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PubMed:9794375 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 32-35 protein denotes HS1
T2 57-92 protein denotes nuclear factor of activated T cells
T3 123-137 cell_line denotes Jurkat T cells
T4 170-173 protein denotes CD3
T5 206-209 protein denotes CD2
T6 214-218 protein denotes CD28
T7 220-223 protein denotes CD3
T8 225-228 protein denotes CD2
T9 234-238 protein denotes CD28
T10 278-291 cell_type denotes T lymphocytes
T11 394-426 protein denotes intracellular signaling proteins
T12 438-441 protein denotes Vav
T13 443-446 protein denotes Cbl
T14 448-477 protein denotes p85 phosphoinositide 3-kinase
T15 487-505 protein denotes Src family kinases
T16 506-509 protein denotes Lck
T17 514-517 protein denotes Fyn
T18 531-534 protein denotes CD3
T19 580-583 protein denotes HS1
T20 587-653 protein denotes 75-kDa hematopoietic cell-specific intracellular signaling protein
T21 703-706 protein denotes HS1
T22 757-760 protein denotes CD3
T23 762-765 protein denotes CD2
T24 771-775 protein denotes CD28
T25 801-808 cell_type denotes T cells
T26 906-909 protein denotes CD3
T27 928-941 protein denotes anti-CD28 mAb
T28 945-954 cell_line denotes CHO cells
T29 970-982 protein denotes CD28 ligands
T30 983-987 protein denotes CD80
T31 991-995 protein denotes CD86
T32 1040-1043 protein denotes HS1
T33 1047-1061 cell_line denotes Jurkat T cells
T34 1108-1111 protein denotes HS1
T35 1127-1142 cell_type denotes mitogenic pairs
T36 1146-1159 protein denotes anti-CD2 mAbs
T37 1186-1211 protein denotes transcription factor NFAT
T38 1213-1248 protein denotes nuclear factor of activated T cells
T39 1273-1277 protein denotes CD28
T40 1285-1288 protein denotes CD2
T41 1310-1313 protein denotes CD3
T42 1343-1346 protein denotes HS1
T43 1379-1382 protein denotes CD3
T44 1391-1394 protein denotes HSI
T45 1439-1465 protein denotes Src family tyrosine kinase
T46 1466-1469 protein denotes Lck
T47 1478-1498 protein denotes tyrosine phosphatase
T48 1499-1503 protein denotes CD45
T49 1521-1525 protein denotes MEK1
T50 1564-1580 protein denotes protein kinase C
T51 1608-1611 protein denotes CD3
T52 1613-1617 protein denotes CD28
T53 1653-1672 protein denotes signaling molecules
T54 1748-1751 protein denotes HSI
T55 1815-1818 protein denotes HS1
T56 1840-1844 protein denotes NFAT

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-219 Sentence denotes Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28.
S2 220-292 Sentence denotes CD3, CD2, and CD28 are functionally distinct receptors on T lymphocytes.
S3 293-518 Sentence denotes Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn.
S4 519-674 Sentence denotes Ligation of CD3 also induces the tyrosine phosphorylation of HS1, a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function.
S5 675-886 Sentence denotes We have examined changes in HS1 phosphorylation after differential stimulation of CD3, CD2, and CD28 to elucidate its role in T cells and to further delineate the signaling pathways recruited by these receptors.
S6 887-1062 Sentence denotes Unlike ligation of CD3, stimulation with anti-CD28 mAb or CHO cells expressing the CD28 ligands CD80 or CD86 did not lead to tyrosine phosphorylation of HS1 in Jurkat T cells.
S7 1063-1250 Sentence denotes Additionally, no tyrosine phosphorylation of HS1 was induced by mitogenic pairs of anti-CD2 mAbs capable of activating the transcription factor NFAT (nuclear factor of activated T cells).
S8 1251-1347 Sentence denotes Costimulation through CD28 and/or CD2 did not modulate the CD3-dependent phosphorylation of HS1.
S9 1348-1592 Sentence denotes In vivo studies indicated that CD3-induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD45, did not require MEK1 kinase activity, and was regulated by protein kinase C activation.
S10 1593-1752 Sentence denotes Thus, although CD3, CD28, and CD2 activate many of the same signaling molecules, they differed in their capacity to induce the tyrosine phosphorylation of HSI.
S11 1753-1872 Sentence denotes Furthermore, activation-dependent tyrosine phosphorylation of HS1 was not required for NFAT transcriptional activation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 57-119 NP denotes nuclear factor of activated T cells transcriptional activation
C2 123-137 NP denotes Jurkat T cells
C4 170-173 NP denotes CD3
C3 170-218 NP denotes CD3 and the costimulatory receptors CD2 and CD28
C6 220-223 NP denotes CD3
C7 225-228 NP denotes CD2
C8 234-238 NP denotes CD28
C5 220-238 NP denotes CD3, CD2, and CD28
C9 278-291 NP denotes T lymphocytes
C10 314-329 NP denotes these receptors
C11 376-517 NP denotes a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn
C13 531-534 NP denotes CD3
C12 519-534 NP denotes Ligation of CD3
C15 580-583 NP denotes HS1
C16 585-673 NP denotes a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function
C14 548-673 NP denotes the tyrosine phosphorylation of HS1, a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function
C17 703-722 NP denotes HS1 phosphorylation
C19 757-760 NP denotes CD3
C20 762-765 NP denotes CD2
C21 771-775 NP denotes CD28
C18 757-775 NP denotes CD3, CD2, and CD28
C22 789-792 NP denotes its
C23 801-808 NP denotes T cells
C24 870-885 NP denotes these receptors
C26 906-909 NP denotes CD3
C25 894-909 NP denotes ligation of CD3
C27 1040-1043 NP denotes HS1
C28 1047-1061 NP denotes Jurkat T cells
C29 1108-1111 NP denotes HS1
C30 1273-1277 NP denotes CD28
C31 1285-1288 NP denotes CD2
C32 1343-1346 NP denotes HS1
C34 1608-1611 NP denotes CD3
C35 1613-1617 NP denotes CD28
C36 1623-1626 NP denotes CD2
C33 1608-1626 NP denotes CD3, CD28, and CD2
C37 1644-1672 NP denotes the same signaling molecules
C38 1674-1678 NP denotes they
C39 1691-1696 NP denotes their
C41 1748-1751 NP denotes HSI
C40 1716-1751 NP denotes the tyrosine phosphorylation of HSI
C42 1815-1818 NP denotes HS1
C43 1840-1871 NP denotes NFAT transcriptional activation
R1 C6 C4 coref-ident CD3,CD3
R2 C5 C3 coref-ident "CD3, CD2, and CD28",CD3 and the costimulatory receptors CD2 and CD28
R3 C9 C2 coref-ident T lymphocytes,Jurkat T cells
R4 C10 C5 coref-ident these receptors,"CD3, CD2, and CD28"
R5 C13 C6 coref-ident CD3,CD3
R6 C16 C15 coref-appos a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function,HS1
R7 C19 C13 coref-ident CD3,CD3
R8 C20 C7 coref-ident CD2,CD2
R9 C21 C8 coref-ident CD28,CD28
R10 C18 C10 coref-ident "CD3, CD2, and CD28",these receptors
R11 C22 C17 coref-pron its,HS1 phosphorylation
R12 C23 C9 coref-ident T cells,T lymphocytes
R13 C24 C18 coref-ident these receptors,"CD3, CD2, and CD28"
R14 C26 C19 coref-ident CD3,CD3
R15 C25 C12 coref-ident ligation of CD3,Ligation of CD3
R16 C27 C15 coref-ident HS1,HS1
R17 C28 C23 coref-ident Jurkat T cells,T cells
R18 C29 C27 coref-ident HS1,HS1
R19 C30 C21 coref-ident CD28,CD28
R20 C31 C20 coref-ident CD2,CD2
R21 C32 C29 coref-ident HS1,HS1
R22 C34 C26 coref-ident CD3,CD3
R23 C35 C30 coref-ident CD28,CD28
R24 C36 C31 coref-ident CD2,CD2
R25 C33 C24 coref-ident "CD3, CD28, and CD2",these receptors
R26 C37 C11 coref-ident the same signaling molecules,"a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn"
R27 C38 C33 coref-pron they,"CD3, CD28, and CD2"
R28 C39 C33 coref-pron their,"CD3, CD28, and CD2"
R29 C41 C32 coref-ident HSI,HS1
R30 C40 C14 coref-ident the tyrosine phosphorylation of HSI,"the tyrosine phosphorylation of HS1, a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function"
R31 C42 C41 coref-ident HS1,HSI
R32 C43 C1 coref-ident NFAT transcriptional activation,nuclear factor of activated T cells transcriptional activation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 32-35 protein_molecule denotes HS1
T2 57-92 protein_family_or_group denotes nuclear factor of activated T cells
T3 123-137 cell_line denotes Jurkat T cells
T4 170-173 protein_molecule denotes CD3
T5 206-209 protein_molecule denotes CD2
T6 214-218 protein_molecule denotes CD28
T7 220-223 protein_molecule denotes CD3
T8 225-228 protein_molecule denotes CD2
T9 234-238 protein_molecule denotes CD28
T10 278-291 cell_type denotes T lymphocytes
T11 348-372 other_name denotes tyrosine phosphorylation
T12 394-426 protein_family_or_group denotes intracellular signaling proteins
T13 438-441 protein_molecule denotes Vav
T14 443-446 protein_molecule denotes Cbl
T15 448-477 protein_molecule denotes p85 phosphoinositide 3-kinase
T16 487-505 protein_family_or_group denotes Src family kinases
T17 506-509 protein_molecule denotes Lck
T18 514-517 protein_molecule denotes Fyn
T19 531-534 protein_molecule denotes CD3
T20 552-576 other_name denotes tyrosine phosphorylation
T21 580-583 protein_molecule denotes HS1
T22 587-653 protein_molecule denotes 75-kDa hematopoietic cell-specific intracellular signaling protein
T23 703-706 protein_molecule denotes HS1
T24 729-753 other_name denotes differential stimulation
T25 757-760 protein_molecule denotes CD3
T26 762-765 protein_molecule denotes CD2
T27 771-775 protein_molecule denotes CD28
T28 801-808 cell_type denotes T cells
T29 838-856 other_name denotes signaling pathways
T30 906-909 protein_molecule denotes CD3
T31 928-933 protein_molecule denotes anti-
T32 933-937 protein_molecule denotes CD28
T33 945-954 cell_line denotes CHO cells
T34 970-974 protein_molecule denotes CD28
T35 983-987 protein_molecule denotes CD80
T36 991-995 protein_molecule denotes CD86
T37 1012-1036 other_name denotes tyrosine phosphorylation
T38 1040-1043 protein_molecule denotes HS1
T39 1047-1061 cell_line denotes Jurkat T cells
T40 1080-1104 other_name denotes tyrosine phosphorylation
T41 1108-1111 protein_molecule denotes HS1
T42 1127-1142 cell_type denotes mitogenic pairs
T43 1146-1151 protein_family_or_group denotes anti-
T44 1151-1154 protein_molecule denotes CD2
T45 1186-1211 protein_family_or_group denotes transcription factor NFAT
T46 1213-1248 protein_family_or_group denotes nuclear factor of activated T cells
T47 1273-1277 protein_molecule denotes CD28
T48 1285-1288 protein_molecule denotes CD2
T49 1310-1313 protein_molecule denotes CD3
T50 1343-1346 protein_molecule denotes HS1
T51 1379-1382 protein_molecule denotes CD3
T52 1391-1394 protein_molecule denotes HSI
T53 1439-1465 protein_family_or_group denotes Src family tyrosine kinase
T54 1466-1469 protein_molecule denotes Lck
T55 1478-1498 protein_family_or_group denotes tyrosine phosphatase
T56 1499-1503 protein_molecule denotes CD45
T57 1521-1525 protein_molecule denotes MEK1
T58 1564-1580 protein_molecule denotes protein kinase C
T59 1608-1611 protein_molecule denotes CD3
T60 1613-1617 protein_molecule denotes CD28
T61 1653-1672 protein_family_or_group denotes signaling molecules
T62 1720-1744 other_name denotes tyrosine phosphorylation
T63 1748-1751 protein_molecule denotes HSI
T64 1787-1811 other_name denotes tyrosine phosphorylation
T65 1815-1818 protein_molecule denotes HS1
T66 1840-1844 protein_family_or_group denotes NFAT