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PubMed:9858225 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-134 Sentence denotes Systemic mastocytosis associated with acute myeloid leukaemia: report of two cases and detection of the c-kit mutation Asp-816 to Val.
TextSentencer_T2 135-226 Sentence denotes A subset of patients with systemic mastocytosis (SM) develop acute myeloid leukaemia (AML).
TextSentencer_T3 227-342 Sentence denotes However, little is known about the biology of such leukaemias and their relationship to the mast cell (MC) lineage.
TextSentencer_T4 343-405 Sentence denotes We report on two female patients who suffered from SM and AML.
TextSentencer_T5 406-509 Sentence denotes According to FAB criteria, the leukaemias were classified as AML-M4 (patient 1) and AML-MO (patient 2).
TextSentencer_T6 510-673 Sentence denotes The coexistence of the two distinct neoplasms (AML and SM) was demonstrable by immunostaining of serial bone marrow (BM) sections with monoclonal antibodies (mAb).
TextSentencer_T7 674-835 Sentence denotes In particular, the MC infiltrates were found to react with mAb against MC-tryptase and MC growth factor receptor c-kit (CD117), but not with mAb to CD15 or CD34.
TextSentencer_T8 836-955 Sentence denotes In contrast, the AML blasts were immunoreactive for CD15 (patient 1) or CD34 (patient 2), but did not express tryptase.
TextSentencer_T9 956-1137 Sentence denotes The c-kit point mutation Asp-->Val at codon 816, considered to play a role in the transformation of MC progenitors, was detected in patient 1 in a BM cell fraction containing 4% MC.
TextSentencer_T10 1138-1203 Sentence denotes However, no c-kit mutation was found in pure AML blasts (<1% MC).
TextSentencer_T11 1204-1310 Sentence denotes These findings argue against an evolution of the AML clone from neoplastic MC or MC-committed progenitors.
T1 0-134 Sentence denotes Systemic mastocytosis associated with acute myeloid leukaemia: report of two cases and detection of the c-kit mutation Asp-816 to Val.
T2 135-226 Sentence denotes A subset of patients with systemic mastocytosis (SM) develop acute myeloid leukaemia (AML).
T3 227-342 Sentence denotes However, little is known about the biology of such leukaemias and their relationship to the mast cell (MC) lineage.
T4 343-405 Sentence denotes We report on two female patients who suffered from SM and AML.
T5 406-509 Sentence denotes According to FAB criteria, the leukaemias were classified as AML-M4 (patient 1) and AML-MO (patient 2).
T6 510-673 Sentence denotes The coexistence of the two distinct neoplasms (AML and SM) was demonstrable by immunostaining of serial bone marrow (BM) sections with monoclonal antibodies (mAb).
T7 674-835 Sentence denotes In particular, the MC infiltrates were found to react with mAb against MC-tryptase and MC growth factor receptor c-kit (CD117), but not with mAb to CD15 or CD34.
T8 836-955 Sentence denotes In contrast, the AML blasts were immunoreactive for CD15 (patient 1) or CD34 (patient 2), but did not express tryptase.
T9 956-1137 Sentence denotes The c-kit point mutation Asp-->Val at codon 816, considered to play a role in the transformation of MC progenitors, was detected in patient 1 in a BM cell fraction containing 4% MC.
T10 1138-1203 Sentence denotes However, no c-kit mutation was found in pure AML blasts (<1% MC).
T11 1204-1310 Sentence denotes These findings argue against an evolution of the AML clone from neoplastic MC or MC-committed progenitors.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 419-422 gene:2187 denotes FAB
T1 467-470 disease:C0023467 denotes AML
T2 419-422 gene:2187 denotes FAB
T3 490-493 disease:C0023467 denotes AML
R1 T0 T1 associated_with FAB,AML
R2 T2 T3 associated_with FAB,AML

PennBioIE

Id Subject Object Predicate Lexical cue
T1 104-109 protein denotes c-kit
T2 110-118 protein denotes mutation
T3 119-122 protein denotes Asp
T4 123-126 protein denotes 816
T5 130-133 protein denotes Val
T6 645-666 protein denotes monoclonal antibodies
T7 668-671 protein denotes mAb
T8 733-736 protein denotes mAb
T9 748-756 protein denotes tryptase
T10 761-786 protein denotes MC growth factor receptor
T11 787-792 protein denotes c-kit
T12 794-799 protein denotes CD117
T13 815-818 protein denotes mAb
T14 822-826 protein denotes CD15
T15 830-834 protein denotes CD34
T16 888-892 protein denotes CD15
T17 908-912 protein denotes CD34
T18 946-954 protein denotes tryptase
T19 960-965 protein denotes c-kit
T20 966-980 protein denotes point mutation
T21 981-984 protein denotes Asp
T22 987-990 protein denotes Val
T23 994-1003 protein denotes codon 816
T24 1150-1155 protein denotes c-kit

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
9858225-0#119#133#geners121913507 119-133 geners121913507 denotes Asp-816 to Val
9858225-0#0#21#diseaseC0221013 0-21 diseaseC0221013 denotes Systemic mastocytosis
9858225-0#38#61#diseaseC0023467 38-61 diseaseC0023467 denotes acute myeloid leukaemia
119#133#geners1219135070#21#diseaseC0221013 9858225-0#119#133#geners121913507 9858225-0#0#21#diseaseC0221013 associated_with Asp-816 to Val,Systemic mastocytosis
119#133#geners12191350738#61#diseaseC0023467 9858225-0#119#133#geners121913507 9858225-0#38#61#diseaseC0023467 associated_with Asp-816 to Val,acute myeloid leukaemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9858225-4#13#16#gene2187 419-422 gene2187 denotes FAB
9858225-4#61#67#diseaseC0023479 467-473 diseaseC0023479 denotes AML-M4
9858225-4#84#87#diseaseC0023467 490-493 diseaseC0023467 denotes AML
9858225-7#52#56#gene2526 888-892 gene2526 denotes CD15
9858225-7#72#76#gene947 908-912 gene947 denotes CD34
9858225-7#17#20#diseaseC0023467 853-856 diseaseC0023467 denotes AML
13#16#gene218761#67#diseaseC0023479 9858225-4#13#16#gene2187 9858225-4#61#67#diseaseC0023479 associated_with FAB,AML-M4
13#16#gene218784#87#diseaseC0023467 9858225-4#13#16#gene2187 9858225-4#84#87#diseaseC0023467 associated_with FAB,AML
52#56#gene252617#20#diseaseC0023467 9858225-7#52#56#gene2526 9858225-7#17#20#diseaseC0023467 associated_with CD15,AML
72#76#gene94717#20#diseaseC0023467 9858225-7#72#76#gene947 9858225-7#17#20#diseaseC0023467 associated_with CD34,AML

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 614-625 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 9-21 HP:0100495 denotes mastocytosis
AB1 170-182 HP:0100495 denotes mastocytosis
AB2 546-555 HP:0002664 denotes neoplasms

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 614-625 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 119-122 ORDO:63442 denotes Asp
AB1 467-473 ORDO:517 denotes AML-M4
AB2 981-984 ORDO:63442 denotes Asp