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PubMed:9916078 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-47 protein denotes mitogen-activated protein kinase
T2 60-73 protein denotes interleukin-8
T3 88-103 cell_type denotes human monocytes
T4 108-131 cell_type denotes polymorphonuclear cells
T5 170-213 protein denotes Mycoplasma fermentans membrane lipoproteins
T6 215-228 protein denotes Interleukin-8
T7 230-234 protein denotes IL-8
T8 241-250 protein denotes chemokine
T9 271-286 protein denotes alpha-chemokine
T10 290-303 protein denotes CXC subfamily
T11 364-373 cell_type denotes monocytes
T12 378-401 cell_type denotes polymorphonuclear cells
T13 403-406 cell_type denotes PMN
T14 409-413 protein denotes IL-8
T15 595-599 protein denotes IL-8
T16 640-696 protein denotes Mycoplasma fermentans lipid-associated membrane proteins
T17 698-703 protein denotes LAMPf
T18 745-749 protein denotes IL-8
T19 753-781 cell_line denotes THP-1 (human monocyte) cells
T20 786-789 cell_type denotes PMN
T21 903-908 protein denotes LAMPf
T22 992-1015 protein denotes protein tyrosine kinase
T23 1023-1055 protein denotes mitogen-activated protein kinase
T24 1137-1141 protein denotes MEK1
T25 1145-1151 protein denotes kinase
T26 1164-1170 protein denotes ERK1/2
T27 1176-1179 protein denotes p38
T28 1287-1291 protein denotes IL-8
T29 1295-1304 cell_type denotes monocytes
T30 1309-1312 cell_type denotes PMN

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-214 Sentence denotes Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins.
S2 215-408 Sentence denotes Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN).
S3 409-610 Sentence denotes IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction.
S4 611-816 Sentence denotes In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS.
S5 817-1065 Sentence denotes It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades.
S6 1066-1349 Sentence denotes By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 88-103 NP denotes human monocytes
C2 108-131 NP denotes polymorphonuclear cells
C3 148-166 NP denotes lipopolysaccharide
C4 170-213 NP denotes Mycoplasma fermentans membrane lipoproteins
C5 215-235 NP denotes Interleukin-8 (IL-8)
C6 239-250 NP denotes a chemokine
C7 251-255 NP denotes that
C8 364-373 NP denotes monocytes
C9 378-407 NP denotes polymorphonuclear cells (PMN)
C10 409-413 NP denotes IL-8
C11 498-522 NP denotes lipopolysaccharide (LPS)
C12 550-564 NP denotes the mechanisms
C13 568-573 NP denotes which
C14 574-586 NP denotes these agents
C15 640-704 NP denotes Mycoplasma fermentans lipid-associated membrane proteins (LAMPf)
C16 745-749 NP denotes IL-8
C17 786-789 NP denotes PMN
C18 812-815 NP denotes LPS
C19 896-899 NP denotes LPS
C20 903-908 NP denotes LAMPf
C21 1075-1096 NP denotes PD-98059 and SB203580
C22 1098-1141 NP denotes two potent and selective inhibitors of MEK1
C23 1287-1291 NP denotes IL-8
C24 1295-1304 NP denotes monocytes
C25 1309-1312 NP denotes PMN
R1 C7 C6 coref-relat that,a chemokine
R2 C8 C1 coref-ident monocytes,human monocytes
R3 C9 C2 coref-ident polymorphonuclear cells (PMN),polymorphonuclear cells
R4 C10 C5 coref-ident IL-8,Interleukin-8 (IL-8)
R5 C11 C3 coref-ident lipopolysaccharide (LPS),lipopolysaccharide
R6 C13 C12 coref-relat which,the mechanisms
R7 C14 C11 coref-ident these agents,lipopolysaccharide (LPS)
R8 C15 C4 coref-ident Mycoplasma fermentans lipid-associated membrane proteins (LAMPf),Mycoplasma fermentans membrane lipoproteins
R9 C16 C10 coref-ident IL-8,IL-8
R10 C17 C9 coref-ident PMN,polymorphonuclear cells (PMN)
R11 C18 C14 coref-ident LPS,these agents
R12 C19 C18 coref-ident LPS,LPS
R13 C20 C15 coref-ident LAMPf,Mycoplasma fermentans lipid-associated membrane proteins (LAMPf)
R14 C22 C21 coref-appos two potent and selective inhibitors of MEK1,PD-98059 and SB203580
R15 C23 C16 coref-ident IL-8,IL-8
R16 C24 C8 coref-ident monocytes,monocytes
R17 C25 C17 coref-ident PMN,PMN

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-47 protein_family_or_group denotes mitogen-activated protein kinase
T2 60-73 protein_molecule denotes interleukin-8
T3 88-103 cell_type denotes human monocytes
T4 108-131 cell_type denotes polymorphonuclear cells
T5 148-166 lipid denotes lipopolysaccharide
T6 170-191 mono_cell denotes Mycoplasma fermentans
T7 215-228 protein_molecule denotes Interleukin-8
T8 230-234 protein_molecule denotes IL-8
T9 241-250 protein_family_or_group denotes chemokine
T10 271-286 protein_family_or_group denotes alpha-chemokine
T11 290-303 protein_family_or_group denotes CXC subfamily
T12 364-373 cell_type denotes monocytes
T13 378-401 cell_type denotes polymorphonuclear cells
T14 403-406 cell_type denotes PMN
T15 409-413 protein_molecule denotes IL-8
T16 441-461 other_name denotes inflammatory stimuli
T17 498-516 lipid denotes lipopolysaccharide
T18 518-521 lipid denotes LPS
T19 595-599 protein_molecule denotes IL-8
T20 640-661 mono_cell denotes Mycoplasma fermentans
T21 698-703 protein_family_or_group denotes LAMPf
T22 745-749 protein_molecule denotes IL-8
T23 753-781 cell_line denotes THP-1 (human monocyte) cells
T24 786-789 cell_type denotes PMN
T25 812-815 lipid denotes LPS
T26 896-899 lipid denotes LPS
T27 903-908 protein_family_or_group denotes LAMPf
T28 935-962 other_name denotes downstream signaling events
T29 992-1015 protein_molecule denotes protein tyrosine kinase
T30 1023-1055 protein_family_or_group denotes mitogen-activated protein kinase
T31 1075-1083 other_organic_compound denotes PD-98059
T32 1088-1096 other_organic_compound denotes SB203580
T33 1113-1133 other_organic_compound denotes selective inhibitors
T34 1137-1141 protein_molecule denotes MEK1
T35 1145-1151 protein_family_or_group denotes kinase
T36 1164-1170 protein_molecule denotes ERK1/2
T37 1176-1179 protein_molecule denotes p38
T38 1287-1291 protein_molecule denotes IL-8
T39 1295-1304 cell_type denotes monocytes
T40 1309-1312 cell_type denotes PMN
T41 1329-1348 other_name denotes bacterial fractions