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PubMed:9834272 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.
T2 123-141 Sentence denotes BACKGROUND & AIMS:
T3 142-226 Sentence denotes Entamoeba histolytica infection of the intestine can induce severe gut inflammation.
T4 227-428 Sentence denotes The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.
T5 429-564 Sentence denotes METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.
T6 565-902 Sentence denotes Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.
T7 903-911 Sentence denotes RESULTS:
T8 912-1146 Sentence denotes Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.
T9 1147-1357 Sentence denotes Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU-INT mice blocked the increase in intestinal permeability observed with amebic infection.
T10 1358-1370 Sentence denotes CONCLUSIONS:
T11 1371-1640 Sentence denotes Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.
T1 0-122 Sentence denotes Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.
T2 123-141 Sentence denotes BACKGROUND & AIMS:
T3 142-226 Sentence denotes Entamoeba histolytica infection of the intestine can induce severe gut inflammation.
T4 227-428 Sentence denotes The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.
T5 429-564 Sentence denotes METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.
T6 565-902 Sentence denotes Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.
T7 903-911 Sentence denotes RESULTS:
T8 912-1146 Sentence denotes Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.
T9 1147-1357 Sentence denotes Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU-INT mice blocked the increase in intestinal permeability observed with amebic infection.
T10 1358-1370 Sentence denotes CONCLUSIONS:
T11 1371-1640 Sentence denotes Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.

DisGeNET

Id Subject Object Predicate Lexical cue
T1 77-102 disease:C0002438 denotes amage in amebic infection
T3 77-102 disease:C0002438 denotes amage in amebic infection
T5 77-102 disease:C0002438 denotes amage in amebic infection
T7 77-102 disease:C0002438 denotes amage in amebic infection
T23 343-352 disease:C0013370 denotes amebiasis
T22 227-230 gene:65125 denotes The
T21 343-352 disease:C0002438 denotes amebiasis
T20 227-230 gene:65125 denotes The
T19 343-352 disease:C0013370 denotes amebiasis
T18 227-230 gene:5970 denotes The
T17 343-352 disease:C0002438 denotes amebiasis
T16 227-230 gene:5970 denotes The
T15 343-352 disease:C0013370 denotes amebiasis
T14 227-230 gene:6857 denotes The
T13 343-352 disease:C0002438 denotes amebiasis
T12 227-230 gene:6857 denotes The
T11 343-352 disease:C0013370 denotes amebiasis
T10 227-230 gene:64689 denotes The
T9 343-352 disease:C0002438 denotes amebiasis
T8 227-230 gene:64689 denotes The
T6 227-230 gene:65125 denotes The
T4 227-230 gene:5970 denotes The
T2 227-230 gene:6857 denotes The
T0 227-230 gene:64689 denotes The
R1 T0 T1 associated_with The,amage in amebic infection
R2 T2 T3 associated_with The,amage in amebic infection
R3 T4 T5 associated_with The,amage in amebic infection
R4 T6 T7 associated_with The,amage in amebic infection
R5 T8 T9 associated_with The,amebiasis
R6 T10 T11 associated_with The,amebiasis
R7 T12 T13 associated_with The,amebiasis
R8 T14 T15 associated_with The,amebiasis
R9 T16 T17 associated_with The,amebiasis
R10 T18 T19 associated_with The,amebiasis
R11 T20 T21 associated_with The,amebiasis
R12 T22 T23 associated_with The,amebiasis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 373-399 cell_type denotes intestinal epithelial cell
T2 571-597 cell_type denotes intestinal epithelial cell
T3 730-747 protein denotes human p65 subunit
T4 751-772 protein denotes nuclear factor kappaB
T5 868-879 cell_type denotes neutrophils
T6 986-1009 protein denotes human interleukin 1beta
T7 1014-1027 protein denotes interleukin 8
T8 1031-1058 cell_type denotes intestinal epithelial cells
T9 1244-1255 cell_type denotes neutrophils
T10 1371-1398 cell_type denotes Intestinal epithelial cells
T11 1618-1639 protein denotes nuclear factor kappaB

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-122 Sentence denotes Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.
S2 123-226 Sentence denotes BACKGROUND & AIMS: Entamoeba histolytica infection of the intestine can induce severe gut inflammation.
S3 227-428 Sentence denotes The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.
S4 429-564 Sentence denotes METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.
S5 565-902 Sentence denotes Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.
S6 903-1146 Sentence denotes RESULTS: Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.
S7 1147-1357 Sentence denotes Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU-INT mice blocked the increase in intestinal permeability observed with amebic infection.
S8 1358-1640 Sentence denotes CONCLUSIONS: Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 106-121 NP denotes human intestine
C2 177-190 NP denotes the intestine
C4 343-352 NP denotes amebiasis
C3 277-352 NP denotes the host inflammatory response in the tissue damage observed with amebiasis
C5 414-427 NP denotes that response
C6 438-462 NP denotes E. histolytica infection
C7 513-563 NP denotes severe combined immunodeficient (SCID-HU-INT) mice
C8 624-640 NP denotes amebic infection
C9 694-722 NP denotes an antisense oligonucleotide
C10 751-772 NP denotes nuclear factor kappaB
C11 833-842 NP denotes amebiasis
C13 885-901 NP denotes SCID-HU-INT mice
C12 868-901 NP denotes neutrophils from SCID-HU-INT mice
C14 930-959 NP denotes the antisense oligonucleotide
C15 1031-1058 NP denotes intestinal epithelial cells
C16 1194-1223 NP denotes the antisense oligonucleotide
C18 1261-1277 NP denotes SCID-HU-INT mice
C17 1244-1277 NP denotes neutrophils from SCID-HU-INT mice
C19 1340-1356 NP denotes amebic infection
C20 1371-1398 NP denotes Intestinal epithelial cells
C21 1497-1522 NP denotes E. histolytica infection;
C22 1618-1639 NP denotes nuclear factor kappaB
R1 C2 C1 coref-ident the intestine,human intestine
R2 C5 C3 coref-ident that response,the host inflammatory response in the tissue damage observed with amebiasis
R3 C11 C4 coref-ident amebiasis,amebiasis
R4 C13 C7 coref-ident SCID-HU-INT mice,severe combined immunodeficient (SCID-HU-INT) mice
R5 C14 C9 coref-ident the antisense oligonucleotide,an antisense oligonucleotide
R6 C16 C14 coref-ident the antisense oligonucleotide,the antisense oligonucleotide
R7 C18 C13 coref-ident SCID-HU-INT mice,SCID-HU-INT mice
R8 C17 C12 coref-ident neutrophils from SCID-HU-INT mice,neutrophils from SCID-HU-INT mice
R9 C19 C8 coref-ident amebic infection,amebic infection
R10 C20 C15 coref-ident Intestinal epithelial cells,intestinal epithelial cells
R11 C21 C6 coref-ident E. histolytica infection;,E. histolytica infection
R12 C22 C10 coref-ident nuclear factor kappaB,nuclear factor kappaB

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-38 other_name denotes Epithelial cell-initiated inflammation
T2 63-82 other_name denotes early tissue damage
T3 86-102 other_name denotes amebic infection
T4 106-121 body_part denotes human intestine
T5 142-163 mono_cell denotes Entamoeba histolytica
T6 202-225 other_name denotes severe gut inflammation
T7 286-307 other_name denotes inflammatory response
T8 315-328 other_name denotes tissue damage
T9 343-352 other_name denotes amebiasis
T10 373-399 cell_type denotes intestinal epithelial cell
T11 438-452 mono_cell denotes E. histolytica
T12 482-509 other_artificial_source denotes human intestinal xenografts
T13 513-563 other_artificial_source denotes severe combined immunodeficient (SCID-HU-INT) mice
T14 571-597 cell_type denotes intestinal epithelial cell
T15 624-640 other_name denotes amebic infection
T16 663-690 other_name denotes intraluminal administration
T17 730-747 protein_subunit denotes human p65 subunit
T18 751-772 protein_complex denotes nuclear factor kappaB
T19 805-818 other_name denotes tissue damage
T20 833-842 other_name denotes amebiasis
T21 868-879 cell_type denotes neutrophils
T22 885-901 other_artificial_source denotes SCID-HU-INT mice
T23 934-959 polynucleotide denotes antisense oligonucleotide
T24 986-1009 protein_molecule denotes human interleukin 1beta
T25 1014-1027 protein_molecule denotes interleukin 8
T26 1031-1058 cell_type denotes intestinal epithelial cells
T27 1100-1114 mono_cell denotes E. histolytica
T28 1169-1190 other_name denotes inflammatory response
T29 1198-1223 polynucleotide denotes antisense oligonucleotide
T30 1244-1255 cell_type denotes neutrophils
T31 1261-1277 other_artificial_source denotes SCID-HU-INT mice
T32 1302-1325 other_name denotes intestinal permeability
T33 1340-1356 other_name denotes amebic infection
T34 1371-1398 cell_type denotes Intestinal epithelial cells
T35 1411-1432 other_name denotes inflammatory response
T36 1448-1467 other_name denotes neutrophil-mediated
T37 1468-1481 other_name denotes tissue damage
T38 1497-1511 mono_cell denotes E. histolytica
T39 1528-1548 other_name denotes inflammatory cascade
T40 1618-1639 protein_complex denotes nuclear factor kappaB