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PubMed:9888865 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine.
T2 86-217 Sentence denotes The expression of tissue factor (TF), the principal initiator of coagulation, is increased during inflammation and atherosclerosis.
T3 218-283 Sentence denotes Both conditions are promoted by lysophosphatidylcholine (lysoPC).
T4 284-447 Sentence denotes We observed in the present study that lysoPC (1 to 10 micromol/L) dose-dependently reduced TF activity in human monocytes, as elicited by lipopolysaccharide (LPS).
T5 448-572 Sentence denotes Lysophosphatidylethanolamine (lysoPE) and other lysophospholipids did not affect LPS-induced TF activity of human monocytes.
T6 573-641 Sentence denotes TF antigen expression as elicited by LPS was also lowered by lysoPC.
T7 642-780 Sentence denotes Phospholipid analyses indicated a selective increase in the lysoPC content of the monocytes after preincubation with the lysophospholipid.
T8 781-874 Sentence denotes LysoPC inhibited the TF activity of Mono Mac-6 cells to a similar extent as in the monocytes.
T9 875-986 Sentence denotes LPS binding to plasma membrane receptors and internalization of LPS into monocytes were not affected by lysoPC.
T10 987-1111 Sentence denotes In contrast, LPS-mediated nuclear binding of nuclear factor-kappaB/Rel to a TF-specific kappaB site was inhibited by lysoPC.
T11 1112-1206 Sentence denotes Induction of TF mRNA expression by LPS tended to be partially reduced by the lysophospholipid.
T12 1207-1265 Sentence denotes Preincubation with lysoPC increased monocytic cAMP levels.
T13 1266-1422 Sentence denotes Inhibition of adenylyl cyclase by pretreatment with 2'-deoxy-3'-adenosine monophosphate partially reversed the inhibition of TF activity promoted by lysoPC.
T14 1423-1605 Sentence denotes In conclusion, lysoPC markedly decreases LPS-mediated TF expression of human monocytes, the effect probably being mediated by both transcriptional and posttranscriptional mechanisms.
T15 1606-1698 Sentence denotes LysoPC may thus attenuate activation of coagulation during inflammation and atherosclerosis.
T1 0-85 Sentence denotes Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine.
T2 86-217 Sentence denotes The expression of tissue factor (TF), the principal initiator of coagulation, is increased during inflammation and atherosclerosis.
T3 218-283 Sentence denotes Both conditions are promoted by lysophosphatidylcholine (lysoPC).
T4 284-447 Sentence denotes We observed in the present study that lysoPC (1 to 10 micromol/L) dose-dependently reduced TF activity in human monocytes, as elicited by lipopolysaccharide (LPS).
T5 448-572 Sentence denotes Lysophosphatidylethanolamine (lysoPE) and other lysophospholipids did not affect LPS-induced TF activity of human monocytes.
T6 573-641 Sentence denotes TF antigen expression as elicited by LPS was also lowered by lysoPC.
T7 642-780 Sentence denotes Phospholipid analyses indicated a selective increase in the lysoPC content of the monocytes after preincubation with the lysophospholipid.
T8 781-874 Sentence denotes LysoPC inhibited the TF activity of Mono Mac-6 cells to a similar extent as in the monocytes.
T9 875-986 Sentence denotes LPS binding to plasma membrane receptors and internalization of LPS into monocytes were not affected by lysoPC.
T10 987-1111 Sentence denotes In contrast, LPS-mediated nuclear binding of nuclear factor-kappaB/Rel to a TF-specific kappaB site was inhibited by lysoPC.
T11 1112-1206 Sentence denotes Induction of TF mRNA expression by LPS tended to be partially reduced by the lysophospholipid.
T12 1207-1265 Sentence denotes Preincubation with lysoPC increased monocytic cAMP levels.
T13 1266-1422 Sentence denotes Inhibition of adenylyl cyclase by pretreatment with 2'-deoxy-3'-adenosine monophosphate partially reversed the inhibition of TF activity promoted by lysoPC.
T14 1423-1605 Sentence denotes In conclusion, lysoPC markedly decreases LPS-mediated TF expression of human monocytes, the effect probably being mediated by both transcriptional and posttranscriptional mechanisms.
T15 1606-1698 Sentence denotes LysoPC may thus attenuate activation of coagulation during inflammation and atherosclerosis.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 28-43 cell_type denotes human monocytes
T2 104-117 protein denotes tissue factor
T3 119-121 protein denotes TF
T4 375-377 protein denotes TF
T5 390-405 cell_type denotes human monocytes
T6 556-571 cell_type denotes human monocytes
T7 724-733 cell_type denotes monocytes
T8 817-833 cell_line denotes Mono Mac-6 cells
T9 864-873 cell_type denotes monocytes
T10 948-957 cell_type denotes monocytes
T11 1032-1057 protein denotes nuclear factor-kappaB/Rel
T12 1063-1086 DNA denotes TF-specific kappaB site
T13 1125-1132 RNA denotes TF mRNA
T14 1280-1296 protein denotes adenylyl cyclase
T15 1318-1353 protein denotes 2'-deoxy-3'-adenosine monophosphate
T16 1494-1509 cell_type denotes human monocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-85 Sentence denotes Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine.
S2 86-217 Sentence denotes The expression of tissue factor (TF), the principal initiator of coagulation, is increased during inflammation and atherosclerosis.
S3 218-283 Sentence denotes Both conditions are promoted by lysophosphatidylcholine (lysoPC).
S4 284-447 Sentence denotes We observed in the present study that lysoPC (1 to 10 micromol/L) dose-dependently reduced TF activity in human monocytes, as elicited by lipopolysaccharide (LPS).
S5 448-572 Sentence denotes Lysophosphatidylethanolamine (lysoPE) and other lysophospholipids did not affect LPS-induced TF activity of human monocytes.
S6 573-641 Sentence denotes TF antigen expression as elicited by LPS was also lowered by lysoPC.
S7 642-780 Sentence denotes Phospholipid analyses indicated a selective increase in the lysoPC content of the monocytes after preincubation with the lysophospholipid.
S8 781-874 Sentence denotes LysoPC inhibited the TF activity of Mono Mac-6 cells to a similar extent as in the monocytes.
S9 875-986 Sentence denotes LPS binding to plasma membrane receptors and internalization of LPS into monocytes were not affected by lysoPC.
S10 987-1111 Sentence denotes In contrast, LPS-mediated nuclear binding of nuclear factor-kappaB/Rel to a TF-specific kappaB site was inhibited by lysoPC.
S11 1112-1206 Sentence denotes Induction of TF mRNA expression by LPS tended to be partially reduced by the lysophospholipid.
S12 1207-1265 Sentence denotes Preincubation with lysoPC increased monocytic cAMP levels.
S13 1266-1422 Sentence denotes Inhibition of adenylyl cyclase by pretreatment with 2'-deoxy-3'-adenosine monophosphate partially reversed the inhibition of TF activity promoted by lysoPC.
S14 1423-1605 Sentence denotes In conclusion, lysoPC markedly decreases LPS-mediated TF expression of human monocytes, the effect probably being mediated by both transcriptional and posttranscriptional mechanisms.
S15 1606-1698 Sentence denotes LysoPC may thus attenuate activation of coagulation during inflammation and atherosclerosis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 28-43 NP denotes human monocytes
C2 61-84 NP denotes lysophosphatidylcholine
C3 104-122 NP denotes tissue factor (TF)
C4 124-162 NP denotes the principal initiator of coagulation
C5 184-216 NP denotes inflammation and atherosclerosis
C6 218-233 NP denotes Both conditions
C7 250-282 NP denotes lysophosphatidylcholine (lysoPC)
C8 322-328 NP denotes lysoPC
C9 390-405 NP denotes human monocytes
C10 422-446 NP denotes lipopolysaccharide (LPS)
C11 448-485 NP denotes Lysophosphatidylethanolamine (lysoPE)
C12 556-571 NP denotes human monocytes
C13 610-613 NP denotes LPS
C14 634-640 NP denotes lysoPC
C15 720-733 NP denotes the monocytes
C16 759-779 NP denotes the lysophospholipid
C17 781-787 NP denotes LysoPC
C18 860-873 NP denotes the monocytes
C19 939-942 NP denotes LPS
C20 948-957 NP denotes monocytes
C21 979-985 NP denotes lysoPC
C22 1104-1110 NP denotes lysoPC
C23 1147-1150 NP denotes LPS
C24 1185-1205 NP denotes the lysophospholipid
C25 1226-1232 NP denotes lysoPC
C26 1415-1421 NP denotes lysoPC
C27 1438-1444 NP denotes lysoPC
C28 1494-1509 NP denotes human monocytes
C29 1606-1612 NP denotes LysoPC
C30 1665-1697 NP denotes inflammation and atherosclerosis
R1 C4 C3 coref-appos the principal initiator of coagulation,tissue factor (TF)
R2 C6 C5 coref-pron Both conditions,inflammation and atherosclerosis
R3 C7 C2 coref-ident lysophosphatidylcholine (lysoPC),lysophosphatidylcholine
R4 C8 C7 coref-ident lysoPC,lysophosphatidylcholine (lysoPC)
R5 C9 C1 coref-ident human monocytes,human monocytes
R6 C12 C9 coref-ident human monocytes,human monocytes
R7 C13 C10 coref-ident LPS,lipopolysaccharide (LPS)
R8 C14 C8 coref-ident lysoPC,lysoPC
R9 C15 C12 coref-ident the monocytes,human monocytes
R10 C16 C11 coref-ident the lysophospholipid,Lysophosphatidylethanolamine (lysoPE)
R11 C17 C14 coref-ident LysoPC,lysoPC
R12 C18 C15 coref-ident the monocytes,the monocytes
R13 C19 C13 coref-ident LPS,LPS
R14 C20 C18 coref-ident monocytes,the monocytes
R15 C21 C17 coref-ident lysoPC,LysoPC
R16 C22 C21 coref-ident lysoPC,lysoPC
R17 C23 C19 coref-ident LPS,LPS
R18 C24 C16 coref-ident the lysophospholipid,the lysophospholipid
R19 C25 C22 coref-ident lysoPC,lysoPC
R20 C26 C25 coref-ident lysoPC,lysoPC
R21 C27 C26 coref-ident lysoPC,lysoPC
R22 C28 C20 coref-ident human monocytes,monocytes
R23 C29 C27 coref-ident LysoPC,lysoPC
R24 C30 C6 coref-ident inflammation and atherosclerosis,Both conditions

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 28-43 cell_type denotes human monocytes
T2 61-84 lipid denotes lysophosphatidylcholine
T3 104-117 protein_family_or_group denotes tissue factor
T4 119-121 protein_family_or_group denotes TF
T5 151-162 other_name denotes coagulation
T6 184-196 other_name denotes inflammation
T7 201-216 other_name denotes atherosclerosis
T8 250-273 lipid denotes lysophosphatidylcholine
T9 275-281 lipid denotes lysoPC
T10 322-328 lipid denotes lysoPC
T11 375-377 protein_family_or_group denotes TF
T12 390-405 cell_type denotes human monocytes
T13 422-440 lipid denotes lipopolysaccharide
T14 442-445 lipid denotes LPS
T15 448-476 other_organic_compound denotes Lysophosphatidylethanolamine
T16 478-484 other_organic_compound denotes lysoPE
T17 496-513 lipid denotes lysophospholipids
T18 529-532 lipid denotes LPS
T19 556-571 cell_type denotes human monocytes
T20 573-594 other_name denotes TF antigen expression
T21 610-613 lipid denotes LPS
T22 634-640 lipid denotes lysoPC
T23 642-663 other_name denotes Phospholipid analyses
T24 702-708 lipid denotes lysoPC
T25 724-733 cell_type denotes monocytes
T26 781-787 lipid denotes LysoPC
T27 802-813 other_name denotes TF activity
T28 817-833 cell_line denotes Mono Mac-6 cells
T29 864-873 cell_type denotes monocytes
T30 875-878 lipid denotes LPS
T31 939-942 lipid denotes LPS
T32 948-957 cell_type denotes monocytes
T33 979-985 lipid denotes lysoPC
T34 1000-1003 lipid denotes LPS
T35 1032-1057 protein_complex denotes nuclear factor-kappaB/Rel
T36 1063-1086 DNA_domain_or_region denotes TF-specific kappaB site
T37 1104-1110 lipid denotes lysoPC
T38 1125-1132 RNA_molecule denotes TF mRNA
T39 1147-1150 lipid denotes LPS
T40 1189-1205 lipid denotes lysophospholipid
T41 1226-1232 lipid denotes lysoPC
T42 1243-1252 other_name denotes monocytic
T43 1253-1257 nucleotide denotes cAMP
T44 1280-1296 protein_complex denotes adenylyl cyclase
T45 1318-1353 protein_molecule denotes 2'-deoxy-3'-adenosine monophosphate
T46 1391-1402 other_name denotes TF activity
T47 1415-1421 lipid denotes lysoPC
T48 1438-1444 lipid denotes lysoPC
T49 1464-1467 lipid denotes LPS
T50 1494-1509 cell_type denotes human monocytes
T51 1606-1612 lipid denotes LysoPC
T52 1646-1657 other_name denotes coagulation
T53 1665-1677 other_name denotes inflammation
T54 1682-1697 other_name denotes atherosclerosis