PubMed:9973402 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	27-36	DNA	denotes	IL-2 gene
T2	51-66	cell_type	denotes	anergic T cells
T3	120-124	protein	denotes	IL-2
T4	214-236	cell_type	denotes	anergic murine T cells
T5	240-269	cell_type	denotes	human Jurkat T leukemia cells
T6	287-300	cell_line	denotes	heterokaryons
T7	383-399	RNA	denotes	murine IL-2 mRNA
T8	456-465	DNA	denotes	IL-2 gene
T9	484-497	cell_line	denotes	Heterokaryons
T10	522-544	cell_type	denotes	anergic murine T cells
T11	548-569	cell_type	denotes	normal murine T cells
T12	596-622	protein	denotes	intracellular IL-2 protein
T13	681-684	protein	denotes	CD3
T14	689-698	protein	denotes	CD28 mAbs
T15	724-740	protein	denotes	protein kinase C
T16	906-940	protein	denotes	dominant-acting repressor molecule
T17	982-991	DNA	denotes	IL-2 gene
T18	1006-1021	cell_type	denotes	anergic T cells

Id	Subject	Object	Predicate	Lexical cue
S1	0-67	Sentence	denotes	Evidence for repression of IL-2 gene activation in anergic T cells.
S2	68-203	Sentence	denotes	The induction of clonal anergy in a T cell inhibits IL-2 secretion because of the development of a proximal signal transduction defect.
S3	204-413	Sentence	denotes	Fusion of anergic murine T cells to human Jurkat T leukemia cells and formation of heterokaryons failed to result in a complementation of this signaling defect and restoration of murine IL-2 mRNA inducibility.
S4	414-483	Sentence	denotes	Instead, signal transduction to the human IL-2 gene became disrupted.
S5	484-766	Sentence	denotes	Heterokaryons formed by the fusion of anergic murine T cells to normal murine T cells also failed to accumulate intracellular IL-2 protein in response to stimulation either with the combination of CD3 and CD28 mAbs or with ionomycin plus a protein kinase C-activating phorbol ester.
S6	767-1022	Sentence	denotes	The results argue against a loss-of-function signaling defect as the sole basis for clonal anergy induction and document the presence of a dominant-acting repressor molecule that inhibits signal transduction to the IL-2 gene within viable anergic T cells.

Id	Subject	Object	Predicate	Lexical cue
C1	214-236	NP	denotes	anergic murine T cells
C2	446-465	NP	denotes	the human IL-2 gene
C3	522-544	NP	denotes	anergic murine T cells
C4	904-940	NP	denotes	a dominant-acting repressor molecule
C5	941-945	NP	denotes	that
C6	978-991	NP	denotes	the IL-2 gene
R1	C3	C1	coref-ident	anergic murine T cells,anergic murine T cells
R2	C5	C4	coref-relat	that,a dominant-acting repressor molecule
R3	C6	C2	coref-ident	the IL-2 gene,the human IL-2 gene

Id	Subject	Object	Predicate	Lexical cue
T1	27-36	DNA_domain_or_region	denotes	IL-2 gene
T2	51-66	cell_type	denotes	anergic T cells
T3	85-98	other_name	denotes	clonal anergy
T4	120-124	protein_molecule	denotes	IL-2
T5	167-202	other_name	denotes	proximal signal transduction defect
T6	214-236	cell_type	denotes	anergic murine T cells
T7	240-269	cell_type	denotes	human Jurkat T leukemia cells
T8	287-300	cell_line	denotes	heterokaryons
T9	383-399	RNA_molecule	denotes	murine IL-2 mRNA
T10	456-465	DNA_domain_or_region	denotes	IL-2 gene
T11	484-497	cell_line	denotes	Heterokaryons
T12	522-544	cell_type	denotes	anergic murine T cells
T13	548-569	cell_type	denotes	normal murine T cells
T14	596-622	protein_molecule	denotes	intracellular IL-2 protein
T15	681-684	protein_family_or_group	denotes	CD3
T16	689-698	protein_family_or_group	denotes	CD28 mAbs
T17	707-716	other_organic_compound	denotes	ionomycin
T18	724-740	protein_molecule	denotes	protein kinase C
T19	851-864	other_name	denotes	clonal anergy
T20	906-940	protein_family_or_group	denotes	dominant-acting repressor molecule
T21	982-991	DNA_domain_or_region	denotes	IL-2 gene
T22	1006-1021	cell_type	denotes	anergic T cells