PubMed:9973373 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	33-49	protein	denotes	Ile50Val variant
T2	57-88	protein	denotes	human IL-4 receptor alpha-chain
T3	92-95	protein	denotes	IgE
T4	127-162	DNA	denotes	IL-4R alpha-chain (IL-4Ralpha) gene
T5	337-341	protein	denotes	IL-4
T6	378-388	protein	denotes	IL-4Ralpha
T7	419-421	protein	denotes	50
T8	447-450	protein	denotes	551
T9	494-499	protein	denotes	STAT6
T10	561-578	DNA	denotes	Iepsilon promoter
T11	582-586	protein	denotes	IL-4
T12	637-641	protein	denotes	IL-4
T13	724-728	protein	denotes	CD23
T14	744-747	protein	denotes	IgE
T15	761-765	protein	denotes	IL-4
T16	784-802	cell_line	denotes	Ile50-bearing PBMC
T17	899-903	protein	denotes	IL-4
T18	1022-1025	protein	denotes	IgE

Id	Subject	Object	Predicate	Lexical cue
S1	0-106	Sentence	denotes	Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.
S2	107-240	Sentence	denotes	Two variants of the IL-4R alpha-chain (IL-4Ralpha) gene have been recently identified in association with different atopic disorders.
S3	241-451	Sentence	denotes	To clarify the etiological relationship between the two variants, we analyzed responsiveness to IL-4 of transfectants with four kinds of IL-4Ralpha carrying either Val or Ile at 50 and either Gln or Arg at 551.
S4	452-650	Sentence	denotes	The substitution of Ile for Val augmented STAT6 activation, proliferation, and transcription activity of the Iepsilon promoter by IL-4, whereas that of Arg for Gln did not change these IL-4 signals.
S5	651-723	Sentence	denotes	Arg551 was not associated with atopic asthma in the Japanese population.
S6	724-838	Sentence	denotes	CD23 expression and IgE synthesis by IL-4 were augmented in Ile50-bearing PBMC, compared with those bearing Val50.
S7	839-1036	Sentence	denotes	Taken together, substitution of Arg551 does not enhance the IL-4 signal for generation of germline epsilon transcript, whereas the substitution of Ile50 contributes to enhancement of IgE synthesis.

Id	Subject	Object	Predicate	Lexical cue
C1	53-88	NP	denotes	the human IL-4 receptor alpha-chain
C2	92-105	NP	denotes	IgE synthesis
C3	107-162	NP	denotes	Two variants of the IL-4R alpha-chain (IL-4Ralpha) gene
C4	289-305	NP	denotes	the two variants
C5	378-388	NP	denotes	IL-4Ralpha
C6	452-468	NP	denotes	The substitution
C7	582-586	NP	denotes	IL-4
C8	596-600	NP	denotes	that
C9	651-657	NP	denotes	Arg551
C10	761-765	NP	denotes	IL-4
C11	871-877	NP	denotes	Arg551
C12	1022-1035	NP	denotes	IgE synthesis
R1	C4	C3	coref-ident	the two variants,Two variants of the IL-4R alpha-chain (IL-4Ralpha) gene
R2	C5	C1	coref-ident	IL-4Ralpha,the human IL-4 receptor alpha-chain
R3	C8	C6	coref-pron	that,The substitution
R4	C10	C7	coref-ident	IL-4,IL-4
R5	C11	C9	coref-ident	Arg551,Arg551
R6	C12	C2	coref-ident	IgE synthesis,IgE synthesis

Id	Subject	Object	Predicate	Lexical cue
T1	33-49	protein_subunit	denotes	Ile50Val variant
T2	57-88	protein_subunit	denotes	human IL-4 receptor alpha-chain
T3	92-95	protein_family_or_group	denotes	IgE
T4	127-144	protein_subunit	denotes	IL-4R alpha-chain
T5	146-156	protein_subunit	denotes	IL-4Ralpha
T6	223-239	other_name	denotes	atopic disorders
T7	337-341	protein_molecule	denotes	IL-4
T8	345-358	other_name	denotes	transfectants
T9	378-388	protein_subunit	denotes	IL-4Ralpha
T10	405-408	amino_acid_monomer	denotes	Val
T11	412-415	amino_acid_monomer	denotes	Ile
T12	419-421	protein_domain_or_region	denotes	50
T13	433-436	amino_acid_monomer	denotes	Gln
T14	440-443	amino_acid_monomer	denotes	Arg
T15	447-450	protein_domain_or_region	denotes	551
T16	480-483	amino_acid_monomer	denotes	Val
T17	494-499	protein_molecule	denotes	STAT6
T18	531-553	other_name	denotes	transcription activity
T19	561-578	DNA_domain_or_region	denotes	Iepsilon promoter
T20	582-586	protein_molecule	denotes	IL-4
T21	604-607	amino_acid_monomer	denotes	Arg
T22	612-615	amino_acid_monomer	denotes	Gln
T23	637-641	protein_molecule	denotes	IL-4
T24	651-657	amino_acid_monomer	denotes	Arg551
T25	682-695	other_name	denotes	atopic asthma
T26	703-722	multi_cell	denotes	Japanese population
T27	724-728	protein_molecule	denotes	CD23
T28	744-747	protein_family_or_group	denotes	IgE
T29	761-765	protein_molecule	denotes	IL-4
T30	784-789	amino_acid_monomer	denotes	Ile50
T31	832-837	amino_acid_monomer	denotes	Val50
T32	871-877	amino_acid_monomer	denotes	Arg551
T33	899-903	protein_molecule	denotes	IL-4
T34	986-991	amino_acid_monomer	denotes	Ile50
T35	1022-1025	protein_family_or_group	denotes	IgE