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PubMed:9862673 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes CD27
T2 31-34 protein denotes IgE
T3 81-95 cell_type denotes memory B cells
T4 101-113 cell_type denotes plasma cells
T5 132-135 protein denotes IgE
T6 149-156 cell_type denotes B cells
T7 191-200 protein denotes cytokines
T8 271-275 protein denotes CD27
T9 303-306 protein denotes IgE
T10 370-385 cell_line denotes B cell cultures
T11 400-403 protein denotes IgE
T12 449-453 protein denotes IL-4
T13 459-472 protein denotes anti-CD40 mAb
T14 474-483 protein denotes anti-CD40
T15 500-518 cell_line denotes CD70 transfectants
T16 568-582 protein denotes anti-CD70 mAb.
T17 583-596 cell_type denotes CD27+ B cells
T18 624-627 protein denotes IgE
T19 723-726 protein denotes IgE
T20 728-732 protein denotes CD27
T21 759-765 cell_type denotes B cell
T22 799-803 protein denotes IL-4
T23 807-811 protein denotes IL-4
T24 817-826 protein denotes anti-CD40
T25 907-920 cell_type denotes CD27+ B cells
T26 938-951 cell_type denotes CD27- B cells
T27 977-980 protein denotes IgE
T28 998-1002 protein denotes CD27
T29 1061-1089 RNA denotes germline epsilon transcripts
T30 1190-1205 cell_line denotes B cell cultures
T31 1247-1259 cell_type denotes plasma cells
T32 1279-1283 protein denotes IL-4
T33 1288-1292 protein denotes CD40
T34 1313-1317 protein denotes CD27
T35 1365-1410 protein denotes positive regulatory domain I-binding factor-1
T36 1469-1473 protein denotes CD27
T37 1477-1484 cell_type denotes B cells
T38 1493-1496 protein denotes IgE
T39 1528-1532 protein denotes IL-4
T40 1537-1541 protein denotes CD40
T41 1584-1596 cell_type denotes plasma cells
T42 1622-1667 protein denotes positive regulatory domain I-binding factor-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-114 Sentence denotes CD27/CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells.
S2 115-236 Sentence denotes The induction of IgE switching in B cells requires several signals given by cytokines and cell contact-delivered signals.
S3 237-317 Sentence denotes Here, we investigated the role of CD27/CD70 interaction in B cell IgE synthesis.
S4 318-485 Sentence denotes The addition of CD27 ligand (CD70) transfectants to B cell cultures increased the IgE synthesis synergistically in the presence of IL-4 plus anti-CD40 mAb (anti-CD40).
S5 486-582 Sentence denotes The effect of CD70 transfectants was dose dependent and was completely blocked by anti-CD70 mAb.
S6 583-727 Sentence denotes CD27+ B cells had the ability to produce IgE, which was increased by contact with CD70 transfectants, whereas CD27- B cells did not produce IgE.
S7 728-827 Sentence denotes CD27/CD70 interaction enhanced B cell proliferation in the presence of IL-4 or IL-4 plus anti-CD40.
S8 828-952 Sentence denotes The augmentation of B cell proliferation by CD70 transfectants was apparent in CD27+ B cells, but was mild in CD27- B cells.
S9 953-1090 Sentence denotes The helper activity for IgE synthesis by the CD27/CD70 interaction did not contribute to the enhancement of germline epsilon transcripts.
S10 1091-1303 Sentence denotes Flow cytometric and morphological analyses demonstrated that the addition of CD70 transfectants to B cell cultures remarkably promoted differentiation into plasma cells in the presence of IL-4 and CD40 signaling.
S11 1304-1411 Sentence denotes Finally, CD27 cross-linking resulted in the up-regulation of positive regulatory domain I-binding factor-1.
S12 1412-1668 Sentence denotes Taken together, our findings indicate that signaling via CD27 on B cells induces IgE synthesis, in cooperation with IL-4 and CD40 signaling, by promoting the generation of plasma cells through up-regulation of positive regulatory domain I-binding factor-1.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-21 NP denotes CD27/CD70 interaction
C2 101-113 NP denotes plasma cells
C3 149-156 NP denotes B cells
C4 271-292 NP denotes CD27/CD70 interaction
C5 296-316 NP denotes B cell IgE synthesis
C6 334-366 NP denotes CD27 ligand (CD70) transfectants
C7 370-385 NP denotes B cell cultures
C8 396-413 NP denotes the IgE synthesis
C9 449-484 NP denotes IL-4 plus anti-CD40 mAb (anti-CD40)
C10 500-518 NP denotes CD70 transfectants
C11 568-581 NP denotes anti-CD70 mAb
C12 583-596 NP denotes CD27+ B cells
C13 624-627 NP denotes IgE
C14 629-634 NP denotes which
C15 665-683 NP denotes CD70 transfectants
C16 693-706 NP denotes CD27- B cells
C17 723-726 NP denotes IgE
C18 728-749 NP denotes CD27/CD70 interaction
C19 759-779 NP denotes B cell proliferation
C20 848-868 NP denotes B cell proliferation
C21 872-890 NP denotes CD70 transfectants
C22 907-920 NP denotes CD27+ B cells
C23 938-951 NP denotes CD27- B cells
C24 977-990 NP denotes IgE synthesis
C25 994-1019 NP denotes the CD27/CD70 interaction
C26 1168-1186 NP denotes CD70 transfectants
C27 1190-1205 NP denotes B cell cultures
C28 1247-1259 NP denotes plasma cells
C29 1279-1302 NP denotes IL-4 and CD40 signaling
C30 1365-1410 NP denotes positive regulatory domain I-binding factor-1
C31 1477-1484 NP denotes B cells
C32 1493-1506 NP denotes IgE synthesis
C33 1528-1551 NP denotes IL-4 and CD40 signaling
C34 1584-1596 NP denotes plasma cells
C35 1622-1667 NP denotes positive regulatory domain I-binding factor-1
R1 C4 C1 coref-ident CD27/CD70 interaction,CD27/CD70 interaction
R2 C8 C5 coref-ident the IgE synthesis,B cell IgE synthesis
R3 C10 C6 coref-ident CD70 transfectants,CD27 ligand (CD70) transfectants
R4 C11 C9 coref-ident anti-CD70 mAb,IL-4 plus anti-CD40 mAb (anti-CD40)
R5 C14 C13 coref-relat which,IgE
R6 C15 C10 coref-ident CD70 transfectants,CD70 transfectants
R7 C17 C13 coref-ident IgE,IgE
R8 C18 C4 coref-ident CD27/CD70 interaction,CD27/CD70 interaction
R9 C20 C19 coref-ident B cell proliferation,B cell proliferation
R10 C21 C15 coref-ident CD70 transfectants,CD70 transfectants
R11 C22 C12 coref-ident CD27+ B cells,CD27+ B cells
R12 C23 C16 coref-ident CD27- B cells,CD27- B cells
R13 C24 C8 coref-ident IgE synthesis,the IgE synthesis
R14 C25 C18 coref-ident the CD27/CD70 interaction,CD27/CD70 interaction
R15 C26 C21 coref-ident CD70 transfectants,CD70 transfectants
R16 C27 C7 coref-ident B cell cultures,B cell cultures
R17 C28 C2 coref-ident plasma cells,plasma cells
R18 C31 C3 coref-ident B cells,B cells
R19 C32 C24 coref-ident IgE synthesis,IgE synthesis
R20 C33 C29 coref-ident IL-4 and CD40 signaling,IL-4 and CD40 signaling
R21 C34 C28 coref-ident plasma cells,plasma cells
R22 C35 C30 coref-ident positive regulatory domain I-binding factor-1,positive regulatory domain I-binding factor-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-4 protein_molecule denotes CD27
T2 31-34 protein_family_or_group denotes IgE
T3 81-95 cell_type denotes memory B cells
T4 101-113 cell_type denotes plasma cells
T5 132-135 protein_family_or_group denotes IgE
T6 149-156 cell_type denotes B cells
T7 191-200 protein_family_or_group denotes cytokines
T8 271-275 protein_molecule denotes CD27
T9 296-302 other_name denotes B cell
T10 303-306 protein_family_or_group denotes IgE
T11 334-366 other_artificial_source denotes CD27 ligand (CD70) transfectants
T12 370-385 cell_line denotes B cell cultures
T13 400-403 protein_family_or_group denotes IgE
T14 449-453 protein_molecule denotes IL-4
T15 459-472 protein_molecule denotes anti-CD40 mAb
T16 474-483 protein_molecule denotes anti-CD40
T17 500-518 cell_line denotes CD70 transfectants
T18 568-582 protein_family_or_group denotes anti-CD70 mAb.
T19 583-596 cell_type denotes CD27+ B cells
T20 624-627 protein_family_or_group denotes IgE
T21 665-683 other_artificial_source denotes CD70 transfectants
T22 693-706 other_artificial_source denotes CD27- B cells
T23 723-726 protein_family_or_group denotes IgE
T24 728-732 protein_molecule denotes CD27
T25 759-765 cell_type denotes B cell
T26 799-803 protein_molecule denotes IL-4
T27 807-811 protein_molecule denotes IL-4
T28 817-826 protein_molecule denotes anti-CD40
T29 848-868 other_name denotes B cell proliferation
T30 872-890 other_artificial_source denotes CD70 transfectants
T31 907-920 cell_type denotes CD27+ B cells
T32 938-951 cell_type denotes CD27- B cells
T33 977-980 protein_family_or_group denotes IgE
T34 998-1002 protein_molecule denotes CD27
T35 1061-1089 RNA_family_or_group denotes germline epsilon transcripts
T36 1168-1186 other_artificial_source denotes CD70 transfectants
T37 1190-1205 cell_line denotes B cell cultures
T38 1247-1259 cell_type denotes plasma cells
T39 1279-1283 protein_molecule denotes IL-4
T40 1288-1292 protein_molecule denotes CD40
T41 1313-1317 protein_molecule denotes CD27
T42 1365-1410 protein_molecule denotes positive regulatory domain I-binding factor-1
T43 1469-1473 protein_molecule denotes CD27
T44 1477-1484 cell_type denotes B cells
T45 1493-1496 protein_family_or_group denotes IgE
T46 1528-1532 protein_molecule denotes IL-4
T47 1537-1541 protein_molecule denotes CD40
T48 1584-1596 cell_type denotes plasma cells
T49 1622-1667 protein_molecule denotes positive regulatory domain I-binding factor-1