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PubMed:9918824 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-21 protein denotes GATA-1
T2 26-35 protein denotes p45 NF-E2
T3 153-169 protein denotes fetal hemoglobin
T4 502-517 DNA denotes erythroid genes
T5 587-618 protein denotes erythroid transcription factors
T6 670-676 protein denotes GATA-1
T7 681-686 protein denotes NF-E2
T8 687-708 protein denotes transcription factors
T9 756-781 cell_line denotes human leukemic K562 cells
T10 837-843 protein denotes GATA-1
T11 848-857 protein denotes p45 NF-E2
T12 957-963 protein denotes GATA-1
T13 967-976 protein denotes p45 NF-E2
T14 1188-1194 protein denotes GATA-1
T15 1199-1204 protein denotes NF-E2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-97 Sentence denotes Requirement of GATA-1 and p45 NF-E2 expression in butyric acid-induced erythroid differentiation.
S2 98-205 Sentence denotes Butyric acid (BA) is known to induce overexpression of fetal hemoglobin and then erythroid differentiation.
S3 206-337 Sentence denotes Therefore, BA is currently under clinical investigation as a potential therapy for the treatment of sickle cell disease and cancer.
S4 338-439 Sentence denotes Nevertheless, the molecular mechanisms involved in BA-induced differentiation remain largely unknown.
S5 440-619 Sentence denotes Previous reports have shown that BA-induced overexpression of erythroid genes occurred at the transcriptional level, suggesting the involvement of erythroid transcription factors.
S6 620-782 Sentence denotes Here, we intend to demonstrate the requirement of GATA-1 and NF-E2 transcription factors in the BA-induced erythroid differentiation of human leukemic K562 cells.
S7 783-897 Sentence denotes Time-course experiments showed that nuclear levels of GATA-1 and p45 NF-E2 proteins increased during BA treatment.
S8 898-1051 Sentence denotes Moreover, antisense oligodeoxynucleotides targeting either GATA-1 or p45 NF-E2 proteins inhibited both protein expression and BA-induced differentiation.
S9 1052-1116 Sentence denotes In contrast, BA-induced cell growth inhibition was not affected.
S10 1117-1243 Sentence denotes These results provide the first direct evidence for the requirement of GATA-1 and NF-E2 in BA-induced differentiation process.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 50-96 NP denotes butyric acid-induced erythroid differentiation
C2 98-115 NP denotes Butyric acid (BA)
C3 179-204 NP denotes erythroid differentiation
C4 217-219 NP denotes BA
C5 389-415 NP denotes BA-induced differentiation
C6 587-618 NP denotes erythroid transcription factors
C7 670-708 NP denotes GATA-1 and NF-E2 transcription factors
C8 712-781 NP denotes the BA-induced erythroid differentiation of human leukemic K562 cells
C9 1024-1050 NP denotes BA-induced differentiation
C10 1208-1242 NP denotes BA-induced differentiation process
R1 C3 C1 coref-ident erythroid differentiation,butyric acid-induced erythroid differentiation
R2 C4 C2 coref-ident BA,Butyric acid (BA)
R3 C5 C3 coref-ident BA-induced differentiation,erythroid differentiation
R4 C7 C6 coref-ident GATA-1 and NF-E2 transcription factors,erythroid transcription factors
R5 C8 C5 coref-ident the BA-induced erythroid differentiation of human leukemic K562 cells,BA-induced differentiation
R6 C9 C8 coref-ident BA-induced differentiation,the BA-induced erythroid differentiation of human leukemic K562 cells
R7 C10 C9 coref-ident BA-induced differentiation process,BA-induced differentiation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-21 protein_molecule denotes GATA-1
T2 26-35 protein_molecule denotes p45 NF-E2
T3 50-62 other_organic_compound denotes butyric acid
T4 98-110 other_organic_compound denotes Butyric acid
T5 112-114 other_organic_compound denotes BA
T6 153-169 protein_complex denotes fetal hemoglobin
T7 179-204 other_name denotes erythroid differentiation
T8 217-219 other_organic_compound denotes BA
T9 306-325 other_name denotes sickle cell disease
T10 330-336 other_name denotes cancer
T11 356-376 other_name denotes molecular mechanisms
T12 389-391 other_organic_compound denotes BA
T13 473-475 other_organic_compound denotes BA
T14 502-517 DNA_family_or_group denotes erythroid genes
T15 534-555 other_name denotes transcriptional level
T16 587-596 protein_family_or_group denotes erythroid
T17 597-618 protein_family_or_group denotes transcription factors
T18 670-676 protein_molecule denotes GATA-1
T19 681-686 protein_molecule denotes NF-E2
T20 687-708 protein_family_or_group denotes transcription factors
T21 716-718 other_organic_compound denotes BA
T22 727-752 other_name denotes erythroid differentiation
T23 756-781 cell_line denotes human leukemic K562 cells
T24 837-843 protein_molecule denotes GATA-1
T25 848-851 protein_molecule denotes p45
T26 852-857 protein_molecule denotes NF-E2
T27 884-886 other_organic_compound denotes BA
T28 908-939 polynucleotide denotes antisense oligodeoxynucleotides
T29 957-963 protein_molecule denotes GATA-1
T30 967-976 protein_molecule denotes p45 NF-E2
T31 1024-1026 other_organic_compound denotes BA
T32 1065-1067 other_organic_compound denotes BA
T33 1188-1194 protein_molecule denotes GATA-1
T34 1199-1204 protein_molecule denotes NF-E2
T35 1208-1210 other_organic_compound denotes BA