PubMed:9794238
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-33 | protein | denotes | IkappaBalpha |
| T2 | 59-67 | protein | denotes | TNFalpha |
| T3 | 96-129 | cell_type | denotes | EBV-infected lymphoblastoid cells |
| T4 | 166-175 | protein | denotes | NF-kappaB |
| T5 | 237-249 | protein | denotes | IkappaBalpha |
| T6 | 255-275 | cell_type | denotes | lymphoblastoid cells |
| T7 | 323-332 | protein | denotes | NF-kappaB |
| T8 | 412-424 | protein | denotes | IkappaBalpha |
| T9 | 551-560 | protein | denotes | cytokines |
| T10 | 587-591 | protein | denotes | BrdU |
| T11 | 691-706 | cell_type | denotes | apoptotic cells |
| T12 | 884-892 | protein | denotes | TNFalpha |
| T13 | 925-943 | cell_line | denotes | transfected clones |
| T14 | 965-995 | cell_line | denotes | IkappaBalpha transfected cells |
| T15 | 1024-1032 | protein | denotes | TNFalpha |
| T16 | 1120-1128 | protein | denotes | TNFalpha |
| T17 | 1168-1185 | cell_line | denotes | transfected cells |
| T18 | 1265-1278 | DNA | denotes | TNFalpha gene |
| T19 | 1310-1319 | protein | denotes | NF-kappaB |
| T20 | 1351-1388 | cell_type | denotes | NF-kappaB protects EBV-infected cells |
| T21 | 1415-1423 | protein | denotes | TNFalpha |
| T22 | 1475-1483 | protein | denotes | cytokine |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-130 | Sentence | denotes | Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells. |
| S2 | 131-276 | Sentence | denotes | In order to understand the role of NF-kappaB in EBV transformation we have established stably transfected IkappaBalpha into lymphoblastoid cells. |
| S3 | 277-425 | Sentence | denotes | Two clones were obtained in which the loss of NF-kappaB binding activity correlated with the constitutive expression of the transgenic IkappaBalpha. |
| S4 | 426-491 | Sentence | denotes | Protein latency expression was determined by immunocytochemistry. |
| S5 | 492-676 | Sentence | denotes | Expression of surface markers, intracytoplasmic content of cytokines cell cycle analysis after BrdU incorporation and DNA staining with propidium iodide were studied by flow cytometry. |
| S6 | 677-764 | Sentence | denotes | Percentage of apoptotic cells was determined by in-situ labelling of DNA strand breaks. |
| S7 | 765-853 | Sentence | denotes | No significative changes in EBV latency nor in cell surface marker expression was found. |
| S8 | 854-944 | Sentence | denotes | In contrast, intracytoplasmic TNFalpha levels were strongly reduced in transfected clones. |
| S9 | 945-1043 | Sentence | denotes | Furthermore, 30% of IkappaBalpha transfected cells were apoptotic after 8 h of TNFalpha treatment. |
| S10 | 1044-1139 | Sentence | denotes | This correlated with a strong reduction of BrdU incorporation after 24 h of TNFalpha treatment. |
| S11 | 1140-1235 | Sentence | denotes | No effect was seen with non transfected cells or with cells transfected with a control plasmid. |
| S12 | 1236-1484 | Sentence | denotes | Our results suggest that the TNFalpha gene could be one of the targets of NF-kappaB in EBV infected cells and that NF-kappaB protects EBV-infected cells from apoptosis induced by TNFalpha, which may favour the proliferative effect of this cytokine. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 166-175 | NP | denotes | NF-kappaB |
| C2 | 277-287 | NP | denotes | Two clones |
| C3 | 305-310 | NP | denotes | which |
| C4 | 587-605 | NP | denotes | BrdU incorporation |
| C5 | 1024-1042 | NP | denotes | TNFalpha treatment |
| C6 | 1087-1105 | NP | denotes | BrdU incorporation |
| C7 | 1120-1138 | NP | denotes | TNFalpha treatment |
| C8 | 1310-1319 | NP | denotes | NF-kappaB |
| C9 | 1323-1341 | NP | denotes | EBV infected cells |
| C10 | 1351-1360 | NP | denotes | NF-kappaB |
| C11 | 1370-1388 | NP | denotes | EBV-infected cells |
| C12 | 1415-1423 | NP | denotes | TNFalpha |
| C13 | 1470-1483 | NP | denotes | this cytokine |
| R1 | C3 | C2 | coref-relat | which,Two clones |
| R2 | C6 | C4 | coref-ident | BrdU incorporation,BrdU incorporation |
| R3 | C7 | C5 | coref-ident | TNFalpha treatment,TNFalpha treatment |
| R4 | C8 | C1 | coref-ident | NF-kappaB,NF-kappaB |
| R5 | C10 | C8 | coref-ident | NF-kappaB,NF-kappaB |
| R6 | C11 | C9 | coref-ident | EBV-infected cells,EBV infected cells |
| R7 | C13 | C12 | coref-ident | this cytokine,TNFalpha |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-33 | protein_molecule | denotes | IkappaBalpha |
| T2 | 59-67 | protein_molecule | denotes | TNFalpha |
| T3 | 96-129 | cell_type | denotes | EBV-infected lymphoblastoid cells |
| T4 | 166-175 | protein_complex | denotes | NF-kappaB |
| T5 | 237-249 | protein_molecule | denotes | IkappaBalpha |
| T6 | 255-275 | cell_type | denotes | lymphoblastoid cells |
| T7 | 323-332 | protein_complex | denotes | NF-kappaB |
| T8 | 370-393 | other_name | denotes | constitutive expression |
| T9 | 412-424 | protein_molecule | denotes | IkappaBalpha |
| T10 | 426-452 | other_name | denotes | Protein latency expression |
| T11 | 471-490 | other_name | denotes | immunocytochemistry |
| T12 | 523-547 | other_name | denotes | intracytoplasmic content |
| T13 | 551-560 | protein_family_or_group | denotes | cytokines |
| T14 | 587-591 | protein_molecule | denotes | BrdU |
| T15 | 628-644 | other_organic_compound | denotes | propidium iodide |
| T16 | 661-675 | other_name | denotes | flow cytometry |
| T17 | 691-706 | cell_type | denotes | apoptotic cells |
| T18 | 725-742 | other_name | denotes | in-situ labelling |
| T19 | 793-796 | virus | denotes | EBV |
| T20 | 812-842 | other_name | denotes | cell surface marker expression |
| T21 | 867-883 | other_name | denotes | intracytoplasmic |
| T22 | 884-892 | protein_molecule | denotes | TNFalpha |
| T23 | 925-943 | cell_line | denotes | transfected clones |
| T24 | 965-977 | protein_molecule | denotes | IkappaBalpha |
| T25 | 1024-1032 | protein_molecule | denotes | TNFalpha |
| T26 | 1087-1091 | nucleotide | denotes | BrdU |
| T27 | 1120-1128 | protein_molecule | denotes | TNFalpha |
| T28 | 1168-1185 | cell_line | denotes | transfected cells |
| T29 | 1265-1273 | protein_molecule | denotes | TNFalpha |
| T30 | 1310-1319 | protein_complex | denotes | NF-kappaB |
| T31 | 1323-1326 | virus | denotes | EBV |
| T32 | 1351-1360 | protein_complex | denotes | NF-kappaB |
| T33 | 1370-1373 | virus | denotes | EBV |
| T34 | 1415-1423 | protein_molecule | denotes | TNFalpha |
| T35 | 1446-1466 | other_name | denotes | proliferative effect |
| T36 | 1475-1483 | protein_family_or_group | denotes | cytokine |