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PubMed:9873047 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Cloning and characterization of RLPK, a novel RSK-related protein kinase.
T2 74-178 Sentence denotes A novel protein kinase whose activity can be stimulated by mitogen in vivo was cloned and characterized.
T3 179-348 Sentence denotes The cDNA of this gene encodes an 802-amino acid protein (termed RLPK) with the highest homology (37% identity) to the two protein kinase families, p90(RSK) and p70(RSK).
T4 349-450 Sentence denotes Like p90(RSR), but not p70(RSK), RLPK also contains two complete nonidentical protein kinase domains.
T5 451-561 Sentence denotes RLPK mRNA is widely expressed in all human tissues examined and is enriched in the brain, heart, and placenta.
T6 562-812 Sentence denotes In HeLa cells, transiently expressed epitope-tagged RLPK can be strongly induced by epidermal growth factor, serum, and phorbol 12-myristate 13-acetate, but only moderately up-regulated by tumor necrosis factor-alpha and other stress-related stimuli.
T7 813-1172 Sentence denotes The activity of RLPK stimulated by epidermal growth factor was not inhibited by several known protein kinase C inhibitors nor by rapamycin, a known specific inhibitor for p70(RSK), but could be inhibited by herbimycin A, a tyrosine kinase inhibitor, and partially inhibited by PD98059 or SB203580, inhibitors for the mitogen-activated protein kinase pathways.
T8 1173-1278 Sentence denotes Recombinant RLPK possesses high phosphorylation activity toward histone 2B and the S6 peptide, RRRLSSLRA.
T9 1279-1420 Sentence denotes Although purified recombinant RLPK can be phosphorylated by ERK2 and p38alpha in vitro, its activity is not affected by this phosphorylation.
T10 1421-1519 Sentence denotes Moreover, the treatment of RLPK with acid phosphatase did not reduce its in vitro kinase activity.
T11 1520-1681 Sentence denotes These data suggest that RLPK is structurally similar to previously isolated RSKs, but its regulatory mechanism may be distinct from either p70(RSK) or p90(RSK)s.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 534-539 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 541-546 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T3 552-560 http://purl.obolibrary.org/obo/MAT_0000279 denotes placenta

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 32-36 protein denotes RLPK
T2 46-49 protein denotes RSK
T3 58-72 protein denotes protein kinase
T4 82-96 protein denotes protein kinase
T5 243-247 protein denotes RLPK
T6 301-315 protein denotes protein kinase
T7 326-334 protein denotes p90(RSK)
T8 339-347 protein denotes p70(RSK)
T9 354-362 protein denotes p90(RSR)
T10 372-380 protein denotes p70(RSK)
T11 382-386 protein denotes RLPK
T12 427-441 protein denotes protein kinase
T13 451-455 protein denotes RLPK
T14 614-618 protein denotes RLPK
T15 646-669 protein denotes epidermal growth factor
T16 751-778 protein denotes tumor necrosis factor-alpha
T17 829-833 protein denotes RLPK
T18 848-871 protein denotes epidermal growth factor
T19 907-923 protein denotes protein kinase C
T20 984-992 protein denotes p70(RSK)
T21 1036-1051 protein denotes tyrosine kinase
T22 1130-1162 protein denotes mitogen-activated protein kinase
T23 1185-1189 protein denotes RLPK
T24 1237-1247 protein denotes histone 2B
T25 1309-1313 protein denotes RLPK
T26 1339-1343 protein denotes ERK2
T27 1348-1356 protein denotes p38alpha
T28 1448-1452 protein denotes RLPK
T29 1458-1474 protein denotes acid phosphatase
T30 1503-1509 protein denotes kinase
T31 1544-1548 protein denotes RLPK
T32 1596-1600 protein denotes RSKs
T33 1659-1667 protein denotes p70(RSK)
T34 1671-1680 protein denotes p90(RSK)s

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 751-756 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 534-539 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 541-546 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T3 552-560 Body_part denotes placenta http://purl.obolibrary.org/obo/MAT_0000279

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 488-493 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 534-539 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 541-546 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T7 552-560 Body_part denotes placenta http://purl.obolibrary.org/obo/UBERON_0001987
T8 646-662 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T9 848-864 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 751-756 Phenotype denotes tumor HP:0002664