PubMed:9835626
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 49-56 | cell_type | denotes | B cells |
| T2 | 80-100 | protein | denotes | metalloproteinases-1 |
| T3 | 328-362 | cell_line | denotes | Burkitt's lymphoma (BL) cell lines |
| T4 | 400-447 | protein | denotes | tissue inhibitor of metalloproteinases (TIMP)-1 |
| T5 | 471-495 | cell_line | denotes | TIMP-1-positive BL lines |
| T6 | 570-576 | protein | denotes | TIMP-1 |
| T7 | 586-592 | protein | denotes | TIMP-2 |
| T8 | 790-814 | cell_line | denotes | TIMP-1-negative BL lines |
| T9 | 816-822 | protein | denotes | TIMP-1 |
| T10 | 856-873 | protein | denotes | metalloproteinase |
| T11 | 921-927 | protein | denotes | TIMP-1 |
| T12 | 983-989 | protein | denotes | TIMP-1 |
| T13 | 1180-1202 | protein | denotes | anti-TIMP-1 antibodies |
| T14 | 1232-1238 | protein | denotes | TIMP-1 |
| T15 | 1285-1291 | protein | denotes | TIMP-1 |
| T16 | 1327-1333 | protein | denotes | Bcl-XL |
| T17 | 1342-1347 | protein | denotes | Bcl-2 |
| T18 | 1369-1378 | protein | denotes | NF-kappaB |
| T19 | 1446-1452 | protein | denotes | TIMP-1 |
| T20 | 1477-1484 | cell_type | denotes | B cells |
| T21 | 1519-1525 | protein | denotes | TIMP-1 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-101 | Sentence | denotes | In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1. |
| S2 | 102-300 | Sentence | denotes | Cellular pathways for induction of programmed cell death (PCD) have been identified, but little is known about specific extracellular matrix processes that may affect apoptosis along those pathways. |
| S3 | 301-448 | Sentence | denotes | In this study, a series of Burkitt's lymphoma (BL) cell lines were assayed for their expression of tissue inhibitor of metalloproteinases (TIMP)-1. |
| S4 | 449-544 | Sentence | denotes | Results indicate that TIMP-1-positive BL lines show resistance to cold-shock-induced apoptosis. |
| S5 | 545-815 | Sentence | denotes | Furthermore, recombinant TIMP-1, but not TIMP-2 or a synthetic metalloproteinase inhibitor (BB-94), confers resistance to apoptosis induced by both CD95-dependent and -independent (cold shock, serum deprivation, and gamma-radiation) pathways in TIMP-1-negative BL lines. |
| S6 | 816-958 | Sentence | denotes | TIMP-1 suppression of PCD is not due to metalloproteinase inhibition, as reduction and alkylation of the TIMP-1 did not abolish this activity. |
| S7 | 959-1135 | Sentence | denotes | Retroviral induction of TIMP-1 not only resulted in cell survival but also in continued DNA synthesis for up to 5 d in the absence of serum, while controls underwent apoptosis. |
| S8 | 1136-1271 | Sentence | denotes | This resistance to apoptosis is reversed by anti-TIMP-1 antibodies, demonstrating that secreted TIMP-1 is active in blocking apoptosis. |
| S9 | 1272-1414 | Sentence | denotes | Furthermore, TIMP-1 upregulation induced expression of Bcl-XL but not Bcl-2 as well as decreased NF-kappaB activity as compared with controls. |
| S10 | 1415-1548 | Sentence | denotes | These results demonstrate that TIMP-1 suppresses apoptosis in B cells and suggests a novel activity for TIMP-1 in tissue homeostasis. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 49-56 | NP | denotes | B cells |
| C3 | 80-100 | NP | denotes | metalloproteinases-1 |
| C2 | 60-100 | NP | denotes | tissue inhibitor of metalloproteinases-1 |
| C5 | 137-164 | NP | denotes | programmed cell death (PCD) |
| C4 | 102-164 | NP | denotes | Cellular pathways for induction of programmed cell death (PCD) |
| C6 | 213-252 | NP | denotes | specific extracellular matrix processes |
| C7 | 253-257 | NP | denotes | that |
| C8 | 269-278 | NP | denotes | apoptosis |
| C9 | 285-299 | NP | denotes | those pathways |
| C10 | 316-362 | NP | denotes | a series of Burkitt's lymphoma (BL) cell lines |
| C11 | 380-385 | NP | denotes | their |
| C13 | 420-447 | NP | denotes | metalloproteinases (TIMP)-1 |
| C12 | 400-447 | NP | denotes | tissue inhibitor of metalloproteinases (TIMP)-1 |
| C14 | 838-841 | NP | denotes | PCD |
| C15 | 856-884 | NP | denotes | metalloproteinase inhibition |
| C16 | 917-927 | NP | denotes | the TIMP-1 |
| C17 | 944-957 | NP | denotes | this activity |
| C18 | 983-989 | NP | denotes | TIMP-1 |
| C19 | 1106-1114 | NP | denotes | controls |
| C20 | 1125-1134 | NP | denotes | apoptosis |
| C21 | 1155-1164 | NP | denotes | apoptosis |
| C22 | 1261-1270 | NP | denotes | apoptosis |
| C23 | 1405-1413 | NP | denotes | controls |
| C24 | 1446-1452 | NP | denotes | TIMP-1 |
| C25 | 1477-1484 | NP | denotes | B cells |
| C26 | 1519-1525 | NP | denotes | TIMP-1 |
| R1 | C7 | C6 | coref-relat | that,specific extracellular matrix processes |
| R2 | C9 | C4 | coref-ident | those pathways,Cellular pathways for induction of programmed cell death (PCD) |
| R3 | C11 | C10 | coref-pron | their,a series of Burkitt's lymphoma (BL) cell lines |
| R4 | C13 | C3 | coref-ident | metalloproteinases (TIMP)-1,metalloproteinases-1 |
| R5 | C12 | C2 | coref-ident | tissue inhibitor of metalloproteinases (TIMP)-1,tissue inhibitor of metalloproteinases-1 |
| R6 | C14 | C5 | coref-ident | PCD,programmed cell death (PCD) |
| R7 | C16 | C13 | coref-ident | the TIMP-1,metalloproteinases (TIMP)-1 |
| R8 | C17 | C15 | coref-ident | this activity,metalloproteinase inhibition |
| R9 | C18 | C16 | coref-ident | TIMP-1,the TIMP-1 |
| R10 | C20 | C8 | coref-ident | apoptosis,apoptosis |
| R11 | C21 | C20 | coref-ident | apoptosis,apoptosis |
| R12 | C22 | C21 | coref-ident | apoptosis,apoptosis |
| R13 | C23 | C19 | coref-ident | controls,controls |
| R14 | C24 | C18 | coref-ident | TIMP-1,TIMP-1 |
| R15 | C25 | C1 | coref-ident | B cells,B cells |
| R16 | C26 | C24 | coref-ident | TIMP-1,TIMP-1 |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-20 | other_name | denotes | In vitro suppression |
| T2 | 49-56 | cell_type | denotes | B cells |
| T3 | 60-76 | other_name | denotes | tissue inhibitor |
| T4 | 80-100 | protein_molecule | denotes | metalloproteinases-1 |
| T5 | 102-119 | other_name | denotes | Cellular pathways |
| T6 | 137-158 | other_name | denotes | programmed cell death |
| T7 | 160-163 | other_name | denotes | PCD |
| T8 | 269-278 | other_name | denotes | apoptosis |
| T9 | 328-362 | cell_line | denotes | Burkitt's lymphoma (BL) cell lines |
| T10 | 400-447 | protein_molecule | denotes | tissue inhibitor of metalloproteinases (TIMP)-1 |
| T11 | 471-477 | protein_molecule | denotes | TIMP-1 |
| T12 | 515-543 | other_name | denotes | cold-shock-induced apoptosis |
| T13 | 570-576 | protein_molecule | denotes | TIMP-1 |
| T14 | 586-592 | protein_molecule | denotes | TIMP-2 |
| T15 | 608-635 | other_organic_compound | denotes | metalloproteinase inhibitor |
| T16 | 637-642 | other_organic_compound | denotes | BB-94 |
| T17 | 667-676 | other_name | denotes | apoptosis |
| T18 | 726-736 | other_name | denotes | cold shock |
| T19 | 738-755 | other_name | denotes | serum deprivation |
| T20 | 761-776 | other_name | denotes | gamma-radiation |
| T21 | 790-796 | protein_molecule | denotes | TIMP-1 |
| T22 | 816-822 | protein_molecule | denotes | TIMP-1 |
| T23 | 838-841 | other_name | denotes | PCD |
| T24 | 856-873 | protein_molecule | denotes | metalloproteinase |
| T25 | 921-927 | protein_molecule | denotes | TIMP-1 |
| T26 | 983-989 | protein_molecule | denotes | TIMP-1 |
| T27 | 1047-1060 | other_name | denotes | DNA synthesis |
| T28 | 1093-1098 | tissue | denotes | serum |
| T29 | 1125-1134 | other_name | denotes | apoptosis |
| T30 | 1155-1164 | other_name | denotes | apoptosis |
| T31 | 1180-1185 | protein_family_or_group | denotes | anti- |
| T32 | 1185-1191 | protein_molecule | denotes | TIMP-1 |
| T33 | 1232-1238 | protein_molecule | denotes | TIMP-1 |
| T34 | 1261-1270 | other_name | denotes | apoptosis |
| T35 | 1285-1291 | protein_molecule | denotes | TIMP-1 |
| T36 | 1327-1333 | protein_molecule | denotes | Bcl-XL |
| T37 | 1342-1347 | protein_molecule | denotes | Bcl-2 |
| T38 | 1369-1378 | protein_complex | denotes | NF-kappaB |
| T39 | 1446-1452 | protein_molecule | denotes | TIMP-1 |
| T40 | 1464-1473 | other_name | denotes | apoptosis |
| T41 | 1477-1484 | cell_type | denotes | B cells |
| T42 | 1500-1514 | other_name | denotes | novel activity |
| T43 | 1519-1525 | protein_molecule | denotes | TIMP-1 |
| T44 | 1529-1547 | other_name | denotes | tissue homeostasis |