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sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion.
T2 96-182 Sentence denotes A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants.
T3 183-374 Sentence denotes Stimulation of neurotransmitter release by alpha-latrotoxin requires its binding to the calcium-independent receptor of alpha-latrotoxin (CIRL), an orphan neuronal G protein-coupled receptor.
T4 375-684 Sentence denotes CIRL consists of two noncovalently bound subunits, p85, a heptahelical integral membrane protein, and p120, a large extracellular polypeptide with domains homologous to lectin, olfactomedin, mucin, the secretin receptor family, and a novel structural motif common for large orphan G protein-coupled receptors.
T5 685-908 Sentence denotes The analysis of CIRL deletion mutants indicates that the high affinity alpha-latrotoxin-binding site is located within residues 467-891, which comprise the first transmembrane segment of p85 and the C-terminal half of p120.
T6 909-1031 Sentence denotes The N-terminal lectin, olfactomedin, and mucin domains of p120 are not required for the interaction with alpha-latrotoxin.
T7 1032-1255 Sentence denotes Soluble p120 and all its fragments, which include the 467-770 residues, bind alpha-latrotoxin with low affinity suggesting the importance of membrane-embedded p85 for the stabilization of the complex of the toxin with p120.
T8 1256-1653 Sentence denotes Two COOH-terminal deletion mutants of CIRL, one with the truncated cytoplasmic domain and the other with only one transmembrane segment left of seven, supported both alpha-latrotoxin-induced calcium uptake in HEK293 cells and alpha-latrotoxin-stimulated secretion when expressed in chromaffin cells, although with a different dose dependence than wild-type CIRL and its N-terminal deletion mutant.
T9 1654-1799 Sentence denotes Thus the signaling domains of CIRL are not critically important for the stimulation of exocytosis in intact chromaffin cells by alpha-latrotoxin.
T1 0-95 Sentence denotes Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion.
T2 96-182 Sentence denotes A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants.
T3 183-374 Sentence denotes Stimulation of neurotransmitter release by alpha-latrotoxin requires its binding to the calcium-independent receptor of alpha-latrotoxin (CIRL), an orphan neuronal G protein-coupled receptor.
T4 375-684 Sentence denotes CIRL consists of two noncovalently bound subunits, p85, a heptahelical integral membrane protein, and p120, a large extracellular polypeptide with domains homologous to lectin, olfactomedin, mucin, the secretin receptor family, and a novel structural motif common for large orphan G protein-coupled receptors.
T5 685-908 Sentence denotes The analysis of CIRL deletion mutants indicates that the high affinity alpha-latrotoxin-binding site is located within residues 467-891, which comprise the first transmembrane segment of p85 and the C-terminal half of p120.
T6 909-1031 Sentence denotes The N-terminal lectin, olfactomedin, and mucin domains of p120 are not required for the interaction with alpha-latrotoxin.
T7 1032-1255 Sentence denotes Soluble p120 and all its fragments, which include the 467-770 residues, bind alpha-latrotoxin with low affinity suggesting the importance of membrane-embedded p85 for the stabilization of the complex of the toxin with p120.
T8 1256-1653 Sentence denotes Two COOH-terminal deletion mutants of CIRL, one with the truncated cytoplasmic domain and the other with only one transmembrane segment left of seven, supported both alpha-latrotoxin-induced calcium uptake in HEK293 cells and alpha-latrotoxin-stimulated secretion when expressed in chromaffin cells, although with a different dose dependence than wild-type CIRL and its N-terminal deletion mutant.
T9 1654-1799 Sentence denotes Thus the signaling domains of CIRL are not critically important for the stimulation of exocytosis in intact chromaffin cells by alpha-latrotoxin.

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion.
T2 96-182 Sentence denotes A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants.
T3 183-374 Sentence denotes Stimulation of neurotransmitter release by alpha-latrotoxin requires its binding to the calcium-independent receptor of alpha-latrotoxin (CIRL), an orphan neuronal G protein-coupled receptor.
T4 375-684 Sentence denotes CIRL consists of two noncovalently bound subunits, p85, a heptahelical integral membrane protein, and p120, a large extracellular polypeptide with domains homologous to lectin, olfactomedin, mucin, the secretin receptor family, and a novel structural motif common for large orphan G protein-coupled receptors.
T5 685-908 Sentence denotes The analysis of CIRL deletion mutants indicates that the high affinity alpha-latrotoxin-binding site is located within residues 467-891, which comprise the first transmembrane segment of p85 and the C-terminal half of p120.
T6 909-1031 Sentence denotes The N-terminal lectin, olfactomedin, and mucin domains of p120 are not required for the interaction with alpha-latrotoxin.
T7 1032-1255 Sentence denotes Soluble p120 and all its fragments, which include the 467-770 residues, bind alpha-latrotoxin with low affinity suggesting the importance of membrane-embedded p85 for the stabilization of the complex of the toxin with p120.
T8 1256-1653 Sentence denotes Two COOH-terminal deletion mutants of CIRL, one with the truncated cytoplasmic domain and the other with only one transmembrane segment left of seven, supported both alpha-latrotoxin-induced calcium uptake in HEK293 cells and alpha-latrotoxin-stimulated secretion when expressed in chromaffin cells, although with a different dose dependence than wild-type CIRL and its N-terminal deletion mutant.
T9 1654-1799 Sentence denotes Thus the signaling domains of CIRL are not critically important for the stimulation of exocytosis in intact chromaffin cells by alpha-latrotoxin.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 455-463 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 491-504 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T5 847-860 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T6 861-868 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914
T7 1173-1181 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T10 1323-1334 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T11 1370-1383 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T12 1384-1391 Body_part denotes segment http://purl.obolibrary.org/obo/UBERON_0000914
T13 1538-1554 Body_part denotes chromaffin cells http://purl.obolibrary.org/obo/UBERON_0001236
T14 1762-1778 Body_part denotes chromaffin cells http://purl.obolibrary.org/obo/UBERON_0001236

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 338-346 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 1538-1554 Cell denotes chromaffin cells http://purl.obolibrary.org/obo/CL:0000166
T3 1762-1778 Cell denotes chromaffin cells http://purl.obolibrary.org/obo/CL:0000166