PubMed:9915799
Annnotations
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 566-571 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| T2 | 610-615 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T3 | 850-855 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| T4 | 1002-1007 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| T5 | 1086-1091 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T6 | 1185-1190 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T7 | 1578-1583 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T8 | 1693-1698 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| T9 | 1703-1708 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T10 | 1718-1723 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| T11 | 1935-1940 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| T12 | 1966-1971 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 74-81 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T3 | 166-185 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
| T4 | 218-225 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 566-571 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| T2 | 610-615 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T3 | 850-855 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| T4 | 1002-1007 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| T5 | 1086-1091 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T6 | 1185-1190 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T7 | 1578-1583 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T8 | 1693-1698 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| T9 | 1703-1708 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| T10 | 1718-1723 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| T11 | 1935-1940 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| T12 | 1966-1971 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-130 | Sentence | denotes | Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. |
| T2 | 131-360 | Sentence | denotes | N-Deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin initiate a series of chemical modifications that ultimately lead to oligosaccharide sequences with specific ligand binding properties. |
| T3 | 361-491 | Sentence | denotes | These reactions are catalyzed by GlcNAc N-deacetylase/N-sulfotransferase (NDST), a monomeric enzyme with two catalytic activities. |
| T4 | 492-617 | Sentence | denotes | Two genes encoding NDST isozymes have been described, one from rat liver (NDST1) and another from murine mastocytoma (NDST2). |
| T5 | 618-767 | Sentence | denotes | Both isozymes are expressed in tissues in varying amounts, but their relative contribution to heparan sulfate formation in any one tissue is unknown. |
| T6 | 768-856 | Sentence | denotes | We now report the identification of a third member of the NDST family, designated NDST3. |
| T7 | 857-995 | Sentence | denotes | A full-length cDNA clone (3.2 kilobase pairs) encoding a 873-amino acid protein was obtained from a human fetal/infant brain cDNA library. |
| T8 | 996-1092 | Sentence | denotes | Human NDST3 (hNDST3) has a nucleotide sequence homologous but not identical to hNDST1 and NDST2. |
| T9 | 1093-1205 | Sentence | denotes | The deduced amino acid sequence shows 70% and 65% amino acid identity to that of hNDST1 and NDST2, respectively. |
| T10 | 1206-1344 | Sentence | denotes | A soluble chimera of hNDST3 and protein A exhibited both N-deacetylase and N-sulfotransferase activity, confirming its enzymatic identity. |
| T11 | 1345-1451 | Sentence | denotes | Northern blot analysis of human fetal brain poly(A)+ RNA showed a single transcript of 6.4 kilobase pairs. |
| T12 | 1452-1629 | Sentence | denotes | Reverse transcription polymerase chain reaction analysis revealed more restricted tissue expression of hNDST3 than hNDST1 and NDST2, and high levels in brain, liver, and kidney. |
| T13 | 1630-1724 | Sentence | denotes | Analysis of Chinese hamster ovary cells revealed expression of NDST1 and NDST2, but not NDST3. |
| T14 | 1725-1861 | Sentence | denotes | In a Chinese hamster ovary cell mutant exhibiting reduced N-sulfotransferase activity and reduced sulfation of heparan sulfate (Bame, K. |
| T15 | 1862-1878 | Sentence | denotes | J., and Esko, J. |
| T16 | 1879-1891 | Sentence | denotes | D. (1989) J. |
| T17 | 1892-1897 | Sentence | denotes | Biol. |
| T18 | 1898-1903 | Sentence | denotes | Chem. |
| T19 | 1904-2066 | Sentence | denotes | 264, 8059-8065), expression of NDST1 was greatly reduced, but NDST2 was expressed normally, suggesting that both enzymes are involved in heparan sulfate assembly. |
| T20 | 2067-2201 | Sentence | denotes | The discovery of multiple NDST isozymes suggests that the assembly of heparan sulfate is much complicated than previously appreciated. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 74-81 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T2 | 74-81 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T3 | 166-185 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
| T4 | 218-225 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T5 | 218-225 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 58-73 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 198-213 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 712-727 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T4 | 1836-1851 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T5 | 2041-2056 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T6 | 2137-2152 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 559-564 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T2 | 976-981 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T3 | 1383-1388 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T4 | 1604-1609 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T5 | 1611-1616 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T6 | 1622-1628 | http://purl.obolibrary.org/obo/MAT_0000119 | denotes | kidney |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 401-433 | https://acgg.asia/db/ggdb/info/gg023 | denotes | N-deacetylase/N-sulfotransferase |
| PD-GlycoGenes20190927-B_T2 | 566-571 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| PD-GlycoGenes20190927-B_T3 | 610-615 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| PD-GlycoGenes20190927-B_T4 | 839-849 | url | denotes | designated |
| PD-GlycoGenes20190927-B_T5 | 850-855 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| PD-GlycoGenes20190927-B_T6 | 1002-1007 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| PD-GlycoGenes20190927-B_T7 | 1017-1020 | https://acgg.asia/db/ggdb/info/gg135 | denotes | has |
| PD-GlycoGenes20190927-B_T8 | 1086-1091 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| PD-GlycoGenes20190927-B_T9 | 1185-1190 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| PD-GlycoGenes20190927-B_T10 | 1578-1583 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| PD-GlycoGenes20190927-B_T11 | 1693-1698 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| PD-GlycoGenes20190927-B_T12 | 1703-1708 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
| PD-GlycoGenes20190927-B_T13 | 1718-1723 | https://acgg.asia/db/ggdb/info/gg022 | denotes | NDST3 |
| PD-GlycoGenes20190927-B_T14 | 1935-1940 | https://acgg.asia/db/ggdb/info/gg020 | denotes | NDST1 |
| PD-GlycoGenes20190927-B_T15 | 1966-1971 | https://acgg.asia/db/ggdb/info/gg021 | denotes | NDST2 |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 82-88 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 166-185 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T3 | 394-400 | chem:24139 | denotes | GlcNAc |
| T1 | 82-88 | chem:24139 | denotes | GlcNAc |
| T2 | 166-185 | chem:24139 | denotes | N-acetylglucosamine |
| T3 | 394-400 | chem:24139 | denotes | GlcNAc |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 559-564 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 976-981 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 1383-1388 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 1604-1609 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T5 | 1611-1616 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T6 | 1622-1628 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/MAT_0000119 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 597-608 | Disease | denotes | mastocytoma | http://purl.obolibrary.org/obo/MONDO_0002724|http://purl.obolibrary.org/obo/MONDO_0003079 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 555-558 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 957-962 | OrganismTaxon | denotes | human | 9606 |
| T4 | 996-1001 | OrganismTaxon | denotes | Human | 9606 |
| T5 | 1371-1376 | OrganismTaxon | denotes | human | 9606 |
| T6 | 1642-1657 | OrganismTaxon | denotes | Chinese hamster | 10029 |
| T7 | 1730-1745 | OrganismTaxon | denotes | Chinese hamster | 10029 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 559-564 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T2 | 749-755 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T3 | 976-981 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 1383-1388 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 1534-1540 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T8 | 1604-1609 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T10 | 1611-1616 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 1622-1628 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T12 | 1658-1663 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T13 | 1746-1751 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1389-1393 | Cell | denotes | poly | http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775 |