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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1.
T2 72-151 Sentence denotes CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor.
T3 152-271 Sentence denotes However, the cellular functions and its role in inflammation, for example, rheumatoid synovitis, are currently unknown.
T4 272-324 Sentence denotes In this study, we propose a novel function for CD44.
T5 325-528 Sentence denotes Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion.
T6 529-991 Sentence denotes Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking.
T7 992-1263 Sentence denotes These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis.
T8 1264-1419 Sentence denotes We therefore propose that such cross-talking among distinct adhesion molecules may be involved in the pathogenesis of inflammation, including RA synovitis.
T1 0-71 Sentence denotes Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1.
T2 72-151 Sentence denotes CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor.
T3 152-271 Sentence denotes However, the cellular functions and its role in inflammation, for example, rheumatoid synovitis, are currently unknown.
T4 272-324 Sentence denotes In this study, we propose a novel function for CD44.
T5 325-528 Sentence denotes Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion.
T6 529-991 Sentence denotes Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking.
T7 992-1263 Sentence denotes These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis.
T8 1264-1419 Sentence denotes We therefore propose that such cross-talking among distinct adhesion molecules may be involved in the pathogenesis of inflammation, including RA synovitis.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 624-628 gene:960 denotes CD44
T1 921-923 disease:C0003873 denotes RA
T2 664-670 gene:7412 denotes VCAM-1
T3 921-923 disease:C0003873 denotes RA
T4 813-819 gene:7412 denotes VCAM-1
T5 921-923 disease:C0003873 denotes RA
T6 824-828 gene:960 denotes CD44
T7 921-923 disease:C0003873 denotes RA
T8 843-868 gene:3725 denotes transcription factor AP-1
T9 921-923 disease:C0003873 denotes RA
T10 972-976 gene:960 denotes CD44
T11 921-923 disease:C0003873 denotes RA
R1 T0 T1 associated_with CD44,RA
R2 T2 T3 associated_with VCAM-1,RA
R3 T4 T5 associated_with VCAM-1,RA
R4 T6 T7 associated_with CD44,RA
R5 T8 T9 associated_with transcription factor AP-1,RA
R6 T10 T11 associated_with CD44,RA

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 17-21 protein denotes CD44
T2 25-50 cell_type denotes rheumatoid synovial cells
T3 64-70 protein denotes VCAM-1
T4 463-469 protein denotes VCAM-1
T5 498-504 protein denotes VCAM-1
T6 555-580 cell_type denotes rheumatoid synovial cells
T7 598-602 protein denotes CD44
T8 624-628 protein denotes CD44
T9 664-670 protein denotes VCAM-1
T10 728-736 protein denotes IL-1beta
T11 813-819 protein denotes VCAM-1
T12 824-828 protein denotes CD44
T13 881-889 protein denotes integrin
T14 921-938 cell_type denotes RA synovial cells
T15 942-949 cell_type denotes T cells
T16 972-976 protein denotes CD44
T17 1036-1053 cell_type denotes RA synovial cells
T18 1098-1102 protein denotes CD44
T19 1121-1127 protein denotes VCAM-1
T20 1143-1149 protein denotes VCAM-1
T21 1171-1178 cell_type denotes T cells
T22 1220-1227 cell_type denotes T cells
T23 1232-1246 cell_type denotes synovial cells

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9973520-5#314#339#gene3725 843-868 gene3725 denotes transcription factor AP-1
9973520-5#392#394#diseaseC0003873 921-923 diseaseC0003873 denotes RA
9973520-6#106#110#gene960 1098-1102 gene960 denotes CD44
9973520-6#129#135#gene7412 1121-1127 gene7412 denotes VCAM-1
9973520-6#151#157#gene7412 1143-1149 gene7412 denotes VCAM-1
9973520-6#44#46#diseaseC0003873 1036-1038 diseaseC0003873 denotes RA
9973520-6#258#260#diseaseC0003873 1250-1252 diseaseC0003873 denotes RA
9973520-6#261#270#diseaseC0039103 1253-1262 diseaseC0039103 denotes synovitis
9973520-6#44#46#diseaseC0003873 1036-1038 diseaseC0003873 denotes RA
9973520-6#258#260#diseaseC0003873 1250-1252 diseaseC0003873 denotes RA
9973520-6#44#46#diseaseC0003873 1036-1038 diseaseC0003873 denotes RA
9973520-6#258#260#diseaseC0003873 1250-1252 diseaseC0003873 denotes RA
9973520-6#261#270#diseaseC0039103 1253-1262 diseaseC0039103 denotes synovitis
314#339#gene3725392#394#diseaseC0003873 9973520-5#314#339#gene3725 9973520-5#392#394#diseaseC0003873 associated_with transcription factor AP-1,RA
106#110#gene96044#46#diseaseC0003873 9973520-6#106#110#gene960 9973520-6#44#46#diseaseC0003873 associated_with CD44,RA
106#110#gene960258#260#diseaseC0003873 9973520-6#106#110#gene960 9973520-6#258#260#diseaseC0003873 associated_with CD44,RA
106#110#gene960261#270#diseaseC0039103 9973520-6#106#110#gene960 9973520-6#261#270#diseaseC0039103 associated_with CD44,synovitis
106#110#gene96044#46#diseaseC0003873 9973520-6#106#110#gene960 9973520-6#44#46#diseaseC0003873 associated_with CD44,RA
106#110#gene960258#260#diseaseC0003873 9973520-6#106#110#gene960 9973520-6#258#260#diseaseC0003873 associated_with CD44,RA
106#110#gene96044#46#diseaseC0003873 9973520-6#106#110#gene960 9973520-6#44#46#diseaseC0003873 associated_with CD44,RA
106#110#gene960258#260#diseaseC0003873 9973520-6#106#110#gene960 9973520-6#258#260#diseaseC0003873 associated_with CD44,RA
106#110#gene960261#270#diseaseC0039103 9973520-6#106#110#gene960 9973520-6#261#270#diseaseC0039103 associated_with CD44,synovitis
129#135#gene741244#46#diseaseC0003873 9973520-6#129#135#gene7412 9973520-6#44#46#diseaseC0003873 associated_with VCAM-1,RA
129#135#gene7412258#260#diseaseC0003873 9973520-6#129#135#gene7412 9973520-6#258#260#diseaseC0003873 associated_with VCAM-1,RA
129#135#gene7412261#270#diseaseC0039103 9973520-6#129#135#gene7412 9973520-6#261#270#diseaseC0039103 associated_with VCAM-1,synovitis
129#135#gene741244#46#diseaseC0003873 9973520-6#129#135#gene7412 9973520-6#44#46#diseaseC0003873 associated_with VCAM-1,RA
129#135#gene7412258#260#diseaseC0003873 9973520-6#129#135#gene7412 9973520-6#258#260#diseaseC0003873 associated_with VCAM-1,RA
129#135#gene741244#46#diseaseC0003873 9973520-6#129#135#gene7412 9973520-6#44#46#diseaseC0003873 associated_with VCAM-1,RA
129#135#gene7412258#260#diseaseC0003873 9973520-6#129#135#gene7412 9973520-6#258#260#diseaseC0003873 associated_with VCAM-1,RA
129#135#gene7412261#270#diseaseC0039103 9973520-6#129#135#gene7412 9973520-6#261#270#diseaseC0039103 associated_with VCAM-1,synovitis
151#157#gene741244#46#diseaseC0003873 9973520-6#151#157#gene7412 9973520-6#44#46#diseaseC0003873 associated_with VCAM-1,RA
151#157#gene7412258#260#diseaseC0003873 9973520-6#151#157#gene7412 9973520-6#258#260#diseaseC0003873 associated_with VCAM-1,RA
151#157#gene7412261#270#diseaseC0039103 9973520-6#151#157#gene7412 9973520-6#261#270#diseaseC0039103 associated_with VCAM-1,synovitis
151#157#gene741244#46#diseaseC0003873 9973520-6#151#157#gene7412 9973520-6#44#46#diseaseC0003873 associated_with VCAM-1,RA
151#157#gene7412258#260#diseaseC0003873 9973520-6#151#157#gene7412 9973520-6#258#260#diseaseC0003873 associated_with VCAM-1,RA
151#157#gene741244#46#diseaseC0003873 9973520-6#151#157#gene7412 9973520-6#44#46#diseaseC0003873 associated_with VCAM-1,RA
151#157#gene7412258#260#diseaseC0003873 9973520-6#151#157#gene7412 9973520-6#258#260#diseaseC0003873 associated_with VCAM-1,RA
151#157#gene7412261#270#diseaseC0039103 9973520-6#151#157#gene7412 9973520-6#261#270#diseaseC0039103 associated_with VCAM-1,synovitis

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-71 Sentence denotes Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1.
S2 72-151 Sentence denotes CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor.
S3 152-271 Sentence denotes However, the cellular functions and its role in inflammation, for example, rheumatoid synovitis, are currently unknown.
S4 272-324 Sentence denotes In this study, we propose a novel function for CD44.
S5 325-528 Sentence denotes Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion.
S6 529-991 Sentence denotes Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking.
S7 992-1263 Sentence denotes These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis.
S8 1264-1419 Sentence denotes We therefore propose that such cross-talking among distinct adhesion molecules may be involved in the pathogenesis of inflammation, including RA synovitis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 17-21 NP denotes CD44
C2 25-50 NP denotes rheumatoid synovial cells
C3 64-70 NP denotes VCAM-1
C4 72-76 NP denotes CD44
C5 116-131 NP denotes hyaluronic acid
C6 188-191 NP denotes its
C7 200-212 NP denotes inflammation
C8 319-323 NP denotes CD44
C9 442-452 NP denotes hyaluronan
C10 463-480 NP denotes VCAM-1 expression
C11 555-580 NP denotes rheumatoid synovial cells
C12 598-603 NP denotes CD44;
C14 624-628 NP denotes CD44
C13 607-628 NP denotes cross-linking of CD44
C15 664-681 NP denotes VCAM-1 expression
C16 686-689 NP denotes its
C17 755-765 NP denotes hyaluronan
C18 813-820 NP denotes VCAM-1;
C19 824-828 NP denotes CD44
C20 921-938 NP denotes RA synovial cells
C21 942-949 NP denotes T cells
C22 972-990 NP denotes CD44 cross-linking
C23 1036-1053 NP denotes RA synovial cells
C24 1074-1089 NP denotes hyaluronic acid
C25 1098-1102 NP denotes CD44
C27 1121-1138 NP denotes VCAM-1 expression
C28 1171-1178 NP denotes T cells
C26 1121-1178 NP denotes VCAM-1 expression and VCAM-1-mediated adhesion to T cells
C29 1180-1185 NP denotes which
C30 1220-1227 NP denotes T cells
C31 1250-1262 NP denotes RA synovitis
C32 1382-1394 NP denotes inflammation
C33 1406-1418 NP denotes RA synovitis
R1 C4 C1 coref-ident CD44,CD44
R2 C6 C4 coref-pron its,CD44
R3 C8 C4 coref-ident CD44,CD44
R4 C11 C2 coref-ident rheumatoid synovial cells,rheumatoid synovial cells
R5 C12 C8 coref-ident CD44;,CD44
R6 C14 C12 coref-ident CD44,CD44;
R7 C15 C10 coref-ident VCAM-1 expression,VCAM-1 expression
R8 C16 C14 coref-pron its,CD44
R9 C17 C9 coref-ident hyaluronan,hyaluronan
R10 C18 C3 coref-ident VCAM-1;,VCAM-1
R11 C19 C14 coref-ident CD44,CD44
R12 C22 C13 coref-ident CD44 cross-linking,cross-linking of CD44
R13 C23 C20 coref-ident RA synovial cells,RA synovial cells
R14 C24 C5 coref-ident hyaluronic acid,hyaluronic acid
R15 C25 C19 coref-ident CD44,CD44
R16 C27 C15 coref-ident VCAM-1 expression,VCAM-1 expression
R17 C28 C21 coref-ident T cells,T cells
R18 C29 C26 coref-relat which,VCAM-1 expression and VCAM-1-mediated adhesion to T cells
R19 C30 C28 coref-ident T cells,T cells
R20 C32 C7 coref-ident inflammation,inflammation
R21 C33 C31 coref-ident RA synovitis,RA synovitis

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 17-21 protein_molecule denotes CD44
T2 25-50 cell_type denotes rheumatoid synovial cells
T3 64-70 protein_molecule denotes VCAM-1
T4 72-76 carbohydrate denotes CD44
T5 116-131 carbohydrate denotes hyaluronic acid
T6 135-150 carbohydrate denotes homing receptor
T7 165-183 other_name denotes cellular functions
T8 319-323 carbohydrate denotes CD44
T9 351-371 other_name denotes rheumatoid arthritis
T10 373-375 other_name denotes RA
T11 408-412 carbohydrate denotes CD44
T12 442-452 carbohydrate denotes hyaluronan
T13 463-469 protein_molecule denotes VCAM-1
T14 498-504 protein_molecule denotes VCAM-1
T15 555-580 cell_type denotes rheumatoid synovial cells
T16 598-602 carbohydrate denotes CD44
T17 624-628 carbohydrate denotes CD44
T18 664-670 protein_molecule denotes VCAM-1
T19 690-708 other_name denotes mRNA transcription
T20 728-736 protein_molecule denotes IL-1beta
T21 755-765 carbohydrate denotes hyaluronan
T22 813-819 protein_molecule denotes VCAM-1
T23 824-828 carbohydrate denotes CD44
T24 881-889 protein_family_or_group denotes integrin
T25 921-923 other_name denotes RA
T26 942-949 cell_type denotes T cells
T27 972-976 protein_molecule denotes CD44
T28 1036-1038 other_name denotes RA
T29 1074-1089 carbohydrate denotes hyaluronic acid
T30 1098-1102 protein_molecule denotes CD44
T31 1121-1127 protein_molecule denotes VCAM-1
T32 1143-1149 protein_molecule denotes VCAM-1
T33 1171-1178 cell_type denotes T cells
T34 1220-1227 cell_type denotes T cells
T35 1232-1246 cell_type denotes synovial cells
T36 1250-1252 other_name denotes RA
T37 1324-1342 other_organic_compound denotes adhesion molecules
T38 1382-1394 other_name denotes inflammation
T39 1406-1408 other_name denotes RA