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PubMed:9800475 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes [Molecular mechanism of cytokine gene expression in Th1 and Th2].
T2 66-214 Sentence denotes Upon activation by antigens, helper T cells differentiate into one of several subsets, characterized by their distinct cytokine-production patterns.
T3 215-404 Sentence denotes Among these subsets, Th1 cells are known to activate cellular immunity resulting in inflammatory response, whereas Th2 cells induce humoral and allergic responses and suppress inflammation.
T4 405-522 Sentence denotes Th1 and Th2 effector functions and their development are attributable to their distinct cytokine expression patterns.
T5 523-715 Sentence denotes Recent reports have demonstrated that differential expression of cell surface molecules, such as adhesion molecule and chemokine receptor, is involved in their recruitment into target tissues.
T6 716-906 Sentence denotes It is, therefore, suggested that clarification of the mechanisms of differential gene expression in Th1/Th2 should lead to rational strategies for manipulating pathological immune responses.
T7 907-1007 Sentence denotes Activation of helper T cells mediated by the T cell receptor induces a series of biochemical events.
T8 1008-1156 Sentence denotes Among them, both the activation of PKC/Ras- and CaM/CN-mediated pathways play a central role in the signal transduction of cytokine gene expression.
T9 1157-1342 Sentence denotes Closer examination using non-transformed murine Th1 and Th2 clones suggested that a balance between the activities of the two signaling pathways contributes to cytokine gene expression.
T10 1343-1479 Sentence denotes We propose that one of the targets of PGE2, whose effect distinguishes Th1 from Th2, resides in the downstream PKC/Ras-mediated pathway.
T1 0-65 Sentence denotes [Molecular mechanism of cytokine gene expression in Th1 and Th2].
T2 66-214 Sentence denotes Upon activation by antigens, helper T cells differentiate into one of several subsets, characterized by their distinct cytokine-production patterns.
T3 215-404 Sentence denotes Among these subsets, Th1 cells are known to activate cellular immunity resulting in inflammatory response, whereas Th2 cells induce humoral and allergic responses and suppress inflammation.
T4 405-522 Sentence denotes Th1 and Th2 effector functions and their development are attributable to their distinct cytokine expression patterns.
T5 523-715 Sentence denotes Recent reports have demonstrated that differential expression of cell surface molecules, such as adhesion molecule and chemokine receptor, is involved in their recruitment into target tissues.
T6 716-906 Sentence denotes It is, therefore, suggested that clarification of the mechanisms of differential gene expression in Th1/Th2 should lead to rational strategies for manipulating pathological immune responses.
T7 907-1007 Sentence denotes Activation of helper T cells mediated by the T cell receptor induces a series of biochemical events.
T8 1008-1156 Sentence denotes Among them, both the activation of PKC/Ras- and CaM/CN-mediated pathways play a central role in the signal transduction of cytokine gene expression.
T9 1157-1342 Sentence denotes Closer examination using non-transformed murine Th1 and Th2 clones suggested that a balance between the activities of the two signaling pathways contributes to cytokine gene expression.
T10 1343-1479 Sentence denotes We propose that one of the targets of PGE2, whose effect distinguishes Th1 from Th2, resides in the downstream PKC/Ras-mediated pathway.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 24-37 DNA denotes cytokine gene
T2 52-55 cell_line denotes Th1
T3 60-63 cell_line denotes Th2
T4 85-93 protein denotes antigens
T5 95-109 cell_type denotes helper T cells
T6 185-193 protein denotes cytokine
T7 236-245 cell_line denotes Th1 cells
T8 330-339 cell_line denotes Th2 cells
T9 493-501 protein denotes cytokine
T10 620-637 protein denotes adhesion molecule
T11 642-660 protein denotes chemokine receptor
T12 816-823 cell_line denotes Th1/Th2
T13 921-935 cell_type denotes helper T cells
T14 1131-1144 DNA denotes cytokine gene
T15 1182-1223 cell_line denotes non-transformed murine Th1 and Th2 clones
T16 1317-1330 DNA denotes cytokine gene
T17 1414-1417 cell_line denotes Th1
T18 1454-1461 protein denotes PKC/Ras

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-64 Sentence denotes [Molecular mechanism of cytokine gene expression in Th1 and Th2]
S2 66-214 Sentence denotes Upon activation by antigens, helper T cells differentiate into one of several subsets, characterized by their distinct cytokine-production patterns.
S3 215-404 Sentence denotes Among these subsets, Th1 cells are known to activate cellular immunity resulting in inflammatory response, whereas Th2 cells induce humoral and allergic responses and suppress inflammation.
S4 405-522 Sentence denotes Th1 and Th2 effector functions and their development are attributable to their distinct cytokine expression patterns.
S5 523-715 Sentence denotes Recent reports have demonstrated that differential expression of cell surface molecules, such as adhesion molecule and chemokine receptor, is involved in their recruitment into target tissues.
S6 716-906 Sentence denotes It is, therefore, suggested that clarification of the mechanisms of differential gene expression in Th1/Th2 should lead to rational strategies for manipulating pathological immune responses.
S7 907-1007 Sentence denotes Activation of helper T cells mediated by the T cell receptor induces a series of biochemical events.
S8 1008-1156 Sentence denotes Among them, both the activation of PKC/Ras- and CaM/CN-mediated pathways play a central role in the signal transduction of cytokine gene expression.
S9 1157-1342 Sentence denotes Closer examination using non-transformed murine Th1 and Th2 clones suggested that a balance between the activities of the two signaling pathways contributes to cytokine gene expression.
S10 1343-1479 Sentence denotes We propose that one of the targets of PGE2, whose effect distinguishes Th1 from Th2, resides in the downstream PKC/Ras-mediated pathway.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 95-109 NP denotes helper T cells
C2 136-151 NP denotes several subsets
C3 170-175 NP denotes their
C4 221-234 NP denotes these subsets
C5 236-245 NP denotes Th1 cells
C6 330-339 NP denotes Th2 cells
C7 588-610 NP denotes cell surface molecules
C8 677-682 NP denotes their
C9 921-935 NP denotes helper T cells
C10 976-1006 NP denotes a series of biochemical events
C11 1014-1018 NP denotes them
C12 1043-1080 NP denotes PKC/Ras- and CaM/CN-mediated pathways
C13 1131-1155 NP denotes cytokine gene expression
C14 1275-1301 NP denotes the two signaling pathways
C15 1317-1341 NP denotes cytokine gene expression
C16 1359-1385 NP denotes one of the targets of PGE2
C17 1387-1392 NP denotes whose
C18 1414-1417 NP denotes Th1
C19 1423-1426 NP denotes Th2
R1 C3 C1 coref-pron their,helper T cells
R2 C4 C2 coref-ident these subsets,several subsets
R3 C8 C7 coref-pron their,cell surface molecules
R4 C9 C1 coref-ident helper T cells,helper T cells
R5 C11 C10 coref-pron them,a series of biochemical events
R6 C14 C12 coref-ident the two signaling pathways,PKC/Ras- and CaM/CN-mediated pathways
R7 C15 C13 coref-ident cytokine gene expression,cytokine gene expression
R8 C17 C16 coref-relat whose,one of the targets of PGE2
R9 C18 C5 coref-ident Th1,Th1 cells
R10 C19 C6 coref-ident Th2,Th2 cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 24-37 DNA_family_or_group denotes cytokine gene
T2 52-55 cell_line denotes Th1
T3 60-63 cell_line denotes Th2
T4 85-93 protein_family_or_group denotes antigens
T5 95-109 cell_type denotes helper T cells
T6 185-193 protein_family_or_group denotes cytokine
T7 236-245 cell_line denotes Th1 cells
T8 268-285 other_name denotes cellular immunity
T9 299-320 other_name denotes inflammatory response
T10 330-339 cell_line denotes Th2 cells
T11 359-377 other_name denotes allergic responses
T12 391-403 other_name denotes inflammation
T13 493-501 protein_family_or_group denotes cytokine
T14 620-637 protein_family_or_group denotes adhesion molecule
T15 642-660 protein_family_or_group denotes chemokine receptor
T16 784-812 other_name denotes differential gene expression
T17 816-823 cell_line denotes Th1/Th2
T18 863-905 other_name denotes manipulating pathological immune responses
T19 921-935 cell_type denotes helper T cells
T20 952-967 other_name denotes T cell receptor
T21 1131-1144 DNA_family_or_group denotes cytokine gene
T22 1317-1330 DNA_family_or_group denotes cytokine gene
T23 1381-1385 peptide denotes PGE2
T24 1414-1417 cell_line denotes Th1
T25 1423-1426 other_artificial_source denotes Th2
T26 1454-1461 protein_molecule denotes PKC/Ras