> top > docs > PubMed:9920778 > annotations

PubMed:9920778 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-174 Sentence denotes Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia.
TextSentencer_T2 175-285 Sentence denotes The human glucocorticoid receptor (GR) is expressed as two alternatively spliced isoforms, GRalpha and GRbeta.
TextSentencer_T3 286-472 Sentence denotes Whereas GRalpha is a hormone-activated transcription factor, GRbeta does not bind glucocorticoids (GCs), is transcriptionally inactive, and is a potential inhibitor of activated GRalpha.
TextSentencer_T4 473-576 Sentence denotes Differential expression of GR isoforms may play a role in generalized or tissue-specific GC resistance.
TextSentencer_T5 577-720 Sentence denotes GCs induce apoptosis in neoplastic lymphoid cells; and, defective apoptosis is implicated in the genesis of chronic lymphocytic leukemia (CLL).
TextSentencer_T6 721-781 Sentence denotes We studied a patient with generalized GC resistance and CLL.
TextSentencer_T7 782-959 Sentence denotes GR number in the patient's transformed lymphocytes was approximately one half that of control cells with a approximately 10-fold reduction in binding affinity for dexamethasone.
TextSentencer_T8 960-1070 Sentence denotes In vitro apoptosis induction in CLL cells was delayed in response to GCs, but not to other apoptosis inducers.
TextSentencer_T9 1071-1267 Sentence denotes Sequencing of the GR cDNA and gene including the 2.3-kb coding region, the intron/exon junctions, the known 5'-regulatory region, and approximately 300 bp of the 3'-region revealed no alterations.
TextSentencer_T10 1268-1497 Sentence denotes Western blot with an N-terminal antibody showed normal levels of immunoreactive GR, but quantitative analysis with isoform-specific C-terminal antibodies revealed a markedly reduced GRalpha expression, and high GRbeta expression.
TextSentencer_T11 1498-1676 Sentence denotes These findings indicate that imbalanced expression of the GR isoforms may be a mechanism of GC resistance, and may have implications for tumorigenesis by enhancing cell survival.
T1 0-174 Sentence denotes Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia.
T2 175-285 Sentence denotes The human glucocorticoid receptor (GR) is expressed as two alternatively spliced isoforms, GRalpha and GRbeta.
T3 286-472 Sentence denotes Whereas GRalpha is a hormone-activated transcription factor, GRbeta does not bind glucocorticoids (GCs), is transcriptionally inactive, and is a potential inhibitor of activated GRalpha.
T4 473-576 Sentence denotes Differential expression of GR isoforms may play a role in generalized or tissue-specific GC resistance.
T5 577-720 Sentence denotes GCs induce apoptosis in neoplastic lymphoid cells; and, defective apoptosis is implicated in the genesis of chronic lymphocytic leukemia (CLL).
T6 721-781 Sentence denotes We studied a patient with generalized GC resistance and CLL.
T7 782-959 Sentence denotes GR number in the patient's transformed lymphocytes was approximately one half that of control cells with a approximately 10-fold reduction in binding affinity for dexamethasone.
T8 960-1070 Sentence denotes In vitro apoptosis induction in CLL cells was delayed in response to GCs, but not to other apoptosis inducers.
T9 1071-1267 Sentence denotes Sequencing of the GR cDNA and gene including the 2.3-kb coding region, the intron/exon junctions, the known 5'-regulatory region, and approximately 300 bp of the 3'-region revealed no alterations.
T10 1268-1497 Sentence denotes Western blot with an N-terminal antibody showed normal levels of immunoreactive GR, but quantitative analysis with isoform-specific C-terminal antibodies revealed a markedly reduced GRalpha expression, and high GRbeta expression.
T11 1498-1676 Sentence denotes These findings indicate that imbalanced expression of the GR isoforms may be a mechanism of GC resistance, and may have implications for tumorigenesis by enhancing cell survival.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1556-1558 gene:2908 denotes GR
T1 1635-1648 disease:C0596263 denotes tumorigenesis
R1 T0 T1 associated_with GR,tumorigenesis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 29-61 protein denotes glucocorticoid receptor isoforms
T2 65-85 cell_type denotes cultured lymphocytes
T3 179-208 protein denotes human glucocorticoid receptor
T4 210-212 protein denotes GR
T5 266-273 protein denotes GRalpha
T6 278-284 protein denotes GRbeta
T7 294-301 protein denotes GRalpha
T8 325-345 protein denotes transcription factor
T9 347-353 protein denotes GRbeta
T10 464-471 protein denotes GRalpha
T11 500-511 protein denotes GR isoforms
T12 601-626 cell_type denotes neoplastic lymphoid cells
T13 809-832 cell_line denotes transformed lymphocytes
T14 992-1001 cell_line denotes CLL cells
T15 1089-1096 DNA denotes GR cDNA
T16 1179-1199 DNA denotes 5'-regulatory region
T17 1233-1242 DNA denotes 3'-region
T18 1333-1350 protein denotes immunoreactive GR
T19 1400-1421 protein denotes C-terminal antibodies
T20 1450-1457 protein denotes GRalpha
T21 1479-1485 protein denotes GRbeta
T22 1556-1567 protein denotes GR isoforms

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9920778-0#29#52#gene2908 29-52 gene2908 denotes glucocorticoid receptor
9920778-0#115#140#diseaseC1841972 115-140 diseaseC1841972 denotes glucocorticoid resistance
29#52#gene2908115#140#diseaseC1841972 9920778-0#29#52#gene2908 9920778-0#115#140#diseaseC1841972 associated_with glucocorticoid receptor,glucocorticoid resistance

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-174 Sentence denotes Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia.
S2 175-285 Sentence denotes The human glucocorticoid receptor (GR) is expressed as two alternatively spliced isoforms, GRalpha and GRbeta.
S3 286-472 Sentence denotes Whereas GRalpha is a hormone-activated transcription factor, GRbeta does not bind glucocorticoids (GCs), is transcriptionally inactive, and is a potential inhibitor of activated GRalpha.
S4 473-576 Sentence denotes Differential expression of GR isoforms may play a role in generalized or tissue-specific GC resistance.
S5 577-720 Sentence denotes GCs induce apoptosis in neoplastic lymphoid cells; and, defective apoptosis is implicated in the genesis of chronic lymphocytic leukemia (CLL).
S6 721-781 Sentence denotes We studied a patient with generalized GC resistance and CLL.
S7 782-959 Sentence denotes GR number in the patient's transformed lymphocytes was approximately one half that of control cells with a approximately 10-fold reduction in binding affinity for dexamethasone.
S8 960-1070 Sentence denotes In vitro apoptosis induction in CLL cells was delayed in response to GCs, but not to other apoptosis inducers.
S9 1071-1267 Sentence denotes Sequencing of the GR cDNA and gene including the 2.3-kb coding region, the intron/exon junctions, the known 5'-regulatory region, and approximately 300 bp of the 3'-region revealed no alterations.
S10 1268-1497 Sentence denotes Western blot with an N-terminal antibody showed normal levels of immunoreactive GR, but quantitative analysis with isoform-specific C-terminal antibodies revealed a markedly reduced GRalpha expression, and high GRbeta expression.
S11 1498-1676 Sentence denotes These findings indicate that imbalanced expression of the GR isoforms may be a mechanism of GC resistance, and may have implications for tumorigenesis by enhancing cell survival.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 25-61 NP denotes the glucocorticoid receptor isoforms
C2 230-264 NP denotes two alternatively spliced isoforms
C4 266-273 NP denotes GRalpha
C5 278-284 NP denotes GRbeta
C3 266-284 NP denotes GRalpha and GRbeta
C6 294-301 NP denotes GRalpha
C7 347-353 NP denotes GRbeta
C8 368-389 NP denotes glucocorticoids (GCs)
C9 500-511 NP denotes GR isoforms
C10 577-580 NP denotes GCs
C11 685-719 NP denotes chronic lymphocytic leukemia (CLL)
C12 777-780 NP denotes CLL
C13 782-791 NP denotes GR number
C14 860-864 NP denotes that
C15 1029-1032 NP denotes GCs
C16 1552-1567 NP denotes the GR isoforms
R1 C2 C1 coref-ident two alternatively spliced isoforms,the glucocorticoid receptor isoforms
R2 C3 C2 coref-appos GRalpha and GRbeta,two alternatively spliced isoforms
R3 C6 C4 coref-ident GRalpha,GRalpha
R4 C7 C5 coref-ident GRbeta,GRbeta
R5 C9 C2 coref-ident GR isoforms,two alternatively spliced isoforms
R6 C10 C8 coref-ident GCs,glucocorticoids (GCs)
R7 C12 C11 coref-ident CLL,chronic lymphocytic leukemia (CLL)
R8 C14 C13 coref-relat that,GR number
R9 C15 C10 coref-ident GCs,GCs
R10 C16 C9 coref-ident the GR isoforms,GR isoforms

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 29-61 protein_family_or_group denotes glucocorticoid receptor isoforms
T2 65-85 cell_type denotes cultured lymphocytes
T3 115-140 other_name denotes glucocorticoid resistance
T4 145-173 other_name denotes chronic lymphocytic leukemia
T5 179-208 protein_family_or_group denotes human glucocorticoid receptor
T6 210-212 protein_family_or_group denotes GR
T7 266-273 protein_molecule denotes GRalpha
T8 278-284 protein_molecule denotes GRbeta
T9 294-301 protein_molecule denotes GRalpha
T10 325-345 protein_family_or_group denotes transcription factor
T11 347-353 protein_molecule denotes GRbeta
T12 368-383 lipid denotes glucocorticoids
T13 385-388 lipid denotes GCs
T14 394-420 other_name denotes transcriptionally inactive
T15 464-471 protein_molecule denotes GRalpha
T16 500-511 protein_family_or_group denotes GR isoforms
T17 562-575 other_name denotes GC resistance
T18 577-580 lipid denotes GCs
T19 588-597 other_name denotes apoptosis
T20 601-626 cell_type denotes neoplastic lymphoid cells
T21 643-652 other_name denotes apoptosis
T22 685-713 other_name denotes chronic lymphocytic leukemia
T23 715-718 other_name denotes CLL
T24 747-758 other_name denotes generalized
T25 759-772 other_name denotes GC resistance
T26 777-780 other_name denotes CLL
T27 782-791 other_name denotes GR number
T28 809-832 cell_line denotes transformed lymphocytes
T29 945-958 lipid denotes dexamethasone
T30 969-978 other_name denotes apoptosis
T31 992-995 other_name denotes CLL
T32 1029-1032 lipid denotes GCs
T33 1051-1060 other_name denotes apoptosis
T34 1089-1096 DNA_family_or_group denotes GR cDNA
T35 1179-1199 DNA_domain_or_region denotes 5'-regulatory region
T36 1233-1242 DNA_domain_or_region denotes 3'-region
T37 1333-1350 protein_family_or_group denotes immunoreactive GR
T38 1400-1421 protein_family_or_group denotes C-terminal antibodies
T39 1450-1457 protein_molecule denotes GRalpha
T40 1479-1485 protein_molecule denotes GRbeta
T41 1527-1548 other_name denotes imbalanced expression
T42 1556-1567 protein_family_or_group denotes GR isoforms
T43 1590-1603 other_name denotes GC resistance
T44 1635-1648 other_name denotes tumorigenesis

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 546-552 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 165-173 HP:0001909 denotes leukemia
AB1 705-713 HP:0001909 denotes leukemia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 546-552 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 115-140 ORDO:786 denotes glucocorticoid resistance