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PubMed:9864163 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-27 protein denotes interleukin-10
T2 70-82 protein denotes superantigen
T3 147-161 protein denotes interleukin-10
T4 163-168 protein denotes IL-10
T5 196-210 cell_type denotes CD4(+) T cells
T6 257-269 protein denotes superantigen
T7 270-298 protein denotes staphylococcal enterotoxin B
T8 300-303 protein denotes SEB
T9 306-311 protein denotes IL-10
T10 337-342 protein denotes IL-10
T11 385-393 protein denotes p27(Kip1
T12 399-417 protein denotes inhibitory protein
T13 483-488 protein denotes IL-10
T14 528-538 protein denotes G1 cyclins
T15 539-541 protein denotes D2
T16 546-548 protein denotes D3
T17 685-690 protein denotes IL-10
T18 702-705 protein denotes SEB
T19 719-732 protein denotes interleukin-2
T20 734-738 protein denotes IL-2
T21 763-767 protein denotes IL-2
T22 771-790 cell_line denotes IL-10-treated cells
T23 847-852 protein denotes IL-10
T24 864-869 protein denotes IL-10
T25 885-902 protein denotes early G1 proteins
T26 903-912 protein denotes p27(Kip1)
T27 917-926 protein denotes cyclin D2
T28 964-968 protein denotes IL-2
T29 996-1000 protein denotes IL-2
T30 1054-1059 protein denotes IL-10
T31 1125-1129 protein denotes IL-2
T32 1183-1188 protein denotes IL-10
T33 1209-1223 cell_type denotes CD4(+) T cells
T34 1284-1289 protein denotes IL-10
T35 1303-1317 cell_type denotes CD4(+) T cells
T36 1319-1324 protein denotes IL-10
T37 1354-1385 protein denotes IL-2 transcriptional regulators
T38 1386-1391 protein denotes c-fos
T39 1396-1401 protein denotes c-jun
T40 1483-1488 protein denotes IL-10
T41 1573-1577 protein denotes IL-2
T42 1616-1625 protein denotes p27(Kip1)
T43 1646-1655 protein denotes D cyclins

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-114 Sentence denotes Mechanism of interleukin-10 inhibition of T-helper cell activation by superantigen at the level of the cell cycle.
S2 115-305 Sentence denotes We have analyzed the effects of interleukin-10 (IL-10) on the entry of quiescent CD4(+) T cells into the cell cycle upon stimulation with the superantigen staphylococcal enterotoxin B (SEB).
S3 306-336 Sentence denotes IL-10 arrested cells at G0/G1.
S4 337-482 Sentence denotes IL-10 treatment prevented the downregulation of p27(Kip1), an inhibitory protein that controls progression out of the G0 phase of the cell cycle.
S5 483-634 Sentence denotes IL-10 also prevented the upregulation of the G1 cyclins D2 and D3, proteins necessary for entry and progression through the G1 phase of the cell cycle.
S6 635-740 Sentence denotes Associated with the inhibition of the cell cycle, IL-10 suppressed SEB induction of interleukin-2 (IL-2).
S7 741-853 Sentence denotes Addition of exogenous IL-2 to IL-10-treated cells significantly reversed the antiproliferative effects of IL-10.
S8 854-969 Sentence denotes Moreover, IL-10 effects on the early G1 proteins p27(Kip1) and cyclin D2 were similarly reversed by exogenous IL-2.
S9 970-1141 Sentence denotes Although this reversal by IL-2 was pronounced, it was not complete, suggesting that IL-10 may have some effects not directly related to the suppression of IL-2 production.
S10 1142-1318 Sentence denotes Cell separation experiments suggest that IL-10 can effect purified CD4(+) T cells directly, providing functional evidence for the presence of IL-10 receptors on CD4(+) T cells.
S11 1319-1443 Sentence denotes IL-10 also inhibited expression of IL-2 transcriptional regulators c-fos and c-jun, which also inhibit other cell functions.
S12 1444-1707 Sentence denotes Our studies show that the mechanism of IL-10 regulation of quiescent CD4(+) T-cell activation is mainly by blocking induction of IL-2 that is critical to downregulation of p27(Kip1) and upregulation of D cyclins in T-cell activation and entry into the cell cycle.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 42-66 NP denotes T-helper cell activation
C2 70-82 NP denotes superantigen
C3 99-113 NP denotes the cell cycle
C4 147-169 NP denotes interleukin-10 (IL-10)
C5 216-230 NP denotes the cell cycle
C6 253-304 NP denotes the superantigen staphylococcal enterotoxin B (SEB)
C7 306-311 NP denotes IL-10
C8 385-394 NP denotes p27(Kip1)
C9 396-417 NP denotes an inhibitory protein
C10 418-422 NP denotes that
C11 467-481 NP denotes the cell cycle
C12 483-488 NP denotes IL-10
C13 524-548 NP denotes the G1 cyclins D2 and D3
C15 619-633 NP denotes the cell cycle
C14 550-633 NP denotes proteins necessary for entry and progression through the G1 phase of the cell cycle
C16 669-683 NP denotes the cell cycle
C17 685-690 NP denotes IL-10
C18 719-739 NP denotes interleukin-2 (IL-2)
C19 753-767 NP denotes exogenous IL-2
C20 847-852 NP denotes IL-10
C21 864-869 NP denotes IL-10
C22 954-968 NP denotes exogenous IL-2
C24 996-1000 NP denotes IL-2
C23 979-1000 NP denotes this reversal by IL-2
C25 1017-1019 NP denotes it
C26 1054-1059 NP denotes IL-10
C27 1183-1188 NP denotes IL-10
C28 1319-1324 NP denotes IL-10
C29 1403-1408 NP denotes which
C30 1560-1577 NP denotes induction of IL-2
C31 1578-1582 NP denotes that
C32 1616-1625 NP denotes p27(Kip1)
C33 1659-1676 NP denotes T-cell activation
C34 1692-1706 NP denotes the cell cycle
R1 C5 C3 coref-ident the cell cycle,the cell cycle
R2 C6 C2 coref-ident the superantigen staphylococcal enterotoxin B (SEB),superantigen
R3 C7 C4 coref-ident IL-10,interleukin-10 (IL-10)
R4 C9 C8 coref-appos an inhibitory protein,p27(Kip1)
R5 C10 C9 coref-relat that,an inhibitory protein
R6 C11 C5 coref-ident the cell cycle,the cell cycle
R7 C12 C7 coref-ident IL-10,IL-10
R8 C15 C11 coref-ident the cell cycle,the cell cycle
R9 C14 C13 coref-appos proteins necessary for entry and progression through the G1 phase of the cell cycle,the G1 cyclins D2 and D3
R10 C16 C15 coref-ident the cell cycle,the cell cycle
R11 C17 C12 coref-ident IL-10,IL-10
R12 C20 C17 coref-ident IL-10,IL-10
R13 C21 C20 coref-ident IL-10,IL-10
R14 C22 C19 coref-ident exogenous IL-2,exogenous IL-2
R15 C24 C18 coref-ident IL-2,interleukin-2 (IL-2)
R16 C25 C23 coref-pron it,this reversal by IL-2
R17 C26 C21 coref-ident IL-10,IL-10
R18 C27 C26 coref-ident IL-10,IL-10
R19 C28 C27 coref-ident IL-10,IL-10
R20 C29 C28 coref-relat which,IL-10
R21 C31 C30 coref-relat that,induction of IL-2
R22 C32 C8 coref-ident p27(Kip1),p27(Kip1)
R23 C33 C1 coref-ident T-cell activation,T-helper cell activation
R24 C34 C16 coref-ident the cell cycle,the cell cycle

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-27 protein_molecule denotes interleukin-10
T2 42-66 other_name denotes T-helper cell activation
T3 70-82 protein_family_or_group denotes superantigen
T4 147-161 protein_molecule denotes interleukin-10
T5 163-168 protein_molecule denotes IL-10
T6 196-210 cell_type denotes CD4(+) T cells
T7 257-269 protein_family_or_group denotes superantigen
T8 270-298 protein_molecule denotes staphylococcal enterotoxin B
T9 300-303 protein_molecule denotes SEB
T10 306-311 protein_molecule denotes IL-10
T11 330-335 other_name denotes G0/G1
T12 337-342 protein_molecule denotes IL-10
T13 385-393 protein_molecule denotes p27(Kip1
T14 399-417 protein_family_or_group denotes inhibitory protein
T15 455-463 other_name denotes G0 phase
T16 471-481 other_name denotes cell cycle
T17 483-488 protein_molecule denotes IL-10
T18 528-538 protein_family_or_group denotes G1 cyclins
T19 539-541 protein_molecule denotes D2
T20 546-548 protein_molecule denotes D3
T21 607-615 other_name denotes G1 phase
T22 623-633 other_name denotes cell cycle
T23 673-683 other_name denotes cell cycle
T24 685-690 protein_molecule denotes IL-10
T25 702-705 protein_molecule denotes SEB
T26 719-732 protein_molecule denotes interleukin-2
T27 734-738 protein_molecule denotes IL-2
T28 763-767 protein_molecule denotes IL-2
T29 771-776 protein_molecule denotes IL-10
T30 847-852 protein_molecule denotes IL-10
T31 864-869 protein_molecule denotes IL-10
T32 885-902 protein_family_or_group denotes early G1 proteins
T33 903-912 protein_molecule denotes p27(Kip1)
T34 917-923 protein_molecule denotes cyclin
T35 924-926 protein_molecule denotes D2
T36 964-968 protein_molecule denotes IL-2
T37 996-1000 protein_molecule denotes IL-2
T38 1054-1059 protein_molecule denotes IL-10
T39 1125-1129 protein_molecule denotes IL-2
T40 1183-1188 protein_molecule denotes IL-10
T41 1209-1223 cell_type denotes CD4(+) T cells
T42 1284-1289 protein_molecule denotes IL-10
T43 1303-1317 cell_type denotes CD4(+) T cells
T44 1319-1324 protein_molecule denotes IL-10
T45 1354-1358 protein_molecule denotes IL-2
T46 1386-1391 protein_molecule denotes c-fos
T47 1396-1401 protein_molecule denotes c-jun
T48 1483-1488 protein_molecule denotes IL-10
T49 1513-1537 other_name denotes CD4(+) T-cell activation
T50 1573-1577 protein_molecule denotes IL-2
T51 1616-1625 protein_molecule denotes p27(Kip1)
T52 1646-1655 protein_family_or_group denotes D cyclins
T53 1696-1706 other_name denotes cell cycle