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PubMed:9882624 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 16-40 protein denotes low-density lipoproteins
T2 70-83 protein denotes interleukin 2
T3 88-109 protein denotes nuclear factor kappaB
T4 128-151 cell_type denotes activated T-lymphocytes
T5 268-292 protein denotes low-density lipoproteins
T6 294-300 protein denotes oxLDLs
T7 409-415 protein denotes oxLDLs
T8 433-460 protein denotes interleukin (IL)-2-receptor
T9 592-598 protein denotes oxLDLs
T10 628-632 protein denotes IL-2
T11 672-693 protein denotes nuclear factor kappaB
T12 695-704 protein denotes NF-kappaB
T13 746-752 protein denotes oxLDLs
T14 803-815 cell_type denotes lymphoblasts
T15 900-911 cell_type denotes lymphocytes
T16 915-934 protein denotes phytohaemagglutinin
T17 972-976 protein denotes IL-2
T18 1008-1011 protein denotes CD3
T19 1102-1111 protein denotes NF-kappaB
T20 1124-1130 protein denotes oxLDLs
T21 1152-1178 protein denotes activation-induced p65/p50
T22 1179-1188 protein denotes NF-kappaB
T23 1274-1283 protein denotes p50 dimer
T24 1369-1396 protein denotes cytosolic inhibitor protein
T25 1397-1410 protein denotes IkappaB-alpha
T26 1492-1498 protein denotes oxLDLs
T27 1540-1552 cell_type denotes T-lymphocyte

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-152 Sentence denotes Mildly oxidized low-density lipoproteins decrease early production of interleukin 2 and nuclear factor kappaB binding to DNA in activated T-lymphocytes.
S2 153-258 Sentence denotes Activated T-lymphocytes are found early in atherosclerosis lesions, but little is known about their role.
S3 259-552 Sentence denotes Oxidized low-density lipoproteins (oxLDLs) are considered to be involved in the pathogenesis of the lesions, and we have previously demonstrated that oxLDLs inhibit not only interleukin (IL)-2-receptor expression on the surface of in vitro-activated T-lymphocytes but also their proliferation.
S4 553-738 Sentence denotes We have now investigated the effect of oxLDLs on blast differentiation, on IL-2 synthesis and on the activation of the nuclear factor kappaB (NF-kappaB) system in activated lymphocytes.
S5 739-953 Sentence denotes Mildly oxLDLs (50 and 100 microgram/ml) decreased the number of lymphoblasts and the level of IL-2 concentration in the culture supernatants after activation of lymphocytes by phytohaemagglutinin and PMA+ionomycin.
S6 954-1088 Sentence denotes The inhibition of IL-2 production was observed in the CD3(+) T-lymphocyte cytoplasm as early as 4 h after activation by PMA+ionomycin.
S7 1089-1298 Sentence denotes The study of NF-kappaB showed that oxLDLs led to a decrease of activation-induced p65/p50 NF-kappaB heterodimer binding to DNA, whereas the presence of the constitutive nuclear form of p50 dimer was unchanged.
S8 1299-1411 Sentence denotes This was correlated with an unchanged level of the active form of the cytosolic inhibitor protein IkappaB-alpha.
S9 1412-1575 Sentence denotes Taken together, these observations suggest that the immunosuppressive effect of oxLDLs might operate via a dysregulation of the T-lymphocyte activation mechanisms.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 121-124 NP denotes DNA
C2 128-151 NP denotes activated T-lymphocytes
C3 153-176 NP denotes Activated T-lymphocytes
C4 196-219 NP denotes atherosclerosis lesions
C5 247-252 NP denotes their
C6 259-301 NP denotes Oxidized low-density lipoproteins (oxLDLs)
C7 355-366 NP denotes the lesions
C8 409-415 NP denotes oxLDLs
C9 433-471 NP denotes interleukin (IL)-2-receptor expression
C10 532-537 NP denotes their
C11 592-598 NP denotes oxLDLs
C12 716-737 NP denotes activated lymphocytes
C13 939-952 NP denotes PMA+ionomycin
C14 1074-1087 NP denotes PMA+ionomycin
C15 1124-1130 NP denotes oxLDLs
C16 1212-1215 NP denotes DNA
C17 1492-1498 NP denotes oxLDLs
R1 C3 C2 coref-ident Activated T-lymphocytes,activated T-lymphocytes
R2 C5 C3 coref-pron their,Activated T-lymphocytes
R3 C7 C4 coref-ident the lesions,atherosclerosis lesions
R4 C8 C6 coref-ident oxLDLs,Oxidized low-density lipoproteins (oxLDLs)
R5 C10 C9 coref-pron their,interleukin (IL)-2-receptor expression
R6 C11 C8 coref-ident oxLDLs,oxLDLs
R7 C12 C3 coref-ident activated lymphocytes,Activated T-lymphocytes
R8 C14 C13 coref-ident PMA+ionomycin,PMA+ionomycin
R9 C15 C11 coref-ident oxLDLs,oxLDLs
R10 C16 C1 coref-ident DNA,DNA
R11 C17 C15 coref-ident oxLDLs,oxLDLs

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 16-40 protein_family_or_group denotes low-density lipoproteins
T2 70-83 protein_molecule denotes interleukin 2
T3 88-109 protein_complex denotes nuclear factor kappaB
T4 128-151 cell_type denotes activated T-lymphocytes
T5 196-219 tissue denotes atherosclerosis lesions
T6 268-292 protein_family_or_group denotes low-density lipoproteins
T7 294-300 protein_family_or_group denotes oxLDLs
T8 409-415 protein_family_or_group denotes oxLDLs
T9 433-460 protein_molecule denotes interleukin (IL)-2-receptor
T10 592-598 protein_family_or_group denotes oxLDLs
T11 602-623 other_name denotes blast differentiation
T12 628-632 protein_molecule denotes IL-2
T13 672-693 protein_complex denotes nuclear factor kappaB
T14 695-704 protein_complex denotes NF-kappaB
T15 746-752 protein_family_or_group denotes oxLDLs
T16 803-815 cell_type denotes lymphoblasts
T17 900-911 cell_type denotes lymphocytes
T18 915-934 protein_molecule denotes phytohaemagglutinin
T19 939-943 other_organic_compound denotes PMA+
T20 943-952 other_organic_compound denotes ionomycin
T21 972-976 protein_molecule denotes IL-2
T22 1008-1011 protein_molecule denotes CD3
T23 1074-1078 other_organic_compound denotes PMA+
T24 1078-1087 other_organic_compound denotes ionomycin
T25 1102-1111 protein_complex denotes NF-kappaB
T26 1124-1130 protein_family_or_group denotes oxLDLs
T27 1152-1175 protein_complex denotes activation-induced p65/
T28 1175-1178 protein_subunit denotes p50
T29 1179-1188 protein_complex denotes NF-kappaB
T30 1274-1277 protein_subunit denotes p50
T31 1369-1396 protein_family_or_group denotes cytosolic inhibitor protein
T32 1397-1410 protein_molecule denotes IkappaB-alpha
T33 1492-1498 protein_family_or_group denotes oxLDLs
T34 1519-1532 other_name denotes dysregulation
T35 1540-1552 cell_type denotes T-lymphocyte