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PubMed:9831865 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 49-63 protein denotes STAT5 proteins
T2 67-71 protein denotes IL-5
T3 76-82 protein denotes GM-CSF
T4 137-173 cell_line denotes human CD34+ hematopoietic stem cells
T5 175-188 protein denotes Interleukin-5
T6 190-194 protein denotes IL-5
T7 200-248 protein denotes granulocyte macrophage-colony stimulating factor
T8 250-256 protein denotes GM-CSF
T9 272-281 protein denotes cytokines
T10 340-356 cell_type denotes myeloid lineages
T11 362-365 protein denotes JAK
T12 365-370 protein denotes /STAT
T13 474-483 protein denotes cytokines
T14 531-540 protein denotes cytokines
T15 567-587 protein denotes 80 kDa STAT5 isoform
T16 742-778 cell_line denotes human CD34+ hematopoietic stem cells
T17 794-805 cell_type denotes eosinophils
T18 930-944 protein denotes STAT5B protein
T19 967-971 protein denotes IL-5
T20 973-991 cell_type denotes eosinophil lineage
T21 997-1003 protein denotes GM-CSF
T22 1005-1023 cell_type denotes neutrophil lineage
T23 1136-1156 protein denotes 80 kDa STAT5 isoform
T24 1184-1217 protein denotes heterodimer DNA-binding complexes
T25 1252-1266 protein denotes STAT5 proteins
T26 1319-1324 protein denotes STAT5

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-174 Sentence denotes Differential activation of functionally distinct STAT5 proteins by IL-5 and GM-CSF during eosinophil and neutrophil differentiation from human CD34+ hematopoietic stem cells.
S2 175-357 Sentence denotes Interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) are important cytokines for the proliferation, differentiation, and activation of myeloid lineages.
S3 358-484 Sentence denotes The JAK/STAT pathway is one of the signaling pathways implicated in mediating biological responses induced by these cytokines.
S4 485-611 Sentence denotes Previous studies have demonstrated that these cytokines predominantly activate an 80 kDa STAT5 isoform in mature granulocytes.
S5 612-822 Sentence denotes To better understand the role of STAT proteins during growth and differentiation of granulocytes, we evaluated differentiation of human CD34+ hematopoietic stem cells ex vivo toward eosinophils and neutrophils.
S6 823-1025 Sentence denotes Bandshift experiments showed that in an early stage of both differentiation pathways (14 days), the 94 kDa STAT5B protein was activated by both IL-5 (eosinophil lineage) and GM-CSF (neutrophil lineage).
S7 1026-1267 Sentence denotes However, during maturation of both lineages (days 21 and 28), increased expression of a functionally distinct 80 kDa STAT5 isoform was observed, resulting in heterodimer DNA-binding complexes containing both the 94 and 80 kDa STAT5 proteins.
S8 1268-1501 Sentence denotes The finding that functionally distinct isoforms of STAT5 are activated during the early and late differentiation stages of granulocytes suggests that they might be involved in regulating different biological functions in these cells.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 27-63 NP denotes functionally distinct STAT5 proteins
C2 67-82 NP denotes IL-5 and GM-CSF
C3 137-173 NP denotes human CD34+ hematopoietic stem cells
C4 175-257 NP denotes Interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF)
C5 468-483 NP denotes these cytokines
C6 525-540 NP denotes these cytokines
C7 564-587 NP denotes an 80 kDa STAT5 isoform
C8 696-708 NP denotes granulocytes
C9 742-786 NP denotes human CD34+ hematopoietic stem cells ex vivo
C10 1112-1156 NP denotes a functionally distinct 80 kDa STAT5 isoform
C11 1268-1279 NP denotes The finding
C12 1280-1284 NP denotes that
C13 1285-1324 NP denotes functionally distinct isoforms of STAT5
C14 1391-1403 NP denotes granulocytes
C15 1418-1422 NP denotes they
C16 1489-1500 NP denotes these cells
R1 C4 C2 coref-ident Interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF),IL-5 and GM-CSF
R2 C5 C4 coref-ident these cytokines,Interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF)
R3 C6 C5 coref-ident these cytokines,these cytokines
R4 C9 C3 coref-ident human CD34+ hematopoietic stem cells ex vivo,human CD34+ hematopoietic stem cells
R5 C10 C7 coref-ident a functionally distinct 80 kDa STAT5 isoform,an 80 kDa STAT5 isoform
R6 C12 C11 coref-relat that,The finding
R7 C13 C1 coref-ident functionally distinct isoforms of STAT5,functionally distinct STAT5 proteins
R8 C14 C8 coref-ident granulocytes,granulocytes
R9 C15 C13 coref-pron they,functionally distinct isoforms of STAT5
R10 C16 C9 coref-ident these cells,human CD34+ hematopoietic stem cells ex vivo

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 49-63 protein_family_or_group denotes STAT5 proteins
T2 67-71 protein_molecule denotes IL-5
T3 76-82 protein_molecule denotes GM-CSF
T4 137-173 cell_line denotes human CD34+ hematopoietic stem cells
T5 175-188 protein_molecule denotes Interleukin-5
T6 190-194 protein_molecule denotes IL-5
T7 200-248 protein_molecule denotes granulocyte macrophage-colony stimulating factor
T8 250-256 protein_molecule denotes GM-CSF
T9 272-281 protein_family_or_group denotes cytokines
T10 290-303 other_name denotes proliferation
T11 305-320 other_name denotes differentiation
T12 340-356 cell_type denotes myeloid lineages
T13 362-365 protein_family_or_group denotes JAK
T14 365-370 protein_family_or_group denotes /STAT
T15 393-411 other_name denotes signaling pathways
T16 436-456 other_name denotes biological responses
T17 474-483 protein_family_or_group denotes cytokines
T18 531-540 protein_family_or_group denotes cytokines
T19 567-587 protein_molecule denotes 80 kDa STAT5 isoform
T20 677-692 other_name denotes differentiation
T21 723-738 other_name denotes differentiation
T22 742-778 cell_line denotes human CD34+ hematopoietic stem cells
T23 794-805 cell_type denotes eosinophils
T24 823-844 other_name denotes Bandshift experiments
T25 883-898 other_name denotes differentiation
T26 930-944 protein_molecule denotes STAT5B protein
T27 967-971 protein_molecule denotes IL-5
T28 973-991 cell_type denotes eosinophil lineage
T29 997-1003 protein_molecule denotes GM-CSF
T30 1005-1023 cell_type denotes neutrophil lineage
T31 1136-1156 protein_molecule denotes 80 kDa STAT5 isoform
T32 1184-1217 protein_complex denotes heterodimer DNA-binding complexes
T33 1252-1266 protein_family_or_group denotes STAT5 proteins
T34 1319-1324 protein_molecule denotes STAT5
T35 1365-1380 other_name denotes differentiation