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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-69 Sentence denotes Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.
T2 70-134 Sentence denotes Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
T3 135-281 Sentence denotes This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).
T4 282-425 Sentence denotes Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.
T5 426-591 Sentence denotes NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).
T6 592-733 Sentence denotes We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.
T7 734-922 Sentence denotes The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.
T8 923-965 Sentence denotes Monocytes were isolated from human donors.
T9 966-1060 Sentence denotes Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).
T10 1061-1239 Sentence denotes Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.
T11 1240-1363 Sentence denotes We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).
T12 1364-1455 Sentence denotes IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).
T13 1456-1574 Sentence denotes After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.
T14 1575-1695 Sentence denotes IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.
T15 1696-1833 Sentence denotes IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.
T1 0-69 Sentence denotes Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.
T2 70-134 Sentence denotes Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
T3 135-281 Sentence denotes This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).
T4 282-425 Sentence denotes Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.
T5 426-591 Sentence denotes NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).
T6 592-733 Sentence denotes We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.
T7 734-922 Sentence denotes The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.
T8 923-965 Sentence denotes Monocytes were isolated from human donors.
T9 966-1060 Sentence denotes Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).
T10 1061-1239 Sentence denotes Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.
T11 1240-1363 Sentence denotes We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).
T12 1364-1455 Sentence denotes IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).
T13 1456-1574 Sentence denotes After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.
T14 1575-1695 Sentence denotes IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.
T15 1696-1833 Sentence denotes IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-14 protein denotes Interleukin-10
T2 37-49 protein denotes kappaB-alpha
T3 53-68 cell_type denotes human monocytes
T4 70-84 protein denotes Interleukin-10
T5 86-91 protein denotes IL-10
T6 197-218 protein denotes inflammatory cytokine
T7 241-268 protein denotes tumor necrosis factor-alpha
T8 270-279 protein denotes TNF-alpha
T9 305-310 protein denotes IL-10
T10 341-361 protein denotes transcription factor
T11 362-383 protein denotes nuclear factor-kappaB
T12 385-394 protein denotes NF-kappaB
T13 426-435 protein denotes NF-kappaB
T14 551-574 protein denotes inhibitory kappaB-alpha
T15 576-589 protein denotes IkappaB-alpha
T16 613-618 protein denotes IL-10
T17 643-652 protein denotes NF-kappaB
T18 678-687 protein denotes TNF-alpha
T19 719-732 protein denotes IkappaB-alpha
T20 791-796 protein denotes IL-10
T21 848-857 protein denotes TNF-alpha
T22 870-879 protein denotes NF-kappaB
T23 896-909 protein denotes IkappaB-alpha
T24 993-1002 protein denotes endotoxin
T25 1043-1048 protein denotes IL-10
T26 1084-1093 protein denotes TNF-alpha
T27 1138-1147 protein denotes NF-kappaB
T28 1202-1215 protein denotes IkappaB-alpha
T29 1282-1297 cell_type denotes human monocytes
T30 1299-1308 protein denotes TNF-alpha
T31 1364-1369 protein denotes IL-10
T32 1396-1405 protein denotes TNF-alpha
T33 1481-1496 cell_type denotes human monocytes
T34 1498-1511 protein denotes IkappaB-alpha
T35 1542-1551 protein denotes NF-kappaB
T36 1575-1580 protein denotes IL-10
T37 1629-1642 protein denotes IkappaB-alpha
T38 1673-1682 protein denotes NF-kappaB
T39 1696-1701 protein denotes IL-10
T40 1735-1744 protein denotes NF-kappaB
T41 1759-1772 protein denotes IkappaB-alpha
T42 1815-1824 protein denotes TNF-alpha

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-14 NP denotes Interleukin-10
C2 26-49 NP denotes inhibitory kappaB-alpha
C3 53-68 NP denotes human monocytes
C4 70-92 NP denotes Interleukin-10 (IL-10)
C5 241-280 NP denotes tumor necrosis factor-alpha (TNF-alpha)
C6 305-310 NP denotes IL-10
C7 323-395 NP denotes activation of the transcription factor nuclear factor-kappaB (NF-kappaB)
C8 426-446 NP denotes NF-kappaB activation
C10 516-519 NP denotes its
C9 516-549 NP denotes its associated inhibitory peptide
C11 551-590 NP denotes inhibitory kappaB-alpha (IkappaB-alpha)
C12 613-618 NP denotes IL-10
C13 628-663 NP denotes human monocyte NF-kappaB activation
C14 719-732 NP denotes IkappaB-alpha
C15 791-796 NP denotes IL-10
C16 800-868 NP denotes lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production
C17 870-890 NP denotes NF-kappaB activation
C18 923-932 NP denotes Monocytes
C19 1037-1048 NP denotes human IL-10
C20 1084-1093 NP denotes TNF-alpha
C21 1282-1297 NP denotes human monocytes
C22 1299-1308 NP denotes TNF-alpha
C23 1364-1369 NP denotes IL-10
C24 1381-1416 NP denotes LPS-stimulated TNF-alpha production
C25 1481-1496 NP denotes human monocytes
C26 1498-1526 NP denotes IkappaB-alpha protein levels
C27 1542-1563 NP denotes NF-kappaB DNA binding
C28 1629-1657 NP denotes IkappaB-alpha protein levels
C29 1673-1694 NP denotes NF-kappaB DNA binding
C30 1696-1701 NP denotes IL-10
C31 1721-1744 NP denotes activation of NF-kappaB
C32 1759-1787 NP denotes IkappaB-alpha protein levels
R1 C4 C1 coref-ident Interleukin-10 (IL-10),Interleukin-10
R2 C6 C4 coref-ident IL-10,Interleukin-10 (IL-10)
R3 C10 C8 coref-pron its,NF-kappaB activation
R4 C9 C2 coref-ident its associated inhibitory peptide,inhibitory kappaB-alpha
R5 C11 C9 coref-appos inhibitory kappaB-alpha (IkappaB-alpha),its associated inhibitory peptide
R6 C12 C6 coref-ident IL-10,IL-10
R7 C13 C7 coref-ident human monocyte NF-kappaB activation,activation of the transcription factor nuclear factor-kappaB (NF-kappaB)
R8 C14 C11 coref-ident IkappaB-alpha,inhibitory kappaB-alpha (IkappaB-alpha)
R9 C15 C12 coref-ident IL-10,IL-10
R10 C17 C13 coref-ident NF-kappaB activation,human monocyte NF-kappaB activation
R11 C18 C3 coref-ident Monocytes,human monocytes
R12 C19 C15 coref-ident human IL-10,IL-10
R13 C20 C5 coref-ident TNF-alpha,tumor necrosis factor-alpha (TNF-alpha)
R14 C21 C18 coref-ident human monocytes,Monocytes
R15 C22 C20 coref-ident TNF-alpha,TNF-alpha
R16 C23 C19 coref-ident IL-10,human IL-10
R17 C24 C16 coref-ident LPS-stimulated TNF-alpha production,lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production
R18 C25 C21 coref-ident human monocytes,human monocytes
R19 C28 C26 coref-ident IkappaB-alpha protein levels,IkappaB-alpha protein levels
R20 C29 C27 coref-ident NF-kappaB DNA binding,NF-kappaB DNA binding
R21 C30 C23 coref-ident IL-10,IL-10
R22 C31 C17 coref-ident activation of NF-kappaB,NF-kappaB activation
R23 C32 C28 coref-ident IkappaB-alpha protein levels,IkappaB-alpha protein levels

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-69 Sentence denotes Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.
S2 70-134 Sentence denotes Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
S3 135-281 Sentence denotes This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).
S4 282-425 Sentence denotes Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.
S5 426-591 Sentence denotes NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).
S6 592-733 Sentence denotes We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.
S7 734-922 Sentence denotes The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.
S8 923-965 Sentence denotes Monocytes were isolated from human donors.
S9 966-1060 Sentence denotes Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).
S10 1061-1239 Sentence denotes Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.
S11 1240-1363 Sentence denotes We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).
S12 1364-1455 Sentence denotes IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).
S13 1456-1574 Sentence denotes After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.
S14 1575-1695 Sentence denotes IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.
S15 1696-1833 Sentence denotes IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 protein_molecule denotes Interleukin-10
T2 37-49 protein_molecule denotes kappaB-alpha
T3 53-68 cell_type denotes human monocytes
T4 70-84 protein_molecule denotes Interleukin-10
T5 86-91 protein_molecule denotes IL-10
T6 115-133 other_name denotes lethal endotoxemia
T7 197-218 protein_family_or_group denotes inflammatory cytokine
T8 241-268 protein_molecule denotes tumor necrosis factor-alpha
T9 270-279 protein_molecule denotes TNF-alpha
T10 305-310 protein_molecule denotes IL-10
T11 341-361 protein_family_or_group denotes transcription factor
T12 362-383 protein_molecule denotes nuclear factor-kappaB
T13 385-394 protein_complex denotes NF-kappaB
T14 426-435 protein_complex denotes NF-kappaB
T15 462-482 other_name denotes inflammatory signals
T16 531-549 peptide denotes inhibitory peptide
T17 551-574 protein_molecule denotes inhibitory kappaB-alpha
T18 576-589 protein_molecule denotes IkappaB-alpha
T19 613-618 protein_molecule denotes IL-10
T20 628-642 other_name denotes human monocyte
T21 643-652 protein_complex denotes NF-kappaB
T22 678-687 protein_molecule denotes TNF-alpha
T23 719-732 protein_molecule denotes IkappaB-alpha
T24 791-796 protein_molecule denotes IL-10
T25 819-847 other_name denotes (LPS)-induced human monocyte
T26 848-857 protein_molecule denotes TNF-alpha
T27 870-879 protein_complex denotes NF-kappaB
T28 896-909 protein_molecule denotes IkappaB-alpha
T29 952-964 multi_cell denotes human donors
T30 993-1002 protein_family_or_group denotes endotoxin
T31 1004-1007 lipid denotes LPS
T32 1043-1048 protein_molecule denotes IL-10
T33 1084-1093 protein_molecule denotes TNF-alpha
T34 1131-1136 other_name denotes ELISA
T35 1138-1147 protein_complex denotes NF-kappaB
T36 1160-1196 other_name denotes electrophoretic mobility shift assay
T37 1202-1215 protein_molecule denotes IkappaB-alpha
T38 1226-1238 other_name denotes Western blot
T39 1263-1266 lipid denotes LPS
T40 1282-1297 cell_type denotes human monocytes
T41 1299-1308 protein_molecule denotes TNF-alpha
T42 1364-1369 protein_molecule denotes IL-10
T43 1381-1384 lipid denotes LPS
T44 1396-1405 protein_molecule denotes TNF-alpha
T45 1444-1447 lipid denotes LPS
T46 1462-1465 lipid denotes LPS
T47 1481-1496 cell_type denotes human monocytes
T48 1498-1511 protein_molecule denotes IkappaB-alpha
T49 1542-1551 protein_complex denotes NF-kappaB
T50 1575-1580 protein_molecule denotes IL-10
T51 1604-1607 lipid denotes LPS
T52 1629-1642 protein_molecule denotes IkappaB-alpha
T53 1673-1682 protein_complex denotes NF-kappaB
T54 1696-1701 protein_molecule denotes IL-10
T55 1735-1744 protein_complex denotes NF-kappaB
T56 1759-1772 protein_molecule denotes IkappaB-alpha
T57 1815-1824 protein_molecule denotes TNF-alpha