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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-10 protein denotes Fas ligand
T2 24-38 cell_type denotes human NK cells
T3 71-98 protein denotes calcineurin-nuclear factors
T4 138-148 protein denotes Fas ligand
T5 150-154 protein denotes FasL
T6 452-464 protein denotes FasL protein
T7 469-473 RNA denotes mRNA
T8 477-495 cell_type denotes activated NK cells
T9 536-540 protein denotes CD16
T10 544-570 cell_type denotes IL-2-preactivated NK cells
T11 649-653 protein denotes FasL
T12 671-675 protein denotes CD16
T13 684-688 protein denotes FasL
T14 902-906 protein denotes FasL
T15 943-947 protein denotes CD16
T16 998-1002 protein denotes FasL
T17 1016-1024 cell_type denotes NK cells
T18 1065-1069 protein denotes CD16
T19 1104-1127 protein denotes NF of activated T cells
T20 1129-1133 protein denotes NFAT
T21 1184-1188 protein denotes NFAT
T22 1332-1336 protein denotes NFAT
T23 1495-1516 protein denotes threonine phosphatase
T24 1532-1536 protein denotes NFAT
T25 1591-1602 protein denotes calcineurin
T26 1607-1611 protein denotes NFAT
T27 1673-1677 protein denotes FasL
T28 1691-1709 cell_type denotes activated NK cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-137 Sentence denotes Fas ligand induction in human NK cells is regulated by redox through a calcineurin-nuclear factors of activated T cell-dependent pathway.
S2 138-266 Sentence denotes Fas ligand (FasL) on cytotoxic lymphocytes is important for mediating apoptosis of activated lymphocytes and other target cells.
S3 267-416 Sentence denotes We have reported that NK cell functions, such as proliferation, cell death, and killing activity, are subject to regulation by cellular redox status.
S4 417-523 Sentence denotes Here, we report that expression of FasL protein and mRNA in activated NK cells is also regulated by redox.
S5 524-665 Sentence denotes Ligation of CD16 on IL-2-preactivated NK cells resulted in reduction of intracellular peroxide level as well as induction of FasL expression.
S6 666-807 Sentence denotes This CD16-induced FasL expression was suppressed by oxidative stress, including thiol deprivation or treatment with hydrogen peroxide (H2O2).
S7 808-918 Sentence denotes Addition of thiol-reducing compounds, such as L-cystine, 2-ME, or N-acetyl cysteine, restored FasL expression.
S8 919-1025 Sentence denotes These data suggest that CD16 stimulation requires cellular reducing status for FasL induction in NK cells.
S9 1026-1200 Sentence denotes Because FasL gene activation following CD16 cross-linking is regulated by the NF of activated T cells (NFAT), we examined the effect of oxidative stresses on NFAT activation.
S10 1201-1412 Sentence denotes Electrophoretic mobility shift assays revealed that both thiol insufficiency and H2O2 treatment suppressed DNA-binding activity of NFAT and that addition of thiol-reducing compounds reversed or even enhanced it.
S11 1413-1548 Sentence denotes Furthermore, these oxidative stresses inhibited activity of calcineurin, a serine/threonine phosphatase that regulates NFAT activation.
S12 1549-1872 Sentence denotes These results suggest that suppression of calcineurin and NFAT activation is a mechanism by which oxidative stress inhibits FasL induction in activated NK cells and further support the hypothesis that thiol-reducing compounds might be required for maintenance of optimal NK functions under physiologic oxidative conditions.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 24-38 NP denotes human NK cells
C2 55-60 NP denotes redox
C3 477-495 NP denotes activated NK cells
C4 517-522 NP denotes redox
C5 649-664 NP denotes FasL expression
C6 718-734 NP denotes oxidative stress
C7 767-806 NP denotes treatment with hydrogen peroxide (H2O2)
C9 820-844 NP denotes thiol-reducing compounds
C8 808-844 NP denotes Addition of thiol-reducing compounds
C10 902-917 NP denotes FasL expression
C11 1016-1024 NP denotes NK cells
C12 1100-1134 NP denotes the NF of activated T cells (NFAT)
C13 1162-1180 NP denotes oxidative stresses
C14 1184-1199 NP denotes NFAT activation
C15 1282-1296 NP denotes H2O2 treatment
C17 1332-1336 NP denotes NFAT
C16 1308-1336 NP denotes DNA-binding activity of NFAT
C19 1358-1382 NP denotes thiol-reducing compounds
C18 1346-1382 NP denotes addition of thiol-reducing compounds
C20 1409-1411 NP denotes it
C21 1426-1450 NP denotes these oxidative stresses
C22 1473-1484 NP denotes calcineurin
C24 1486-1516 NP denotes a serine/threonine phosphatase
C25 1517-1521 NP denotes that
C26 1532-1547 NP denotes NFAT activation
C23 1486-1547 NP denotes a serine/threonine phosphatase that regulates NFAT activation
C27 1591-1602 NP denotes calcineurin
C28 1607-1622 NP denotes NFAT activation
C29 1626-1637 NP denotes a mechanism
C30 1641-1646 NP denotes which
C31 1647-1663 NP denotes oxidative stress
C32 1691-1709 NP denotes activated NK cells
C33 1730-1744 NP denotes the hypothesis
C34 1745-1749 NP denotes that
C35 1750-1774 NP denotes thiol-reducing compounds
R1 C4 C2 coref-ident redox,redox
R2 C10 C5 coref-ident FasL expression,FasL expression
R3 C11 C1 coref-ident NK cells,human NK cells
R4 C15 C7 coref-ident H2O2 treatment,treatment with hydrogen peroxide (H2O2)
R5 C17 C12 coref-ident NFAT,the NF of activated T cells (NFAT)
R6 C19 C9 coref-ident thiol-reducing compounds,thiol-reducing compounds
R7 C18 C8 coref-ident addition of thiol-reducing compounds,Addition of thiol-reducing compounds
R8 C20 C16 coref-pron it,DNA-binding activity of NFAT
R9 C21 C13 coref-ident these oxidative stresses,oxidative stresses
R10 C25 C24 coref-relat that,a serine/threonine phosphatase
R11 C26 C14 coref-ident NFAT activation,NFAT activation
R12 C23 C22 coref-appos a serine/threonine phosphatase that regulates NFAT activation,calcineurin
R13 C27 C22 coref-ident calcineurin,calcineurin
R14 C28 C26 coref-ident NFAT activation,NFAT activation
R15 C30 C29 coref-relat which,a mechanism
R16 C31 C6 coref-ident oxidative stress,oxidative stress
R17 C32 C3 coref-ident activated NK cells,activated NK cells
R18 C34 C33 coref-relat that,the hypothesis
R19 C35 C19 coref-ident thiol-reducing compounds,thiol-reducing compounds

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-10 protein_molecule denotes Fas ligand
T2 24-38 cell_type denotes human NK cells
T3 71-98 protein_family_or_group denotes calcineurin-nuclear factors
T4 138-148 protein_molecule denotes Fas ligand
T5 150-154 protein_molecule denotes FasL
T6 438-448 other_name denotes expression
T7 452-464 protein_molecule denotes FasL protein
T8 469-473 RNA_molecule denotes mRNA
T9 477-495 cell_type denotes activated NK cells
T10 536-540 protein_molecule denotes CD16
T11 544-549 cell_type denotes IL-2-
T12 549-570 cell_type denotes preactivated NK cells
T13 596-624 other_name denotes intracellular peroxide level
T14 649-653 protein_molecule denotes FasL
T15 671-675 protein_molecule denotes CD16
T16 684-688 protein_molecule denotes FasL
T17 718-734 other_name denotes oxidative stress
T18 746-763 other_name denotes thiol deprivation
T19 782-799 inorganic denotes hydrogen peroxide
T20 801-805 inorganic denotes H2O2
T21 854-863 amino_acid_monomer denotes L-cystine
T22 865-869 amino_acid_monomer denotes 2-ME
T23 874-891 amino_acid_monomer denotes N-acetyl cysteine
T24 902-906 protein_molecule denotes FasL
T25 943-947 protein_molecule denotes CD16
T26 998-1002 protein_molecule denotes FasL
T27 1016-1024 cell_type denotes NK cells
T28 1065-1069 protein_molecule denotes CD16
T29 1104-1119 protein_molecule denotes NF of activated
T30 1120-1127 cell_type denotes T cells
T31 1129-1133 protein_molecule denotes NFAT
T32 1162-1180 other_name denotes oxidative stresses
T33 1184-1188 protein_family_or_group denotes NFAT
T34 1201-1238 other_name denotes Electrophoretic mobility shift assays
T35 1282-1286 inorganic denotes H2O2
T36 1308-1328 other_name denotes DNA-binding activity
T37 1332-1336 protein_family_or_group denotes NFAT
T38 1358-1382 other_organic_compound denotes thiol-reducing compounds
T39 1432-1450 other_name denotes oxidative stresses
T40 1488-1494 amino_acid_monomer denotes serine
T41 1495-1504 amino_acid_monomer denotes threonine
T42 1532-1536 protein_family_or_group denotes NFAT
T43 1591-1602 protein_molecule denotes calcineurin
T44 1607-1611 protein_family_or_group denotes NFAT
T45 1647-1663 other_name denotes oxidative stress
T46 1673-1677 protein_molecule denotes FasL
T47 1691-1700 cell_type denotes activated
T48 1701-1709 cell_type denotes NK cells
T49 1750-1774 other_organic_compound denotes thiol-reducing compounds
T50 1820-1832 other_name denotes NK functions
T51 1839-1871 other_name denotes physiologic oxidative conditions