PubMed:9860137 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9860137","sourcedb":"PubMed","sourceid":"9860137","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9860137","text":"Enhanced differentiation of HL-60 leukemia cells to macrophages induced by ciprofibrate.\nCiprofibrate, an hypolipidaemic peroxisome proliferator, induced differentiation of HL-60 cells. The effect was greatly potentiated by phorbol 12-myristate 13-acetate at a concentration where neither phorbol ester nor ciprofibrate alone had any effect on these cells. As occurs for HL-60 cell differentiation induced by high phorbol ester concentration, the ciprofibrate-induced phorbol ester-dependent differentiation of HL-60 cells proceeded through the monocytic/macrophage pathway and induced the phosphorylation of proteins with similar molecular weights suggesting that increased protein kinase C activity may be involved in the effect. The peroxisome proliferator-activated receptor (PPARalpha) transcription factor is expressed in HL-60 cells, but no changes were observed in its expression upon HL-60 cell 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