| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-95 |
Sentence |
denotes |
Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells. |
| TextSentencer_T2 |
96-226 |
Sentence |
denotes |
Intact mycobacteria and mycobacterial cell wall extracts have been shown to inhibit the growth of human and murine bladder cancer. |
| TextSentencer_T3 |
227-284 |
Sentence |
denotes |
Their mechanism of action is, however, poorly understood. |
| TextSentencer_T4 |
285-465 |
Sentence |
denotes |
Mycobacterium phlei mycobacterial cell complex (MCC) is a cell wall preparation that has mycobacterial DNA in the form of short oligonucleotides complexed on the cell wall surface. |
| TextSentencer_T5 |
466-783 |
Sentence |
denotes |
In this study, we have investigated the possibility that MCC has anti-cancer activity that is mediated by two different mechanisms--a direct effect on cancer cell proliferation and viability and an indirect effect mediated by the production of interleukin 12 (IL-12), a cytokine known to possess anti-cancer activity. |
| TextSentencer_T6 |
784-1114 |
Sentence |
denotes |
We have found that, although MCC is a potent inducer of IL-12 and IL-6 synthesis in monocytes and macrophages either in vitro or in vivo, it is unable to induce the synthesis of either IL-12, IL-6 or granulocyte-macrophage colony-stimulating factor (GM-CSF) by the human transitional bladder cancer cell lines HT-1197 and HT-1376. |
| TextSentencer_T7 |
1115-1294 |
Sentence |
denotes |
MCC is not directly cytotoxic towards these cancer cells, but induces apoptosis as determined by nuclear DNA fragmentation and by the release of nuclear mitotic apparatus protein. |
| TextSentencer_T8 |
1295-1385 |
Sentence |
denotes |
Mycobacterium phlei DNA associated with MCC is responsible for the induction of apoptosis. |
| TextSentencer_T9 |
1386-1663 |
Sentence |
denotes |
Our results indicate that MCC directly effects bladder cancer cells by inhibiting cellular proliferation through the induction of apoptosis, and has the potential for an indirect anti-cancer activity by stimulating cancer-infiltrating monocytes/macrophages to synthesize IL-12. |
| T1 |
0-95 |
Sentence |
denotes |
Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells. |
| T2 |
96-226 |
Sentence |
denotes |
Intact mycobacteria and mycobacterial cell wall extracts have been shown to inhibit the growth of human and murine bladder cancer. |
| T3 |
227-284 |
Sentence |
denotes |
Their mechanism of action is, however, poorly understood. |
| T4 |
285-465 |
Sentence |
denotes |
Mycobacterium phlei mycobacterial cell complex (MCC) is a cell wall preparation that has mycobacterial DNA in the form of short oligonucleotides complexed on the cell wall surface. |
| T5 |
466-783 |
Sentence |
denotes |
In this study, we have investigated the possibility that MCC has anti-cancer activity that is mediated by two different mechanisms--a direct effect on cancer cell proliferation and viability and an indirect effect mediated by the production of interleukin 12 (IL-12), a cytokine known to possess anti-cancer activity. |
| T6 |
784-1114 |
Sentence |
denotes |
We have found that, although MCC is a potent inducer of IL-12 and IL-6 synthesis in monocytes and macrophages either in vitro or in vivo, it is unable to induce the synthesis of either IL-12, IL-6 or granulocyte-macrophage colony-stimulating factor (GM-CSF) by the human transitional bladder cancer cell lines HT-1197 and HT-1376. |
| T7 |
1115-1294 |
Sentence |
denotes |
MCC is not directly cytotoxic towards these cancer cells, but induces apoptosis as determined by nuclear DNA fragmentation and by the release of nuclear mitotic apparatus protein. |
| T8 |
1295-1385 |
Sentence |
denotes |
Mycobacterium phlei DNA associated with MCC is responsible for the induction of apoptosis. |
| T9 |
1386-1663 |
Sentence |
denotes |
Our results indicate that MCC directly effects bladder cancer cells by inhibiting cellular proliferation through the induction of apoptosis, and has the potential for an indirect anti-cancer activity by stimulating cancer-infiltrating monocytes/macrophages to synthesize IL-12. |
