PubMed:9886433
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 39-58 | cell_type | denotes | naive human T cells |
| T2 | 97-112 | cell_type | denotes | dendritic cells |
| T3 | 180-195 | cell_type | denotes | Dendritic cells |
| T4 | 197-199 | cell_type | denotes | DC |
| T5 | 212-215 | cell_type | denotes | APC |
| T6 | 322-330 | cell_type | denotes | human DC |
| T7 | 365-383 | cell_type | denotes | naive CD4+ T cells |
| T8 | 387-395 | protein | denotes | epitopes |
| T9 | 403-436 | protein | denotes | immediate early 62 (IE62) protein |
| T10 | 487-491 | protein | denotes | CD4+ |
| T11 | 592-608 | protein | denotes | VZV IE62 protein |
| T12 | 628-635 | cell_type | denotes | T cells |
| T13 | 640-642 | cell_type | denotes | DC |
| T14 | 730-743 | cell_type | denotes | naive T cells |
| T15 | 969-971 | cell_type | denotes | DC |
| T16 | 975-978 | cell_type | denotes | APC |
| T17 | 980-989 | cell_type | denotes | Monocytes |
| T18 | 1005-1008 | cell_type | denotes | APC |
| T19 | 1163-1170 | cell_type | denotes | T cells |
| T20 | 1285-1287 | cell_type | denotes | DC |
| T21 | 1340-1349 | cell_type | denotes | monocytes |
| T22 | 1353-1356 | cell_type | denotes | APC |
| T23 | 1604-1606 | cell_type | denotes | DC |
| T24 | 1610-1613 | cell_type | denotes | APC |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-179 | Sentence | denotes | Comparison of primary sensitization of naive human T cells to varicella-zoster virus peptides by dendritic cells in vitro with responses elicited in vivo by varicella vaccination. |
| S2 | 180-262 | Sentence | denotes | Dendritic cells (DC) are potent APC during primary and secondary immune responses. |
| S3 | 263-469 | Sentence | denotes | The first objective of this study was to determine whether human DC mediate in vitro sensitization of naive CD4+ T cells to epitopes of the immediate early 62 (IE62) protein of varicella zoster virus (VZV). |
| S4 | 470-671 | Sentence | denotes | The induction of CD4+ T cell proliferative responses to eight synthetic peptides representing amino acid sequences of the VZV IE62 protein was assessed using T cells and DC from VZV-susceptible donors. |
| S5 | 672-833 | Sentence | denotes | The second objective was to compare in vitro responses of naive T cells with responses to VZV peptides induced in vivo after immunization with varicella vaccine. |
| S6 | 834-979 | Sentence | denotes | T cell proliferation was induced by three peptides, P1, P4, and P7, in 71-100% of the donors tested before and after vaccination using DC as APC. |
| S7 | 980-1050 | Sentence | denotes | Monocytes were effective APC for VZV peptides only after immunization. |
| S8 | 1051-1214 | Sentence | denotes | Two peptides, P2 and P8, induced naive T cell proliferation less effectively and were also less immunogenic for T cells from vaccinated or naturally immune donors. |
| S9 | 1215-1521 | Sentence | denotes | T cell recognition of specific peptides was concordant between naive, DC-mediated responses, and postvaccine responses using monocytes as APC in 69% of comparisons (p = 0.05; chi2); the predictive value of a positive response to an IE62 peptide before immunization for T cell sensitization in vivo was 82%. |
| S10 | 1522-1707 | Sentence | denotes | These observations indicate that primary T cell responses detected in vitro using DC as APC may be useful to characterize the potential immunogenicity of viral protein epitopes in vivo. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 39-58 | NP | denotes | naive human T cells |
| C2 | 62-93 | NP | denotes | varicella-zoster virus peptides |
| C3 | 97-112 | NP | denotes | dendritic cells |
| C4 | 180-200 | NP | denotes | Dendritic cells (DC) |
| C5 | 205-215 | NP | denotes | potent APC |
| C6 | 322-330 | NP | denotes | human DC |
| C7 | 399-468 | NP | denotes | the immediate early 62 (IE62) protein of varicella zoster virus (VZV) |
| C8 | 588-608 | NP | denotes | the VZV IE62 protein |
| C9 | 730-743 | NP | denotes | naive T cells |
| C10 | 762-774 | NP | denotes | VZV peptides |
| C11 | 797-832 | NP | denotes | immunization with varicella vaccine |
| C12 | 870-884 | NP | denotes | three peptides |
| C13 | 886-900 | NP | denotes | P1, P4, and P7 |
| C14 | 969-971 | NP | denotes | DC |
| C15 | 975-978 | NP | denotes | APC |
| C16 | 980-989 | NP | denotes | Monocytes |
| C17 | 995-1008 | NP | denotes | effective APC |
| C18 | 1013-1025 | NP | denotes | VZV peptides |
| C19 | 1037-1049 | NP | denotes | immunization |
| C20 | 1051-1063 | NP | denotes | Two peptides |
| C21 | 1065-1074 | NP | denotes | P2 and P8 |
| C22 | 1340-1349 | NP | denotes | monocytes |
| C23 | 1353-1356 | NP | denotes | APC |
| C24 | 1604-1606 | NP | denotes | DC |
| C25 | 1610-1613 | NP | denotes | APC |
| R1 | C4 | C3 | coref-ident | Dendritic cells (DC),dendritic cells |
| R2 | C6 | C4 | coref-ident | human DC,Dendritic cells (DC) |
| R3 | C8 | C7 | coref-ident | the VZV IE62 protein,the immediate early 62 (IE62) protein of varicella zoster virus (VZV) |
| R4 | C9 | C1 | coref-ident | naive T cells,naive human T cells |
| R5 | C10 | C2 | coref-ident | VZV peptides,varicella-zoster virus peptides |
| R6 | C13 | C12 | coref-appos | "P1, P4, and P7",three peptides |
| R7 | C14 | C6 | coref-ident | DC,human DC |
| R8 | C15 | C5 | coref-ident | APC,potent APC |
| R9 | C17 | C15 | coref-ident | effective APC,APC |
| R10 | C18 | C10 | coref-ident | VZV peptides,VZV peptides |
| R11 | C19 | C11 | coref-ident | immunization,immunization with varicella vaccine |
| R12 | C21 | C20 | coref-appos | P2 and P8,Two peptides |
| R13 | C22 | C16 | coref-ident | monocytes,Monocytes |
| R14 | C23 | C17 | coref-ident | APC,effective APC |
| R15 | C24 | C14 | coref-ident | DC,DC |
| R16 | C25 | C23 | coref-ident | APC,APC |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-35 | other_name | denotes | primary sensitization |
| T2 | 39-58 | cell_type | denotes | naive human T cells |
| T3 | 62-84 | virus | denotes | varicella-zoster virus |
| T4 | 97-112 | cell_type | denotes | dendritic cells |
| T5 | 157-178 | other_name | denotes | varicella vaccination |
| T6 | 180-195 | cell_type | denotes | Dendritic cells |
| T7 | 197-199 | cell_type | denotes | DC |
| T8 | 212-215 | cell_type | denotes | APC |
| T9 | 322-327 | cell_type | denotes | human |
| T10 | 328-330 | cell_type | denotes | DC |
| T11 | 365-383 | cell_type | denotes | naive CD4+ T cells |
| T12 | 387-395 | protein_domain_or_region | denotes | epitopes |
| T13 | 403-436 | protein_molecule | denotes | immediate early 62 (IE62) protein |
| T14 | 440-462 | virus | denotes | varicella zoster virus |
| T15 | 464-467 | virus | denotes | VZV |
| T16 | 487-491 | protein_molecule | denotes | CD4+ |
| T17 | 532-550 | peptide | denotes | synthetic peptides |
| T18 | 592-595 | virus | denotes | VZV |
| T19 | 628-635 | cell_type | denotes | T cells |
| T20 | 640-642 | cell_type | denotes | DC |
| T21 | 648-651 | virus | denotes | VZV |
| T22 | 730-743 | cell_type | denotes | naive T cells |
| T23 | 762-765 | virus | denotes | VZV |
| T24 | 815-832 | other_organic_compound | denotes | varicella vaccine |
| T25 | 834-854 | other_name | denotes | T cell proliferation |
| T26 | 876-884 | peptide | denotes | peptides |
| T27 | 886-888 | peptide | denotes | P1 |
| T28 | 890-892 | peptide | denotes | P4 |
| T29 | 898-900 | peptide | denotes | P7 |
| T30 | 969-971 | cell_type | denotes | DC |
| T31 | 975-978 | cell_type | denotes | APC |
| T32 | 980-989 | cell_type | denotes | Monocytes |
| T33 | 1005-1008 | cell_type | denotes | APC |
| T34 | 1013-1016 | virus | denotes | VZV |
| T35 | 1017-1025 | peptide | denotes | peptides |
| T36 | 1055-1063 | peptide | denotes | peptides |
| T37 | 1065-1067 | peptide | denotes | P2 |
| T38 | 1072-1074 | peptide | denotes | P8 |
| T39 | 1090-1110 | other_name | denotes | T cell proliferation |
| T40 | 1163-1170 | cell_type | denotes | T cells |
| T41 | 1190-1213 | other_name | denotes | naturally immune donors |
| T42 | 1246-1254 | peptide | denotes | peptides |
| T43 | 1278-1284 | other_name | denotes | naive, |
| T44 | 1285-1287 | cell_type | denotes | DC |
| T45 | 1340-1349 | cell_type | denotes | monocytes |
| T46 | 1353-1356 | cell_type | denotes | APC |
| T47 | 1447-1459 | peptide | denotes | IE62 peptide |
| T48 | 1484-1504 | other_name | denotes | T cell sensitization |
| T49 | 1555-1579 | other_name | denotes | primary T cell responses |
| T50 | 1604-1606 | cell_type | denotes | DC |
| T51 | 1610-1613 | cell_type | denotes | APC |
| T52 | 1648-1672 | other_name | denotes | potential immunogenicity |
| T53 | 1676-1698 | peptide | denotes | viral protein epitopes |