PubMed:9826539 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-10	DNA	denotes	Spi-1/PU.1
T2	11-25	DNA	denotes	proto-oncogene
T3	97-107	cell_line	denotes	K562 cells
T4	109-119	protein	denotes	Spi-1/PU.1
T5	125-159	protein	denotes	hematopoietic transcription factor
T6	167-177	protein	denotes	Ets family
T7	227-232	protein	denotes	spi-1
T8	273-301	cell_type	denotes	human myeloid leukemia cells
T9	303-313	cell_line	denotes	K562 cells
T10	345-368	DNA	denotes	spi-1 expression vector
T11	374-396	cell_line	denotes	transfected cell lines
T12	426-436	RNA	denotes	spi-1 mRNA
T13	458-463	protein	denotes	Spi-1
T14	490-513	cell_line	denotes	spi-1 transfected cells
T15	650-655	protein	denotes	spi-1
T16	758-777	cell_line	denotes	spi-1 transfectants
T17	785-790	protein	denotes	spi-1
T18	902-907	DNA	denotes	Spi-1
T19	934-962	cell_line	denotes	human myeloid leukemia cells

Id	Subject	Object	Predicate	Lexical cue
S1	0-108	Sentence	denotes	Spi-1/PU.1 proto-oncogene induces opposite effects on monocytic and erythroid differentiation of K562 cells.
S2	109-178	Sentence	denotes	Spi-1/PU.1 is a hematopoietic transcription factor of the Ets family.
S3	179-369	Sentence	denotes	To analyze the effects of ectopic expression of spi-1 on the proliferation/differentiation of human myeloid leukemia cells, K562 cells were stably transfected with a spi-1 expression vector.
S4	370-485	Sentence	denotes	The transfected cell lines expressed elevated levels of spi-1 mRNA and protein and high Spi-1-DNA binding activity.
S5	486-577	Sentence	denotes	The spi-1 transfected cells showed reduced growth rates and reduced clonogenic cell growth.
S6	578-855	Sentence	denotes	When the erythroid and monocytic differentiation markers were analyzed, spi-1 overexpression resulted in opposite effects: erythroid differentiation was significantly inhibited in spi-1 transfectants, while spi-1 overexpression increased the monocytic differentiation of cells.
S7	856-963	Sentence	denotes	These results indicate a differential role of Spi-1 on the differentiation of human myeloid leukemia cells.

Id	Subject	Object	Predicate	Lexical cue
C1	97-107	NP	denotes	K562 cells
C2	227-232	NP	denotes	spi-1
C3	273-301	NP	denotes	human myeloid leukemia cells
C4	303-313	NP	denotes	K562 cells
C5	650-670	NP	denotes	spi-1 overexpression
C6	785-805	NP	denotes	spi-1 overexpression
C7	849-854	NP	denotes	cells
C8	902-907	NP	denotes	Spi-1
C9	934-962	NP	denotes	human myeloid leukemia cells
R1	C4	C1	coref-ident	K562 cells,K562 cells
R2	C6	C5	coref-ident	spi-1 overexpression,spi-1 overexpression
R3	C7	C4	coref-ident	cells,K562 cells
R4	C8	C2	coref-ident	Spi-1,spi-1
R5	C9	C3	coref-ident	human myeloid leukemia cells,human myeloid leukemia cells

Id	Subject	Object	Predicate	Lexical cue
T1	0-10	DNA_domain_or_region	denotes	Spi-1/PU.1
T2	11-25	DNA_family_or_group	denotes	proto-oncogene
T3	97-107	cell_line	denotes	K562 cells
T4	109-119	protein_molecule	denotes	Spi-1/PU.1
T5	125-159	protein_family_or_group	denotes	hematopoietic transcription factor
T6	167-177	protein_family_or_group	denotes	Ets family
T7	227-232	protein_molecule	denotes	spi-1
T8	240-269	other_name	denotes	proliferation/differentiation
T9	273-301	cell_type	denotes	human myeloid leukemia cells
T10	303-313	cell_line	denotes	K562 cells
T11	345-350	protein_molecule	denotes	spi-1
T12	374-396	cell_line	denotes	transfected cell lines
T13	426-431	protein_molecule	denotes	spi-1
T14	458-463	protein_molecule	denotes	Spi-1
T15	490-495	protein_molecule	denotes	spi-1
T16	554-576	other_name	denotes	clonogenic cell growth
T17	650-655	protein_molecule	denotes	spi-1
T18	701-726	other_name	denotes	erythroid differentiation
T19	758-763	protein_molecule	denotes	spi-1
T20	785-790	protein_molecule	denotes	spi-1
T21	820-845	other_name	denotes	monocytic differentiation
T22	902-907	DNA_molecule	denotes	Spi-1
T23	934-962	cell_line	denotes	human myeloid leukemia cells