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PubMed:9847317 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-149 Sentence denotes Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination.
TextSentencer_T2 150-352 Sentence denotes The development of an effective human immunodeficiency virus type 1 (HIV-1) vaccine is likely to depend on knowledge of circulating variants of genes other than the commonly sequenced gag and env genes.
TextSentencer_T3 353-500 Sentence denotes In addition, full-genome data are particularly limited for HIV-1 subtype C, currently the most commonly transmitted subtype in India and worldwide.
TextSentencer_T4 501-626 Sentence denotes Likewise, little is known about sequence variation of HIV-1 in India, the country facing the largest burden of HIV worldwide.
TextSentencer_T5 627-787 Sentence denotes Therefore, the objective of this study was to clone and characterize the complete genome of HIV-1 from seroconverters infected with subtype C variants in India.
TextSentencer_T6 788-968 Sentence denotes Cocultured HIV-1 isolates were obtained from six seroincident individuals from Pune, India, and virtually full-length HIV-1 genomes were amplified, cloned, and sequenced from each.
TextSentencer_T7 969-1234 Sentence denotes Sequence analysis revealed that five of the six genomes were of subtype C, while one was a mosaic of subtypes A and C, with multiple breakpoints in env, nef, and the 3' long terminal repeat as determined by both maximal chi2 analysis and phylogenetic bootstrapping.
TextSentencer_T8 1235-1323 Sentence denotes Sequences were compared for preservation of known cytotoxic T lymphocyte (CTL) epitopes.
TextSentencer_T9 1324-1418 Sentence denotes Compared with those of the HIV-1LAI sequence, 38% of well-defined CTL epitopes were identical.
TextSentencer_T10 1419-1558 Sentence denotes The proportion of nonconservative substitutions for Env, at 61%, was higher (P < 0.001) than those for Gag (24%), Pol (18%), and Nef (32%).
TextSentencer_T11 1559-1703 Sentence denotes Therefore, characterized CTL epitopes demonstrated substantial differences from subtype B laboratory strains, which were most pronounced in Env.
TextSentencer_T12 1704-1933 Sentence denotes Because these clones were obtained from Indian seroconverters, they are likely to facilitate vaccine-related efforts in India by providing potential antigens for vaccine candidates as well as for assays of vaccine responsiveness.
T1 0-149 Sentence denotes Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination.
T2 150-352 Sentence denotes The development of an effective human immunodeficiency virus type 1 (HIV-1) vaccine is likely to depend on knowledge of circulating variants of genes other than the commonly sequenced gag and env genes.
T3 353-500 Sentence denotes In addition, full-genome data are particularly limited for HIV-1 subtype C, currently the most commonly transmitted subtype in India and worldwide.
T4 501-626 Sentence denotes Likewise, little is known about sequence variation of HIV-1 in India, the country facing the largest burden of HIV worldwide.
T5 627-787 Sentence denotes Therefore, the objective of this study was to clone and characterize the complete genome of HIV-1 from seroconverters infected with subtype C variants in India.
T6 788-968 Sentence denotes Cocultured HIV-1 isolates were obtained from six seroincident individuals from Pune, India, and virtually full-length HIV-1 genomes were amplified, cloned, and sequenced from each.
T7 969-1234 Sentence denotes Sequence analysis revealed that five of the six genomes were of subtype C, while one was a mosaic of subtypes A and C, with multiple breakpoints in env, nef, and the 3' long terminal repeat as determined by both maximal chi2 analysis and phylogenetic bootstrapping.
T8 1235-1323 Sentence denotes Sequences were compared for preservation of known cytotoxic T lymphocyte (CTL) epitopes.
T9 1324-1418 Sentence denotes Compared with those of the HIV-1LAI sequence, 38% of well-defined CTL epitopes were identical.
T10 1419-1558 Sentence denotes The proportion of nonconservative substitutions for Env, at 61%, was higher (P < 0.001) than those for Gag (24%), Pol (18%), and Nef (32%).
T11 1559-1703 Sentence denotes Therefore, characterized CTL epitopes demonstrated substantial differences from subtype B laboratory strains, which were most pronounced in Env.
T12 1704-1933 Sentence denotes Because these clones were obtained from Indian seroconverters, they are likely to facilitate vaccine-related efforts in India by providing potential antigens for vaccine candidates as well as for assays of vaccine responsiveness.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 342-345 gene:100775105 denotes env
T1 219-222 disease:C0019693 denotes HIV
T2 342-345 gene:30816 denotes env
T3 219-222 disease:C0019693 denotes HIV
T4 342-345 gene:100616444 denotes env
T5 219-222 disease:C0019693 denotes HIV
R1 T0 T1 associated_with env,HIV
R2 T2 T3 associated_with env,HIV
R3 T4 T5 associated_with env,HIV

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1760 342-345 gene:100775105 denotes env
T1761 182-210 disease:C3854222 denotes human immunodeficiency virus
R1 T1760 T1761 associated_with env,human immunodeficiency virus
R2 T1760 T1761 associated_with env,human immunodeficiency virus
R3 T1760 T1761 associated_with env,human immunodeficiency virus

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 583-589 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing