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sentences

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.
T2 98-250 Sentence denotes Ligation of either CD80 (B7-1) or CD86 (B7-2), two principal ligands for CD28, is thought to skew the immune response toward Th1 or Th2 differentiation.
T3 251-367 Sentence denotes We have examined early signal transduction pathways recruited following T cell stimulation with either CD80 or CD86.
T4 368-584 Sentence denotes Purified human peripheral T cells or Jurkat T cells were stimulated with Chinese hamster ovary (CHO) cells expressing either human CD80 (CHO-CD80) or human CD86 (CHO-CD86) or with anti-CD28 monoclonal antibody (mAb).
T5 585-787 Sentence denotes In the presence of phorbol 12-myristate 13-acetate, both CHO-CD80 and CHO-CD86, like anti-CD28 mAb, were capable of stimulating cytokine production from both human peripheral T cells and Jurkat T cells.
T6 788-904 Sentence denotes Both CHO-CD80 and CHO-CD86, in the presence of anti-CD3 mAb, costimulated NFAT-dependent transcriptional activation.
T7 905-1045 Sentence denotes Several intracellular signaling proteins, such as CBL and VAV, were phosphorylated on tyrosine in response to CD80, CD86, and anti-CD28 mAb.
T8 1046-1320 Sentence denotes Surprisingly, although stimulation of Jurkat T cells with either CHO-CD80 or anti-CD28 mAb resulted in robust tyrosine phosphorylation of CD28 itself, ligation with CHO-CD86 was unable to induce detectable CD28 tyrosyl phosphorylation over a range of stimulation conditions.
T9 1321-1561 Sentence denotes In addition, the association of phosphoinositide 3-kinase with CD28 and enhanced tyrosine phosphorylation of phospholipase Cgamma were seen after anti-CD28 mAb and CHO-CD80 stimulation but to a much lesser extent after CHO-CD86 stimulation.
T10 1562-1863 Sentence denotes Thus, ligation of CD28 with either CD80 or CD86 leads to shared early signal transduction events such as the tyrosine phosphorylation of CBL and VAV, to NFAT-mediated transcriptional activation, and to the costimulation of interleukin-2 and granulocyte-macrophage colony-stimulating factor production.
T11 1864-2083 Sentence denotes However, CD80 and CD86 also induce distinct signal transduction pathways including the tyrosine phosphorylation of CD28 and phospholipase Cgamma1 and the SH2-dependent association of phosphoinositide 3-kinase with CD28.
T12 2084-2289 Sentence denotes These quantitative, if not qualitative, differences between signaling initiated by these two ligands for CD28 may contribute to functional differences (e.g. Th1 or Th2 differentiation) in T cell responses.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes CD80
T2 9-13 protein denotes CD86
T3 92-96 protein denotes CD28
T4 117-121 protein denotes CD80
T5 123-127 protein denotes B7-1
T6 132-136 protein denotes CD86
T7 138-142 protein denotes B7-2
T8 171-175 protein denotes CD28
T9 354-358 protein denotes CD80
T10 362-366 protein denotes CD86
T11 368-401 cell_line denotes Purified human peripheral T cells
T12 405-419 cell_line denotes Jurkat T cells
T13 493-503 protein denotes human CD80
T14 505-513 protein denotes CHO-CD80
T15 518-528 protein denotes human CD86
T16 530-538 protein denotes CHO-CD86
T17 548-577 protein denotes anti-CD28 monoclonal antibody
T18 642-650 protein denotes CHO-CD80
T19 655-663 protein denotes CHO-CD86
T20 670-683 protein denotes anti-CD28 mAb
T21 713-721 protein denotes cytokine
T22 743-767 cell_type denotes human peripheral T cells
T23 772-786 cell_line denotes Jurkat T cells
T24 793-801 protein denotes CHO-CD80
T25 806-814 protein denotes CHO-CD86
T26 835-847 protein denotes anti-CD3 mAb
T27 862-866 protein denotes NFAT
T28 927-945 protein denotes signaling proteins
T29 955-958 protein denotes CBL
T30 963-966 protein denotes VAV
T31 1015-1019 protein denotes CD80
T32 1021-1025 protein denotes CD86
T33 1031-1044 protein denotes anti-CD28 mAb
T34 1084-1098 cell_line denotes Jurkat T cells
T35 1111-1119 protein denotes CHO-CD80
T36 1123-1136 protein denotes anti-CD28 mAb
T37 1184-1188 protein denotes CD28
T38 1211-1219 protein denotes CHO-CD86
T39 1252-1256 protein denotes CD28
T40 1353-1378 protein denotes phosphoinositide 3-kinase
T41 1384-1388 protein denotes CD28
T42 1540-1548 protein denotes CHO-CD86
T43 1580-1584 protein denotes CD28
T44 1597-1601 protein denotes CD80
T45 1605-1609 protein denotes CD86
T46 1699-1702 protein denotes CBL
T47 1707-1710 protein denotes VAV
T48 1715-1719 protein denotes NFAT
T49 1785-1798 protein denotes interleukin-2
T50 1803-1851 protein denotes granulocyte-macrophage colony-stimulating factor
T51 1873-1877 protein denotes CD80
T52 1882-1886 protein denotes CD86
T53 1979-1983 protein denotes CD28
T54 1988-2009 protein denotes phospholipase Cgamma1
T55 2018-2021 protein denotes SH2
T56 2047-2072 protein denotes phosphoinositide 3-kinase
T57 2078-2082 protein denotes CD28
T58 2189-2193 protein denotes CD28

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes CD80
T2 9-13 protein denotes CD86
T3 92-96 protein denotes CD28
T4 117-121 protein denotes CD80
T5 123-127 protein denotes B7-1
T6 132-136 protein denotes CD86
T7 138-142 protein denotes B7-2
T8 171-175 protein denotes CD28
T9 354-358 protein denotes CD80
T10 362-366 protein denotes CD86
T11 499-503 protein denotes CD80
T12 509-513 protein denotes CD80
T13 524-528 protein denotes CD86
T14 534-538 protein denotes CD86
T15 553-557 protein denotes CD28
T16 646-650 protein denotes CD80
T17 659-663 protein denotes CD86
T18 675-679 protein denotes CD28
T19 713-721 protein denotes cytokine
T20 797-801 protein denotes CD80
T21 810-814 protein denotes CD86
T22 840-843 protein denotes CD3
T23 862-866 protein denotes NFAT
T24 955-958 protein denotes CBL
T25 963-966 protein denotes VAV
T26 1015-1019 protein denotes CD80
T27 1021-1025 protein denotes CD86
T28 1036-1040 protein denotes CD28
T29 1115-1119 protein denotes CD80
T30 1128-1132 protein denotes CD28
T31 1184-1188 protein denotes CD28
T32 1215-1219 protein denotes CD86
T33 1252-1256 protein denotes CD28
T34 1353-1378 protein denotes phosphoinositide 3-kinase
T35 1384-1388 protein denotes CD28
T36 1430-1450 protein denotes phospholipase Cgamma
T37 1472-1476 protein denotes CD28
T38 1489-1493 protein denotes CD80
T39 1544-1548 protein denotes CD86
T40 1580-1584 protein denotes CD28
T41 1597-1601 protein denotes CD80
T42 1605-1609 protein denotes CD86
T43 1699-1702 protein denotes CBL
T44 1707-1710 protein denotes VAV
T45 1715-1719 protein denotes NFAT
T46 1785-1798 protein denotes interleukin-2
T47 1803-1851 protein denotes granulocyte-macrophage colony-stimulating factor
T48 1873-1877 protein denotes CD80
T49 1882-1886 protein denotes CD86
T50 1979-1983 protein denotes CD28
T51 1988-2009 protein denotes phospholipase Cgamma1
T52 2047-2072 protein denotes phosphoinositide 3-kinase
T53 2078-2082 protein denotes CD28
T54 2189-2193 protein denotes CD28

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-97 Sentence denotes CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.
S2 98-250 Sentence denotes Ligation of either CD80 (B7-1) or CD86 (B7-2), two principal ligands for CD28, is thought to skew the immune response toward Th1 or Th2 differentiation.
S3 251-367 Sentence denotes We have examined early signal transduction pathways recruited following T cell stimulation with either CD80 or CD86.
S4 368-584 Sentence denotes Purified human peripheral T cells or Jurkat T cells were stimulated with Chinese hamster ovary (CHO) cells expressing either human CD80 (CHO-CD80) or human CD86 (CHO-CD86) or with anti-CD28 monoclonal antibody (mAb).
S5 585-787 Sentence denotes In the presence of phorbol 12-myristate 13-acetate, both CHO-CD80 and CHO-CD86, like anti-CD28 mAb, were capable of stimulating cytokine production from both human peripheral T cells and Jurkat T cells.
S6 788-904 Sentence denotes Both CHO-CD80 and CHO-CD86, in the presence of anti-CD3 mAb, costimulated NFAT-dependent transcriptional activation.
S7 905-1045 Sentence denotes Several intracellular signaling proteins, such as CBL and VAV, were phosphorylated on tyrosine in response to CD80, CD86, and anti-CD28 mAb.
S8 1046-1320 Sentence denotes Surprisingly, although stimulation of Jurkat T cells with either CHO-CD80 or anti-CD28 mAb resulted in robust tyrosine phosphorylation of CD28 itself, ligation with CHO-CD86 was unable to induce detectable CD28 tyrosyl phosphorylation over a range of stimulation conditions.
S9 1321-1561 Sentence denotes In addition, the association of phosphoinositide 3-kinase with CD28 and enhanced tyrosine phosphorylation of phospholipase Cgamma were seen after anti-CD28 mAb and CHO-CD80 stimulation but to a much lesser extent after CHO-CD86 stimulation.
S10 1562-1863 Sentence denotes Thus, ligation of CD28 with either CD80 or CD86 leads to shared early signal transduction events such as the tyrosine phosphorylation of CBL and VAV, to NFAT-mediated transcriptional activation, and to the costimulation of interleukin-2 and granulocyte-macrophage colony-stimulating factor production.
S11 1864-2083 Sentence denotes However, CD80 and CD86 also induce distinct signal transduction pathways including the tyrosine phosphorylation of CD28 and phospholipase Cgamma1 and the SH2-dependent association of phosphoinositide 3-kinase with CD28.
S12 2084-2289 Sentence denotes These quantitative, if not qualitative, differences between signaling initiated by these two ligands for CD28 may contribute to functional differences (e.g. Th1 or Th2 differentiation) in T cell responses.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-13 NP denotes CD80 and CD86
C2 36-41 NP denotes their
C4 92-96 NP denotes CD28
C3 60-96 NP denotes the tyrosine phosphorylation of CD28
C5 117-143 NP denotes CD80 (B7-1) or CD86 (B7-2)
C7 171-175 NP denotes CD28
C6 145-175 NP denotes two principal ligands for CD28
C8 354-366 NP denotes CD80 or CD86
C9 368-401 NP denotes Purified human peripheral T cells
C10 405-419 NP denotes Jurkat T cells
C11 493-514 NP denotes human CD80 (CHO-CD80)
C12 518-539 NP denotes human CD86 (CHO-CD86)
C13 548-583 NP denotes anti-CD28 monoclonal antibody (mAb)
C15 642-650 NP denotes CHO-CD80
C16 655-663 NP denotes CHO-CD86
C14 637-663 NP denotes both CHO-CD80 and CHO-CD86
C17 670-683 NP denotes anti-CD28 mAb
C18 743-767 NP denotes human peripheral T cells
C19 772-786 NP denotes Jurkat T cells
C21 793-801 NP denotes CHO-CD80
C22 806-814 NP denotes CHO-CD86
C20 788-814 NP denotes Both CHO-CD80 and CHO-CD86
C23 1031-1044 NP denotes anti-CD28 mAb
C24 1084-1098 NP denotes Jurkat T cells
C25 1111-1119 NP denotes CHO-CD80
C26 1123-1136 NP denotes anti-CD28 mAb
C27 1184-1188 NP denotes CD28
C28 1189-1195 NP denotes itself
C29 1211-1219 NP denotes CHO-CD86
C30 1384-1388 NP denotes CD28
C31 1580-1584 NP denotes CD28
C32 1597-1609 NP denotes CD80 or CD86
C33 1873-1886 NP denotes CD80 and CD86
C35 1979-1983 NP denotes CD28
C34 1947-1983 NP denotes the tyrosine phosphorylation of CD28
C36 2078-2082 NP denotes CD28
C37 2167-2184 NP denotes these two ligands
C38 2189-2193 NP denotes CD28
R1 C2 C1 coref-pron their,CD80 and CD86
R2 C7 C4 coref-ident CD28,CD28
R3 C6 C5 coref-appos two principal ligands for CD28,CD80 (B7-1) or CD86 (B7-2)
R4 C8 C5 coref-ident CD80 or CD86,CD80 (B7-1) or CD86 (B7-2)
R5 C15 C11 coref-ident CHO-CD80,human CD80 (CHO-CD80)
R6 C16 C12 coref-ident CHO-CD86,human CD86 (CHO-CD86)
R7 C17 C13 coref-ident anti-CD28 mAb,anti-CD28 monoclonal antibody (mAb)
R8 C18 C9 coref-ident human peripheral T cells,Purified human peripheral T cells
R9 C19 C10 coref-ident Jurkat T cells,Jurkat T cells
R10 C21 C15 coref-ident CHO-CD80,CHO-CD80
R11 C22 C16 coref-ident CHO-CD86,CHO-CD86
R12 C20 C14 coref-ident Both CHO-CD80 and CHO-CD86,both CHO-CD80 and CHO-CD86
R13 C23 C17 coref-ident anti-CD28 mAb,anti-CD28 mAb
R14 C24 C19 coref-ident Jurkat T cells,Jurkat T cells
R15 C25 C21 coref-ident CHO-CD80,CHO-CD80
R16 C26 C23 coref-ident anti-CD28 mAb,anti-CD28 mAb
R17 C27 C7 coref-ident CD28,CD28
R18 C28 C27 coref-pron itself,CD28
R19 C29 C22 coref-ident CHO-CD86,CHO-CD86
R20 C30 C27 coref-ident CD28,CD28
R21 C31 C30 coref-ident CD28,CD28
R22 C32 C8 coref-ident CD80 or CD86,CD80 or CD86
R23 C33 C1 coref-ident CD80 and CD86,CD80 and CD86
R24 C35 C31 coref-ident CD28,CD28
R25 C34 C3 coref-ident the tyrosine phosphorylation of CD28,the tyrosine phosphorylation of CD28
R26 C36 C35 coref-ident CD28,CD28
R27 C37 C33 coref-ident these two ligands,CD80 and CD86
R28 C38 C36 coref-ident CD28,CD28

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-4 protein_molecule denotes CD80
T2 9-13 protein_molecule denotes CD86
T3 64-72 amino_acid_monomer denotes tyrosine
T4 92-96 protein_molecule denotes CD28
T5 117-121 protein_molecule denotes CD80
T6 123-127 protein_molecule denotes B7-1
T7 132-136 protein_molecule denotes CD86
T8 138-142 protein_molecule denotes B7-2
T9 171-175 protein_molecule denotes CD28
T10 274-302 other_name denotes signal transduction pathways
T11 323-341 other_name denotes T cell stimulation
T12 354-358 protein_molecule denotes CD80
T13 362-366 protein_molecule denotes CD86
T14 368-401 cell_line denotes Purified human peripheral T cells
T15 405-419 cell_line denotes Jurkat T cells
T16 493-498 protein_molecule denotes human
T17 499-503 protein_molecule denotes CD80
T18 505-513 protein_molecule denotes CHO-CD80
T19 518-528 protein_molecule denotes human CD86
T20 530-538 protein_molecule denotes CHO-CD86
T21 548-553 protein_molecule denotes anti-
T22 553-557 protein_molecule denotes CD28
T23 604-635 other_organic_compound denotes phorbol 12-myristate 13-acetate
T24 642-650 protein_molecule denotes CHO-CD80
T25 655-663 protein_molecule denotes CHO-CD86
T26 670-683 protein_molecule denotes anti-CD28 mAb
T27 713-721 protein_family_or_group denotes cytokine
T28 743-767 cell_type denotes human peripheral T cells
T29 772-786 cell_line denotes Jurkat T cells
T30 793-801 protein_molecule denotes CHO-CD80
T31 806-814 protein_molecule denotes CHO-CD86
T32 835-847 protein_molecule denotes anti-CD3 mAb
T33 862-866 protein_family_or_group denotes NFAT
T34 927-945 protein_family_or_group denotes signaling proteins
T35 955-958 protein_molecule denotes CBL
T36 963-966 protein_molecule denotes VAV
T37 991-999 amino_acid_monomer denotes tyrosine
T38 1015-1019 protein_molecule denotes CD80
T39 1021-1025 protein_molecule denotes CD86
T40 1031-1044 protein_molecule denotes anti-CD28 mAb
T41 1084-1098 cell_line denotes Jurkat T cells
T42 1111-1119 protein_molecule denotes CHO-CD80
T43 1123-1136 protein_molecule denotes anti-CD28 mAb
T44 1156-1164 amino_acid_monomer denotes tyrosine
T45 1184-1188 protein_molecule denotes CD28
T46 1211-1219 protein_molecule denotes CHO-CD86
T47 1252-1256 protein_molecule denotes CD28
T48 1353-1378 protein_molecule denotes phosphoinositide 3-kinase
T49 1384-1388 protein_molecule denotes CD28
T50 1402-1410 amino_acid_monomer denotes tyrosine
T51 1540-1548 protein_molecule denotes CHO-CD86
T52 1580-1584 protein_molecule denotes CD28
T53 1597-1601 protein_molecule denotes CD80
T54 1605-1609 protein_molecule denotes CD86
T55 1671-1679 amino_acid_monomer denotes tyrosine
T56 1699-1702 protein_molecule denotes CBL
T57 1707-1710 protein_molecule denotes VAV
T58 1715-1719 protein_family_or_group denotes NFAT
T59 1785-1798 protein_molecule denotes interleukin-2
T60 1803-1851 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T61 1873-1877 protein_molecule denotes CD80
T62 1882-1886 protein_molecule denotes CD86
T63 1908-1936 other_name denotes signal transduction pathways
T64 1951-1959 amino_acid_monomer denotes tyrosine
T65 1979-1983 protein_molecule denotes CD28
T66 1988-2009 protein_molecule denotes phospholipase Cgamma1
T67 2018-2021 protein_molecule denotes SH2
T68 2047-2072 protein_molecule denotes phosphoinositide 3-kinase
T69 2078-2082 protein_molecule denotes CD28
T70 2189-2193 protein_molecule denotes CD28
T71 2272-2288 other_name denotes T cell responses

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T2 441-456 OrganismTaxon denotes Chinese hamster 10029
T3 493-498 OrganismTaxon denotes human 9606
T4 518-523 OrganismTaxon denotes human 9606
T5 743-748 OrganismTaxon denotes human 9606
T1 377-382 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 323-329 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T2 457-462 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T3 913-926 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T4 1803-1814 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T5 1815-1825 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T6 2272-2278 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 323-329 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T2 394-401 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 412-419 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 760-767 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 779-786 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T6 1091-1098 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T7 1803-1814 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T8 1815-1825 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T10 2272-2278 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084