> top > docs > PubMed:9884409 > annotations

PubMed:9884409 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-130 Sentence denotes The role of a single N-linked glycosylation site for a functional epitope of herpes simplex virus type 1 envelope glycoprotein gC.
TextSentencer_T2 131-436 Sentence denotes A monoclonal antibody, B1C1, binding to an epitope of antigenic site II of the herpes simplex virus type 1 (HSV-1) glycoprotein gC-1, is a potent inhibitor of two important biological functions of gC-1: its binding to cell surface heparan sulfate and its binding to the receptor for complement factor C3b.
TextSentencer_T3 437-614 Sentence denotes Here, we have analyzed a B1C1-resistant HSV-1 variant (HSV-12762/B1C1B4.2), obtained after passage of wild type HSV-1 (HSV-12762) in the presence of high concentrations of B1C1.
TextSentencer_T4 615-802 Sentence denotes The transport of newly synthesized mutant gC-1 to the cell surface was comparable to that of wild type glycoprotein, but no binding of surface-associated mutant gC-1 to B1C1 was detected.
TextSentencer_T5 803-879 Sentence denotes However, mutant and wild type gC-1 bound equally well to other site II Mabs.
TextSentencer_T6 880-947 Sentence denotes Attachment of wild type but not mutant virus was inhibited by B1C1.
TextSentencer_T7 948-1119 Sentence denotes Sequencing of the mutant gC-1 gene revealed only one nucleotide change, resulting in replacement of Thr150 by an Ile, in turn destroying an N-glycosylation site at Asn148.
TextSentencer_T8 1120-1258 Sentence denotes Loss of one complex type N-linked glycan was confirmed by endoglycosidase digestion and subsequent SDS-polyacrylamide gel electrophoresis.
TextSentencer_T9 1259-1442 Sentence denotes Circular dichroism analysis of purified gC-1 from cells infected with mutant or wild type virus did not reveal any difference in secondary structure between mutant and wild type gC-1.
TextSentencer_T10 1443-1583 Sentence denotes It was not possible to obtain a B1C1-resistant phenotype by nucleotide-directed mutagenesis of gC-1 where Asn148 was changed to a glutamine.
TextSentencer_T11 1584-1721 Sentence denotes These data demonstrated that the threonine of the glycosylation site and not the N-linked glycan in itself was essential for B1C1 binding
T1 0-130 Sentence denotes The role of a single N-linked glycosylation site for a functional epitope of herpes simplex virus type 1 envelope glycoprotein gC.
T2 131-436 Sentence denotes A monoclonal antibody, B1C1, binding to an epitope of antigenic site II of the herpes simplex virus type 1 (HSV-1) glycoprotein gC-1, is a potent inhibitor of two important biological functions of gC-1: its binding to cell surface heparan sulfate and its binding to the receptor for complement factor C3b.
T3 437-614 Sentence denotes Here, we have analyzed a B1C1-resistant HSV-1 variant (HSV-12762/B1C1B4.2), obtained after passage of wild type HSV-1 (HSV-12762) in the presence of high concentrations of B1C1.
T4 615-802 Sentence denotes The transport of newly synthesized mutant gC-1 to the cell surface was comparable to that of wild type glycoprotein, but no binding of surface-associated mutant gC-1 to B1C1 was detected.
T5 803-947 Sentence denotes However, mutant and wild type gC-1 bound equally well to other site II Mabs. Attachment of wild type but not mutant virus was inhibited by B1C1.
T6 948-1119 Sentence denotes Sequencing of the mutant gC-1 gene revealed only one nucleotide change, resulting in replacement of Thr150 by an Ile, in turn destroying an N-glycosylation site at Asn148.
T7 1120-1258 Sentence denotes Loss of one complex type N-linked glycan was confirmed by endoglycosidase digestion and subsequent SDS-polyacrylamide gel electrophoresis.
T8 1259-1442 Sentence denotes Circular dichroism analysis of purified gC-1 from cells infected with mutant or wild type virus did not reveal any difference in secondary structure between mutant and wild type gC-1.
T9 1443-1583 Sentence denotes It was not possible to obtain a B1C1-resistant phenotype by nucleotide-directed mutagenesis of gC-1 where Asn148 was changed to a glutamine.
T10 1584-1721 Sentence denotes These data demonstrated that the threonine of the glycosylation site and not the N-linked glycan in itself was essential for B1C1 binding
T1 0-130 Sentence denotes The role of a single N-linked glycosylation site for a functional epitope of herpes simplex virus type 1 envelope glycoprotein gC.
T2 131-436 Sentence denotes A monoclonal antibody, B1C1, binding to an epitope of antigenic site II of the herpes simplex virus type 1 (HSV-1) glycoprotein gC-1, is a potent inhibitor of two important biological functions of gC-1: its binding to cell surface heparan sulfate and its binding to the receptor for complement factor C3b.
T3 437-614 Sentence denotes Here, we have analyzed a B1C1-resistant HSV-1 variant (HSV-12762/B1C1B4.2), obtained after passage of wild type HSV-1 (HSV-12762) in the presence of high concentrations of B1C1.
T4 615-802 Sentence denotes The transport of newly synthesized mutant gC-1 to the cell surface was comparable to that of wild type glycoprotein, but no binding of surface-associated mutant gC-1 to B1C1 was detected.
T5 803-879 Sentence denotes However, mutant and wild type gC-1 bound equally well to other site II Mabs.
T6 880-947 Sentence denotes Attachment of wild type but not mutant virus was inhibited by B1C1.
T7 948-1119 Sentence denotes Sequencing of the mutant gC-1 gene revealed only one nucleotide change, resulting in replacement of Thr150 by an Ile, in turn destroying an N-glycosylation site at Asn148.
T8 1120-1258 Sentence denotes Loss of one complex type N-linked glycan was confirmed by endoglycosidase digestion and subsequent SDS-polyacrylamide gel electrophoresis.
T9 1259-1442 Sentence denotes Circular dichroism analysis of purified gC-1 from cells infected with mutant or wild type virus did not reveal any difference in secondary structure between mutant and wild type gC-1.
T10 1443-1583 Sentence denotes It was not possible to obtain a B1C1-resistant phenotype by nucleotide-directed mutagenesis of gC-1 where Asn148 was changed to a glutamine.
T11 1584-1721 Sentence denotes These data demonstrated that the threonine of the glycosylation site and not the N-linked glycan in itself was essential for B1C1 binding

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 362-377 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 77-104 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC569 denotes herpes simplex virus type 1
_T2 77-104 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC520 denotes herpes simplex virus type 1
_T3 210-237 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC569 denotes herpes simplex virus type 1
_T4 210-237 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC520 denotes herpes simplex virus type 1

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T24 978-982 FMAID:198663 denotes gene
_T1 84-91 FMAID:178366 denotes simplex
_T2 114-126 FMAID:167256 denotes glycoprotein
_T3 114-126 FMAID:62925 denotes glycoprotein
_T4 144-152 FMAID:167180 denotes antibody
_T5 217-224 FMAID:178366 denotes simplex
_T6 246-258 FMAID:62925 denotes glycoprotein
_T7 246-258 FMAID:167256 denotes glycoprotein
_T8 349-361 FMAID:212684 denotes cell surface
_T9 349-361 FMAID:200942 denotes cell surface
_T10 354-361 FMAID:50594 denotes surface
_T11 354-361 FMAID:146300 denotes surface
_T12 362-369 FMAID:67110 denotes heparan
_T13 362-369 FMAID:165191 denotes heparan
_T14 362-377 FMAID:63023 denotes heparan sulfate
_T15 362-377 FMAID:167405 denotes heparan sulfate
_T16 669-681 FMAID:212684 denotes cell surface
_T17 669-681 FMAID:200942 denotes cell surface
_T18 674-681 FMAID:50594 denotes surface
_T19 674-681 FMAID:146300 denotes surface
_T20 718-730 FMAID:62925 denotes glycoprotein
_T21 718-730 FMAID:167256 denotes glycoprotein
_T22 750-757 FMAID:146300 denotes surface
_T23 750-757 FMAID:50594 denotes surface
_T25 1001-1011 FMAID:82740 denotes nucleotide
_T26 1001-1011 FMAID:196729 denotes nucleotide
_T27 1309-1314 FMAID:68646 denotes cells
_T28 1309-1314 FMAID:169002 denotes cells
_T29 1503-1513 FMAID:196729 denotes nucleotide
_T30 1503-1513 FMAID:82740 denotes nucleotide
_T31 1573-1582 FMAID:196741 denotes glutamine
_T32 1573-1582 FMAID:82752 denotes glutamine
_T33 1617-1626 FMAID:82765 denotes threonine
_T34 1617-1626 FMAID:196754 denotes threonine

uniprot-human

Id Subject Object Predicate Lexical cue
T1 1219-1222 http://www.uniprot.org/uniprot/P20132 denotes SDS

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 77-102 http://purl.bioontology.org/ontology/NCBITAXON/126283 denotes herpes simplex virus type
T2 92-97 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T3 133-143 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T4 210-235 http://purl.bioontology.org/ontology/NCBITAXON/126283 denotes herpes simplex virus type
T5 225-230 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T6 304-324 http://purl.bioontology.org/ontology/STY/T039 denotes biological functions
T7 401-413 http://purl.bioontology.org/ontology/STY/T192 denotes receptor for
T8 919-924 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T9 1309-1314 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 1349-1354 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus

GO-BP

Id Subject Object Predicate Lexical cue
T1 30-43 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T2 1090-1103 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T3 1634-1647 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T4 370-377 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T5 619-628 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T6 1194-1203 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion

GO-MF

Id Subject Object Predicate Lexical cue
T1 144-152 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2 160-167 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 338-345 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 386-393 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 739-746 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 1714-1721 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 160-167 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 338-345 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 386-393 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 739-746 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T11 1714-1721 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T12 160-167 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 338-345 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T14 386-393 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T15 739-746 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T16 1714-1721 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T17 160-167 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18 338-345 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19 386-393 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T20 739-746 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T21 1714-1721 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22 386-409 http://purl.obolibrary.org/obo/GO_0005102 denotes binding to the receptor
T23 718-746 http://purl.obolibrary.org/obo/GO_0001948 denotes glycoprotein, but no binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 105-113 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope
T2 349-353 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 669-673 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 1309-1314 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 349-361 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T6 669-681 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 259-263 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T2 328-332 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T3 657-661 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T4 776-780 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T5 833-837 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T6 973-977 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T7 1299-1303 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T8 1437-1441 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1
Lectin_T9 1538-1542 https://acgg.asia/db/lfdb/LfDB0053 denotes gC-1

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 362-377 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 77-91 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T2 210-224 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes The role of a single N-linked glycosylation site for a functional epitope of herpes simplex virus type 1 envelope glycoprotein gC.
T2 131-436 Sentence denotes A monoclonal antibody, B1C1, binding to an epitope of antigenic site II of the herpes simplex virus type 1 (HSV-1) glycoprotein gC-1, is a potent inhibitor of two important biological functions of gC-1: its binding to cell surface heparan sulfate and its binding to the receptor for complement factor C3b.
T3 437-614 Sentence denotes Here, we have analyzed a B1C1-resistant HSV-1 variant (HSV-12762/B1C1B4.2), obtained after passage of wild type HSV-1 (HSV-12762) in the presence of high concentrations of B1C1.
T4 615-802 Sentence denotes The transport of newly synthesized mutant gC-1 to the cell surface was comparable to that of wild type glycoprotein, but no binding of surface-associated mutant gC-1 to B1C1 was detected.
T5 803-947 Sentence denotes However, mutant and wild type gC-1 bound equally well to other site II Mabs. Attachment of wild type but not mutant virus was inhibited by B1C1.
T6 948-1119 Sentence denotes Sequencing of the mutant gC-1 gene revealed only one nucleotide change, resulting in replacement of Thr150 by an Ile, in turn destroying an N-glycosylation site at Asn148.
T7 1120-1258 Sentence denotes Loss of one complex type N-linked glycan was confirmed by endoglycosidase digestion and subsequent SDS-polyacrylamide gel electrophoresis.
T8 1259-1442 Sentence denotes Circular dichroism analysis of purified gC-1 from cells infected with mutant or wild type virus did not reveal any difference in secondary structure between mutant and wild type gC-1.
T9 1443-1583 Sentence denotes It was not possible to obtain a B1C1-resistant phenotype by nucleotide-directed mutagenesis of gC-1 where Asn148 was changed to a glutamine.
T10 1584-1721 Sentence denotes These data demonstrated that the threonine of the glycosylation site and not the N-linked glycan in itself was essential for B1C1 binding

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 77-91 Disease denotes herpes simplex MONDO:0004609
T2 210-224 Disease denotes herpes simplex MONDO:0004609

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 84-97 Organism denotes simplex virus 10294
T2 217-230 Organism denotes simplex virus 10294

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 362-377 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 84-91 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350
T2 105-113 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T3 217-224 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 349-361 Body_part denotes cell surface FMA:67653
T2 669-681 Body_part denotes cell surface FMA:67653

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 84-97 OrganismTaxon denotes simplex virus 10294
T2 217-230 OrganismTaxon denotes simplex virus 10294

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 84-91 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350
T2 105-113 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T3 217-224 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350