitogen-activated protein kinase, which is NLS-independent, was not affected by pretreatment of cells with the lectin.
T10 1541-1749 Sentence denotes These results suggest that the anti-proliferative effect of ABL is likely to be a consequence of the lectin trafficking to the nuclear periphery, where it blocks NLS-dependent protein uptake into the nucleus.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 199-209 https://glytoucan.org/Structures/Glycans/G00031MO denotes TF antigen

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 571-576 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 571-576 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 227-230 Disease denotes ABL http://purl.obolibrary.org/obo/MONDO_0008692
T2 528-531 Disease denotes ABL http://purl.obolibrary.org/obo/MONDO_0008692
T3 571-583 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T4 673-676 Disease denotes ABL http://purl.obolibrary.org/obo/MONDO_0008692
T5 1148-1151 Disease denotes ABL http://purl.obolibrary.org/obo/MONDO_0008692
T6 1267-1270 Disease denotes NLS http://purl.obolibrary.org/obo/MONDO_0000179
T7 1362-1365 Disease denotes ABL http://purl.obolibrary.org/obo/MONDO_0008692
T8 1465-1468 Disease denotes NLS http://purl.obolibrary.org/obo/MONDO_0000179
T9 1601-1604 Disease denotes ABL http://purl.obolibrary.org/obo/MONDO_0008692
T10 1703-1706 Disease denotes NLS http://purl.obolibrary.org/obo/MONDO_0000179

Lectin-Jamboree-small

Id Subject Object Predicate Lexical cue glycosmos_id
T1 227-230 Lectin denotes ABL GL_001756
T2 528-531 Lectin denotes ABL GL_001756
T3 673-676 Lectin denotes ABL GL_001756
T4 1148-1151 Lectin denotes ABL GL_001756
T5 1362-1365 Lectin denotes ABL GL_001756
T6 1601-1604 Lectin denotes ABL GL_001756

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-171 Sentence denotes Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import.
T2 172-357 Sentence denotes The Galbeta1-3GalNAcalpha (TF antigen)-binding lectin (ABL) from the common edible mushroom (Agaricus bisporus) has a potent anti-proliferative effect without any apparent cytotoxicity.
T3 358-447 Sentence denotes This unusual combination of properties prompted investigation of its mechanism of action.
T4 448-590 Sentence denotes In contrast to soluble lectin, agarose-immobilized, and hence noninternalizable ABL had no effect on proliferation of HT29 colon cancer cells.
T5 591-766 Sentence denotes Electron microscopy of HT29 cells incubated with fluorescein- and gold-conjugated ABL showed internalization of the lectin into endocytotic vesicles and multivesicular bodies.
T6 767-996 Sentence denotes Confocal microscopy showed perinuclear accumulation of fluorescein isothiocyanate-conjugated lectin, which also inhibits HT29 cell proliferation, raising the possibility that the lectin might interfere with nuclear pore function.
T7 997-1152 Sentence denotes Transport of heat shock protein 70 into the nucleus in response to heat shock was blocked by preincubation of HT29 cells for 6 h with 40 micrograms/ml ABL.
T8 1153-1366 Sentence denotes In digitonin-permeabilized cells, nuclear uptake of bovine albumin conjugated to a nuclear localization sequence (NLS)-containing peptide was also inhibited by a 15-min preincubation with 40-100 micrograms/ml ABL.
T9 1367-1540 Sentence denotes In contrast, serum-stimulated nuclear translocation of mitogen-activated protein kinase, which is NLS-independent, was not affected by pretreatment of cells with the lectin.
T10 1541-1749 Sentence denotes These results suggest that the anti-proliferative effect of ABL is likely to be a consequence of the lectin trafficking to the nuclear periphery, where it blocks NLS-dependent protein uptake into the nucleus.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 17-34 OrganismTaxon denotes Agaricus bisporus 5341
T2 265-282 OrganismTaxon denotes Agaricus bisporus 5341
T3 1205-1211 OrganismTaxon denotes bovine 9913

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 70-85 Body_part denotes epithelial cell http://purl.obolibrary.org/obo/CL_0000066
T2 571-576 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T3 982-986 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T4 1041-1048 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T6 1741-1748 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 571-583 Phenotype denotes colon cancer HP:0003003
T2 1015-1020 Phenotype denotes shock HP:0031273
T3 1069-1074 Phenotype denotes shock HP:0031273

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 70-85 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066
T2 577-589 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064