> top > docs > PubMed:9822657 > annotations

PubMed:9822657 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Components of a calmodulin-dependent protein kinase cascade.
T2 61-190 Sentence denotes Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.
T3 191-389 Sentence denotes Ca2+/calmodulin-dependent protein kinases I and IV (CaMKI and CaMKIV, respectively) require phosphorylation on an equivalent single Thr in the activation loop of subdomain VIII for maximal activity.
T4 390-512 Sentence denotes Two distinct CaMKI/IV kinases, CaMKKalpha and CaMKKbeta, were purified from rat brain and partially sequenced (Edelman, A.
T5 513-545 Sentence denotes M., Mitchelhill, K., Selbert, M.
T6 546-562 Sentence denotes A., Anderson, K.
T7 563-575 Sentence denotes A., Hook, S.
T8 576-608 Sentence denotes S., Stapleton, D., Goldstein, E.
T9 609-622 Sentence denotes G., Means, A.
T10 623-639 Sentence denotes R., and Kemp, B.
T11 640-652 Sentence denotes E. (1996) J.
T12 653-658 Sentence denotes Biol.
T13 659-664 Sentence denotes Chem.
T14 665-683 Sentence denotes 271, 10806-10810).
T15 684-922 Sentence denotes We report here the cloning and sequencing of cDNAs for human and rat CaMKKbeta, tissue and regional brain localization of CaMKKbeta protein, and mRNA and functional characterization of recombinant CaMKKbeta in vitro and in Jurkat T cells.
T16 923-1077 Sentence denotes The sequences of human and rat CaMKKbeta demonstrate 65% identity and 80% similarity with CaMKKalpha and 30-40% identity with CaMKI and CaMKIV themselves.
T17 1078-1220 Sentence denotes CaMKKbeta is broadly distributed among rat tissues with highest levels in CaMKIV-expressing tissues such as brain, thymus, spleen, and testis.
T18 1221-1294 Sentence denotes In brain, CaMKKbeta tracks more closely with CaMKIV than does CaMKKalpha.
T19 1295-1470 Sentence denotes Bacterially expressed CaMKKbeta undergoes intramolecular autophosphorylation, is regulated by Ca2+/CaM, and phosphorylates CaMKI and CaMKIV on Thr177 and Thr200, respectively.
T20 1471-1649 Sentence denotes CaMKKbeta activates both CaMKI and CaMKIV when coexpressed in Jurkat T cells as judged by phosphorylated cAMP response element-binding protein-dependent reporter gene expression.
T21 1650-1793 Sentence denotes CaMKKbeta activity is enhanced by elevation of intracellular Ca2+, although substantial activity is observed at the resting Ca2+ concentration.
T22 1794-1965 Sentence denotes The strict Ca2+ requirement of CaMKIV-dependent phosphorylation of cAMP response element-binding protein, is therefore controlled at the level of CaMKIV rather than CaMKK.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 470-475 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 784-789 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T3 1186-1191 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T4 1193-1199 http://purl.obolibrary.org/obo/MAT_0000080 denotes thymus
T5 1201-1207 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T6 1213-1219 http://purl.obolibrary.org/obo/MAT_0000132 denotes testis
T7 1224-1229 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 470-475 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 784-789 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 1186-1191 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T4 1193-1199 Body_part denotes thymus http://purl.obolibrary.org/obo/MAT_0000080
T5 1201-1207 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085
T6 1213-1219 Body_part denotes testis http://purl.obolibrary.org/obo/MAT_0000132
T7 1224-1229 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 466-469 OrganismTaxon denotes rat 10114|10116
T3 739-744 OrganismTaxon denotes human 9606
T4 749-752 OrganismTaxon denotes rat 10114|10116
T6 940-945 OrganismTaxon denotes human 9606
T7 950-953 OrganismTaxon denotes rat 10114|10116
T9 1117-1120 OrganismTaxon denotes rat 10114|10116
T11 1193-1199 OrganismTaxon denotes thymus 49990

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 470-475 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 764-770 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T4 784-789 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T6 1186-1191 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T8 1193-1199 Body_part denotes thymus http://purl.obolibrary.org/obo/UBERON_0002370
T9 1201-1207 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T10 1213-1219 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T11 1224-1229 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T13 1697-1710 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 914-921 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 1540-1547 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084