PubMed:9988731
Annnotations
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 199-209 | Glycan_Motif | denotes | TF antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-171 | Sentence | denotes | Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. |
T2 | 172-357 | Sentence | denotes | The Galbeta1-3GalNAcalpha (TF antigen)-binding lectin (ABL) from the common edible mushroom (Agaricus bisporus) has a potent anti-proliferative effect without any apparent cytotoxicity. |
T3 | 358-447 | Sentence | denotes | This unusual combination of properties prompted investigation of its mechanism of action. |
T4 | 448-590 | Sentence | denotes | In contrast to soluble lectin, agarose-immobilized, and hence noninternalizable ABL had no effect on proliferation of HT29 colon cancer cells. |
T5 | 591-766 | Sentence | denotes | Electron microscopy of HT29 cells incubated with fluorescein- and gold-conjugated ABL showed internalization of the lectin into endocytotic vesicles and multivesicular bodies. |
T6 | 767-996 | Sentence | denotes | Confocal microscopy showed perinuclear accumulation of fluorescein isothiocyanate-conjugated lectin, which also inhibits HT29 cell proliferation, raising the possibility that the lectin might interfere with nuclear pore function. |
T7 | 997-1152 | Sentence | denotes | Transport of heat shock protein 70 into the nucleus in response to heat shock was blocked by preincubation of HT29 cells for 6 h with 40 micrograms/ml ABL. |
T8 | 1153-1366 | Sentence | denotes | In digitonin-permeabilized cells, nuclear uptake of bovine albumin conjugated to a nuclear localization sequence (NLS)-containing peptide was also inhibited by a 15-min preincubation with 40-100 micrograms/ml ABL. |
T9 | 1367-1540 | Sentence | denotes | In contrast, serum-stimulated nuclear translocation of mitogen-activated protein kinase, which is NLS-independent, was not affected by pretreatment of cells with the lectin. |
T10 | 1541-1749 | Sentence | denotes | These results suggest that the anti-proliferative effect of ABL is likely to be a consequence of the lectin trafficking to the nuclear periphery, where it blocks NLS-dependent protein uptake into the nucleus. |
T1 | 0-171 | Sentence | denotes | Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. |
T2 | 172-357 | Sentence | denotes | The Galbeta1-3GalNAcalpha (TF antigen)-binding lectin (ABL) from the common edible mushroom (Agaricus bisporus) has a potent anti-proliferative effect without any apparent cytotoxicity. |
T3 | 358-447 | Sentence | denotes | This unusual combination of properties prompted investigation of its mechanism of action. |
T4 | 448-590 | Sentence | denotes | In contrast to soluble lectin, agarose-immobilized, and hence noninternalizable ABL had no effect on proliferation of HT29 colon cancer cells. |
T5 | 591-766 | Sentence | denotes | Electron microscopy of HT29 cells incubated with fluorescein- and gold-conjugated ABL showed internalization of the lectin into endocytotic vesicles and multivesicular bodies. |
T6 | 767-996 | Sentence | denotes | Confocal microscopy showed perinuclear accumulation of fluorescein isothiocyanate-conjugated lectin, which also inhibits HT29 cell proliferation, raising the possibility that the lectin might interfere with nuclear pore function. |
T7 | 997-1152 | Sentence | denotes | Transport of heat shock protein 70 into the nucleus in response to heat shock was blocked by preincubation of HT29 cells for 6 h with 40 micrograms/ml ABL. |
T8 | 1153-1366 | Sentence | denotes | In digitonin-permeabilized cells, nuclear uptake of bovine albumin conjugated to a nuclear localization sequence (NLS)-containing peptide was also inhibited by a 15-min preincubation with 40-100 micrograms/ml ABL. |
T9 | 1367-1540 | Sentence | denotes | In contrast, serum-stimulated nuclear translocation of mitogen-activated protein kinase, which is NLS-independent, was not affected by pretreatment of cells with the lectin. |
T10 | 1541-1749 | Sentence | denotes | These results suggest that the anti-proliferative effect of ABL is likely to be a consequence of the lectin trafficking to the nuclear periphery, where it blocks NLS-dependent protein uptake into the nucleus. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 199-209 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | TF antigen |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 571-576 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colon |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 571-576 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 227-230 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
T2 | 528-531 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
T3 | 571-583 | Disease | denotes | colon cancer | http://purl.obolibrary.org/obo/MONDO_0021063 |
T4 | 673-676 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
T5 | 1148-1151 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
T6 | 1267-1270 | Disease | denotes | NLS | http://purl.obolibrary.org/obo/MONDO_0000179 |
T7 | 1362-1365 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
T8 | 1465-1468 | Disease | denotes | NLS | http://purl.obolibrary.org/obo/MONDO_0000179 |
T9 | 1601-1604 | Disease | denotes | ABL | http://purl.obolibrary.org/obo/MONDO_0008692 |
T10 | 1703-1706 | Disease | denotes | NLS | http://purl.obolibrary.org/obo/MONDO_0000179 |
Lectin-Jamboree-small
Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
---|---|---|---|---|---|
T1 | 227-230 | Lectin | denotes | ABL | GL_001756 |
T2 | 528-531 | Lectin | denotes | ABL | GL_001756 |
T3 | 673-676 | Lectin | denotes | ABL | GL_001756 |
T4 | 1148-1151 | Lectin | denotes | ABL | GL_001756 |
T5 | 1362-1365 | Lectin | denotes | ABL | GL_001756 |
T6 | 1601-1604 | Lectin | denotes | ABL | GL_001756 |
Lectin-Jamboree-Sentence
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-171 | Sentence | denotes | Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. |
T2 | 172-357 | Sentence | denotes | The Galbeta1-3GalNAcalpha (TF antigen)-binding lectin (ABL) from the common edible mushroom (Agaricus bisporus) has a potent anti-proliferative effect without any apparent cytotoxicity. |
T3 | 358-447 | Sentence | denotes | This unusual combination of properties prompted investigation of its mechanism of action. |
T4 | 448-590 | Sentence | denotes | In contrast to soluble lectin, agarose-immobilized, and hence noninternalizable ABL had no effect on proliferation of HT29 colon cancer cells. |
T5 | 591-766 | Sentence | denotes | Electron microscopy of HT29 cells incubated with fluorescein- and gold-conjugated ABL showed internalization of the lectin into endocytotic vesicles and multivesicular bodies. |
T6 | 767-996 | Sentence | denotes | Confocal microscopy showed perinuclear accumulation of fluorescein isothiocyanate-conjugated lectin, which also inhibits HT29 cell proliferation, raising the possibility that the lectin might interfere with nuclear pore function. |
T7 | 997-1152 | Sentence | denotes | Transport of heat shock protein 70 into the nucleus in response to heat shock was blocked by preincubation of HT29 cells for 6 h with 40 micrograms/ml ABL. |
T8 | 1153-1366 | Sentence | denotes | In digitonin-permeabilized cells, nuclear uptake of bovine albumin conjugated to a nuclear localization sequence (NLS)-containing peptide was also inhibited by a 15-min preincubation with 40-100 micrograms/ml ABL. |
T9 | 1367-1540 | Sentence | denotes | In contrast, serum-stimulated nuclear translocation of mitogen-activated protein kinase, which is NLS-independent, was not affected by pretreatment of cells with the lectin. |
T10 | 1541-1749 | Sentence | denotes | These results suggest that the anti-proliferative effect of ABL is likely to be a consequence of the lectin trafficking to the nuclear periphery, where it blocks NLS-dependent protein uptake into the nucleus. |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 17-34 | OrganismTaxon | denotes | Agaricus bisporus | 5341 |
T2 | 265-282 | OrganismTaxon | denotes | Agaricus bisporus | 5341 |
T3 | 1205-1211 | OrganismTaxon | denotes | bovine | 9913 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 70-85 | Body_part | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL_0000066 |
T2 | 571-576 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
T3 | 982-986 | Body_part | denotes | pore | http://purl.obolibrary.org/obo/UBERON_0008915 |
T4 | 1041-1048 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
T6 | 1741-1748 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 571-583 | Phenotype | denotes | colon cancer | HP:0003003 |
T2 | 1015-1020 | Phenotype | denotes | shock | HP:0031273 |
T3 | 1069-1074 | Phenotype | denotes | shock | HP:0031273 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 70-85 | Cell | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL:0000066 |
T2 | 577-589 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |