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PubMed:9840924 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes Tpl-2
T2 14-18 protein denotes IL-2
T3 33-45 cell_line denotes T-cell lines
T4 102-106 protein denotes NFAT
T5 111-120 protein denotes NF-kappaB
T6 126-138 protein denotes Tpl-2 kinase
T7 153-188 protein denotes nuclear factor of activated T cells
T8 190-194 protein denotes NFAT
T9 208-212 protein denotes IL-2
T10 227-239 cell_line denotes T-cell lines
T11 281-294 DNA denotes IL-2 promoter
T12 298-303 protein denotes Tpl-2
T13 320-346 protein denotes mutant signaling molecules
T14 364-396 protein denotes mitogen-activated protein kinase
T15 398-402 protein denotes MAPK
T16 411-422 protein denotes calcineurin
T17 422-427 protein denotes /NFAT
T18 472-491 protein denotes signaling molecules
T19 595-599 protein denotes MAPK
T20 608-619 protein denotes calcineurin
T21 619-624 protein denotes /NFAT
T22 688-701 DNA denotes IL-2 promoter
T23 705-710 protein denotes Tpl-2
T24 739-752 DNA denotes IL-2 promoter
T25 760-788 DNA denotes NFAT-driven minimal promoter
T26 835-839 protein denotes Raf1
T27 866-879 DNA denotes IL-2 promoter
T28 900-905 protein denotes Tpl-2
T29 931-969 protein denotes dominant negative mutant MEK1S218/222A
T30 1032-1036 protein denotes NFAT
T31 1040-1044 protein denotes MAPK
T32 1103-1107 protein denotes MAPK
T33 1111-1116 protein denotes Tpl-2
T34 1170-1174 protein denotes MEK1
T35 1179-1183 protein denotes MEK2
T36 1240-1253 DNA denotes IL-2 promoter
T37 1287-1291 protein denotes NFAT
T38 1337-1340 protein denotes MEK
T39 1367-1372 cell_line denotes COS-1
T40 1377-1387 cell_line denotes EL-4 cells
T41 1463-1468 protein denotes Tpl-2
T42 1472-1481 protein denotes NF-kappaB
T43 1511-1524 DNA denotes IL-2 promoter
T44 1532-1560 DNA denotes NFAT-driven minimal promoter
T45 1564-1569 protein denotes Tpl-2
T46 1595-1619 protein denotes dominant negative mutant
T47 1620-1633 protein denotes NFAT delta418
T48 1672-1683 protein denotes calcineurin
T49 1728-1733 protein denotes Tpl-2
T50 1743-1747 protein denotes NFAT
T51 1884-1889 protein denotes Bcl-2
T52 1893-1901 protein denotes Bcl-X(L)

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-121 Sentence denotes Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB.
S2 122-240 Sentence denotes The Tpl-2 kinase activates the nuclear factor of activated T cells (NFAT) and induces IL-2 expression in T-cell lines.
S3 241-521 Sentence denotes Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase (MAPK) or the calcineurin/NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways.
S4 522-711 Sentence denotes We, therefore, conclude that signals generated by the convergence of the MAPK and the calcineurin/NFAT pathway are necessary and sufficient for the activation of the IL-2 promoter by Tpl-2.
S5 712-840 Sentence denotes The activation of both the IL-2 promoter and an NFAT-driven minimal promoter were shown to depend on signals transduced by Raf1.
S6 841-1007 Sentence denotes However, it was only the IL-2 promoter whose activation by Tpl-2 was fully blocked by the dominant negative mutant MEK1S218/222A and the MEK1/MEK2 inhibitor PD098059.
S7 1008-1184 Sentence denotes Since the activation of NFAT is MAPK-dependent these findings suggested that the activation of MAPK by Tpl-2 is either independent or only partially dependent on MEK1 and MEK2.
S8 1185-1351 Sentence denotes In addition, they suggested that the activation of the IL-2 promoter is under the control of not only NFAT but also a second factor whose activation is MEK-dependent.
S9 1352-1482 Sentence denotes Experiments in COS-1 and EL-4 cells confirmed both hypotheses and revealed that the second factor activated by Tpl-2 is NF-kappaB.
S10 1483-1847 Sentence denotes While the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418, it was only partially blocked by the calcineurin inhibitor cyclosporin A suggesting that the Tpl-2-mediated NFAT activation is under the control of a combination of calcineurin-dependent and independent pathways.
S11 1848-1902 Sentence denotes Both pathways were fully blocked by Bcl-2 or Bcl-X(L).

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-5 NP denotes Tpl-2
C2 14-45 NP denotes IL-2 expression in T-cell lines
C3 60-87 NP denotes multiple signaling pathways
C4 88-92 NP denotes that
C5 102-106 NP denotes NFAT
C6 111-120 NP denotes NF-kappaB
C7 122-138 NP denotes The Tpl-2 kinase
C8 149-195 NP denotes the nuclear factor of activated T cells (NFAT)
C9 208-239 NP denotes IL-2 expression in T-cell lines
C11 277-294 NP denotes the IL-2 promoter
C12 298-303 NP denotes Tpl-2
C10 259-303 NP denotes the activation of the IL-2 promoter by Tpl-2
C13 320-346 NP denotes mutant signaling molecules
C14 347-351 NP denotes that
C15 360-436 NP denotes the mitogen-activated protein kinase (MAPK) or the calcineurin/NFAT pathways
C16 456-491 NP denotes combinations of signaling molecules
C17 492-496 NP denotes that
C18 506-520 NP denotes these pathways
C19 591-632 NP denotes the MAPK and the calcineurin/NFAT pathway
C21 684-701 NP denotes the IL-2 promoter
C22 705-710 NP denotes Tpl-2
C20 666-710 NP denotes the activation of the IL-2 promoter by Tpl-2
C23 730-788 NP denotes both the IL-2 promoter and an NFAT-driven minimal promoter
C24 862-879 NP denotes the IL-2 promoter
C25 880-885 NP denotes whose
C26 900-905 NP denotes Tpl-2
C27 1032-1036 NP denotes NFAT
C28 1055-1069 NP denotes these findings
C29 1111-1116 NP denotes Tpl-2
C30 1198-1202 NP denotes they
C31 1236-1253 NP denotes the IL-2 promoter
C32 1287-1291 NP denotes NFAT
C33 1301-1316 NP denotes a second factor
C34 1317-1322 NP denotes whose
C36 1463-1468 NP denotes Tpl-2
C35 1432-1468 NP denotes the second factor activated by Tpl-2
C37 1472-1481 NP denotes NF-kappaB
C40 1507-1524 NP denotes the IL-2 promoter
C39 1507-1560 NP denotes the IL-2 promoter and an NFAT-driven minimal promoter
C41 1564-1569 NP denotes Tpl-2
C38 1489-1569 NP denotes the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2
C42 1635-1637 NP denotes it
C43 1800-1846 NP denotes calcineurin-dependent and independent pathways
C44 1848-1861 NP denotes Both pathways
R1 C4 C3 coref-relat that,multiple signaling pathways
R2 C7 C1 coref-ident The Tpl-2 kinase,Tpl-2
R3 C8 C5 coref-ident the nuclear factor of activated T cells (NFAT),NFAT
R4 C9 C2 coref-ident IL-2 expression in T-cell lines,IL-2 expression in T-cell lines
R5 C12 C7 coref-ident Tpl-2,The Tpl-2 kinase
R6 C14 C13 coref-relat that,mutant signaling molecules
R7 C17 C16 coref-relat that,combinations of signaling molecules
R8 C18 C15 coref-ident these pathways,the mitogen-activated protein kinase (MAPK) or the calcineurin/NFAT pathways
R9 C19 C18 coref-ident the MAPK and the calcineurin/NFAT pathway,these pathways
R10 C21 C11 coref-ident the IL-2 promoter,the IL-2 promoter
R11 C22 C12 coref-ident Tpl-2,Tpl-2
R12 C20 C10 coref-ident the activation of the IL-2 promoter by Tpl-2,the activation of the IL-2 promoter by Tpl-2
R13 C24 C21 coref-ident the IL-2 promoter,the IL-2 promoter
R14 C25 C24 coref-pron whose,the IL-2 promoter
R15 C26 C22 coref-ident Tpl-2,Tpl-2
R16 C27 C8 coref-ident NFAT,the nuclear factor of activated T cells (NFAT)
R17 C29 C26 coref-ident Tpl-2,Tpl-2
R18 C30 C28 coref-pron they,these findings
R19 C31 C24 coref-ident the IL-2 promoter,the IL-2 promoter
R20 C32 C27 coref-ident NFAT,NFAT
R21 C34 C33 coref-pron whose,a second factor
R22 C36 C29 coref-ident Tpl-2,Tpl-2
R23 C35 C33 coref-ident the second factor activated by Tpl-2,a second factor
R24 C37 C6 coref-ident NF-kappaB,NF-kappaB
R25 C40 C31 coref-ident the IL-2 promoter,the IL-2 promoter
R26 C39 C23 coref-ident the IL-2 promoter and an NFAT-driven minimal promoter,both the IL-2 promoter and an NFAT-driven minimal promoter
R27 C41 C36 coref-ident Tpl-2,Tpl-2
R28 C42 C38 coref-pron it,the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2
R29 C44 C43 coref-ident Both pathways,calcineurin-dependent and independent pathways

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes Tpl-2
T2 14-18 protein_molecule denotes IL-2
T3 33-45 cell_line denotes T-cell lines
T4 69-87 other_name denotes signaling pathways
T5 102-106 protein_molecule denotes NFAT
T6 111-120 protein_complex denotes NF-kappaB
T7 126-131 protein_molecule denotes Tpl-2
T8 153-188 protein_molecule denotes nuclear factor of activated T cells
T9 190-194 protein_molecule denotes NFAT
T10 208-212 protein_molecule denotes IL-2
T11 227-239 cell_line denotes T-cell lines
T12 281-285 protein_molecule denotes IL-2
T13 298-303 protein_molecule denotes Tpl-2
T14 320-346 protein_family_or_group denotes mutant signaling molecules
T15 364-396 protein_family_or_group denotes mitogen-activated protein kinase
T16 398-402 protein_family_or_group denotes MAPK
T17 411-422 protein_molecule denotes calcineurin
T18 422-427 protein_molecule denotes /NFAT
T19 472-491 protein_family_or_group denotes signaling molecules
T20 595-599 other_name denotes MAPK
T21 608-619 protein_molecule denotes calcineurin
T22 619-624 protein_molecule denotes /NFAT
T23 688-692 protein_molecule denotes IL-2
T24 705-710 protein_molecule denotes Tpl-2
T25 739-752 DNA_domain_or_region denotes IL-2 promoter
T26 760-764 protein_molecule denotes NFAT
T27 835-839 protein_molecule denotes Raf1
T28 866-870 protein_molecule denotes IL-2
T29 900-905 protein_molecule denotes Tpl-2
T30 931-955 protein_molecule denotes dominant negative mutant
T31 956-969 protein_molecule denotes MEK1S218/222A
T32 978-997 other_organic_compound denotes MEK1/MEK2 inhibitor
T33 998-1006 other_organic_compound denotes PD098059
T34 1032-1036 protein_molecule denotes NFAT
T35 1040-1044 protein_family_or_group denotes MAPK
T36 1103-1107 protein_family_or_group denotes MAPK
T37 1111-1116 protein_molecule denotes Tpl-2
T38 1170-1174 protein_molecule denotes MEK1
T39 1179-1183 protein_molecule denotes MEK2
T40 1240-1244 protein_molecule denotes IL-2
T41 1287-1291 protein_molecule denotes NFAT
T42 1337-1340 protein_family_or_group denotes MEK
T43 1367-1372 cell_line denotes COS-1
T44 1377-1387 cell_line denotes EL-4 cells
T45 1463-1468 protein_molecule denotes Tpl-2
T46 1472-1481 protein_complex denotes NF-kappaB
T47 1511-1515 protein_molecule denotes IL-2
T48 1532-1536 protein_molecule denotes NFAT
T49 1564-1569 protein_molecule denotes Tpl-2
T50 1595-1619 protein_family_or_group denotes dominant negative mutant
T51 1620-1624 protein_molecule denotes NFAT
T52 1672-1683 protein_molecule denotes calcineurin
T53 1694-1707 other_organic_compound denotes cyclosporin A
T54 1728-1733 protein_molecule denotes Tpl-2
T55 1743-1747 protein_molecule denotes NFAT
T56 1884-1889 protein_molecule denotes Bcl-2
T57 1893-1901 protein_molecule denotes Bcl-X(L)