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PubMed:9885213 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 20-49 protein denotes CCAAT-box binding factor NF-Y
T2 103-112 protein denotes A subunit
T3 174-195 DNA denotes tissue-specific genes
T4 217-237 protein denotes transcription factor
T5 284-288 protein denotes NF-Y
T6 348-352 protein denotes NF-Y
T7 398-418 protein denotes transcription factor
T8 450-461 DNA denotes CCAAT motif
T9 477-495 DNA denotes 5' promoter region
T10 545-566 cell_type denotes circulating monocytes
T11 568-572 protein denotes NF-Y
T12 613-624 DNA denotes CCAAT motif
T13 640-658 DNA denotes promoters of genes
T14 667-714 DNA denotes major histocompatibility complex (MHC) class II
T15 716-725 DNA denotes gp91-phox
T16 727-730 DNA denotes mig
T17 818-822 protein denotes NF-Y
T18 884-888 protein denotes NF-Y
T19 938-942 protein denotes NF-Y
T20 955-976 cell_type denotes circulating monocytes
T21 1004-1013 protein denotes A subunit
T22 1056-1060 protein denotes NF-Y
T23 1060-1069 protein denotes A subunit
T24 1079-1083 protein denotes NF-Y
T25 1118-1131 protein denotes NF-YA protein
T26 1226-1236 RNA denotes NF-YA mRNA
T27 1336-1362 cell_type denotes freshly isolated monocytes
T28 1453-1457 protein denotes NF-Y
T29 1457-1466 protein denotes A subunit
T30 1546-1562 cell_type denotes mature monocytes
T31 1611-1626 protein denotes cut/CDP protein
T32 1670-1685 DNA denotes gpc91-phox gene
T33 1711-1715 protein denotes NF-Y
T34 1731-1739 DNA denotes CAAT box
T35 1754-1763 cell_type denotes monocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-238 Sentence denotes The activity of the CCAAT-box binding factor NF-Y is modulated through the regulated expression of its A subunit during monocyte to macrophage differentiation: regulation of tissue-specific genes through a ubiquitous transcription factor.
S2 239-347 Sentence denotes In this study, we analyzed the regulation of NF-Y expression during human monocyte to macrophage maturation.
S3 348-523 Sentence denotes NF-Y is a ubiquitous and evolutionarily conserved transcription factor that binds specifically to the CCAAT motif present in the 5' promoter region of a wide variety of genes.
S4 524-871 Sentence denotes We show here that in circulating monocytes, NF-Y binding activity is not detected on the CCAAT motif present in the promoters of genes such as major histocompatibility complex (MHC) class II, gp91-phox, mig, and fibronectin, whereas during macrophage differentiation, a progressive increase in NF-Y binding activity is observed on these promoters.
S5 872-1014 Sentence denotes Analysis of NF-Y subunit expression indicates that the absence of NF-Y activity in circulating monocytes is caused by a lack of the A subunit.
S6 1015-1092 Sentence denotes Furthermore, addition of the recombinant NF-YA subunit restores NF-Y binding.
S7 1093-1216 Sentence denotes We show that the lack of NF-YA protein is due to posttranscriptional regulation and not to a specific proteolytic activity.
S8 1217-1426 Sentence denotes In fact, NF-YA mRNA is present at the same level at all days of monocyte cultivation, whereas the protein is absent in freshly isolated monocytes but is progressively synthesized during the maturation process.
S9 1427-1563 Sentence denotes We thus conclude that the NF-YA subunit plays a relevant role in activating transcription of genes highly expressed in mature monocytes.
S10 1564-1764 Sentence denotes In line with this conclusion, we show that the cut/CDP protein, a transcriptional repressor that inhibits gpc91-phox gene expression by preventing NF-Y binding to the CAAT box, is absent in monocytes.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 16-49 NP denotes the CCAAT-box binding factor NF-Y
C3 99-102 NP denotes its
C2 99-112 NP denotes its A subunit
C4 348-352 NP denotes NF-Y
C5 419-423 NP denotes that
C6 446-461 NP denotes the CCAAT motif
C7 545-566 NP denotes circulating monocytes
C8 568-589 NP denotes NF-Y binding activity
C9 609-624 NP denotes the CCAAT motif
C10 636-747 NP denotes the promoters of genes such as major histocompatibility complex (MHC) class II, gp91-phox, mig, and fibronectin
C11 818-839 NP denotes NF-Y binding activity
C12 855-870 NP denotes these promoters
C13 955-976 NP denotes circulating monocytes
C14 1000-1013 NP denotes the A subunit
C15 1079-1091 NP denotes NF-Y binding
C16 1118-1131 NP denotes NF-YA protein
C17 1311-1322 NP denotes the protein
C18 1449-1466 NP denotes the NF-YA subunit
C19 1607-1626 NP denotes the cut/CDP protein
C21 1628-1655 NP denotes a transcriptional repressor
C22 1656-1660 NP denotes that
C23 1711-1723 NP denotes NF-Y binding
C20 1628-1739 NP denotes a transcriptional repressor that inhibits gpc91-phox gene expression by preventing NF-Y binding to the CAAT box
R1 C3 C1 coref-pron its,the CCAAT-box binding factor NF-Y
R2 C4 C1 coref-ident NF-Y,the CCAAT-box binding factor NF-Y
R3 C5 C4 coref-relat that,NF-Y
R4 C9 C6 coref-ident the CCAAT motif,the CCAAT motif
R5 C11 C8 coref-ident NF-Y binding activity,NF-Y binding activity
R6 C12 C10 coref-ident these promoters,"the promoters of genes such as major histocompatibility complex (MHC) class II, gp91-phox, mig, and fibronectin"
R7 C13 C7 coref-ident circulating monocytes,circulating monocytes
R8 C14 C2 coref-ident the A subunit,its A subunit
R9 C17 C16 coref-ident the protein,NF-YA protein
R10 C18 C14 coref-ident the NF-YA subunit,the A subunit
R11 C22 C21 coref-relat that,a transcriptional repressor
R12 C23 C15 coref-ident NF-Y binding,NF-Y binding
R13 C20 C19 coref-appos a transcriptional repressor that inhibits gpc91-phox gene expression by preventing NF-Y binding to the CAAT box,the cut/CDP protein

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 20-29 DNA_domain_or_region denotes CCAAT-box
T2 45-49 protein_molecule denotes NF-Y
T3 103-112 protein_subunit denotes A subunit
T4 120-158 other_name denotes monocyte to macrophage differentiation
T5 174-195 DNA_family_or_group denotes tissue-specific genes
T6 217-237 protein_family_or_group denotes transcription factor
T7 284-288 protein_molecule denotes NF-Y
T8 325-346 other_name denotes macrophage maturation
T9 348-352 protein_molecule denotes NF-Y
T10 398-418 protein_family_or_group denotes transcription factor
T11 450-461 DNA_domain_or_region denotes CCAAT motif
T12 477-495 DNA_domain_or_region denotes 5' promoter region
T13 545-566 cell_type denotes circulating monocytes
T14 568-572 protein_molecule denotes NF-Y
T15 613-624 DNA_domain_or_region denotes CCAAT motif
T16 640-658 DNA_domain_or_region denotes promoters of genes
T17 667-714 DNA_family_or_group denotes major histocompatibility complex (MHC) class II
T18 716-725 DNA_domain_or_region denotes gp91-phox
T19 727-730 DNA_domain_or_region denotes mig
T20 764-790 other_name denotes macrophage differentiation
T21 818-822 protein_molecule denotes NF-Y
T22 884-888 protein_molecule denotes NF-Y
T23 938-942 protein_molecule denotes NF-Y
T24 955-976 cell_type denotes circulating monocytes
T25 1004-1013 protein_subunit denotes A subunit
T26 1056-1060 protein_molecule denotes NF-Y
T27 1060-1069 protein_subunit denotes A subunit
T28 1079-1083 protein_molecule denotes NF-Y
T29 1118-1131 protein_molecule denotes NF-YA protein
T30 1226-1231 protein_molecule denotes NF-YA
T31 1281-1301 other_name denotes monocyte cultivation
T32 1336-1362 cell_type denotes freshly isolated monocytes
T33 1407-1425 other_name denotes maturation process
T34 1453-1457 protein_molecule denotes NF-Y
T35 1457-1466 protein_subunit denotes A subunit
T36 1546-1562 cell_type denotes mature monocytes
T37 1611-1626 protein_molecule denotes cut/CDP protein
T38 1670-1685 DNA_domain_or_region denotes gpc91-phox gene
T39 1711-1715 protein_molecule denotes NF-Y
T40 1731-1739 DNA_domain_or_region denotes CAAT box
T41 1754-1763 cell_type denotes monocytes