PubMed:9831170 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-14	protein	denotes	Thrombopoietin
T2	33-47	protein	denotes	Thrombopoietin
T3	49-52	protein	denotes	TPO
T4	312-342	cell_type	denotes	hematopoietic progenitor cells
T5	354-364	cell_type	denotes	stem cells
T6	366-369	protein	denotes	TPO
T7	446-449	protein	denotes	TPO
T8	518-530	protein	denotes	Mpl receptor
T9	577-589	protein	denotes	Mpl receptor
T10	609-643	protein	denotes	hematopoietin receptor superfamily
T11	791-795	protein	denotes	JAK2
T12	795-801	protein	denotes	/STAT5
T13	883-887	protein	denotes	MAPK
T14	963-966	protein	denotes	TPO

Id	Subject	Object	Predicate	Lexical cue
S1	0-32	Sentence	denotes	Thrombopoietin and its receptor.
S2	33-214	Sentence	denotes	Thrombopoietin (TPO), the primary physiological regulator of platelet production, was initially thought to be a lineage-specific factor acting predominantly on megakaryocytopoiesis.
S3	215-365	Sentence	denotes	Detailed studies establish that this cytokine mediates biological effects on a broad spectrum of hematopoietic progenitor cells, including stem cells.
S4	366-438	Sentence	denotes	TPO is a hormone constitutively produced mainly by the liver and kidney.
S5	439-572	Sentence	denotes	Plasma TPO levels are regulated by the platelet and megakaryocyte mass through Mpl receptor binding, internalization and degradation.
S6	573-678	Sentence	denotes	The Mpl receptor is a member of the hematopoietin receptor superfamily lacking intrinsic kinase activity.
S7	679-896	Sentence	denotes	Upon ligand-induced Mpl homodimerization, the major signaling events for proliferation are mediated through the JAK2/STAT5 pathway, while differentiation might occur through a prolonged activation of the MAPK pathway.
S8	897-1070	Sentence	denotes	Preclinical and clinical studies demonstrate the potential use of TPO in a variety of contexts, but it is too early to evaluate its benefit in reducing platelet transfusion.

Id	Subject	Object	Predicate	Lexical cue
C1	0-14	NP	denotes	Thrombopoietin
C2	19-22	NP	denotes	its
C3	33-53	NP	denotes	Thrombopoietin (TPO)
C4	55-113	NP	denotes	the primary physiological regulator of platelet production
C5	247-260	NP	denotes	this cytokine
C6	366-369	NP	denotes	TPO
C7	963-966	NP	denotes	TPO
C8	1025-1028	NP	denotes	its
R1	C2	C1	coref-pron	its,Thrombopoietin
R2	C3	C1	coref-ident	Thrombopoietin (TPO),Thrombopoietin
R3	C4	C3	coref-appos	the primary physiological regulator of platelet production,Thrombopoietin (TPO)
R4	C5	C3	coref-ident	this cytokine,Thrombopoietin (TPO)
R5	C6	C5	coref-ident	TPO,this cytokine
R6	C7	C6	coref-ident	TPO,TPO
R7	C8	C7	coref-pron	its,TPO

Id	Subject	Object	Predicate	Lexical cue
T1	0-14	protein_molecule	denotes	Thrombopoietin
T2	33-47	protein_molecule	denotes	Thrombopoietin
T3	49-52	protein_molecule	denotes	TPO
T4	59-90	other_name	denotes	primary physiological regulator
T5	94-113	other_name	denotes	platelet production
T6	193-213	other_name	denotes	megakaryocytopoiesis
T7	312-342	cell_type	denotes	hematopoietic progenitor cells
T8	354-364	cell_type	denotes	stem cells
T9	366-369	protein_molecule	denotes	TPO
T10	421-426	body_part	denotes	liver
T11	431-437	body_part	denotes	kidney
T12	439-445	other_name	denotes	Plasma
T13	446-449	protein_molecule	denotes	TPO
T14	518-530	protein_family_or_group	denotes	Mpl receptor
T15	540-555	other_name	denotes	internalization
T16	560-571	other_name	denotes	degradation
T17	577-589	protein_family_or_group	denotes	Mpl receptor
T18	609-643	protein_family_or_group	denotes	hematopoietin receptor superfamily
T19	662-677	other_name	denotes	kinase activity
T20	699-719	other_name	denotes	Mpl homodimerization
T21	791-795	protein_molecule	denotes	JAK2
T22	795-801	protein_molecule	denotes	/STAT5
T23	883-887	protein_family_or_group	denotes	MAPK
T24	963-966	protein_molecule	denotes	TPO
T25	1049-1069	other_name	denotes	platelet transfusion