PubMed:9869602 JSONTXT

{"project":"NCBI-Disease-Corpus-GPT5-withguidelines","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T3","span":{"begin":337,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":932,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-GPT5-noguidelines","denotations":[{"id":"T1","span":{"begin":89,"end":93},"obj":"Modifier"},{"id":"T2","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":337,"end":345},"obj":"Modifier"},{"id":"T5","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":473,"end":499},"obj":"CompositeMention"},{"id":"T7","span":{"begin":600,"end":643},"obj":"CompositeMention"},{"id":"T8","span":{"begin":758,"end":770},"obj":"Modifier"},{"id":"T9","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":932,"end":940},"obj":"Modifier"},{"id":"T11","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T12","span":{"begin":1007,"end":1016},"obj":"Modifier"},{"id":"T13","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T14","span":{"begin":1024,"end":1028},"obj":"Modifier"},{"id":"T15","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T16","span":{"begin":1150,"end":1200},"obj":"CompositeMention"},{"id":"T17","span":{"begin":1278,"end":1288},"obj":"Modifier"},{"id":"T18","span":{"begin":1293,"end":1298},"obj":"Modifier"},{"id":"T19","span":{"begin":1300,"end":1307},"obj":"DiseaseClass"},{"id":"T20","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-GPT5-guidelineprompt","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"Modifier"},{"id":"T2","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T3","span":{"begin":337,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"Modifier"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"Modifier"},{"id":"T7","span":{"begin":932,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"Modifier"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-Moderated1","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T3","span":{"begin":337,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":932,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":25,"end":28},"obj":"gene:324"},{"id":"T1","span":{"begin":98,"end":115},"obj":"disease:C0009402"},{"id":"T2","span":{"begin":25,"end":28},"obj":"gene:324"},{"id":"T3","span":{"begin":98,"end":115},"obj":"disease:C1527249"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"9869602-0#18#24#geners1801155","span":{"begin":264,"end":270},"obj":"geners1801155"},{"id":"9869602-0#98#115#diseaseC0009402","span":{"begin":482,"end":499},"obj":"diseaseC0009402"},{"id":"9869602-0#98#115#diseaseC1527249","span":{"begin":482,"end":499},"obj":"diseaseC1527249"}],"relations":[{"id":"18#24#geners180115598#115#diseaseC0009402","pred":"associated_with","subj":"9869602-0#18#24#geners1801155","obj":"9869602-0#98#115#diseaseC0009402"},{"id":"18#24#geners180115598#115#diseaseC1527249","pred":"associated_with","subj":"9869602-0#18#24#geners1801155","obj":"9869602-0#98#115#diseaseC1527249"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBIDiseaseCorpus","denotations":[{"id":"T1","span":{"begin":25,"end":28},"obj":"Modifier:D011125"},{"id":"T2","span":{"begin":98,"end":115},"obj":"SpecificDisease:D015179"},{"id":"T3","span":{"begin":203,"end":220},"obj":"Modifier:D015179"},{"id":"T4","span":{"begin":271,"end":274},"obj":"Modifier:D011125"},{"id":"T5","span":{"begin":346,"end":363},"obj":"Modifier:D015179"},{"id":"T6","span":{"begin":482,"end":499},"obj":"SpecificDisease:D015179"},{"id":"T7","span":{"begin":634,"end":643},"obj":"DiseaseClass:D009369"},{"id":"T8","span":{"begin":775,"end":792},"obj":"SpecificDisease:D015179"},{"id":"T9","span":{"begin":941,"end":947},"obj":"DiseaseClass:D009369"},{"id":"T10","span":{"begin":1017,"end":1023},"obj":"Modifier:D009369"},{"id":"T11","span":{"begin":1030,"end":1050},"obj":"SpecificDisease:D015179"},{"id":"T12","span":{"begin":1191,"end":1200},"obj":"DiseaseClass:D009369"},{"id":"T13","span":{"begin":1278,"end":1307},"obj":"CompositeMention:D009369|D015179"},{"id":"T14","span":{"begin":1374,"end":1391},"obj":"SpecificDisease:D015179"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Test","denotations":[{"id":"T672","span":{"begin":25,"end":28},"obj":"Modifier"},{"id":"T673","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T674","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T675","span":{"begin":271,"end":274},"obj":"Modifier"},{"id":"T676","span":{"begin":346,"end":363},"obj":"Modifier"},{"id":"T677","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T678","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T679","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T680","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T681","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T682","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T683","span":{"begin":1191,"end":1200},"obj":"DiseaseClass"},{"id":"T684","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T685","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"attributes":[{"id":"A672","pred":"database_id","subj":"T672","obj":"D011125"},{"id":"A673","pred":"database_id","subj":"T673","obj":"D015179"},{"id":"A674","pred":"database_id","subj":"T674","obj":"D015179"},{"id":"A675","pred":"database_id","subj":"T675","obj":"D011125"},{"id":"A676","pred":"database_id","subj":"T676","obj":"D015179"},{"id":"A677","pred":"database_id","subj":"T677","obj":"D015179"},{"id":"A678","pred":"database_id","subj":"T678","obj":"D009369"},{"id":"A679","pred":"database_id","subj":"T679","obj":"D015179"},{"id":"A680","pred":"database_id","subj":"T680","obj":"D009369"},{"id":"A681","pred":"database_id","subj":"T681","obj":"D009369"},{"id":"A682","pred":"database_id","subj":"T682","obj":"D015179"},{"id":"A683","pred":"database_id","subj":"T683","obj":"D009369"},{"id":"A684","pred":"database_id","subj":"T684","obj":"D009369|D015179"},{"id":"A685","pred":"database_id","subj":"T685","obj":"D015179"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Test-Assistant-Knowledge","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"DiseaseClass"},{"id":"T2","span":{"begin":203,"end":220},"obj":"DiseaseClass"},{"id":"T3","span":{"begin":346,"end":363},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":482,"end":499},"obj":"DiseaseClass"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"DiseaseClass"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"DiseaseClass"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Test-4o-NoGuidelineInPrompt","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":932,"end":947},"obj":"CompositeMention"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-o3-2","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T3","span":{"begin":346,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-high-o3-1","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1041,"end":1050},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1191,"end":1200},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1300,"end":1307},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-high-o3-2","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":337,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":932,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1278,"end":1307},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Test-4o-GuidelineInPrompt","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"Modifier"},{"id":"T2","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T3","span":{"begin":346,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"Modifier"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"Modifier"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"Modifier"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-UpdatedGuideline","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-humanintheloop","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1288},"obj":"DiseaseClass"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"DiseaseClass"},{"id":"T13","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-rezarta1","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1288},"obj":"DiseaseClass"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"DiseaseClass"},{"id":"T13","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-All","denotations":[{"id":"T672","span":{"begin":25,"end":28},"obj":"Modifier"},{"id":"T673","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T674","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T675","span":{"begin":271,"end":274},"obj":"Modifier"},{"id":"T676","span":{"begin":346,"end":363},"obj":"Modifier"},{"id":"T677","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T678","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T679","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T680","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T681","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T682","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T683","span":{"begin":1191,"end":1200},"obj":"DiseaseClass"},{"id":"T684","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T685","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"attributes":[{"id":"A672","pred":"database_id","subj":"T672","obj":"D011125"},{"id":"A673","pred":"database_id","subj":"T673","obj":"D015179"},{"id":"A674","pred":"database_id","subj":"T674","obj":"D015179"},{"id":"A675","pred":"database_id","subj":"T675","obj":"D011125"},{"id":"A676","pred":"database_id","subj":"T676","obj":"D015179"},{"id":"A677","pred":"database_id","subj":"T677","obj":"D015179"},{"id":"A678","pred":"database_id","subj":"T678","obj":"D009369"},{"id":"A679","pred":"database_id","subj":"T679","obj":"D015179"},{"id":"A680","pred":"database_id","subj":"T680","obj":"D009369"},{"id":"A681","pred":"database_id","subj":"T681","obj":"D009369"},{"id":"A682","pred":"database_id","subj":"T682","obj":"D015179"},{"id":"A683","pred":"database_id","subj":"T683","obj":"D009369"},{"id":"A684","pred":"database_id","subj":"T684","obj":"D009369|D015179"},{"id":"A685","pred":"database_id","subj":"T685","obj":"D015179"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-2stage-All","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"Modifier"},{"id":"T2","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T3","span":{"begin":346,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"Modifier"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"Modifier"},{"id":"T7","span":{"begin":941,"end":947},"obj":"Modifier"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"Modifier"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"Modifier"},{"id":"T11","span":{"begin":1278,"end":1288},"obj":"Modifier"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"Modifier"},{"id":"T13","span":{"begin":1374,"end":1391},"obj":"Modifier"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-rezarta-All","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"Modifier"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"Modifier"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"Modifier"},{"id":"T7","span":{"begin":941,"end":947},"obj":"Modifier"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"Modifier"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"Modifier"},{"id":"T11","span":{"begin":1278,"end":1288},"obj":"Modifier"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"Modifier"},{"id":"T13","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-4oGuideline-All","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"Modifier"},{"id":"T2","span":{"begin":203,"end":220},"obj":"Modifier"},{"id":"T3","span":{"begin":346,"end":363},"obj":"Modifier"},{"id":"T4","span":{"begin":482,"end":499},"obj":"Modifier"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"Modifier"},{"id":"T7","span":{"begin":941,"end":947},"obj":"Modifier"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1288},"obj":"Modifier"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"DiseaseClass"},{"id":"T13","span":{"begin":1374,"end":1391},"obj":"Modifier"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"NCBI-Disease-Corpus-Simple-All","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"Modifier"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"Modifier"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1307},"obj":"CompositeMention"},{"id":"T12","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"123456","denotations":[{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"},{"id":"T11","span":{"begin":1278,"end":1288},"obj":"DiseaseClass"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"DiseaseClass"},{"id":"T13","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}

{"project":"12345","denotations":[{"id":"T11","span":{"begin":1278,"end":1288},"obj":"DiseaseClass"},{"id":"T12","span":{"begin":1300,"end":1307},"obj":"DiseaseClass"},{"id":"T13","span":{"begin":1374,"end":1391},"obj":"SpecificDisease"},{"id":"T1","span":{"begin":98,"end":115},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":203,"end":220},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":346,"end":363},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":482,"end":499},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":634,"end":643},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":775,"end":792},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":941,"end":947},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":1017,"end":1023},"obj":"DiseaseClass"},{"id":"T9","span":{"begin":1030,"end":1050},"obj":"DiseaseClass"},{"id":"T10","span":{"begin":1180,"end":1200},"obj":"DiseaseClass"}],"text":"Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nBACKGROUND \u0026 AIMS: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer.\nMETHODS: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method.\nRESULTS: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia.\nCONCLUSIONS: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis."}