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PubMed:9845517 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes Stat6
T2 21-43 DNA denotes interleukin-4 promoter
T3 56-63 cell_type denotes T cells
T4 88-113 cell_type denotes naive T-helper (Th) cells
T5 119-155 cell_type denotes cytokine-secreting effector Th cells
T6 205-224 protein denotes exogenous cytokines
T7 226-239 protein denotes Interleukin-4
T8 241-245 protein denotes IL-4
T9 318-322 protein denotes IL-4
T10 358-362 protein denotes IL-4
T11 470-491 protein denotes transcription factors
T12 531-546 DNA denotes promoter region
T13 548-604 protein denotes Nuclear factor of activated T cell (NFAT) family members
T14 640-644 protein denotes IL-4
T15 728-741 DNA denotes IL-4 promoter
T16 777-781 protein denotes IL-4
T17 808-817 DNA denotes IL-4 gene
T18 846-932 protein denotes IL-4-activated transcription factor signal transducer and activator of transcription 6
T19 934-939 protein denotes Stat6
T20 990-995 protein denotes Stat6
T21 1038-1057 DNA denotes human IL-4 promoter
T22 1124-1152 DNA denotes P1, P2, and P4 NFAT elements
T23 1181-1186 protein denotes Stat6
T24 1201-1205 protein denotes IL-4
T25 1229-1234 protein denotes Stat6
T26 1252-1259 cell_type denotes T cells
T27 1282-1306 DNA denotes IL-4 promoter constructs
T28 1357-1386 DNA denotes multimerized response element
T29 1396-1417 DNA denotes germline IgE promoter
T30 1440-1444 protein denotes IL-4
T31 1448-1477 cell_type denotes Stat6-expressing Jurkat cells
T32 1490-1509 DNA denotes human IL-4 promoter
T33 1583-1588 protein denotes Stat6
T34 1659-1663 protein denotes IL-4

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-64 Sentence denotes Stat6 inhibits human interleukin-4 promoter activity in T cells.
S2 65-225 Sentence denotes The differentiation of naive T-helper (Th) cells into cytokine-secreting effector Th cells requires exposure to multiple signals, including exogenous cytokines.
S3 226-343 Sentence denotes Interleukin-4 (IL-4) plays a major role in this process by promoting the differentiation of IL-4-secreting Th2 cells.
S4 344-547 Sentence denotes In Th2 cells, IL-4 gene expression is tightly controlled at the level of transcription by the coordinated binding of multiple transcription factors to regulatory elements in the proximal promoter region.
S5 548-742 Sentence denotes Nuclear factor of activated T cell (NFAT) family members play a critical role in regulating IL-4 transcription and interact with up to five sequences (termed P0 through P4) in the IL-4 promoter.
S6 743-969 Sentence denotes The molecular mechanisms by which IL-4 induces expression of the IL-4 gene are not known, although the IL-4-activated transcription factor signal transducer and activator of transcription 6 (Stat6) is required for this effect.
S7 970-1099 Sentence denotes We report here that Stat6 interacts with three binding sites in the human IL-4 promoter by electrophoretic mobility shift assays.
S8 1100-1153 Sentence denotes These sites overlap the P1, P2, and P4 NFAT elements.
S9 1154-1332 Sentence denotes To investigate the role of Stat6 in regulating IL-4 transcription, we used Stat6-deficient Jurkat T cells with different intact IL-4 promoter constructs in cotransfection assays.
S10 1333-1549 Sentence denotes We show that, whereas a multimerized response element from the germline IgE promoter was highly induced by IL-4 in Stat6-expressing Jurkat cells, the intact human IL-4 promoter was repressed under similar conditions.
S11 1550-1702 Sentence denotes We conclude that the function of Stat6 is highly dependent on promoter context and that this factor promotes IL-4 gene expression in an indirect manner.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-5 NP denotes Stat6
C2 226-246 NP denotes Interleukin-4 (IL-4)
C3 358-378 NP denotes IL-4 gene expression
C4 640-658 NP denotes IL-4 transcription
C5 724-741 NP denotes the IL-4 promoter
C6 743-767 NP denotes The molecular mechanisms
C7 771-776 NP denotes which
C8 777-781 NP denotes IL-4
C9 790-817 NP denotes expression of the IL-4 gene
C10 842-940 NP denotes the IL-4-activated transcription factor signal transducer and activator of transcription 6 (Stat6)
C11 990-995 NP denotes Stat6
C13 1034-1057 NP denotes the human IL-4 promoter
C12 1011-1057 NP denotes three binding sites in the human IL-4 promoter
C14 1100-1111 NP denotes These sites
C15 1201-1219 NP denotes IL-4 transcription
C16 1440-1444 NP denotes IL-4
C17 1583-1588 NP denotes Stat6
C18 1638-1649 NP denotes this factor
C19 1659-1679 NP denotes IL-4 gene expression
R1 C7 C6 coref-relat which,The molecular mechanisms
R2 C8 C2 coref-ident IL-4,Interleukin-4 (IL-4)
R3 C9 C3 coref-ident expression of the IL-4 gene,IL-4 gene expression
R4 C10 C1 coref-ident the IL-4-activated transcription factor signal transducer and activator of transcription 6 (Stat6),Stat6
R5 C11 C10 coref-ident Stat6,the IL-4-activated transcription factor signal transducer and activator of transcription 6 (Stat6)
R6 C13 C5 coref-ident the human IL-4 promoter,the IL-4 promoter
R7 C14 C12 coref-ident These sites,three binding sites in the human IL-4 promoter
R8 C15 C4 coref-ident IL-4 transcription,IL-4 transcription
R9 C16 C8 coref-ident IL-4,IL-4
R10 C18 C17 coref-ident this factor,Stat6
R11 C19 C9 coref-ident IL-4 gene expression,expression of the IL-4 gene

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes Stat6
T2 15-20 other_name denotes human
T3 21-43 DNA_domain_or_region denotes interleukin-4 promoter
T4 56-63 cell_type denotes T cells
T5 88-113 cell_type denotes naive T-helper (Th) cells
T6 119-127 protein_family_or_group denotes cytokine
T7 205-224 protein_family_or_group denotes exogenous cytokines
T8 226-239 protein_molecule denotes Interleukin-4
T9 241-245 protein_molecule denotes IL-4
T10 318-322 protein_molecule denotes IL-4
T11 358-362 protein_molecule denotes IL-4
T12 470-491 protein_family_or_group denotes transcription factors
T13 531-546 DNA_domain_or_region denotes promoter region
T14 548-604 protein_family_or_group denotes Nuclear factor of activated T cell (NFAT) family members
T15 640-644 protein_molecule denotes IL-4
T16 728-741 DNA_domain_or_region denotes IL-4 promoter
T17 777-781 protein_molecule denotes IL-4
T18 808-812 protein_molecule denotes IL-4
T19 846-850 protein_molecule denotes IL-4
T20 861-881 protein_family_or_group denotes transcription factor
T21 934-939 protein_molecule denotes Stat6
T22 990-995 protein_molecule denotes Stat6
T23 1038-1057 DNA_domain_or_region denotes human IL-4 promoter
T24 1061-1098 other_name denotes electrophoretic mobility shift assays
T25 1181-1186 protein_molecule denotes Stat6
T26 1201-1205 protein_molecule denotes IL-4
T27 1229-1234 protein_molecule denotes Stat6
T28 1252-1259 cell_type denotes T cells
T29 1282-1295 DNA_domain_or_region denotes IL-4 promoter
T30 1357-1386 DNA_domain_or_region denotes multimerized response element
T31 1396-1417 DNA_domain_or_region denotes germline IgE promoter
T32 1440-1444 protein_molecule denotes IL-4
T33 1448-1453 protein_molecule denotes Stat6
T34 1490-1495 DNA_domain_or_region denotes human
T35 1496-1509 DNA_domain_or_region denotes IL-4 promoter
T36 1583-1588 protein_molecule denotes Stat6
T37 1659-1663 protein_molecule denotes IL-4