> top > docs > PubMed:9886419 > annotations

PubMed:9886419 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-18 protein denotes IL-6
T2 32-72 cell_type denotes human peripheral blood mononuclear cells
T3 76-79 protein denotes C3a
T4 84-95 protein denotes C3a(desArg)
T5 101-114 protein denotes anaphylatoxin
T6 115-118 protein denotes C3a
T7 252-255 protein denotes C3a
T8 260-271 protein denotes C3a(desArg)
T9 316-320 protein denotes IL-6
T10 330-335 cell_type denotes PBMCs
T11 380-388 protein denotes IL-1beta
T12 390-393 protein denotes C3a
T13 397-408 protein denotes C3a(desArg)
T14 469-473 protein denotes IL-6
T15 489-493 cell_type denotes PBMC
T16 522-530 protein denotes IL-1beta
T17 537-540 protein denotes C3a
T18 545-556 protein denotes C3a(desArg)
T19 579-583 protein denotes IL-6
T20 595-599 cell_type denotes PBMC
T21 634-637 protein denotes C3a
T22 682-691 cell_type denotes monocytes
T23 797-800 protein denotes C3a
T24 951-954 protein denotes C3a
T25 987-990 protein denotes C3a
T26 994-998 protein denotes IL-6
T27 1047-1056 cell_type denotes monocytes
T28 1093-1096 protein denotes C3a
T29 1108-1119 protein denotes C3a(desArg)
T30 1132-1145 RNA denotes -induced mRNA
T31 1157-1161 protein denotes IL-6
T32 1179-1184 cell_type denotes PBMCs
T33 1190-1205 protein denotes pertussis toxin
T34 1231-1234 protein denotes C3a
T35 1239-1250 protein denotes C3a(desArg)
T36 1321-1330 protein denotes G protein
T37 1392-1395 protein denotes C3a
T38 1400-1411 protein denotes C3a(desArg)
T39 1428-1437 protein denotes NF-kappaB
T40 1442-1462 protein denotes activating protein-1
T41 1508-1517 protein denotes NF-kappaB
T42 1522-1542 protein denotes activating protein-1
T43 1610-1613 protein denotes C3a
T44 1634-1646 protein denotes des-Arg form

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-96 Sentence denotes Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg).
S2 97-206 Sentence denotes The anaphylatoxin C3a has been reported to have immunomodulatory effects on a number of different cell types.
S3 207-389 Sentence denotes In this study we investigated the effects of C3a and C3a(desArg) on gene expression and protein secretion of IL-6 in human PBMCs, either alone or in combination with LPS or IL-1beta.
S4 390-474 Sentence denotes C3a or C3a(desArg) alone exhibited no effect on the expression or secretion of IL-6.
S5 475-627 Sentence denotes However, when PBMC were stimulated with LPS or IL-1beta, both C3a and C3a(desArg) were found to enhance IL-6 release by PBMC in a dose-dependent manner.
S6 628-867 Sentence denotes Since C3a has been shown to induce PGE2 production by monocytes, and PGE2 has been shown to influence cytokine production, we investigated the potential role of PGE2 in C3a-mediated enhancement of LPS- and IL-1beta-induced IL-6 production.
S7 868-1057 Sentence denotes Indomethacin blocked PGE2 release, but had no influence on the observed effects of C3a, suggesting that the effects of C3a on IL-6 production are independent of PGE2 formation by monocytes.
S8 1058-1162 Sentence denotes Northern blot analysis showed that C3a as well as C3a(desArg) enhanced LPS-induced mRNA levels for IL-6.
S9 1163-1347 Sentence denotes Pretreatment of PBMCs with pertussis toxin blocked the functions of C3a and C3a(desArg), indicating that the actions of these two molecules are mediated by a G protein-coupled pathway.
S10 1348-1471 Sentence denotes Furthermore, we investigated the effects of C3a and C3a(desArg) on induction of NF-kappaB and activating protein-1 binding.
S11 1472-1560 Sentence denotes Both molecules enhanced LPS-induced NF-kappaB and activating protein-1 binding activity.
S12 1561-1689 Sentence denotes These results demonstrate the capacity of intact C3a and its circulating des-Arg form to exert immunmodulatory effects in vitro.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 76-79 NP denotes C3a
C3 84-95 NP denotes C3a(desArg)
C1 76-95 NP denotes C3a and C3a(desArg)
C4 97-118 NP denotes The anaphylatoxin C3a
C5 145-169 NP denotes immunomodulatory effects
C7 252-255 NP denotes C3a
C8 260-271 NP denotes C3a(desArg)
C6 252-271 NP denotes C3a and C3a(desArg)
C9 316-320 NP denotes IL-6
C10 324-335 NP denotes human PBMCs
C11 373-388 NP denotes LPS or IL-1beta
C12 390-393 NP denotes C3a
C13 397-408 NP denotes C3a(desArg)
C14 469-473 NP denotes IL-6
C15 489-493 NP denotes PBMC
C16 515-530 NP denotes LPS or IL-1beta
C18 537-540 NP denotes C3a
C19 545-556 NP denotes C3a(desArg)
C17 532-556 NP denotes both C3a and C3a(desArg)
C20 595-599 NP denotes PBMC
C21 634-637 NP denotes C3a
C22 682-691 NP denotes monocytes
C23 697-701 NP denotes PGE2
C24 789-793 NP denotes PGE2
C25 825-866 NP denotes LPS- and IL-1beta-induced IL-6 production
C26 951-954 NP denotes C3a
C27 987-990 NP denotes C3a
C28 994-1009 NP denotes IL-6 production
C29 1047-1056 NP denotes monocytes
C30 1093-1096 NP denotes C3a
C31 1108-1119 NP denotes C3a(desArg)
C32 1157-1161 NP denotes IL-6
C33 1179-1184 NP denotes PBMCs
C35 1231-1234 NP denotes C3a
C36 1239-1250 NP denotes C3a(desArg)
C34 1231-1250 NP denotes C3a and C3a(desArg)
C37 1283-1302 NP denotes these two molecules
C39 1392-1395 NP denotes C3a
C40 1400-1411 NP denotes C3a(desArg)
C38 1392-1411 NP denotes C3a and C3a(desArg)
C41 1472-1486 NP denotes Both molecules
C42 1603-1613 NP denotes intact C3a
C44 1618-1621 NP denotes its
C43 1618-1646 NP denotes its circulating des-Arg form
C45 1656-1679 NP denotes immunmodulatory effects
R1 C4 C2 coref-ident The anaphylatoxin C3a,C3a
R2 C7 C4 coref-ident C3a,The anaphylatoxin C3a
R3 C8 C3 coref-ident C3a(desArg),C3a(desArg)
R4 C6 C1 coref-ident C3a and C3a(desArg),C3a and C3a(desArg)
R5 C12 C7 coref-ident C3a,C3a
R6 C13 C8 coref-ident C3a(desArg),C3a(desArg)
R7 C14 C9 coref-ident IL-6,IL-6
R8 C15 C10 coref-ident PBMC,human PBMCs
R9 C16 C11 coref-ident LPS or IL-1beta,LPS or IL-1beta
R10 C18 C12 coref-ident C3a,C3a
R11 C19 C13 coref-ident C3a(desArg),C3a(desArg)
R12 C17 C6 coref-ident both C3a and C3a(desArg),C3a and C3a(desArg)
R13 C20 C15 coref-ident PBMC,PBMC
R14 C21 C18 coref-ident C3a,C3a
R15 C24 C23 coref-ident PGE2,PGE2
R16 C26 C21 coref-ident C3a,C3a
R17 C27 C26 coref-ident C3a,C3a
R18 C28 C25 coref-ident IL-6 production,LPS- and IL-1beta-induced IL-6 production
R19 C29 C22 coref-ident monocytes,monocytes
R20 C30 C27 coref-ident C3a,C3a
R21 C31 C19 coref-ident C3a(desArg),C3a(desArg)
R22 C32 C14 coref-ident IL-6,IL-6
R23 C33 C20 coref-ident PBMCs,PBMC
R24 C35 C30 coref-ident C3a,C3a
R25 C36 C31 coref-ident C3a(desArg),C3a(desArg)
R26 C34 C17 coref-ident C3a and C3a(desArg),both C3a and C3a(desArg)
R27 C37 C34 coref-ident these two molecules,C3a and C3a(desArg)
R28 C39 C35 coref-ident C3a,C3a
R29 C40 C36 coref-ident C3a(desArg),C3a(desArg)
R30 C38 C37 coref-ident C3a and C3a(desArg),these two molecules
R31 C41 C38 coref-pron Both molecules,C3a and C3a(desArg)
R32 C44 C42 coref-pron its,intact C3a
R33 C43 C40 coref-ident its circulating des-Arg form,C3a(desArg)
R34 C45 C5 coref-ident immunmodulatory effects,immunomodulatory effects

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-18 protein_molecule denotes IL-6
T2 32-72 cell_type denotes human peripheral blood mononuclear cells
T3 76-79 protein_molecule denotes C3a
T4 84-95 protein_molecule denotes C3a(desArg)
T5 101-114 protein_family_or_group denotes anaphylatoxin
T6 115-118 protein_molecule denotes C3a
T7 252-255 protein_molecule denotes C3a
T8 260-271 protein_molecule denotes C3a(desArg)
T9 275-290 other_name denotes gene expression
T10 295-312 other_name denotes protein secretion
T11 316-320 protein_molecule denotes IL-6
T12 330-335 cell_type denotes PBMCs
T13 373-376 lipid denotes LPS
T14 380-388 protein_molecule denotes IL-1beta
T15 390-393 protein_molecule denotes C3a
T16 397-408 protein_molecule denotes C3a(desArg)
T17 469-473 protein_molecule denotes IL-6
T18 489-493 cell_type denotes PBMC
T19 515-518 lipid denotes LPS
T20 522-530 protein_molecule denotes IL-1beta
T21 537-540 protein_molecule denotes C3a
T22 545-556 protein_molecule denotes C3a(desArg)
T23 579-583 protein_molecule denotes IL-6
T24 595-599 cell_type denotes PBMC
T25 605-626 other_name denotes dose-dependent manner
T26 634-637 protein_molecule denotes C3a
T27 663-667 lipid denotes PGE2
T28 682-691 cell_type denotes monocytes
T29 697-701 lipid denotes PGE2
T30 789-793 lipid denotes PGE2
T31 797-800 protein_molecule denotes C3a
T32 889-893 lipid denotes PGE2
T33 951-954 protein_molecule denotes C3a
T34 987-990 protein_molecule denotes C3a
T35 994-998 protein_molecule denotes IL-6
T36 1029-1033 lipid denotes PGE2
T37 1047-1056 cell_type denotes monocytes
T38 1058-1080 other_name denotes Northern blot analysis
T39 1093-1096 protein_molecule denotes C3a
T40 1108-1119 protein_molecule denotes C3a(desArg)
T41 1129-1132 lipid denotes LPS
T42 1132-1145 RNA_family_or_group denotes -induced mRNA
T43 1157-1161 protein_molecule denotes IL-6
T44 1179-1184 cell_type denotes PBMCs
T45 1190-1205 protein_molecule denotes pertussis toxin
T46 1231-1234 protein_molecule denotes C3a
T47 1239-1250 protein_molecule denotes C3a(desArg)
T48 1321-1330 protein_family_or_group denotes G protein
T49 1392-1395 protein_molecule denotes C3a
T50 1400-1411 protein_molecule denotes C3a(desArg)
T51 1428-1437 protein_complex denotes NF-kappaB
T52 1442-1462 protein_molecule denotes activating protein-1
T53 1496-1499 lipid denotes LPS
T54 1508-1517 protein_complex denotes NF-kappaB
T55 1522-1542 protein_molecule denotes activating protein-1
T56 1610-1613 protein_molecule denotes C3a
T57 1634-1646 protein_molecule denotes des-Arg form
T58 1656-1679 other_name denotes immunmodulatory effects