Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-80 |
Sentence |
denotes |
Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma. |
T2 |
81-192 |
Sentence |
denotes |
GLUCOCORTICOIDS are potent inhibitors of inflammatory processes and are widely used in the treatment of asthma. |
T3 |
193-517 |
Sentence |
denotes |
The anti-inflammatory effects are mediated either by direct binding of the glucocorticoid/glucocorticoid receptor complex to glucocorticoid responsive elements in the promoter region of genes, or by an interaction of this complex with other transcription factors, in particular activating protein-1 or nuclear factor-kappaB. |
T4 |
518-665 |
Sentence |
denotes |
Glucocorticoids inhibit many inflammation-associated molecules such as cytokines, chemokines, arachidonic acid metabolites, and adhesion molecules. |
T5 |
666-749 |
Sentence |
denotes |
In contrast, anti-inflammatory mediators often are up-regulated by glucocorticoids. |
T6 |
750-927 |
Sentence |
denotes |
In vivo studies have shown that treatment of asthmatic patients with inhaled glucocorticoids inhibits the bronchial inflammation and simultaneously improves their lung function. |
T7 |
928-1073 |
Sentence |
denotes |
In this review, our current knowledge of the mechanism of action of glucocorticoids and their anti-inflammatory potential in asthma is described. |
T8 |
1074-1263 |
Sentence |
denotes |
Since bronchial epithelial cells may be important targets for glucocorticoid therapy in asthma, the effects of glucocorticoids on epithelial expressed inflammatory genes will be emphasized. |
T1 |
0-80 |
Sentence |
denotes |
Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma. |
T2 |
81-192 |
Sentence |
denotes |
GLUCOCORTICOIDS are potent inhibitors of inflammatory processes and are widely used in the treatment of asthma. |
T3 |
193-517 |
Sentence |
denotes |
The anti-inflammatory effects are mediated either by direct binding of the glucocorticoid/glucocorticoid receptor complex to glucocorticoid responsive elements in the promoter region of genes, or by an interaction of this complex with other transcription factors, in particular activating protein-1 or nuclear factor-kappaB. |
T4 |
518-665 |
Sentence |
denotes |
Glucocorticoids inhibit many inflammation-associated molecules such as cytokines, chemokines, arachidonic acid metabolites, and adhesion molecules. |
T5 |
666-749 |
Sentence |
denotes |
In contrast, anti-inflammatory mediators often are up-regulated by glucocorticoids. |
T6 |
750-927 |
Sentence |
denotes |
In vivo studies have shown that treatment of asthmatic patients with inhaled glucocorticoids inhibits the bronchial inflammation and simultaneously improves their lung function. |
T7 |
928-1073 |
Sentence |
denotes |
In this review, our current knowledge of the mechanism of action of glucocorticoids and their anti-inflammatory potential in asthma is described. |
T8 |
1074-1263 |
Sentence |
denotes |
Since bronchial epithelial cells may be important targets for glucocorticoid therapy in asthma, the effects of glucocorticoids on epithelial expressed inflammatory genes will be emphasized. |